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The influence of arterial stiffness in heart failure:a clinical review

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Journal of Geriatric Cardiology 2021年第2期18卷 135-140页

作者： mauro Feola Department of Cardiology Ospedale Regina Montis RegalisMondovìItaly

Vascular aging in large arteries plays an important role in contributing to cardiovascular morbidity and mortality.[1]Structural changes include an increase in wall thickness,intima-media thickening ratio is widely at... 详细信息

关键词： aging stiffness attributed

Precise Agriculture:Effective Deep Learning Strategies to Detect Pest Insects

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IEEE/CAA Journal of Automatica Sinica 2022年第2期9卷 246-258页

作者： Luca Butera Alberto Ferrante mauro Jermini mauro Prevostini Cesare Alippi Universitàdella Svizzera italiana Faculty of InformaticsLugano 6900Switzerland Agroscope Research Centre CadenazzoCadenazzo 6594Switzerland IEEE

Pest insect monitoring and control is crucial to ensure a safe and profitable crop growth in all plantation types,as well as guarantee food quality and limited use of *** aim at extending traditional monitoring by means of traps,by involving the general public in reporting the presence of insects by using *** includes the largely unexplored problem of detecting insects in images that are taken in noncontrolled ***,pest insects are,in many cases,extremely similar to other species that are ***,computer vision algorithms must not be fooled by these similar insects,not to raise unmotivated *** this work,we study the capabilities of state-of-the-art(SoA)object detection models based on convolutional neural networks(CNN)for the task of detecting beetle-like pest insects on nonhomogeneous images taken outdoors by different ***,we focus on disambiguating a pest insect from similar harmless *** consider not only detection performance of different models,but also required computational *** study aims at providing a baseline model for this kind of *** results show the suitability of current SoA models for this application,highlighting how FasterRCNN with a MobileNetV3 backbone is a particularly good starting point for accuracy and inference execution *** combination provided a mean average precision score of 92.66%that can be considered qualitatively at least as good as the score obtained by other authors that adopted more specific models.

关键词： Computer vision machine learning neural network pest insect pest monitoring Popillia japonica precise agriculture

State of the art and computational aspects of time-dependent waiting models for non-signalised intersections

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Journal of Traffic and Transportation Engineering(English Edition) 2020年第6期7卷 808-831页

作者： Raffaele mauro Andrea Pompigna Department of Civil Environmental and Mechanical EngineeringUniversity of TrentoTrento 38123Italy

Time-dependent models are of great importance in highway engineering as they are appropriate for evaluating waiting times and queue lengths at intersections,which are integral parts of various activities in planning,verification and decision support for *** reviewing the literature of the main time-dependent models based on the coordinate transformation method and a discussion about some computational issues in time-evolution profiles for non-signalised intersections,the paper identifies the requirements these models have to satisfy in order to be used as"basic"cases for analysing complex evolutionary ***"basic"cases are presented with their timedependent equations for vehicle waiting times and vehicle number;they have been completed and dimensionally homogenised in this *** they are recursive,these formulas can be applied for sequential intervals in the time domain in both vehicles and passenger car *** closed-form expressions for state variables show to be mutually equivalent in comparison with discrete event simulation models and imbedded Markov chain *** all the three models the paper presents a common deterministic simplification for average waiting time,with good approximation results in the tested *** proposed time-dependent formulas will contribute to a better adherence to the real phenomena,compared to the extremely simplified and unrealistic methods suggested by the international manuals for level of service *** proposed formulas will be useful for current applications and possible future development in order to meet the emerging needs of road and transport engineering.

关键词： Traffic engineering Priority system Non-signalised intersections Time-dependent queue model Shared queue delay Coordinate transformation method

A multi-class time-dependent model for the analysis of waiting phenomena at a motorway tollgate

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Journal of Traffic and Transportation Engineering(English Edition) 2021年第2期8卷 237-256页

作者： Andrea Pompigna Raffaele mauro Department of Civil Environmental and Mechanical EngineeringUniversity of TrentoTrento 38123Italy

The planning, design and operational management of motorway toll booths are of great interest in traffic engineering, as these facilities directly influence the quality of the service offered to users. This paper focuses on a time-dependent queue model based on the coordinates transformation criterion for operations assessment at a motorway tollgate. This model allows to face the whole spectrum of situations that may characterize a toll booth,some of which often fall outside the boundaries of the probabilistic theory for stationary *** paper proposes an M=G=1 multi-class queue model for the evaluation of evolutionary profiles of waiting times and queue lengths by closed-form equations. The results obtained for three numerical test cases show a good approximation level, compared with the mean values of queue parameters obtained reiterating a discrete-state simulation *** proposed time-dependent equations will be useful in technical cases, allowing to operate quickly and compactly even when probabilistic queue theory is not applicable or produce unrealistic results, and the burden of complexity of the simulation approach is not conveniently absorbable. The discussion highlights a significant flexibility of the model proposed in addressing situations with conventional vehicles, i.e., with total human control and proposes some considerations for application in future scenarios with the presence of connected vehicles(CVs).

关键词： Traffic engineering Time-dependent queue model Shared queue Coordinate transformation method Tollgate

Magnetic challenge against gastroesophageal reflux

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World Journal of Gastroenterology 2021年第48期27卷 8227-8241页

作者： mauro Bortolotti Via Massarenti 48 Bologna 40138Italy

Almost 15 years have passed since the first paper on the possibility of using magnets to prevent gastro-esophageal reflux(GER)was published and so it is time to assess the results obtained with the first magnetic device available on the market,the Linx magnetic sphincter augmentation(MSA)and to consider what other options are *** demonstrated an anti-reflux activity similar to that of Nissen fundoplication,considered the“gold standard”surgical treatment for GER disease,and caused less gas-bloating and a better ability to allow vomiting and ***,unlike Nissen fundoplication,this magnetic device is burdened by complications,which are roughly similar to those of the non-magnetic anti-reflux Angelchik prosthesis,that,after considerable use in the eighties,was shelved due to these *** is interesting to note that some of these complications show the same pathophysiological mechanism in both *** upcoming new magnetic devices should avoid these complications,as their anti-reflux magnetic mechanism is completely *** experiments in animals regarding these new magnetic appliances were examined,remarking their advantages and drawbacks,but the way to apply them in surgical practice is long and difficult,although worthy,as they represent the future of magnetic surgery.

关键词： Gastro-esophageal reflux disease Magnetic sphincter augmentation device Nissen fundoplication Angelchik prosthesis Lower esophageal sphincter Dysphagia

The Wnt/β-catenin signaling:a multifunctional target for neuroprotective and regenerative strategies in Parkinson's disease

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Neural Regeneration Research 2023年第2期18卷 306-308页

作者： Annalucia Serafino mauro Cozzolino Institute of Translational Pharmacology-National Research Council of Italy RomeItaly

Parkinson's disease(PD)is the most frequent movement disorder and the second most prevalent age-related neurodegenerative disease(ND)*** the clinical point of view,it is characterized by severe motor complications,inc... 详细信息

关键词： protective clinical rigidity

Cognitive impairment in heart failure patients

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Journal of Geriatric Cardiology 2014年第4期11卷 316-328页

作者： Laura Leto mauro Feola School of Geriatry University of Turin Italy Cardiovascular Rehabilitation Heart Failure Unit Ospedale SS Trinita ' Via Ospedale 4-12045 Fossano Italy

Cognitive damage in heart failure （HF） involves different domains thus interfering with the ability for single patient to self-care and to cope with treatment regimens, modifying symptoms and health behaviours. Many cerebral and functional changes were detected in brain imaging, involving areas of both grey and white matter deputed to cognition. Although various instruments are available to explore cognition, no consensus was obtained on better tools to be used in HF population. Reduction in cerebral blood flow, decreased cardiac output, altera-tions of cerebrovascular reactivity and modification of blood pressure levels are the main features involved in the etiopathogenetic mecha-nisms of cognitive deficit. Several cardiac variables, laboratory parameters, demographic and clinical elements were studied for their possible relation with cognition and should be properly evaluated to define patients at increased risk of impairment. The present review gathers avail-able data pointing out assured information and discussing possible areas of research development.

关键词： Heart failure Cognitive impairment Blood pressure

Optical absorption of （Ag-Au）133（SCH3）52 bimetallic monolayer-protected clusters

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Progress in Natural Science:Materials International 2016年第5期26卷 467-476页

作者： Alessandro Fortunelli mauro Stener CNR-ICCOM Consiglio Nazionale delle Ricerche Dipartimento di Scienze Chimiche e Farmaceutiche Università di Trieste

The evolution of the optical absorption spectrum of bimetallic Ag-Au monolayer-protected clusters（MPC）obtained by progressively doping Ag into the experimentally known structure of Au133（SR）52was predicted via rigorous time-dependent density-functional theory（TDDFT） calculations. In addition to monometallic Au133（SR）52and Ag133（SR）52species, 5 different（Ag-Au）133（SCH3）52homotops were considered with varying Ag content and site positioning, and their electronic structure and optical response were analyzed in terms of Projected Density Of States（PDOS）, the induced or transition electron density, and Transition Component Maps（TCM） at selected excitation energies. It was found that Ag doping led to the effects rather different from those encountered in bare metal clusters. And it was also observed that Ag doping could produce structured spectral features, especially in the 3–4 eV range but also in the optical region if Ag atoms were located in the sub-staple region, as rationalized by the accompanying electronic analysis. Additionally, Au doping into the staples of Ag-rich MPC also gave rise to a more homogeneous induced electron density. These findings show the great sensitivity of the electronic response of MPC nanoalloy systems to the exact location of the alloying sites.

关键词： Nanoalloys Gold nanomolecules Electronic excited states Homotops Transition electron density

Is patient satisfaction sufficient to validate endoscopic anti-reflux treatments?

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World Journal of Gastroenterology 2022年第28期28卷 3743-3746页

作者： mauro Bortolotti Department of Internal Medicine and Gastroenterology S.Orsola-Malpighi PolyclinicUniversity of BolognaBologna 40138Italy

Endoscopic anti-reflux treatment is emerging as a new option for gastroesophageal reflux disease(GERD)treatment in patients with the same indications as for laparoscopic *** are many techniques,the first of which are transoral incisionless fundoplication(TIF)and nonablative radio-frequency(STRETTA)that have been tested with comparative studies and randomized controlled trials,whereas the other more recent ones still require a deeper *** purpose of the latter is to verify whether reflux is abolished or significantly reduced after intervention,whether there is a valid high pressure zone at the gastroesophageal junction,and whether esophagitis,when present,has *** in a certain number of cases,and especially in the more recently introduced ones,the evaluation has been based almost exclusively on subjective criteria,such as improvement in the quality of life,remission of heartburn and regurgitation,and reduction or suspension of antacid and antisecretory drug ***,with the most studied techniques such as TIF and STRETTA,an improvement in symptoms better than that of laparoscopic fundoplication can often be observed,whereas the number of acid episodes and acid exposure time are similar or higher,as if the acid refluxes are better tolerated by these *** suspicion of a local hyposensitivity taking place after antireflux endoscopic intervention seems confirmed by a Bernstein test at least for *** examination should be done for all the other techniques,both old and new,to identify the ones that reassure rather than *** conclusion,the evaluation of the effectiveness of the endoscopic anti-reflux techniques should not be based exclusively on subjective criteria,but should also be confirmed by objective examinations,because there might be a gap between the improvement in symptoms declared by the patient and the underlying pathophysiologic alterations of GERD.

关键词： Endoscopic anti-reflux treatment Transoral incisionless fundoplication Nonablative radio-frequency Anti-reflux mucosectomy Gastro-esophageal reflux disease Laparoscopic Nissen fundoplication