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Clinical outcomes of non-operative management and clinical observation in non-angioembolised hepatic trauma: A systematic review of the literature

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Chinese Journal of Traumatology 2022年第5期25卷 257-263页

作者： Francesco Virdis mauro Podda Salomone Di Saverio Jayant Kumar Roberto Bini Carlos Pilasi Isabella Reccia Trauma and Acute Care Surgery Unit Ospedale NiguardaMilano20162Italy General and Emergency Surgery Policlinico Universitario di MonserratoCagliari0910 Italy General and Endocrine Surgery Ospedaledi CircoloFondazione MacchiVarese21100 Italy Abdominal Transplantation Surgery University of ChicagoChicago5801USA General and Trauma Surgery San Juan de Dios HospitalSantiago8350488Chile Haepato-Biliary-Pancreatic Uni Hammersmith Hospital Imperial CllegeLondonW120TSUK

Purpose: Liver is the most frequently injured organ in abdominal trauma. Today non-operative management (NOM) is considered as the standard of care in hemodynamically stable patients, with or without the adjunct of angioembolisation (AE). This systematic review assesses the incidence of complications in patients who sustained liver injuries and were treated with simple clinical observation. Given the differences in indications of treatment and severity of liver trauma and acknowledging the limitations of this study, an analysis of the results has been done in reference to the complications in patients who were treated with AE. Methods: A systematic literature review searched "liver trauma" , "hepatic trauma" , "conservative management" , "non operative management" on MEDLINE (via PubMed), Cochrane Central Register of Controlled Trials databases, EMBASE, and Google Scholar, to identify studies published on the conservative management of traumatic liver injuries between January 1990 and June 2020. Patients with traumatic liver injuries (blunt and penetrating) treated by NOM, described at least one outcome of interests and provided morbidity outcomes from NOM were included in this study. Studies reported the outcome of NOM without separating liver from other solid organs;studies reported NOM complications together with those post-intervention;case reports;studies including less than 5 cases;studies not written in English;and studies including patients who had NOM with AE as primary management were excluded. Efficacy of NOM and overall morbidity and mortality were assessed, the specific causes of morbidity were investigated, and the American Association for the Surgery of Trauma classification was used in all the studies analysed. Statistical significance has been calculated using the Chi-square test. Results: A total of 19 studies qualified for inclusion criteria were in this review. The NOM success rate ranged from 85% to 99%. The most commonly reported complications

关键词： Liver Trauma Non-operative management Angioembolization

Clinical spectrum and currently available treatment of typeⅠinterferonopathy Aicardi-Goutières syndrome

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World Journal of Pediatrics 2023年第7期19卷 635-643页

作者： Giovanni Battista Dell'Isola Gianluca Dini Kaleb Logan Culpepper Katherin Elizabeth Portwood Pietro Ferrara Giuseppe Di Cara Alberto Verrotti mauro Lodolo Department of Pediatrics University of PerugiaGiorgio Menghini Square06129 PerugiaItaly Department of Neurology Jacksonville University of FloridaFloridaUSA Department of Pediatrics Division of Child NeurologyUniversity of FloridaUF Health Shands Children's HospitalGainesvilleFLUSA Unit of Pediatrics Campus Bio-Medico UniversityRomeItaly

Background Aicardi-Goutières syndrome(AGS)is a genetically determined disorder with a variable *** the original description of AGS,advances in gene sequencing techniques have resulted in a significant broadening of the phenotypic spectrum associated with AGS genes,and new clinical pictures have emerged beyond the classic *** aim of this review is to provide a comprehensive analysis of the clinical spectrum of AGS and report currently available treatments and new immunosuppressive *** sources Literature reviews and original research articles were collected from databases,including PubMed and *** articles about AGS were *** The involvement of the nervous system certainly represents the major cause of mortality and morbidity in AGS ***,other clinical manifestations,such as chilblains,hepatosplenomegaly,and hematological disturbances,may lead to the diagnosis and considerably impact the prognosis and overall quality of life of these *** approaches of AGS are limited to interventions aimed at specific symptoms and the management of multiple ***,advances in understanding the pathogenesis of AGS could open new and more effective *** The over-activation of innate immunity due to upregulated interferon production plays a critical role in AGS,leading to multi-organ damage with the main involvement of the central nervous *** date,there is no specific and effective treatment for *** drugs specifically targeting the interferon pathway may bring new hope to AGS patients.

关键词： Aicardi-Goutieres syndrome Immunosuppressive drugs Interferon-α Neuroinflammation Systemic lupus erythematosus

Cognitive impairment in heart failure patients

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Journal of Geriatric Cardiology 2014年第4期11卷 316-328页

作者： Laura Leto mauro Feola School of Geriatry University of Turin Italy Cardiovascular Rehabilitation Heart Failure Unit Ospedale SS Trinita ' Via Ospedale 4-12045 Fossano Italy

在心失败(HF ) 的认知损坏包含因此为单身的病人防碍能力到自顾的不同领域，修改症状和健康行为并且应付治疗政体。许多服、功能的变化在大脑成像被检测，包含灰、白的物质的区域派了到认知。尽管各种各样的仪器是可得到的探索认知，没... 详细信息

在心失败(HF ) 的认知损坏包含因此为单身的病人防碍能力到自顾的不同领域，修改症状和健康行为并且应付治疗政体。许多服、功能的变化在大脑成像被检测，包含灰、白的物质的区域派了到认知。尽管各种各样的仪器是可得到的探索认知，没有一致在在 HF 人口要过去常的更好的工具上被获得。在服的血流动的减小，减少的心脏的输出，血压层次的脑血管的反应和修正的改变是涉及认知赤字的 etiopathogenetic 机制的主要特征。几个心脏的变量，实验室参数，人口统计、临床的元素与认知为他们的可能的关系被学习并且应该适当地被评估在缺陷的增加的风险定义病人。现在的评论收集指出保证信息并且讨论研究开发的可能的区域的可得到的数据。

关键词：心脏患者衰竭 Altera公司损伤治疗方案心输出量共享机制

A critical review of pancreatectomy with concomitant superior mesenteric artery resection and intestinal autotransplantation

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Hepatobiliary Surgery and Nutrition 2023年第5期12卷 756-758页

作者： Benedetto Ielpo Patricia Sánchez-Velázquez Gemma Vellalta mauro Podda Fernando Burdio Hepato-Biliary and Pancreatic Surgery Unit Department of SurgeryHospital del MarHospital del Mar Research InstituteUniversity Pompeu-FabraBarcelonaSpain Department of Surgical Science University of CagliariCagliariItaly

We have read with great interest the study by Liang et *** the role of radical resection combined with intestinal autotransplantation for locally advanced pancreatic cancer after neoadjuvant therapy(1).The study may a... 详细信息

关键词： Pancreatic cancer arterial resection neoadjuvant treatment intestinal autotransplantation

Decellularized extracellular matrix particle-based biomaterials for cartilage repair applications

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Journal of Materials Science & Technology 2023年第29期160卷 194-203页

作者： Peng Guo Nan Jiang Carina Mini Gregor Miklosic Songsong Zhu Andrea J.Vernengo Matteo D’Este Sibylle Grad mauro Alini Zhen Li AO Research Institute Davos Davos 7270Switzerland Department of Spine Surgery The Sixth Affiliated HospitalSun Yat-sen UniversityGuangzhou 510655China State Key Laboratory of Oral Diseases and National Clinical Research Center for Oral Disease and West China Hospital of Stomatology Sichuan UniversityChengdu 610041China Institute for Biomechanics ETH ZürichZürich 8093Switzerland

Cartilage Decellularized ExtraCellular Matrix(dECM)materials have shown promising cartilage regenera-tion capacity due to their chondrogenic ***,the limited retention of ECM components and the reduced integrity of functional ECM molecules during traditional decellularization processes im-pair the biomimicry of these *** current study aims to fabricate biomimetic materials con-taining decellularized cartilage particles that have an intact molecular structure and native composition as biomaterial inks and hydrogels for cartilage *** this,we established a novel two-fraction de-cellularization strategy for the preparation of reconstituted dECM(rdECM)particles by mixing the two-fraction components,as well as a one-fraction decellularization strategy for the preparation of biomimetic dECM(bdECM)*** acid-tyramine(THA)hydrogels containing rdECM or bdECM particles were produced and characterized via rheological test,swelling and stability evaluation,and compression *** results showed that our novel decellularization strategies preserved intact proteoglycans and collagen at a higher retention rate with adequate DNA removal compared to traditional methods of *** addition of rdECM or bdECM particles significantly increased the shear moduli of the THA bioinks while preserving their shear-thinning *** particle-embedded THA hydrogels also achieved long-term stability with a swelling ratio of 70%and high retention of glycosaminoglycans and collagen after long-term incubation,while rdECM particle-embedded THA hydrogels showed unsat-isfactory stability as self-standing *** to pure THA hydrogels,the addition of bdECM particles significantly enhanced the compression *** summary,our decellularization methods are successful in the retention of functional and intact cartilage components with high *** rdECM and bdECM particles can be supplemented in THA bioinks for biomimet

关键词： Cartilage tissue engineering Decellularized extracellular matrix Proteoglycan integrity Biomimetic hydrogels Biomaterial Bioink

Optical absorption of (Ag-Au)133(SCH3)52 bimetallic monolayer-protected clusters

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Progress in Natural Science:Materials International 2016年第5期26卷 467-476页

作者： Alessandro Fortunelli mauro Stener CNR-ICCOM Consiglio Nazionale delle Ricerche Dipartimento di Scienze Chimiche e Farmaceutiche Università di Trieste

The evolution of the optical absorption spectrum of bimetallic Ag-Au monolayer-protected clusters(MPC)obtained by progressively doping Ag into the experimentally known structure of Au133(SR)52was predicted via rigorous time-dependent density-functional theory(TDDFT) calculations. In addition to monometallic Au133(SR)52and Ag133(SR)52species, 5 different(Ag-Au)133(SCH3)52homotops were considered with varying Ag content and site positioning, and their electronic structure and optical response were analyzed in terms of Projected Density Of States(PDOS), the induced or transition electron density, and Transition Component Maps(TCM) at selected excitation energies. It was found that Ag doping led to the effects rather different from those encountered in bare metal clusters. And it was also observed that Ag doping could produce structured spectral features, especially in the 3–4 eV range but also in the optical region if Ag atoms were located in the sub-staple region, as rationalized by the accompanying electronic analysis. Additionally, Au doping into the staples of Ag-rich MPC also gave rise to a more homogeneous induced electron density. These findings show the great sensitivity of the electronic response of MPC nanoalloy systems to the exact location of the alloying sites.

关键词： Nanoalloys Gold nanomolecules Electronic excited states Homotops Transition electron density

Repellent and Insecticidal Activity of Naphthoquinones from the Heartwood of Tectona grandis on Incisitermes marginipennis(Latreille)

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Phyton-International Journal of Experimental Botany 2023年第7期92卷 2165-2181页

作者： Crisanto Velázquez-Becerra Gu Yen Ambriz-Ortiz Rafael Torres-Martínez mauro Manuel Martínez-Pacheco Facultad de Ingeniería en Tecnología de la Madera Universidad Michoacana de San Nicolás de HidalgoMoreliaMéxico Escuela Nacional de Estudios Superiores Unidad MoreliaMoreliaMéxico Instituto de Investigaciones Químico-Biológicas Universidad Michoacana de San Nicolás de HidalgoMoreliaMéxico

Wood is a lignocellulosic material that,because of its organic nature,is a source of nutrients for bacteria,fungi,and *** marginipennis(Latreille)is an interesting dry wood-boring *** it is an extremely destructive pest,difficult to control due to its cryptic lifestyle,and for its role in the biogeochemical cycle of carbon and other elements;it is a fundamental *** use of less toxic and eco-friendly substances is important for protecting domestic,cultural,and historical heritage made of wood or lignocellulosic *** aim of this study was to evaluate the biological activity of various naphthoquinones extracted from the heartwood of *** on ***,heartwood flour was used for Soxhlet-type extractions to isolate and characterize the heartwood compounds by thin-layer *** identify the heartwood compounds,nuclear magnetic resonance and gas chromatography coupled to a mass spectrometer were *** information obtained was supported using the Interactive Spectroscopy *** identified heartwood compounds were lapachol,tectoquinone,deoxylapachol,dehydro-α-lapachone,tectol and *** nymphal termites of *** as a biological model,the isolated and identified molecules were under three different tests(repellent,insecticide and protective)and their biological activity was individually *** results showed that the molecules obtained have a repellent-protective effect against ***,although not in all cases,these molecules have high percentages of mortality and decreased the weight loss of the treated material exposed to ***.

关键词： Naphthoquinones dry wood termite Incisitermes marginipennis wood preservatives

Intravascular contrast agents in diagnostic applications： Use of red blood cells to improve the lifespan and efficacy of blood pool contrast agents

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Nano Research 2017年第3期10卷 731-766页

作者： Antonella Antonelli Carla Sfara mauro Magnani Department of Biomolecular Sciences Biochemistry and Molecular Biology Section University of Urbino 'Carlo Bo' Via Saffi 2 61029Urbino (PU) Italy

In medicine, discrimination between pathologies and normal areas is of great importance, and in most cases, such discrimination is made possible by novel imaging technologies. Numerous modalities have been developed to visualize tissue vascularization in cardiovascular diseases or during angiogenic and vasculogenic processes. Here, we report the recent advances in vasculature imaging, providing an overview of the current non-invasive approaches in biomedical diagnostics and potential future strategies for prognostic assessment of vessel diseases, such as aneurysms and coronary artery occlusion leading to myocardial infarction. There are several contrast agents （CAs） available to improve the visibility of specific tissues at the early stage of diseases, allowing for rapid treatment. However, CAs are also hampered by numerous limitations, including rapid diffusion from blood vessels into the interstitial space, toxicity, and low sensitivity. Extravasation from blood vessels leads to a rapid loss of the image. If the contrast medium can fully be confined to the vascular space, high-resolution structural and functional vascular imaging could be obtained. Many scientists have contributed new materials and/or new carrier systems. For example, the use of red blood cells （RBCs） as CA-delivery systems appears to provide a scalable alternative to current procedures that allows adequate vascular imaging. Recognition and removal of CAs from the circulation can be prevented and/or delayed by using RBCs as biomimetic CA-carriers, and this technology should be clinically validated.

关键词： diagnostic applications magnetic resonanceimaging (MRI) vascular contrast agents red blood cells medical imaging new tomography

Exit strategies in inflammatory bowel disease:Looking beyond antitumor necrosis factors

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World Journal of Clinical Cases 2023年第12期11卷 2657-2669页

作者： Federica Crispino Andrea Michielan mauro Grova Chiara Tieppo Marta Mazza Teresa Marzia Rogger Franco Armelao Azienda Provinciale per i Servizi Sanitari Gastroenterology and Digestive Endoscopy UnitSanta Chiara HospitalTrento 38122Italy Inflammatory Bowel Disease Unit Department of MedicineAzienda Ospedaliera Ospedali RiunitiVilla Sofia-CervelloPalermo 90146Italy

The long-term management of patients with inflammatory bowel disease(IBD)is still a matter of debate,and no clear guidelines have been *** clinical practice,gastroenterologists often have to deal with patients in prolonged remission after immunomodulatory or immunosuppressive *** planning an exit strategy for drug withdrawal,the risk of disease relapse must be balanced against the risk of drug-related adverse events and healthcare ***,there is still a dearth of data on the withdrawal of novel biologics,such as the anti-α4β7 integrin antibody(vedolizumab)and anti-IL12/23 antibody(ustekinumab),as well as the small molecule *** for estimating the risk of disease relapse and the efficacy of retreatment should be evaluated according to the patient's age and IBD *** models should guide clinicians in programming a temporary drug withdrawal after discussing realistic outcomes with the *** would shift the paradigm from an exit strategy to a holiday strategy.

关键词： Exit strategy Biologic withdrawal Drug holiday Vedolizumab Ustekinumab Tofacitinib