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Comparison between hepatocellular carcinoma prognostic scores:A 10-year single-center experience and brief review of the current literature

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World Journal of Hepatology 2020年第12期12卷 1239-1257页

作者： Michele Campigotto mauro giuffrè Anna Colombo Alessia Visintin Alessandro Aversano Martina Budel Flora Masutti Cristiana Abazia Lory Saveria Croce Dipartimento Universitario Clinico di Scienze Mediche Chirurgiche e Della SaluteUniversitàdegli Studi di TriesteTrieste 34149Italy Clinica Patologie del Fegato Azienda Sanitaria Universitaria Giuliano IsontinaTrieste 34149Italy

BACKGROUND Hepatocellular carcinoma(HCC)represents the most common primitive liver malignancy.A relevant concern involves the lack of agreement on staging systems,prognostic scores,and treatment allocation *** To compare the survival rates among already developed prognostic *** We retrospectively evaluated 140 patients with HCC diagnosed between February 2006 and November *** were categorized according to 15 prognostic scoring systems and estimated median survivals were compared with those available from the current medical *** The median overall survival of the cohort of patients was 35(17;67)mo,and it was statistically different in relation to treatment choice,ultrasound surveillance,and serum *** Italian Liver Cancer(***)tumor staging system performed best in predicting survival according to stage allocation among all 15 evaluated prognostic *** the *** prognostic system,28.6%,40.7%,22.1%,and 8.6%of patients fell within stages 0-1,2-3,4-5 and>5 *** median survival was 57.9 mo for stages 0-1,43 mo for stages 2-3,21.7 mo for stages 4-5,and 10.4 mo for stage>*** 1-,3-,and 5-year survival rates were respectively 95%,65%,and 20%,for stages 0-1;94.7%,43.9%and 26.3%for stages 2-3;71%,25.8%and 16.1%for stages 4-5;and 50%,16.7%and 8.3%for stage>*** the same time,although statistically significant in prognostic stratification,the most commonly used Barcelona Clinic Liver Cancer system showed one of the most relevant differences in median survival,especially for stages A and C,when compared to the medical *** fact,10.7%,59.3%,27.1%,1.4%,and 0%of patients were stratified into stages 0,A,B,C,and D *** median survival was>81.1 mo for stage 0,44.9 mo for stage A,21.3 mo for stage B,and 3.1 mo for stage *** 1-,3-,and 5-year survival rates were respectively 86.7%,60%,and 46.7%for stage 0;91.6%,50.6%,and 20.5%for stage A;73.7%,23.7%and 13.2%for stage B;and

关键词： Hepatocellular carcinoma Prognostic score system Prognostic factors Survival analysis Barcelona Clinic Liver Cancer score system Italian Liver Cancer score system

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High fecal calprotectin levels are associated with SARS-CoV-2 intestinal shedding in COVID-19 patients:A proof-of-concept study

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World Journal of Gastroenterology 2021年第22期27卷 3130-3137页

作者： Verena Zerbato Stefano Di Bella mauro giuffrè Anna Wladyslawa Jaracz Ylenia Gobbo Diego Luppino Paolo Macor Ludovica Segat Raffaella Koncan Pierlanfranco D'Agaro Michael Valentini Lory Saveria Crocé Maurizio Ruscio Roberto Luzzati Infectious Diseases Unit Trieste University Hospital(ASUGI)Trieste 34125Italy Infectious Diseases Unit Clinical Department of MedicalSurgical and Health SciencesTrieste UniversityTrieste 34123Italy Liver Unit Clinical Department of MedicalSurgical and Health SciencesTrieste UniversityTrieste 34127Italy Department of Life Sciences Trieste UniversityTrieste 34127Italy Department of Hygiene and Public Health Unit Trieste University Hospital(ASUGI)Trieste 34125Italy Division of Laboratory Medicine Trieste University Hospital(ASUGI)Trieste 34125Italy

BACKGROUND One third of coronavirus disease 2019(COVID-19)patients have gastrointestinal *** acute respiratory syndrome coronavirus 2(SARS-CoV-2)RNA has been detected in stool samples of approximately 50%of COVID-19 *** calprotectin is a marker of gastrointestinal inflammation in the general *** To investigate if fecal calprotectin correlates with SARS-CoV-2 intestinal shedding in COVID-19 patients with *** Patients with SARS-CoV-2 pneumonia admitted to the Infectious Disease Unit(University Hospital of Trieste,Italy)from September to November 2020 were consecutively enrolled in the *** samples were collected and analyzed for quantification of fecal calprotectin(normal value<50 mg/kg)and SARS-CoV-2 RNA presence by polymerase chain reaction(PCR).Inter-group differences were determined between patients with and without diarrhea and patients with and without detection of fecal *** We enrolled 51 adults(40 males)with SARS-CoV-2 *** patients(20%)presented with ***-time-PCR of SARS-CoV-2 in stools was positive in 39 patients(76%),in all patients with diarrhea(100%)and in more than two thirds(29/41,71%)of patients without *** was one of the most common comorbidities(13 patients,25%);all obese patients(100%)(P=0.021)tested positive for fecal *** fecal calprotectin levels were 60 mg/kg[interquartile range(IQR)21;108];higher fecal calprotectin levels were found in the group with SARS-CoV-2 in stools(74 mg/kg,IQR 29;132.5)compared to the group without SARS-CoV-2(39 mg/kg,IQR 14;71)(P<0.001).CONCLUSION High fecal calprotectin levels among COVID-19 patients correlate with SARSCoV-2 detection in stools supporting the hypothesis that this virus can lead to bowel inflammation and potentially to the‘leaky gut’syndrome.

关键词： COVID-19 SARS-CoV-2 Obesity Fecal calprotectin Gut Viral shedding

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The influence of arterial stiffness in heart failure:a clinical review

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Journal of Geriatric Cardiology 2021年第2期18卷 135-140页

作者： mauro Feola Department of Cardiology Ospedale Regina Montis RegalisMondovìItaly

Vascular aging in large arteries plays an important role in contributing to cardiovascular morbidity and mortality.[1]Structural changes include an increase in wall thickness,intima-media thickening ratio is widely at... 详细信息

关键词： aging stiffness attributed

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Precise Agriculture:Effective Deep Learning Strategies to Detect Pest Insects

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IEEE/CAA Journal of Automatica Sinica 2022年第2期9卷 246-258页

作者： Luca Butera Alberto Ferrante mauro Jermini mauro Prevostini Cesare Alippi Universitàdella Svizzera italiana Faculty of InformaticsLugano 6900Switzerland Agroscope Research Centre CadenazzoCadenazzo 6594Switzerland IEEE

Pest insect monitoring and control is crucial to ensure a safe and profitable crop growth in all plantation types,as well as guarantee food quality and limited use of *** aim at extending traditional monitoring by means of traps,by involving the general public in reporting the presence of insects by using *** includes the largely unexplored problem of detecting insects in images that are taken in noncontrolled ***,pest insects are,in many cases,extremely similar to other species that are ***,computer vision algorithms must not be fooled by these similar insects,not to raise unmotivated *** this work,we study the capabilities of state-of-the-art(SoA)object detection models based on convolutional neural networks(CNN)for the task of detecting beetle-like pest insects on nonhomogeneous images taken outdoors by different ***,we focus on disambiguating a pest insect from similar harmless *** consider not only detection performance of different models,but also required computational *** study aims at providing a baseline model for this kind of *** results show the suitability of current SoA models for this application,highlighting how FasterRCNN with a MobileNetV3 backbone is a particularly good starting point for accuracy and inference execution *** combination provided a mean average precision score of 92.66%that can be considered qualitatively at least as good as the score obtained by other authors that adopted more specific models.

关键词： Computer vision machine learning neural network pest insect pest monitoring Popillia japonica precise agriculture

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Gastric electrical stimulation for gastroparesis:A goal greatly pursued,but not yet attained

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World Journal of Gastroenterology 2011年第3期17卷 273-282页

作者： mauro Bortolotti Department of Internal Medicine and Gastroenterology University of Bologna

The lack of an effective medical treatment for gastroparesis has pushed the research of new techniques of gastric electrical stimulation (GES) for nearly half a century of experimentation with a large variety of electrical stimuli delivered to the gastric wall of animals and patients with gastroparesis. Three principal methods are currently available: gastric low-frequency/high-energy GES with long pulse stimulation, high-frequency/low-energy GES with short pulse stimulation and neural sequential GES. The first method aims to reset a regular slow wave rhythm, but has variable effects on contractions and requires devices with large and heavy batteries unsuitable for implantation. High-frequency/low-energy GES, although inadequate to restore a normal gastric electro-mechanical activity, improves dyspeptic symptoms, such as nausea and vomiting, giving patients a better quality of life together with a more satisfactory nutritional status and is suitable for implantation. Unfortunately, the numerous clinical studies using this type of GES, with the exception of two, were not controlled and there is a need for definitive verification of the effectiveness of this technique to justify the cost and the risks of this procedure. The last method, which is neural sequential GES, consists of a microprocessor-controlled sequential activation of a series of annular electrodes along the distal two thirds of the stomach and is able to induce propagated contractions causing forceful emptying of the gastric content. The latter method is the most promising, but has been used only in animals and needs to be tested in patients with gastroparesis before it is regarded as a solution for this disease.

关键词： Gastric electrical stimulation Gastric emptying Gastric motility Gastric myoelectric activity Gastroparesis Prokinetic drugs

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State of the art and computational aspects of time-dependent waiting models for non-signalised intersections

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Journal of Traffic and Transportation Engineering(English Edition) 2020年第6期7卷 808-831页

作者： Raffaele mauro Andrea Pompigna Department of Civil Environmental and Mechanical EngineeringUniversity of TrentoTrento 38123Italy

Time-dependent models are of great importance in highway engineering as they are appropriate for evaluating waiting times and queue lengths at intersections,which are integral parts of various activities in planning,verification and decision support for *** reviewing the literature of the main time-dependent models based on the coordinate transformation method and a discussion about some computational issues in time-evolution profiles for non-signalised intersections,the paper identifies the requirements these models have to satisfy in order to be used as"basic"cases for analysing complex evolutionary ***"basic"cases are presented with their timedependent equations for vehicle waiting times and vehicle number;they have been completed and dimensionally homogenised in this *** they are recursive,these formulas can be applied for sequential intervals in the time domain in both vehicles and passenger car *** closed-form expressions for state variables show to be mutually equivalent in comparison with discrete event simulation models and imbedded Markov chain *** all the three models the paper presents a common deterministic simplification for average waiting time,with good approximation results in the tested *** proposed time-dependent formulas will contribute to a better adherence to the real phenomena,compared to the extremely simplified and unrealistic methods suggested by the international manuals for level of service *** proposed formulas will be useful for current applications and possible future development in order to meet the emerging needs of road and transport engineering.

关键词： Traffic engineering Priority system Non-signalised intersections Time-dependent queue model Shared queue delay Coordinate transformation method

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A multi-class time-dependent model for the analysis of waiting phenomena at a motorway tollgate

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Journal of Traffic and Transportation Engineering(English Edition) 2021年第2期8卷 237-256页

作者： Andrea Pompigna Raffaele mauro Department of Civil Environmental and Mechanical EngineeringUniversity of TrentoTrento 38123Italy

The planning, design and operational management of motorway toll booths are of great interest in traffic engineering, as these facilities directly influence the quality of the service offered to users. This paper focuses on a time-dependent queue model based on the coordinates transformation criterion for operations assessment at a motorway tollgate. This model allows to face the whole spectrum of situations that may characterize a toll booth,some of which often fall outside the boundaries of the probabilistic theory for stationary *** paper proposes an M=G=1 multi-class queue model for the evaluation of evolutionary profiles of waiting times and queue lengths by closed-form equations. The results obtained for three numerical test cases show a good approximation level, compared with the mean values of queue parameters obtained reiterating a discrete-state simulation *** proposed time-dependent equations will be useful in technical cases, allowing to operate quickly and compactly even when probabilistic queue theory is not applicable or produce unrealistic results, and the burden of complexity of the simulation approach is not conveniently absorbable. The discussion highlights a significant flexibility of the model proposed in addressing situations with conventional vehicles, i.e., with total human control and proposes some considerations for application in future scenarios with the presence of connected vehicles(CVs).

关键词： Traffic engineering Time-dependent queue model Shared queue Coordinate transformation method Tollgate

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Magnetic challenge against gastroesophageal reflux

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World Journal of Gastroenterology 2021年第48期27卷 8227-8241页

作者： mauro Bortolotti Via Massarenti 48 Bologna 40138Italy

Almost 15 years have passed since the first paper on the possibility of using magnets to prevent gastro-esophageal reflux(GER)was published and so it is time to assess the results obtained with the first magnetic device available on the market,the Linx magnetic sphincter augmentation(MSA)and to consider what other options are *** demonstrated an anti-reflux activity similar to that of Nissen fundoplication,considered the“gold standard”surgical treatment for GER disease,and caused less gas-bloating and a better ability to allow vomiting and ***,unlike Nissen fundoplication,this magnetic device is burdened by complications,which are roughly similar to those of the non-magnetic anti-reflux Angelchik prosthesis,that,after considerable use in the eighties,was shelved due to these *** is interesting to note that some of these complications show the same pathophysiological mechanism in both *** upcoming new magnetic devices should avoid these complications,as their anti-reflux magnetic mechanism is completely *** experiments in animals regarding these new magnetic appliances were examined,remarking their advantages and drawbacks,but the way to apply them in surgical practice is long and difficult,although worthy,as they represent the future of magnetic surgery.

关键词： Gastro-esophageal reflux disease Magnetic sphincter augmentation device Nissen fundoplication Angelchik prosthesis Lower esophageal sphincter Dysphagia

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The Wnt/β-catenin signaling:a multifunctional target for neuroprotective and regenerative strategies in Parkinson's disease

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Neural Regeneration Research 2023年第2期18卷 306-308页

作者： Annalucia Serafino mauro Cozzolino Institute of Translational Pharmacology-National Research Council of Italy RomeItaly

Parkinson's disease(PD)is the most frequent movement disorder and the second most prevalent age-related neurodegenerative disease(ND)*** the clinical point of view,it is characterized by severe motor complications,inc... 详细信息

关键词： protective clinical rigidity

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Cognitive impairment in heart failure patients

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Journal of Geriatric Cardiology 2014年第4期11卷 316-328页

作者： Laura Leto mauro Feola School of Geriatry University of Turin Italy Cardiovascular Rehabilitation Heart Failure Unit Ospedale SS Trinita ' Via Ospedale 4-12045 Fossano Italy

Cognitive damage in heart failure （HF） involves different domains thus interfering with the ability for single patient to self-care and to cope with treatment regimens, modifying symptoms and health behaviours. Many cerebral and functional changes were detected in brain imaging, involving areas of both grey and white matter deputed to cognition. Although various instruments are available to explore cognition, no consensus was obtained on better tools to be used in HF population. Reduction in cerebral blood flow, decreased cardiac output, altera-tions of cerebrovascular reactivity and modification of blood pressure levels are the main features involved in the etiopathogenetic mecha-nisms of cognitive deficit. Several cardiac variables, laboratory parameters, demographic and clinical elements were studied for their possible relation with cognition and should be properly evaluated to define patients at increased risk of impairment. The present review gathers avail-able data pointing out assured information and discussing possible areas of research development.

关键词： Heart failure Cognitive impairment Blood pressure

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