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Overview of acidic deep eutectic solvents on synthesis,properties and applications

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Green Energy & Environment 2020年第1期5卷 8-21页

作者： Hao Qin Xutao Hu Jingwen Wang Hongye cheng Lifang Chen Zhiwen Qi max Planck Partner Group at the State Key Laboratory of Chemical Engineering School of Chemical EngineeringEast China University of Science and Technology

This review divides the acidic deep eutectic solvents(ADES) into Br?nsted and Lewis DES according to their diversity of acidic *** hydrogen bond donors and halide salts for formulating an ADES are classified, the synthesis methods are described, and the physicochemical properties including freezing point, acidity, density, viscosity and conductivity are presented. Furthermore, the applications of Br?nsted acidic deep eutectic solvents(BADES) and Lewis acidic deep eutectic solvents(LADES) are overviewed, respectively, covering the fields in dissolution, extraction, organic reaction and metal electrodeposition. It is expected that the ADES has great potential to replace the pollutional mineral acid, expensive and unstable solid acid, and costly ionic liquid in many acid-employed chemical processes, thus meeting the demands of green chemistry.

关键词： Acidic deep eutectic solvent Brφnsted acidity Lewis acidity Green chemistry

替米沙坦片在中国健康受试者的生物等效性研究

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中国临床药理学杂志 2024年第2期40卷 249-253页

作者：孙成张燕房红霞陈桂英章晓娟孙洪勋姜彬淄博万杰肿瘤医院Ⅰ期临床试验研究室山东淄博255213 武汉宏韧生物医药股份有限公司湖北武汉430000 淄博万杰制药有限公司山东淄博255200

目的评价替米沙坦片(80 mg)受试制剂与参比制剂在中国健康受试者中的生物等效性。方法采用单中心、随机、开放、两制剂、单次给药、餐后三周期三序列部分重复交叉和空腹四周期两序列完全重复交叉的生物等效性试验设计。餐后和空腹试验... 详细信息

目的评价替米沙坦片(80 mg)受试制剂与参比制剂在中国健康受试者中的生物等效性。方法采用单中心、随机、开放、两制剂、单次给药、餐后三周期三序列部分重复交叉和空腹四周期两序列完全重复交叉的生物等效性试验设计。餐后和空腹试验分别入组33和32例健康受试者,每周期分别单次口服受试制剂或参比制剂80 mg,用液相色谱-串联质谱法测定血浆中替米沙坦的浓度,用WinNonlin 8.3计算药代动力学参数,并用SAS 9.4进行统计分析。结果空腹条件下口服替米沙坦片受试制剂或参比制剂后的主要药代动力学参数:C_(max)分别为(556.10±456.06)和(580.99±533.50)ng·mL^(-1),AUC_(0-t)分别为(3475.15±3785.16)和(3450.54±3681.02)ng·mL^(-1)·h,AUC_(0-∞)分别为(3214.06±2272.06)和(3194.84±2187.45)ng·mL^(-1)·h,2种制剂C_(max)、AUC_(0-t)和AUC_(0-∞)几何均值比值及其90%置信区间,均落在80.00%~125.00%;餐后条件下口服替米沙坦片受试制剂或参比制剂后的主要药代动力学参数:C_(max)分别为(299.26±124.72)和(291.29±126.34)ng·mL^(-1),AUC_(0-t)分别为(3682.24±2799.72)和(3636.71±2158.42)ng·mL^(-1)·h,AUC_(0-∞)分别为(3544.53±1553.06)和(3969.38±2528.22)ng·mL^(-1)·h,2种制剂C_(max)、AUC_(0-t)和AUC_(0-∞)几何均值比值及其90%置信区间,均落在80.00%~125.00%。结论空腹和餐后条件下,替米沙坦片受试和参比制剂在中国健康受试者中具有生物等效性。

关键词：替米沙坦片生物等效性药代动力学参数

Effect of water on extractive desulfurization of fuel oils using ionic liquids： A COSMO-RS and experimental study

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Chinese Journal of Chemical Engineering 2017年第2期25卷 159-165页

作者： Zhen Song Dian Yu Qian Zeng Jingjing Zhang Hongye cheng Lifang Chen Zhiwen Qi max Planck Partner Group at the State Key Laboratory of Chemical Engineering School of Chemical Engineering East Chino University of Sdence and Technology Shanghai 200237 China

When evaluating ionic liquids （ILs） for extractive desulfurization （EDS） of fuel oils, the inevitable presence of water in the system may have a significant and in many cases strongly negative effect. However, few studies have considered this particular issue and a promoted water effect on EDS is scarcely reported. In this work, COSMO-RS was firstly employed to calculate the capacity and selectivity for EDS of various IL/H20 mixtures, which cover different IL characters and a wide water concentration range. Experiments were then conducted with a representative IL [C4MIM]IH2P04], whose stable and even promoted extraction performance with a small amount of water was suggested by COSMO-RS. Through analyses of the desulfurization ratio, the cross- solubility and the water content in the desulfurized fuel, the promoted effect of water within a certain range （〈 10 wt%） was experimentally demonstrated. Moreover, such effect of water was explained combining the viscosity, the solvent-solute interactions and the COSMO-RS based analysis.

关键词： Extractive desulfudzationIonic liquidsCOSMO-RSWater content effect

Supervised Vessels Classification Based on Feature Selection

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Journal of Computer Science & Technology 2017年第6期32卷 1222-1230页

作者： Bei-Ji Zou Yao Chen cheng-Zhang Zhu Zai-Liang Chen Zi-Qian Zhang School of Information Science and Engineering Central South University Changsha 410083 China ‘Mobile Health' Ministry of Education-China Mobile Joint Laboratory Central South University Changsha 410083 China College of Literature and Journalism Central South University Changsha 410083 China

Arterial-venous classification of retinal blood vessels is important for the automatic detection of cardiovascular diseases such as hypertensive retinopathy and stroke. In this paper, we propose an arterial-venous classification （AVC） method, which focuses on feature extraction and selection from vessel centerline pixels. The vessel centerline is extracted after the preprocessing of vessel segmentation and optic disc （OD） localization. Then, a region of interest （ROI） is extracted around OD, and the most efficient features of each centerline pixel in ROI are selected from the local features, grey-level co-occurrence matrix （GLCM） features, and an adaptive local binary patten （A-LBP） feature by using a max-relevance and min-redundancy （mRMR） scheme. Finally, a feature-weighted K-nearest neighbor （FW-KNN） algorithm is used to classify the arterial-venous vessels. The experimental results on the DRIVE database and INSPIRE-AVR database achieve the high accuracy of 88.65% and 88.51% in ROI, respectively.

关键词： fundus image arterial-venous classification adaptive local binary patten(A-LBP) feature selection feature-weighted K-nearest neighbor(FW-KNN)

Vault predicting after implantable collamer lens implantation using random forest network based on different features in ultrasound biomicroscopy images

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国际眼科杂志:英文版 2023年第10期16卷 1561-1567页

作者： Bin Fang Qiu-Jian Zhu Hui Yang Li-cheng Fan School of Mechanical and Electrical Engineering Soochow UniversitySuzhou 215100Jiangsu ProvinceChina Lixiang Eye Hospital of Soochow University Suzhou 215021 Jiangsu ProvinceChina

AIM:To analyze ultrasound biomicroscopy(UBM)images using random forest network to find new features to make predictions about vault after implantable collamer lens(ICL)***:A total of 450 UBM images were collected from the Lixiang Eye Hospital to provide the patient’s preoperative parameters as well as the vault of the ICL after *** vault was set as the prediction target,and the input elements were mainly ciliary sulcus shape parameters,which included 6 angular parameters,2 area parameters,and 2 parameters,distance between ciliary sulci,and anterior chamber height.A random forest regression model was applied to predict the vault,with the number of base estimators(n_estimators)of 2000,the maximum tree depth(max_depth)of 17,the number of tree features(max_features)of Auto,and the random state(random_state)of ***:Among the parameters selected in this study,the distance between ciliary sulci had a greater importance proportion,reaching 52%before parameter optimization is performed,and other features had less influence,with an importance proportion of about 5%.The importance of the distance between the ciliary sulci increased to 53% after parameter optimization,and the importance of angle 3 and area 1 increased to 5% and 8%respectively,while the importance of the other parameters remained unchanged,and the distance between the ciliary sulci was considered the most important *** features,although they accounted for a relatively small proportion,also had an impact on the vault *** parameter optimization,the best prediction results were obtained,with a predicted mean value of 763.688μm and an actual mean value of 776.9304μ*** R²was 0.4456 and the root mean square error was ***:A study based on UBM images using random forest network can be performed for prediction of the vault after ICL implantation and can provide some reference for ICL size selection.

关键词： random forest network ultrasound biomicroscopy images vault prediction implantable collamer lens

Plant metabolism paves the way for breeding crops with high nutritional value and stable yield

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Science China(Life Sciences) 2021年第12期64卷 2202-2205页

作者： cheng Jin Chuanying Fang Yuanyuan Zhang Alisdair R.Fernie Jie Luo College of Tropical Crops Hainan UniversityHaikou 572208China max Planck Institute of Molecular Plant Physiology Potsdam-Golm 14476Germany Centre of Plant Systems Biology and Biotechnology Plovdiv 4000Bulgaria

Plant metabolites often harbor diverse bioactivities;for humans,plant-derived bioactive metabolites are indispensable for ***,plants produce these metabolites to keep themselves *** the domestication and improvement of crops,humans largely focused on increased yield to support population *** example,large seed sizes,high seed weights,and low seed shattering were selected in cereal crops,whereas fruit sizes and shapes were selected in vegetable crops.

关键词： crops breeding Plant

格列吡嗪片在中国健康受试者中的生物等效性研究

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中国临床药理学杂志 2024年第11期40卷 1628-1632页

作者：郑飞浪程林忠李海菊杨璐刘泽源王素玲长治医学院附属和平医院药剂科山西长治046000 长治医学院附属和平医院药物临床试验机构山西长治046000 中国人民解放军总医院第五医学中心药物临床试验机构北京100039

目的研究2种格列吡嗪片制剂在中国健康受试者的生物等效性。方法用单剂量、随机、开放、两周期、自身交叉对照试验设计,空腹试验、餐后试验各入组28例健康受试者,2个周期分别口服格列吡嗪片受试制剂或参比制剂5 mg。用液相色谱串联质谱... 详细信息

目的研究2种格列吡嗪片制剂在中国健康受试者的生物等效性。方法用单剂量、随机、开放、两周期、自身交叉对照试验设计,空腹试验、餐后试验各入组28例健康受试者,2个周期分别口服格列吡嗪片受试制剂或参比制剂5 mg。用液相色谱串联质谱法测定给药后不同时间点格列吡嗪的血药浓度,用非房室模型计算药代动力学参数,评价2种制剂的生物等效性。结果空腹试验中格列吡嗪受试制剂和参比制剂的主要药代动力学参数:C_(max)分别为(551.60±91.26)和(518.10±105.10)ng·mL^(-1),AUC_(0-t)分别为(3074.33±861.91)和(3026.77±934.25)h·ng·mL^(-1),AUC_(0-∞)分别为(3204.85±990.78)和(3166.35±1107.36)h·ng·mL^(-1)。餐后试验中格列吡嗪受试制剂和参比制剂的主要药代动力学参数C_(max)分别为(517.30±98.97)和(472.80±114.48)ng·mL^(-1),AUC_(0-t)分别为(3001.12±830.87)和(2932.79±736.35)h·ng·mL^(-1),AUC_(0-∞)分别为(3067.00±918.84)和(2997.44±819.14)h·ng·mL^(-1)。受试制剂与参比制剂主要药代动力学参数C_(max)、AUC_(0-t)和AUC_(0-∞)经对数转换后几何均值比值的90%置信区间均在80.00%~125.00%。空腹组与餐后组均未发生严重不良事件。结论2种格列吡嗪片在空腹及餐后状态下均具有生物等效性,且安全性良好。

关键词：格列吡嗪片生物等效性药代动力学安全性

The ALMA-QUARKS Survey.Ⅰ.Survey Description and Data Reduction

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Research in Astronomy and Astrophysics 2024年第2期24卷 104-124页

作者：刘训川 Tie Liu Lei Zhu Guido Garay Hong-Li Liu Paul Goldsmith Neal Evans Kee-Tae Kim Sheng-Yuan Liu Fengwei Xu Xing Lu Anandmayee Tej Xiaofeng Mai Leonardo Bronfman Shanghuo Li Diego Mardones Amelia Stutz Ken'ichi Tatematsu Ke Wang Qizhou Zhang Sheng-Li Qin Jianwen Zhou Qiuyi Luo Siju Zhang Yu cheng Jinhua He Qilao Gu Ziyang Li Zhenying Zhang Suinan Zhang Anindya Saha Lokesh Dewangan Patricio Sanhueza Zhiqiang Shen Shanghai Astronomical Observatory Chinese Academy of SciencesShanghai 200030China Chinese Academy of Sciences South America Center for Astronomy National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China Departamento de Astronomía Universidad de ChileLas Condes7591245 SantiagoChile School of Physics and Astronomy Yunnan UniversityKunming 650091China Jet Propulsion Laboratory California Institute of Technology4800 Oak Grove DrivePasadena CA 91109USA Department of Astronomy The University of Texas at AustinTX 78712-1205USA Korea Astronomy and Space Science Institute 776 Daedeokdae-roYuseong-guDaejeon 34055Republic of Korea Institute of Astronomy and Astrophysics Academia SinicaRoosevelt RoadTaipei 10617China Kavli Institute for Astronomy and Astrophysics Peking UniversityBeijing 100871China Department of Astronomy School of PhysicsPeking UniversityBeijing 100871China Indian Institute of Space Science and Technology Thiruvananthapuram 695547KeralaIndia max Planck Institute for Astronomy Königstuhl 17D-69117 HeidelbergGermany Departamento de Astronomía Universidad de ConcepciónCasilla 160-CConcepciónChile Nobeyama Radio Observatory National Astronomical Observatory of JapanNational Institutes of Natural Sciences462-2 NobeyamaMinamimakiMinamisakuNagano 384-1305Japan Center for Astrophysics∣Harvard&Smithsonian 60 Garden StreetCambridgeMA 02138USA max-Planck-Institut für Radioastronomie Auf dem Hügel 69D-53125 BonnGermany School of Astronomy and Space Sciences University of Chinese Academy of SciencesBeijing 100049China National Astronomical Observatory of Japan 2-21-1 OsawaMitakaTokyo181-8588Japan Yunnan Observatories Chinese Academy of SciencesKunming 650216China Physical Research Laboratory NavrangpuraAhmedabad-380009India Astronomical Science Program The Graduate University for Advanced StudiesSOKENDAI2-21-1 OsawaMitakaTokyo 181-8588Japan University of Science and Technology Korea(UST)217 Gajeong-roYuseong-guDaejeon 34113Republic o

This paper presents an overview of the QUARKS survey,which stands for Querying Underlying mechanisms of massive star formation with ALMA-Resolved gas Kinematics and Structures."The QUARKS survey is observing139 massive clumps covered by 156 pointings at Atacama Large Millimeter/submillimeter Array(ALMA)Band 6(λ~1.3 mm).In conjunction with data obtained from the ALMA-ATOMS survey at Band 3(λ~3 mm),QUARKS aims to carry out an unbiased statistical investigation of massive star formation process within protoclusters down to a scale of 1000 *** overview paper describes the observations and data reduction of the QUARKS survey,and gives a first look at an exemplar source,the mini-starburst Sgr B2(M).The wide-b and width(7.5 GHz)and high-angular-resolution(~0."3)observations of the QUARKS survey allow for the resolution of much more compact cores than those could be done by the ATOMS survey,and to detect previously unrevealed fainter filamentary *** spectral windows cover transitions of species including CO,SO,N_(2)D^(+),SiO,H_(30)α,H_(2)CO,CH_(3)CN,and many other complex organic molecules,tracing gas components with different temperatures and spatial *** aims to deepen our understanding of several scientific topics of massive star formation,such as the mass transport within protoclusters by(hub-)filamentary structures,the existence of massive starless cores,the physical and chemical properties of dense cores within protoclusters,and the feedback from already formed high-mass young protostars.

关键词： stars formation-stars kinematics and dynamics-ISM clouds-ISM molecules

种植密度对玉米籽粒灌浆特性和干物质积累的影响

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农学学报 2024年第8期14卷 1-8页

作者：杨美丽王帮太鹿红卫程建梅苏玉杰赵树政张晓春程翠秦贵文鹤壁市农业科学院河南鹤壁458030

为探明不同种植密度下玉米籽粒灌浆特性、植株干物质积累、产量及其构成因素的变化规律及相关性。本研究在2021—2022年以中高产玉米品种‘永优1573’、‘永优1593’为试验材料,设置3个密度6.00万、7.50万、9.00万株/hm~2。结果表明,不... 详细信息

为探明不同种植密度下玉米籽粒灌浆特性、植株干物质积累、产量及其构成因素的变化规律及相关性。本研究在2021—2022年以中高产玉米品种‘永优1573’、‘永优1593’为试验材料,设置3个密度6.00万、7.50万、9.00万株/hm~2。结果表明,不同种植密度下,籽粒百粒重呈“快增-慢增”的上升趋势,籽粒灌浆速率呈“先增后降”的单峰曲线变化,灌浆峰值出现在授粉后22 d左右;增加种植密度使理论最大百粒重(a)、籽粒最大灌浆速率(R_(max))、平均灌浆速率(R_(mean))以及灌浆达到最大速率时的籽粒重(W_(max))均显著降低,且单株产量与百粒重、穗粒数、W_(max)、R_(max)和R_(mean)呈显著正相关。授粉后植株干物质积累随着密度的增加而降低,高密度下降更显著,灌浆前期植株营养器官比重较大,灌浆中后期植株各器官所占比重依次为籽粒>茎鞘>叶片>穗轴>苞叶,茎鞘干重对籽粒产量的贡献率最大。增加种植密度使不同玉米品种穗长、穗粗、穗粒数、单株产量降低,秃尖长增加,单位面积产量在7.50万株/hm~2时最高。品种间差异显著,‘永优1573’百粒重小于‘永优1593’,穗粒数和单位面积产量则是前者大于后者,百粒重和穗粒数共同影响单位面积产量。本研究为中高产玉米品种选择最佳种植密度和提高玉米产量提供理论依据,对实现豫北地区夏玉米高效增产也具有指导意义。

关键词：玉米种植密度灌浆特性干物质积累产量

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