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Tango Controls and data pipeline for petawatt laser experiments

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High Power Laser Science and Engineering 2023年第4期11卷 2-8页

作者： Nils Weiße Leonard Doyle johannes Gebhard Felix Balling Florian Schweiger Florian Haberstroh Laura D.Geulig jinpu Lin Faran Irshad jannik Esslinger Sonja Gerlach max Gilljohann Vignesh Vaidyanathan Dennis Siebert Andreas Münzer Gregor Schilling jörg Schreiber Peter G.Thirolf Stefan Karsch Andreas Döpp Ludwig-maximilians-Universität München GarchingGermany

The Centre for Advanced Laser Applications in Garching,Germany,is home to the ATLAS-3000 multi-petawatt laser,dedicated to research on laser particle acceleration and its applications.A control system based on Tango Controls is implemented for both the laser and four experimental *** device server approach features high modularity,which,in addition to the hardware control,enables a quick extension of the system and allows for automated data acquisition of the laser parameters and experimental data for each laser *** this paper we present an overview of our implementation of the control system,as well as our advances in terms of experimental operation,online supervision and data *** also give an outlook on advanced experimental supervision and online data evaluation–where the data can be processed in a pipeline–which is being developed on the basis of this infrastructure.

关键词： data processing high-power laser experiments laser-plasma acceleration online diagnostics

The unique ORF8 protein from SARS-CoV-2 binds to human dendritic cells and induces a hyper-inflammatory cytokine storm

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journal of Molecular Cell Biology 2023年第10期15卷 39-53页

作者： Matthias Hamdorf Thomas Imhof Ben Bailey-Elkin janina Betz Sebastian jTheobald Alexander Simonis Veronica Di Cristanziano Lutz Gieselmann Felix Dewald Clara Lehmann max Augustin Florian Klein Miguel AAlejandre Alcazar Robert Rongisch Mario Fabri jan Rybniker Heike Goebel jörg Stetefeld Bent Brachvogel Claus Cursiefen Manuel Koch Felix Bock Cornea Lab Experimental Ophthalmology Department of OphthalmologyFaculty of Medicine and University Hospital Cologne50937 CologneGermany Terasaki Institute for Biomedical Innovation Los AngelesCA 90024USA Center for Biochemistry Faculty of Medicine and University Hospital Cologne50931 CologneGermany Institute for Experimental Dentistry and Oral Musculoskeletal Biology Faculty of Medicine and University Hospital Cologne50931 CologneGermany Department of Microbiology University of ManitobaWinnipeg MB R3B 2E9 ManitobaCanada Department I of Internal Medicine Division of Infectious DiseasesFaculty of Medicine and University Hospital Cologne50937 CologneGermany Center for Molecular Medicine Cologne University of Cologne50931 CologneGermany Institute of Virology Faculty of Medicine and University Hospital Cologne50935 CologneGermany German Center for Infection Research(DZIF) Partner Site Bonn-Cologne50931 CologneGermany Department of Children and Adolescent Medicine Faculty of Medicine and University Hospital Cologne50931 CologneGermany Cologne Excellence Cluster Stress Responses in Aging-associated Diseases 50931 CologneGermany Institute for Lung Health(ILH) Universities of Gießen and Marburg Lung CentreMember of the German Center for Lung Research35392 GießenGermany Dermatology Faculty of Medicine and University Hospital Cologne50937 CologneGermany Institute of Pathology Faculty of Medicine and University Hospital Cologne50937 CologneGermany Department of Pediatrics and Adolescent Medicine Experimental NeonatologyFaculty of Medicine and University Hospital Cologne50931 CologneGermany

The novel coronavirus pandemic,first reported in December 2019,was caused by the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).SARS-CoV-2 infection leads to a strong immune response and activation of antigen-presenting cells,which can elicit acute respiratory distress syndrome(ARDS)characterized by the rapid onset of widespread inflammation,the so-called cytokine *** response to viral infections,monocytes are recruited into the lung and subsequently differentiate into dendritic cells(DCs).DCs are critical players in the development of acute lung inflammation that causes ***,we focus on the interaction of a specific SARS-CoV-2 open reading frame protein,ORF8,with *** show that ORF8 binds to DCs,causes pre-maturation of differentiating DCs,and induces the secretion of multiple proinflammatory cytokines by these *** addition,we identified DC-SIGN as a possible interaction partner of ORF8 on *** of ORF8 leads to reduced production of IL-1β,IL-6,IL-12p70,TNF-α,MCP-1(also named CCL2),and IL-10 by ***,a neutralizing antibody blocking the ORF8-mediated cytokine and chemokine response could be an improved therapeutic strategy against SARS-CoV-2.

关键词： COVID-19 SARS-CoV-2 ORF8 cytokine storm dendritic cells

High concentration of calcium ions in Golgi apparatus

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Cell Research 1994年第1期4卷 97-108页

作者： XUE SHAOBAI M. RoBERT NICOUD jIE CUI D.j.ARNDT jOVIN(Depariment of Biology, Beijing Normal University, Beijing 100875, China)(max-Planck-Institute fur Biophysikalische Chemie,Gottingen, Germany) Department of Biology Beijing Normal University Beijing China max-Planck-Institute fSr Biophysikalische Chemie GSttingen Germany

The interphase NIH3T3 cells were vitally fluorescentstained with calcium indicator fluo-3 and Glogi probe C6NBD-ceramide, and then the single cells were examined by laser scanning confocal microscopy (LSCFM) for subcellular distributions of Ca2+ and the location of Golgi apparatus. In these cells, the intracellular Ca2+ were found to be highly concentrated in the Golgi apparatus. The changes of distribution of cytosolic high Ca2+ region and the Golgi apparatus coincided with the cell cycle *** calcium free medium, when the plasma membrane of the cells which had been loaded with fluo-3/AM were permeated by digitonin, the fluorescence of the Golgi region decreased far less than that of the cytosol. Our results indicated that the Glogi lumen retained significantly high concentration of free calcium.

关键词： intracellular free calcium fluo-3/AM Golgi apparatus C6-NBD-ceramide laser scanning confocal microscopy intracellular calcium store

Ionic Liquid-Stabilized Single-Atom Rh Catalyst Against Leaching

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CCS Chemistry 2021年第10期3卷 1814-1822页

作者： Shipeng Ding max jHülsey Hua An Qian He Hiroyuki Asakura Min Gao jun-ya Hasegawa Tsunehiro Tanaka Ning Yan Department of Chemical and Biomolecular Engineering National University of SingaporeSingapore 117585 joint School of the National University of Singapore and Tianjin University International Campus of Tianjin UniversityBinhai New CityFuzhou 350207 Department of Materials Science and Engineering National University of SingaporeSingapore 117575 Department of Molecular Engineering Graduate School of EngineeringJapan and Elements Strategy Initiative for Catalysts and Batteries(ESICB)Kyoto UniversityKyoto 615-8510615-8245 Institute for Catalysis Hokkaido UniversitySapporo 001-0021

Single-atom catalysts(SACs)are promising in some reactions typically promoted by homogeneous ***,the leaching of active species from the support in liquid-phase reactions hinders their potential ***,taking the hydroformylation reaction as an example,we report ionic liquid(IL)-induced stabilization of single Rh atoms against *** the ILs examined.

关键词： single-atom catalysts electrostatic stab ilization ionic liquid leaching

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用作成像元件的曼金镜

航空兵器 1984年第6期 38-42页

作者： max j Riedl 汪国驹

在注重轴上象质的情况下,应该考虑使用曼金镜。它同窄光谱窗口的一起应用具有特殊意义。曼金镜是一个世纪以前由法国军官阿·曼金研制的一种独特的折反式光学元件。它基本上是一种第二面为反射面的负弯月形透镜。我们可选择两个球形表... 详细信息

在注重轴上象质的情况下,应该考虑使用曼金镜。它同窄光谱窗口的一起应用具有特殊意义。曼金镜是一个世纪以前由法国军官阿·曼金研制的一种独特的折反式光学元件。它基本上是一种第二面为反射面的负弯月形透镜。我们可选择两个球形表面中第一面的曲率来校正该反射镜的球差。使用曼金镜,可以避免非球形反射面的昂贵制造工艺。

关键词： TSC 金镜球差

Manufacture and characterization of graphene membranes with suspended silicon proof masses for MEMS and NEMS applications

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Microsystems & Nanoengineering 2020年第1期6卷 1050-1066页

作者： Xuge Fan Anderson D.Smith Fredrik Forsberg Stefan Wagner Stephan Schroder Sayedeh Shirin Afyouni Akbari Andreas C.Fischer Luis Guillermo Villanueva Mikael Ostling max C.Lemme Frank Niklaus Division of Micro and Nanosystems School of Electrical Engineering and Computer ScienceKTH Royal Institute of TechnologySE-10044 StockholmSweden Division of Integrated Devices and Circuits School of Electrical Engineering and Computer ScienceKTH Royal Institute of TechnologySE-16440 KistaSweden Faculty of Electrical Engineering and Information Technology RWTH Aachen UniversityOtto-Blumenthal-Str.2552074 AachenGermany Advanced NEMS Group École Polytechnique Fédérale de Lausanne(EPFL)1015 LausanneSwitzerland Silex Microsystems AB 17526 JärfällaSweden AMO GmbH Advanced Microelectronic Center Aachen(AMICA)Otto-Blumnethal-Str.2552074 AachenGermany

Graphene’s unparalleled strength,chemical stability,ultimate surface-to-volume ratio and excellent electronic properties make it an ideal candidate as a material for membranes in micro-and nanoelectromechanical systems(MEMS and NEMS).However,the integration of graphene into MEMS or NEMS devices and suspended structures such as proof masses on graphene membranes raises several technological challenges,including collapse and rupture of the *** have developed a robust route for realizing membranes made of double-layer CVD graphene and suspending large silicon proof masses on membranes with high *** have demonstrated the manufacture of square graphene membranes with side lengths from 7µm to 110µm,and suspended proof masses consisting of solid silicon cubes that are from 5µm×5µm×16.4µm to 100µm×100µm×16.4µm in *** approach is compatible with wafer-scale MEMS and semiconductor manufacturing technologies,and the manufacturing yields of the graphene membranes with suspended proof masses were>90%,with>70%of the graphene membranes having>90%graphene area without visible *** measured resonance frequencies of the realized structures ranged from tens to hundreds of kHz,with quality factors ranging from 63 to *** graphene membranes with suspended proof masses were extremely robust,and were able to withstand indentation forces from an atomic force microscope(AFM)tip of up to~*** proposed approach for the reliable and large-scale manufacture of graphene membranes with suspended proof masses will enable the development and study of innovative NEMS devices with new functionalities and improved performances.

关键词： proof characterization hundreds

Optimal C-arm angulation during transcatheter aortic valve replacement: Accuracy of a rotational C-arm computed tomography based three dimensional heart model

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World journal of Cardiology 2016年第10期8卷 606-614页

作者： Verena Veulemans Sabine Mollus Axel Saalbach max Pietsch Katharina Hellhammer Tobias Zeus Ralf Westenfeld jürgen Weese Malte Kelm jan Balzer Department of Medicine Division of Cardiology Pulmonary Diseases Vascular Medicine University Hospital Düsseldorf Philips Research Europe Philips GmbH Innovative Technologies Research Laboratories

AIMTo investigate the accuracy of a rotational C-arm CT-based 3D heart model to predict an optimal C-arm configuration during transcatheter aortic valve replacement (TAVR).METHODSRotational C-arm CT (RCT) under rapid ventricular pacing was performed in 57 consecutive patients with severe aortic stenosis as part of the pre-procedural cardiac catheterization. With prototype software each RCT data set was segmented using a 3D heart model. From that the line of perpendicularity curve was obtained that generates a perpendicular view of the aortic annulus according to the right-cusp rule. To evaluate the accuracy of a model-based overlay we compared model- and expert-derived aortic root *** all 57 patients in the RCT cohort diameter measurements were obtained from two independent operators and were compared to the model-based measurements. The inter-observer variability was measured to be in the range of 0°-12.96° of angular C-arm displacement for two independent operators. The model-to-operator agreement was 0°-13.82°. The model-based and expert measurements of aortic root diameters evaluated at the aortic annulus (r = 0.79, P junction (r = 0.92, P < 0.01) correlated on a high level and the Bland-Altman analysis showed good agreement. The interobserver measurements did not show a significant *** segmentation of the aortic root using an anatomical model can accurately predict an optimal C-arm configuration, potentially simplifying current clinical workflows before and during TAVR.

关键词： Aortic stenosis Imaging modalities Degenerative valve disease Transcatheter aortic valve replacement

Multifrequency Polarization Variations in the Quasar 0917+624

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Chinese journal of Astronomy and Astrophysics 2002年第4期2卷 325-346页

作者： Shan－jieQian A.Kraus 等 NationalAstronomicalObservatories ChineseAcademyofSciencesBeijing100012 max－Planck－InstitutfuerRadioastronomie AufdemHuegel6953121BonnGermany

We present a detailed analysis of multi-frequency observations of linear polarization in the intraday variable quasar 0917+624 (z = 1.44). The observations were made in May 1989 at five frequencies (1.4, 2.7, 5.0, 8.3 and 15GHz) with the VLA and the Effelsberg 100 m-telescope and in December 1988 at two frequencies (2.7 and 5.0 GHz) with the latter. It is shown that the relationship between the variations of the polarized and total flux density is highly wavelength dependent, and the multi-frequency polarization behavior may be essential for investigating the mechanisms causing these variations. It is shown that the variations observed at 20 cm can be interpreted in terms of refractive interstellar scintillation. However, after subtracting the variation due to scintillation, three 'features' emerged in the light-curve of the polarized flux density, indicating an additional variable component. Interestingly, these features are shown to be correlated with the variations at 2-6 cm, thus indicating that these features and the associated variations are due to some intrinsic causes. Moreover, a very rapid polarization angle swing of - 180° observed in December 1988 which cannot be explained by refractive interstellar scintillation, may also be produced by an intrinsic mechanism. Accordingly, we use a shock model to explain the polarization variations observed at the higher frequencies, although scintillation could also exist. The shock model can explain not only the variation of intensity, but also the time variation of its degree and angle of polarization, including the rapid swing of the polarization angle. It is shown that the degree and angle of polarization of the shock need only vary slightly in order to account for the observed complicated behaviour of polarization.

关键词： radio continuum: galaxies - polarization - quasars: individual (QSO0917+624)

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Optimization of performance of the KM2A full array using the Crab Nebula

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Chinese Physics C 2024年第6期48卷 169-178页

作者：曹臻 F.Aharonian 安琪阿西克古白云翔包逸炜 D.Bastieri 毕效军毕玉江蔡金庭曹晴曹文羽曹喆常进常劲帆陈尚明陈恩生陈亮陈林陈龙陈明君陈玛丽陈起辉陈素弘陈天禄陈阳程宁程耀东崔明阳崔树旺崔晓红崔昱东戴本忠代洪亮戴子高单增罗布 D.della Volpe 董绪强段凯凯樊军辉范一中方军方堃冯存峰封莉冯少辉丰晓婷冯有亮 S.Gabici 高博高川东高林青高启高卫高伟康葛茂茂耿利斯 G.Giacinti 龚光华苟全补顾旻皓郭福来郭晓磊郭义庆郭莹莹韩毅昂何会海贺昊宁何佳银何新波何钰 M.Heller 贺远强侯博文侯超侯贤胡红波胡铨胡世聪黄代绘黄天奇黄文俊黄性涛黄晓渊黄勇黄志成季筱璐贾焕玉贾康江琨姜晓巍姜泽军金敏康明铭柯通 D.Kuleshov.K.Kurinov 李兵兵李澄李骢李丹李飞李海波李会财李华阳李军李剑李捷李凯李文龙李文莲李秀荣李昕李一卓李哲黎卓梁恩维梁云峰林苏杰刘冰刘成刘栋刘虎刘海东刘佳刘江来刘金艳刘茂元柳若愚刘四明刘伟刘怡刘以农鲁睿罗晴吕洪魁马伯强马玲玲马欣华毛基荣闵振 W.Mitthumsiri 穆慧君南云程 A.Neronov 区子维庞彬宇 P.Pattarakijwanich 裴致远齐孟尧祁业情乔冰强秦家军 D.Ruffolo A.Sáiz D.Semikoz 邵澄宇邵琅 O.Shchegolev 盛祥东舒富文宋慧超 Yu.V.Stenkin V.Stepanov 苏扬孙秦宁孙晓娜孙志斌谭柏轩唐庆文唐泽波田文武王超王昌贝王广威王洪光王惠惠王建成汪凯王利苹王玲玉王培汉王冉王为王祥高王祥玉王阳王玉东王岩谨王忠海王仲翔王振王铮韦大明魏俊杰魏永健文韬吴超勇吴含荣武莎吴雪峰吴雨生席邵强夏捷夏君集项光漫肖迪泫肖刚辛广广辛玉良邢祎熊峥徐东莲徐仁峰徐仁新徐伟立薛良闫大海颜景志颜田杨朝文杨帆杨冯帆杨何文杨佳盈杨莉莉杨明洁杨睿智杨深邦姚玉华姚志国叶一锰尹丽巧尹娜游晓浩游智勇于艳红袁强岳华曾厚敦曾婷轩曾玮查敏张彬彬张丰张海明张恒英张建立张丽霞张力张鹏飞张佩佩张瑞张少博张少如张寿山张潇张笑鹏张云峰张毅张勇赵兵赵静赵雷赵立志赵世平郑福周斌周浩周佳能周猛周平周荣周勋秀祝成光祝凤荣朱辉朱科军左雄 LHAASO Collaboration Key Laboratory of Particle Astrophyics&Experimental Physics Division&Computing Center Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Beijing 100049China Tianfu Cosmic Ray Research Center Chengdu 610000China Dublin Institute for Advanced Studies 31 Fitzwilliam Place2 DublinIreland max-Planck-Institut for Nuclear Physics P.O.Box 10398069029 HeidelbergGermany State Key Laboratory of Particle Detection and Electronics China University of Science and Technology of China Hefei 230026China School of Physical Science and Technology&School of Information Science and Technology Southwest Jiaotong UniversityChengdu 610031China School of Astronomy and Space Science Nanjing UniversityNanjing 210023China Center for Astrophysics Guangzhou UniversityGuangzhou 510006China Hebei Normal University Shijiazhuang 050024China Key Laboratory of Dark Matter and Space Astronomy&Key Laboratory of Radio Astronomy Purple Mountain ObservatoryChinese Academy of SciencesNanjing 210023China Tsung-Dao Lee Institute&School of Physics and Astronomy Shanghai Jiao Tong UniversityShanghai 200240China Key Laboratory for Research in Galaxies and Cosmology Shanghai Astronomical ObservatoryChinese Academy of SciencesShanghai 200030China Key Laboratory of Cosmic Rays(Tibet University) Ministry of EducationLhasa 850000TibetChina National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China School of Physics and Astronomy(Zhuhai)&School of Physics(Guangzhou)&Sino-French Institute of Nuclear Engineering and Technology(Zhuhai) Sun Yat-sen UniversityZhuhai 519000&Guangzhou 510275China School of Physics and Astronomy Yunnan UniversityKunming 650091China Département de Physique Nucléaire et Corpusculaire Facultéde SciencesUniversitéde Genève24 Quai Ernest Ansermet1211 GenevaSwitzerland Institute of Frontier and Interdisciplinary Science Shandong UniversityQingdao 266237China APC Universit'e Paris Cit'eCNRS/IN2P3CEA/IRFUObservat

The full array of the Large High Altitude Air Shower Observatory(LHAASO)has been in operation since july *** its kilometer-square array(KM2A),we optimized the selection criteria for very high and ultrahigh energyγ-rays using data collected from August 2021 to August 2022,resulting in an improvement in significance of the detection in the Crab Nebula of approximately 15%,compared with that of previous *** the implementation of these new selection criteria,the angular resolution was also significantly improved by approximately 10%at tens of *** aspects of the full KM2A array performance,such as the pointing error,were also calibrated using the Crab *** resulting energy spectrum of the Crab Nebula in the energy range of 10-1000 TeV are well fitted by a log-parabola model,which is consistent with the previous results from LHAASO and other experiments.

关键词： γ-ray Crab Nebula significance