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Non-anatomical liver resection for hepatocellular carcinoma:the SegSubTe classification to overcome the problem of heterogeneity

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Hepatobiliary & Pancreatic Diseases International 2024年第3期23卷 265-271页

作者： Mattia Garancini Alessandro Fogliati mauro Alessandro Scotti Cristina Ciulli Francesca Carissimi Antonio Rovere Luca Gianotti Fabrizio Romano Unit of Hepatobiliopancreatic Surgery Department of SurgeryASST-MonzaSan Gerardo HospitalUniversity of Milano-Bicoccavia Pergolesi 33MonzaMB 20052Italy Interventional Radiology Department of RadiologyASST-MonzaSan Gerardo HospitalMilano-Bicocca Universityvia Pergolesi 33MonzaMB 20052Italy

Background:The superiority of anatomical resection(AR)***-anatomical resection(NAR)in the surgical management of hepatocellular carcinoma(HCC)is *** are well-defined procedures,whereas the lack of NAR standardization results in heterogeneous *** study aimed to introduce the SegSubTe classification for NAR detailing the appropriateness of the level of surgical section of the Glissonean pedicles feeding the ***:A single-center retrospective analysis of pre-and postoperative imaging of consecutive patients treated with NAR for single HCC between 2012 and 2020 was *** quality of surgery was assessed classifying the type of vascular supply and the level of surgical section(segmental,subsegmental or terminal next to the tumor)of vascular pedicles feeding the HCCs;then,the population was divided in“SegSubTe-IN”or“SegSubTe-OUT”groups,and the tumor recurrence and survival were ***:Ninety-seven patients who underwent NAR were included;76%were SegSubTe-IN and 24%were *** disease recurrence,local recurrence and cut-edge recurrence in the SegSubTe-IN ***-OUT groups were 50%vs.83%(P=0.006),20%vs.52%(P=0.003)and 16%vs.39%(P=0.020),***-OUT odds ratio for local recurrence was 4.1 at univariate regression ***-,three-,and five-year disease-free survival rates in the SegSubTe-IN ***-OUT groups were 81%,58%and 35%vs.46%,21%and 11%,respectively(P<0.001).Conclusions:The SegSubTe classification is a useful tool to stratify and standardize NAR for HCC,aiming at improving long-term oncological outcomes and reducing the heterogeneity of quality of NAR for HCC.

关键词： Hepatocellular carcinoma Intraoperative ultrasound Liver surgery Computed tomography Surgical procedure

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Predicting cardiovascular events in out-of-hospital patients presenting with atypical chest pain and complete left bundle branch block: role of CTA and echocardiographic Global Longitudinal Strain

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Journal of Geriatric Cardiology 2024年第7期21卷 760-767页

作者： Guido Pastorini Fabio Anastasio Anna Botto Valentina Tardivo mauro Feola Cardiology Division Regina Montis Regalis HospitalASLCN1Mondovi’Italy Intensive Care Regina Montis Re-galis HospitalASLCN1 Mondovi’Italy School of Geriatry University of MedicineTurinItaly

Background Out-of-hospital patients presenting with atypical chest pain and complete left bundle branch block(LBBB)have to be stratified for the presence of coronary artery disease and the risk of developing heart failure(HF).We investigated the pro-gnostic role of coronary CT-angiography(CTA)and echocardiographic global longitudinal strain(GLS)in those patients in a mid-term *** Out-of-hospital patients with LBBB underwent echocardiography and a 64-slice CT angiography were evaluated *** of HF or a cardiovascular death were the events *** Seventy-eight patients(32 female;mean age:66.0±10.4 years were *** a follow-up of 33 months(IQR:17-77),one patient(1.5%)experienced a cardiovascular death,14 patients(17.9%)required urgent outpatient visits due to acute de-compensated HF(12 hospitalizations).Echocardiography showed a slightly reduced left ventricular ejection fraction(LVEF)(50.0%±9.8%)and GLS within the normal range(-16.2%±4.1%).CTA analysis showed coronary stenosis>50%in 28 patients(35.9%).A high Agatston score(>100)was observed in 29.5%.Notably,25 patients(32.1%)were diagnosed with left main coron-ary artery disease and 15 patients(16.7%)underwent revascularization during the follow *** associations were ob-served between events and LVEF(P=0.001),diastolic dysfunction grade≥2(P=0.02),GLS(P<0.001),multiple coronary stenos-is(P=0.04)and Agatston score(P=0.05).Multivariate analysis confirmed the relationships with LVEF(R^(2)=0.89,P<0.001),dia-stolic dysfunction(R^(2)=3.30,P=0.04),GLS(R^(2)=1.43,P<0.001),and Agatston score(R^(2)=1.01,P=0.05).Conclusions In patients with complete LBBB,CTA and GLS identified those at a high risk of development HF.

关键词： patients echocardiographic branch

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Characterization of Arroyo Verde Epithermal Deposit:Paragenesis,Mineral Geochemistry,Geochronology and Fluid Inclusions in Lower Chon Aike Volcanism,Argentina

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Journal of Earth Science 2024年第1期35卷 62-84页

作者： Cecilia Pavón Pivetta Leonardo Benedini Paulo Marcos Ma.Agustina Cócola Mercedes Virginia Barros Daniel Gregori Leonardo Strazzere Anderson Costa dos Santos mauro C.Geraldes Instituto Geologico del Sur(INGEOSUR) Universidad Nacional del Sur(UNS)-Consejo Nacional de Investigaciones Cientificas y Tecnicas(CONICET)Bahia Blanca 8000Argentina Dpto.de Geologia Universidad Nacional del Sur(UNS)Bahia Blanca 8000Argentina Universidad Nacional de Rio Negro Instituto de Investigacion en Paleobiologia y GeologiaGeneral Roca 8332Argentina Universidade do Estado do Rio de Janeiro Faculdade de GeologiaDepartamento de Mineralogia e Petrologia igneaRiodeJaneiro20559-900Brazil Geobiotec Departamento de GeocienciasUniversidade de AveiroAveiro 3800-002Portuga

Arroyo Verde epithermal deposit,in the North Patagonia region of Argentina,is located within the Lower Chon Aike volcanism and is developed between 192.6±2.5 Ma(mineralization host rock)and 189.5±2.6 Ma(overlying lava).Marifil volcanic complex is the host rock for these veins,veinlets and *** particular small deposit has developed low to intermediate sulphidation characteristics,with gangue mineral textures associated with several ore *** probe microanalysis determines electrum,silver minerals such as acanthite,and tetrahedrite,related Ag-Cu minerals like jalpaite,mckinstryite,stromeyerite,and base metals like chalcopyrite,sphalerite,galena and *** inclusions in quartz of two out of five events indicate that these Low Jurassic veins were formed due to subtle boiling and dilution mechanisms and by low-salinity(3.4 wt.%to 6.7 wt.%NaCl Eq)magmatic-hydrothermal fluid at 225 to 310℃.The fluid inclusion measurements that indicate boiling(Event 3)were plotted,and based on this data,we interpret that the Arroyo Verde deposit has been eroded between 550 and 700 *** particular character has not been previously recorded for other sectors of the eastern north Patagonian region.

关键词： epithermal deposit Ag minerals mineral geochemistry fluid inclusions Chon Aike geochronology

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Homocysteinemia and Depression in Community-Dwelling Older Adults: The Cohort Longitudinal Study “InveCeAb” (Brain Aging in Abbiategrasso)

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Health 2024年第1期16卷 22-36页

作者： mauro Colombo Annalisa Davin Elena Rolandi Michele Rossi Riccardo Ferrari Erica Spina Antonio Guaita Golgi Cenci Foundation Abbiategrasso Italy

Depression is a major health problem, especially for elderly people. According to the “homocysteine hypothesis of depression”, high homocysteine levels may cause depression of mood via cerebrovascular diseases. Whilst biologically plausible, such hypothesis needs yet confirmation. We aimed at: 1) studying the relationships between homocysteinemia (HCY) and depression in a community-dwelling cohort of people aged 70 to 75 years at baseline;2) investigating plasma levels of HCY and 3) comparing these levels between males and females, in the same population. We exploited the data from four waves (2010, 2012, 2014 and 2018) of the longitudinal study “InveCeAb”, with specific regard towards mood assessment, by Geriatric Depression Scale (GDS) scoring, and diagnosis of clinically relevant or subthreshold depression. HCY plasma levels were measured in the waves 2012, 2014 and 2018. Sample attrition was due mainly to death or overall worsening. No statistically significant differences were found in plasma homocysteine levels in each wave, according to depressive symptoms. No correlations were found between plasma HCY levels in each wave with their corresponding GDS scores, even after adjustment for folate and cobalamin blood concentrations. Dichotomized levels of HCY (≤15 vs >15 μM/l) were not associated with dichotomized GDS scores (≤4 vs higher), clinically relevant and subthreshold depression diagnosis and any antidepressive use, in any wave. First (2012) HCY levels increased with participants’ increasing age, cross-sectionally. Listwise HCY concentrations decreased along the 3 waves. HCY levels were always higher in males than in females. Our results may challenge the “homocysteine hypothesis” of depression, whilst supporting the role of high homocysteinemia as a marker of overall bad health.

关键词： Homocysteinemia Depression Aging Cohort

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Endodontic irrigants from a comprehensive perspective

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World Journal of Clinical Cases 2024年第21期12卷 4460-4468页

作者： Rayana Duarte Khoury Lara Steffany de Carvalho mauro Felipe Rios do Nascimento Fadi Alhussain AmjadAbu Hasna Department of Restorative Dentistry Endodontics DivisionInstitute of Science and TechnologySão Paulo State UniversitySão Josédos Campos 12245000SPBrazil Department of Biosciences and Oral Diagnosis Institute of Science and TechnologySão Paulo State UniversitySão Josédos Campos 12245000SPBrazil School of Dentistry The National Institute of Higher Education and Postgraduate Studies Padre Gervásio-INAPÓSPouso Alegre 37550-121MGBrazil School of Dentistry Syrian Private UniversityAl Kiswah 877C+P2DamascusSyria School of Dentistry Universidad Espíritu SantoSamborondón 092301Ecuador

This review article explores the fundamental principles of modern endodontics with a focus on root canal cleaning and *** reviews commonly used endodontic irrigant,namely sodium hypochlorite(NaOCl),herbal extracts,chlorhexidine(CHX),and chelating agents,highlighting their properties,applications,and potential ***,a key antimicrobial agent,demonstrates effectiveness against various microorganisms but poses challenges such as high *** extracts,gaining recognition in endodontics,present an alternative with potential advantages in preserving dentin ***,known for its broad-spectrum antimicrobial activity,is discussed in both liquid and gel formulations,emphasizing its role in reducing smear layer formation and preserving hybrid layer *** agents,specifically ethylenediaminetetraacetic acid and citric acid,play a vital role in removing the smear layer,enhancing dentin permeability,and facilitating the penetration of antimicrobial *** review article underscores the importance of careful application and consideration of each irrigant's properties to ensure safe and effective endodontic *** serves as a valuable guide for clinicians in selecting appropriate irrigants based on specific treatment requirements.

关键词： Root canal irrigants Sodium hypochlorite Chlorhexidine Chelating agents Plant extracts

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Analysis of Perinatal Outcomes of Twin Pregnancy in a Referral Hospital for High Risk

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Open Journal of Obstetrics and Gynecology 2024年第7期14卷 983-995页

作者： Eduarda Paim Pedro Lucas Carneiro Ferreira Luciano Selistre Fernanda Grossi José mauro Madi Gabriela Françoes Rostirolla Mdica Residente do Programa de Residncia em Ginecologia e Obstetrcia Hospital Geral de Caxias do Sul Rio Grande do Sul Brasil Faculdade de Medicina Universidade de Caxias do Sul Rio Grande do Sul Brasil Programa de Ps-Graduao Universidade de Caxias do Sul Rio Grande do Sul Brasil Servio de Ginecologia e Obstetrcia Hospital Geral de Caxias do Sul Rio Grande do Sul Brasil

Introduction: The incidence of twin pregnancies has increased significantly in recent decades. These pregnancies require more attention due to their worse outcomes than singleton pregnancies. Objective: To analyze the characteristics and perinatal outcomes of twin pregnancies at the Caxias do Sul General Hospital. Methods: This is a descriptive and retrospective study that included all births related to twin pregnancies between March 1998 and June 2018. Maternal and perinatal variables were analyzed. Descriptive analyses were carried out using measures of central tendency and dispersion for continuous variables (mean and standard deviation or median and interquartile range), according to a prior assessment of distribution using the Shapiro-Wilk test, and absolute (n) and relative (n%) frequencies for categorical variables. Results: 172 pairs of twins/21,972 births (0.8%) were identified. There was a high percentage of interpartum interval of less than 12 months, adherence and prenatal visits, body mass index, and need for neonatal intensive care. Stillbirth and neomortality rates were within acceptable parameters. Conclusion: The sample studied showed a percentage similar to that in the literature, a high rate of maternal and perinatal complications, characterizing it as a high-risk fetal pregnancy.

关键词： Pregnancy Twin Pregnancy High Risk Pregnancy Morbidity Perinatal Mortality Perinatal Results

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元屏幕的力量和“透明性2.0”的意识形态

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北京电影学院学报 2024年第6期 45-51页

作者： [意]莫罗·卡波内卫俊(译) 法国里昂第三大学哲学系

“元―屏幕”是一种跨历史的同时展示又隐藏的原则,它所具有的启发性价值可能会对屏幕人类学的构建有所贡献。在不同的历史-文化背景下,屏幕以不同的方式发挥其使可见化和使不可见化的权力,换句话说,元―屏幕在不同的历史―文化背景下... 详细信息

“元―屏幕”是一种跨历史的同时展示又隐藏的原则,它所具有的启发性价值可能会对屏幕人类学的构建有所贡献。在不同的历史-文化背景下,屏幕以不同的方式发挥其使可见化和使不可见化的权力,换句话说,元―屏幕在不同的历史―文化背景下促成不同的可见性政体。在今天的西方社会,屏幕被定义为显示屏:显示屏就是绝对的用来展示的表面,因而就是绝对透明的表面。这说明西方有关透明性的意识形态进入“透明性2.0”阶段,这个阶段的人们追求绝对的透明性和直接性,把可见性和真相直接等同起来,而忽略了没有隐藏就不可能有展示。

关键词：元屏幕可见性政体透明性2.0 屏幕显示屏

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The influence of arterial stiffness in heart failure:a clinical review

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Journal of Geriatric Cardiology 2021年第2期18卷 135-140页

作者： mauro Feola Department of Cardiology Ospedale Regina Montis RegalisMondovìItaly

Vascular aging in large arteries plays an important role in contributing to cardiovascular morbidity and mortality.[1]Structural changes include an increase in wall thickness,intima-media thickening ratio is widely at... 详细信息

关键词： aging stiffness attributed

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Precise Agriculture:Effective Deep Learning Strategies to Detect Pest Insects

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IEEE/CAA Journal of Automatica Sinica 2022年第2期9卷 246-258页

作者： Luca Butera Alberto Ferrante mauro Jermini mauro Prevostini Cesare Alippi Universitàdella Svizzera italiana Faculty of InformaticsLugano 6900Switzerland Agroscope Research Centre CadenazzoCadenazzo 6594Switzerland IEEE

Pest insect monitoring and control is crucial to ensure a safe and profitable crop growth in all plantation types,as well as guarantee food quality and limited use of *** aim at extending traditional monitoring by means of traps,by involving the general public in reporting the presence of insects by using *** includes the largely unexplored problem of detecting insects in images that are taken in noncontrolled ***,pest insects are,in many cases,extremely similar to other species that are ***,computer vision algorithms must not be fooled by these similar insects,not to raise unmotivated *** this work,we study the capabilities of state-of-the-art(SoA)object detection models based on convolutional neural networks(CNN)for the task of detecting beetle-like pest insects on nonhomogeneous images taken outdoors by different ***,we focus on disambiguating a pest insect from similar harmless *** consider not only detection performance of different models,but also required computational *** study aims at providing a baseline model for this kind of *** results show the suitability of current SoA models for this application,highlighting how FasterRCNN with a MobileNetV3 backbone is a particularly good starting point for accuracy and inference execution *** combination provided a mean average precision score of 92.66%that can be considered qualitatively at least as good as the score obtained by other authors that adopted more specific models.

关键词： Computer vision machine learning neural network pest insect pest monitoring Popillia japonica precise agriculture

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Gastric electrical stimulation for gastroparesis:A goal greatly pursued,but not yet attained

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World Journal of Gastroenterology 2011年第3期17卷 273-282页

作者： mauro Bortolotti Department of Internal Medicine and Gastroenterology University of Bologna

The lack of an effective medical treatment for gastroparesis has pushed the research of new techniques of gastric electrical stimulation (GES) for nearly half a century of experimentation with a large variety of electrical stimuli delivered to the gastric wall of animals and patients with gastroparesis. Three principal methods are currently available: gastric low-frequency/high-energy GES with long pulse stimulation, high-frequency/low-energy GES with short pulse stimulation and neural sequential GES. The first method aims to reset a regular slow wave rhythm, but has variable effects on contractions and requires devices with large and heavy batteries unsuitable for implantation. High-frequency/low-energy GES, although inadequate to restore a normal gastric electro-mechanical activity, improves dyspeptic symptoms, such as nausea and vomiting, giving patients a better quality of life together with a more satisfactory nutritional status and is suitable for implantation. Unfortunately, the numerous clinical studies using this type of GES, with the exception of two, were not controlled and there is a need for definitive verification of the effectiveness of this technique to justify the cost and the risks of this procedure. The last method, which is neural sequential GES, consists of a microprocessor-controlled sequential activation of a series of annular electrodes along the distal two thirds of the stomach and is able to induce propagated contractions causing forceful emptying of the gastric content. The latter method is the most promising, but has been used only in animals and needs to be tested in patients with gastroparesis before it is regarded as a solution for this disease.

关键词： Gastric electrical stimulation Gastric emptying Gastric motility Gastric myoelectric activity Gastroparesis Prokinetic drugs

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