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Simultaneous screening and classification of diabetic retinopathy and age-related macular degeneration based on fundus photos——a prospective analysis of the RetCAD system

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International Journal of Ophthalmology(English edition) 2022年第12期15卷 1985-1993页

作者： Christos Skevas Hanah Weindler max Levering Jonne Engelberts Mark van Grinsven Toam katz University Clinic Eppendorf Hamburg Hamburg 20246Germany Thirona B.V. Toernooiveld 3006525 ECNijmegenThe Netherlands

AIM:To assess the accuracy of an artificial intelligence(AI)based software(Ret CAD,Thirona,The Netherlands)to identify and grade age-related macular degeneration(AMD)and diabetic retinopathy(DR)simultaneously based on fundus ***:This prospective study included 1245 eyes of 630 patients attending an ophthalmology day-care *** photos were acquired and parallel graded by the Ret CAD AI software and by an expert reference examiner for image quality,and staging of AMD and *** was provided by a second expert examiner in case of disagreement between the AI software and the reference *** analysis was performed on eye-level and on patient-level,by summarizing the individual image level-gradings into and eye-level or patient-level score,*** performance of the Ret CAD system was measured using receiver operating characteristics(ROC)analysis and sensitivity and specificity for both AMD and DR were ***:The Ret CAD achieved an area under the ROC(Az)of 0.926 with a sensitivity of 84.6%at a specificity of 84.0%for image *** image level,the Ret CAD software achieved Az values of 0.964 and 0.961 with sensitivity/specificity pairs of 98.2%/79.1%and 83.9%/93.3%for AMD and DR,*** patient level,the Ret CAD software achieved Az values of 0.960 and 0.948 with sensitivity/specificity pairs of 97.3%/73.3%and 80.0%/90.1%for AMD and DR,*** adjudication by the second expert examiner sensitivity/specificity increases on patient-level to 98.6%/78.3%and 100.0%/92.3%for AMD and DR,***:The Ret CAD offers very good sensitivity and specificity compared to manual grading by experts and is in line with that obtained by similar automated grading *** Ret CAD AI software enables simultaneous grading of both AMD and DR based on the same fundus *** sensitivity may be adjusted according to the desired acceptable sensitivity and *** simplicity cloud base i

关键词： RetCAD age-related macular degeneration diabetic retinopathy

WEST BERKELEY PUBLIC LIBRARY:A CASE STUDY IN ZERO-NET ENERGY LIGHTING DESIGN

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Journal of Green Building 2015年第2期10卷 25-41页

作者： max Pierson Minuscule San Francisco CA 94102 USA

Designing lighting for zero-net energy buildings poses unique and fascinating design *** the challenge of providing lighting loads on the order of.1W/sqft2,these projects require toolsets beyond the typical scope of a light-ing design consultant,including detailed controls design and photometric pre-dictions of available *** new roles are part of a broader trend in lighting design as,driven by new code requirements and a general push towards high-performing buildings,lighting design is becoming a more technical,metrics-driven ***’s a delicate balancing act here,and indeed we have the same responsibility to these projects as any other:lighting that is comfortable and functional for the occupants,that supports the architectural gesture,and that is available within the project *** the task is not simply to design the absolute minimum energy density(although yes,also that),but rather to identify ways in which all of these constraints may be harmonized,and embrace the collaborative and iterative workflow that these projects *** case study is written for architects,engineers,owners and others that want an overview of the lighting design process for ultra-low energy density buildings.I’ll gloss both the absolute basics and the more esoteric technical details in favor of discussing practical techniques that we used successfully to further the project goals,and the trade-offs we confronted.

关键词： Lighting Design Zero-Net Public Space Daylighting

Auxiliary Equations Approach for the Stochastic Unsteady Navier-Stokes Equations with Additive Random Noise

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Numerical Mathematics(Theory,Methods and Applications) 2020年第1期13卷 1-26页

作者： Wenju Zhao max Gunzburger Department of Mathematics Southern University of Science and TechnologyShenzhenGuangdong 518055China Department of Scientific Computing Florida State UniversityTallahasseeFL 32304USA

This paper presents a Martingale regularization method for the stochas-tic Navier–Stokes equations with additive *** original system is split into two equivalent parts,the linear stochastic Stokes equations with Martingale solution and the stochastic modified Navier–Stokes equations with relatively-higher ***,a fractional Laplace operator is introduced to regularize the noise *** stability and convergence of numerical scheme for the pathwise modified Navier–Stokes equations are *** comparisons of non-regularized and reg-ularized noises for the Navier–Stokes system are numerically presented to further demonstrate the efficiency of our numerical scheme.

关键词： Stochastic Navier-Stokes equations Martingale regularization method Galerkin finite element method white noise

Data democracy–increased supply of geospatial information and expanded participatory processes in the production of data

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International Journal of Digital Earth 2015年第9期8卷 679-693页

作者： max Craglia Lea Shanley European Commission Joint Research CentreIspraItaly Gaylord Nelson Institute for Environmental Studies University of WisconsinMadisonWIUSA

The global landscape in the supply,co-creation and use of geospatial data is changing very rapidly with new satellites,sensors and mobile devices reconfiguring the traditional lines of demand and supply and the number of actors *** this paper we chart some of these technology-led developments and then focus on the opportunities they have created for the increased participation of the public in generating and contributing information for a wide range of uses,scientific and *** all this information is open or geospatial,but sufficiently large portions of it are to make it one of the most significant phenomena of the last *** fact,we argue that while satellite and sensors have exponentially increased the volumes of geospatial information available,the participation of the public is transformative because it expands the range of participants and stakeholders in society using and producing geospatial information,with opportunities for more direct participation in science,politics and social action.

关键词： citizen science volunteered geographic information geospatial data

Reliability-based congestion pricing model under endogenous equilibrated market penetration and compliance rate of ATIS

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Journal of Central South University 2015年第3期22卷 1155-1165页

作者：钟绍鹏邓卫 Bushell max School of Transportation and Logistics Dalian University of Technology School of Transportation Southeast University Pedestrian and Bicycle Information Center University of North Carolina at Chapel Hill

A reliability-based stochastic system optimum congestion pricing(SSOCP) model with endogenous market penetration and compliance rate in an advanced traveler information systems(ATIS) environment was proposed. All travelers were divided into two classes. The first guided travelers were referred to as the equipped travelers who follow ATIS advice, while the second unguided travelers were referred to as the unequipped travelers and the equipped travelers who do not follow the ATIS advice(also referred to as non-complied travelers). Travelers were assumed to take travel time, congestion pricing, and travel time reliability into account when making travel route choice decisions. In order to arrive at on time, travelers needed to allow for a safety margin to their *** market penetration of ATIS was determined by a continuous increasing function of the information benefit, and the ATIS compliance rate of equipped travelers was given as the probability of the actually experienced travel costs of guided travelers less than or equal to those of unguided travelers. The analysis results could enhance our understanding of the effect of travel demand level and travel time reliability confidence level on the ATIS market penetration and compliance rate; and the effect of travel time perception variation of guided and unguided travelers on the mean travel cost savings(MTCS) of the equipped travelers, the ATIS market penetration, compliance rate, and the total network effective travel time(TNETT).

关键词： reliability advanced traveler information systems market penetration compliance rate stochastic system optimum congestion pricing non-additive path cost

Electrolyser design controls position-divergent C–H carboxylation

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Science China Chemistry 2023年第6期66卷 1549-1550页

作者： max Surke Rong Zhao Lutz Ackermann Institut für Organische und Biomolekulare Chemie Georg-August-Universitot GottingenTammannstraBe 237077 GotingenGermany Wohler Research Institute for Sustainable Chemistry Georg-August-Universitot GottingenTammannstraBe 237077 GotingenGermany German Center for Cardiovascular Research(DZHK) Potsdamer StraBe 5810785 BerlinGermany

In recent years,molecular electrochemistry has undergone a remarkable renaissance to surface as a sustainable strategy for organic synthesis and catalysis,gaining considerable momentum by the use of renewable forms of energy[1,2].Modern organic electrochemistry has the unique power to control chemo-,regio-,and position-selectivities through the judicious choice of the electrode material,the applied potential or an additional catalyst,among others[1,2].Despite the major advances in molecular electrochemistry,these approaches continue to predominantly rely on non-renewable fossil resources.

关键词： electrochemistry momentum catalysis

Three paternally imprinted regions are sequentially required in prenatal and postnatal mouse development

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Science China(Life Sciences) 2020年第1期63卷 165-168页

作者： max Jiahua Li Xiajun Li School of Life Sciences and Technology Shanghai Tech University

Reproduction in mammals is primarily through fertilization of the oocytes and sperms generated by the females and males,*** of two haploid genomes leads to formation of the diploid zygotes,which sequentially gives rise to the pre-implantation and post-implantation embryos before live pups are *** asexual reproduction does occur in lower animals such as amphibians,it has never been achieved in mammals before until very recently.

关键词： sequentially implantation primarily

Colonies of ants allocate exploratory individuals to where they are ecologically needed

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Current Zoology 2023年第5期69卷 585-591页

作者： max Madrzyk Noa Pinter-Wollman Department of Ecology and Evolutionary Biology University of CaliforniaLos AngelesCAUSA

Individual differences in behavior have large consequences for the way in which ecology impacts *** differ in how they explore their environment and how exploratory behavior benefits *** group-living animals,behavioral heterogeneity can be beneficial because different individuals perform different *** example,exploratory individuals may discover new food sources and recruit group members to exploit the food,while less exploratory individuals forgo the risks of *** we ask how individual variation in exploratory behavior affects the ability of Argentine ant Linepithema humile colonies to(1)locate novel food sources,(2)exploit known food resources,and(3)respond to disruptions while *** address these questions,we conducted field experiments on *** foraging trails in which we manipulated food availability near and at the foraging trails and disrupted the foraging *** sampled individuals based on their response to the perturbations in the field and tested their exploratory behavior in the *** found that exploratory individuals benefit the colony by locating novel foods and increasing resource exploitation,but they do not play an important role in the recovery of a foraging trail after ***,the benefits of behavioral heterogeneity to the group,specifically in exploratory behavior,differ across ecological contexts.

关键词： exploration foraging individual variation novel resources recruitment resilience

A Tropical View on Landau-Ginzburg Models

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Acta Mathematica Sinica,English Series 2024年第1期40卷 329-382页

作者： Michael CARL max PUMPERLA Bernd SIEBERT Alfred-Delp-Str.2 73430 AalenGermany IU Internationale Hochschule Juri-Gagarin-Ring 15299084 ErfurtGermany AnyscaleInc.2080 Addison St Ste 7BerkeleyCA 94704USA Department of Mathematics The Univ.of Texas at Austin2515 SpeedwayAustinTX 78712USA

This paper,largely written in 2009/2010,fits Landau-Ginzburg models into the mirror symmetry program pursued by the last author jointly with Mark Gross since *** point of view transparently brings in tropical disks of Maslov index 2 via the notion of broken lines,previously introduced in two dimensions by Mark Gross in his study of mirror symmetry for P2.A ma jor insight is the equivalence of properness of the Landau-Ginzburg potential with smoothness of the anticanonical divisor on the mirror *** obtain proper superpotentials which agree on an open part with those classically known for toric *** include mirror LG models for non-singular and singular del Pezzo surfaces,Hirzebruch surfaces and some Fano threefolds.

关键词： Landau-Ginzburg model mirror symmetry tropical disk broken line wall structure scattering diagram Gross-Siebert program del Pezzo surface toric degeneration