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Interventional strategies in infected necrotizing pancreatitis:Indications,timing,and outcomes

World Journal of Gastroenterology 2022年第27期28卷 3383-3397页

作者： Birte Purschke Louisa Bolm max nikolaus meyer Hiroki Sato Department of Gastrointestinal Surgery Massachusetts General HospitalBostonMA 02114United States Department of Radiation Oncology Massachusetts General HospitalBostonMA 02114United States Department of Medicine Asahikawa Medical UniversityAsahikawa 0788510HokkaidoJapan Department of Gastroenterology Asahikawa Kosei HospitalAsahikawa 0788211HokkaidoJapan

Acute pancreatitis(AP)is one of the most common gastrointestinal diseases and remains a life-threatening *** AP resolves to restitutio ad integrum in approximately 80%of patients,it can progress to necrotizing pancreatitis(NP).NP is associated with superinfection in a third of patients,leading to an increase in mortality rate of up to 40%.Accurate and early diagnosis of NP and associated complications,as well as state-of-the-art therapy are essential to improve patient *** emerging role of endoscopy and recent trials on multidisciplinary management of NP established the“step-up approach”.This approach starts with endoscopic interventions and can be escalated to other interventional and ultimately surgical procedures if *** showed that this approach decreases the incidence of new multiple-organ failure as well as the risk of interventional ***,the optimal interventional sequence and timing of interventional procedures remain *** review aims to summarize the indications,timing,and treatment outcomes for infected NP and to provide guidance on multidisciplinary decision-making.

关键词： Pancreatitis Acute necrotizing pancreatitis Necrosis Superinfection Endoscopy Surgery

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Modulating effects of acyl-CoA synthetase 5-derived mitochondrial Wnt2B palmitoylation on intestinal Wnt activity

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World Journal of Gastroenterology 2014年第40期20卷 14855-14864页

作者： Christina Klaus Ursula Schneider Christian Hedberg Anke K Schütz Jürgen Bernhagen Herbert Waldmann nikolaus Gassler Elke Kaemmerer Institute of Pathology RWTH Aachen University 52074 Aachen Germany Department of Chemical Biology Max Planck Institute of Molecular Physiology 44227 Dortmund Germany Department of Biochemistry and Molecular Cell Biology RWTH Aachen University 52074 Aachen Germany Department of Pediatrics RWTH Aachen University 52074 Aachen Germany

AIM: To investigate the role of acyl-CoA synthetase 5 (ACSL5) activity in Wnt signaling in intestinal surface epithelia.

关键词： Acyl-CoA synthetases Wnt signaling Palmitoylation Intestinal barrier Carcinogenesis

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