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Climatic influences on cardiovascular diseases

World Journal of Cardiology 2022年第3期14卷 152-169页

作者： maurizio giuseppe abrignani Alberto Lombardo Annabella Braschi NicolòRenda Vincenzo abrignani Operative Unit of Cardiology Department of MedicineS.Antonio Abate Hospital of TrapaniASP TrapaniTrapani 91100Italy Department of Internal Medicine Department of PsychologyEducational Science and Human MovementUniversity of PalermoPalermo 90100Italy Department of Mental Health ASP TrapaniTrapani 91100Italy School of Medicine University of BolognaBologna 40126Italy

Classical risk factors only partially account for variations in cardiovascular disease incidence;therefore,also other so far unknown features,among which meteorological factors,may influence heart diseases(mainly coronary heart diseases,but also heart failure,arrhythmias,aortic dissection and stroke)*** most studied phenomenon is ambient *** relation between mortality,as well as cardiovascular diseases incidence,and temperature appears graphically as a"U"*** to cold,heat and heat waves is associated with an increased risk of acute coronary *** climatic variables,such as humidity,atmospheric pressure,sunlight hours,wind strength and direction and rain/snow precipitations have been hypothesized as related to fatal and nonfatal cardiovascular diseases *** limitation of these studies is the unavailability of data on individual exposure to weather *** of weather may vary depending on other factors,such as population disease profile and age *** stress may increase direct and indirect risks to human health via different,complex pathophysiological pathways and exogenous and endogenous *** data have attracted growing interest because of the recent earth’s climate change,with consequent increasing ambient temperatures and climatic *** review evaluates the evidence base for cardiac health consequences of climate conditions,and it also explores potential further implications.

关键词： Weather Climate Meteorology Cardiovascular diseases Myocardial infarction Angina pectoris

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Proton pump inhibitors and gastroprotection in patients treated with antithrombotic drugs: A cardiologic point of view

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世界心脏病学杂志:英文版(电子版) 2023年第8期15卷 375-394页

作者： maurizio giuseppe abrignani Alberto Lombardo Annabella Braschi Nicolo Renda Vincenzo abrignani Operative Unit of Cardiology P.Borsellino HospitalASP TrapaniMarsala 91025TrapaniItaly Operative Unit of Cardiology S.Antonio Abate HospitalASP TrapaniErice 91100TrapaniItaly Department of Psychology Educational Science and Human MovementUniversity of PalermoPalermo 90100Italy Department of Direction CTA SalusGibellina 91024TrapaniItaly Operative Unit of Internal Medicine with Stroke Care Department of Health PromotionMother and Child CareInternal Medicine and Medical Specialties(ProMISE)“G.D’Alessandro”University of PalermoPalermo 90100Italy

Aspirin,other antiplatelet agents,and anticoagulant drugs are used across a wide spectrum of cardiovascular and cerebrovascular diseases.A concomitant proton pump inhibitor(PPI)treatment is often prescribed in these patients,as gastrointestinal complications are relatively *** the other hand,a potential increased risk of cardiovascular events has been suggested in patients treated with PPIs;in particular,it has been discussed whether these drugs may reduce the cardiovascular protection of clopidogrel,due to pharmacodynamic and pharmacokinetic interactions through hepatic ***,the concomitant use of clopidogrel and omeprazole or esomeprazole has been *** contrast,it remains less known whether PPI use may affect the clinical efficacy of ticagrelor and prasugrel,new P2Y12 receptor *** guidelines recommend PPI use in combination with antiplatelet treatment in patients with risk factors for gastrointestinal bleeding,including advanced age,concurrent use of anticoagulants,steroids,or non-steroidal anti-inflammatory drugs,and Helicobacter pylori(***)*** patients taking oral anticoagulant with risk factors for gastrointestinal bleeding,PPIs could be recommended,even if their usefulness deserves further *** infection should always be investigated and treated in patients with a history of peptic ulcer disease(with or without complication)treated with antithrombotic *** present review summarizes the current knowledge regarding the widespread combined use of platelet inhibitors,anticoagulants,and PPIs,discussing consequent clinical implications.

关键词： Antithrombotic drugs Anticoagulants Aspirin Clopidogrel Gastrointestinal bleeding Proton pump inhibitors

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Time trends in antithrombotic therapy prescription patterns: Realworld monocentric study in hospitalized patients with atrial fibrillation

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World Journal of Cardiology 2022年第11期14卷 576-598页

作者： maurizio giuseppe abrignani Alberto Lombardo Annabella Braschi NicolòRenda Vincenzo abrignani Renzo M Lombardo Operative Unit of Cardiology Department of MedicineS.Antonio Abate Hospital of TrapaniASP TrapaniTrapani 91100TrapaniItaly Department of Psychology Educational Science and Human MovementUniversity of PalermoPalermo 90100PalermoItaly Department of Medicine and Surgery University of ParmaParma 43100ParmaItaly Operative Unit of Internal Medicine with Stroke Care Department of Health PromotionMother and Child CareInternal Medicine and Medical Specialties(ProMISE)"G.D'Alessandro"University of PalermoPalermo 90100PalermoItaly Department of Cardiology Operative Unit of CardiologyDepartment of MedicineS.Antonio Abate Hospital of TrapaniTrapani 91100TrapaniItaly

BACKGROUND Since 2010,the European Society of Cardiology has extended prescription criteria for oral antithrombotic therapy(OAT)in atrial fibrillation(AF).Direct oral anticoagulants(DOACs)were upgraded from an IIAa recommendation in 2012 to an IA in *** real-world scenarios,however,OAC prescription is still suboptimal,mainly for *** To evaluate OAT temporal prescription patterns in a cohort of patients hospitalized with AF in a Cardiology *** A retrospective observational study was conducted on a cohort of hospitalized patients in a secondary setting(Trapani,Italy)from 2010 to 2021 with AF as the main or secondary *** 4089 consecutive patients,the variables extracted from the Cardiology department database were:Sex,age,time of hospitalization,antithrombotic therapy(warfarin,acenocoumarol,apixaban,dabigatran,edoxaban,rivaroxaban,aspirin,clopidogrel,other antiplatelet agents,low molecular weight heparin,and fondaparinux),diagnosis at discharge and used *** features are presented as percentage values for categorized variables and as mean+/-SD for categorized *** From January 1st,2010 to October 6th,2021,25132 patients were hospitalized in our department;4089(16.27%,mean age 75.59+/-10.82)were discharged with AF diagnosis;of them,2245 were males(54.81%,mean age 73.56+/-11.45)and 1851 females(45.19%,mean age 78.06+/-9.47).Average length of stay was 5.76+/-4.88 days;154 patients died and 88 were moved to other Departments/*** was the main diagnosis in 899 patients(21.94%).The most frequent main diagnosis in patients with AF was acute myocardial infarction(1973 discharges,48.19%).The most frequent secondary cardiac diagnosis was chronic coronary syndrome(1864 discharges,45.51%),and the most frequent secondary associated condition was arterial hypertension(1010 discharges,24.66%).For the analysis of antithrombotic treatments,the final sample included 3067 patients,after excluding in-hospital deaths,transferre

关键词： Atrial fibrillation Antithrombotic agents Time series Warfarin Direct-acting oral anticoagulants Aspirin

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Frequency of and reasons behind non-listing in adult patients referred for liver transplantation: Results from a retrospective study

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World Journal of Transplantation 2024年第2期14卷 99-106页

作者： Marco Biolato Luca Miele giuseppe Marrone Claudia Tarli Antonio Liguori Rosaria Calia Giovanni Addolorato Salvatore Agnes Antonio Gasbarrini maurizio Pompili Antonio Grieco Department of Medical and Surgical Sciences CEMADFondazione Policlinico Universitario Agostino Gemelli IRCCSRome 00168Italy Department of Translational Medicine and Surgery Catholic University of Sacred HeartRome 00168Italy

BACKGROUND Few studies have evaluated the frequency of and the reasons behind the refusal of listing liver transplantation *** To assess the ineligibility rate for liver transplantation and its *** A single-center retrospective study was conducted on adult patients which entailed a formal multidisciplinary assessment for liver transplantation *** predictors for listing were evaluated using multivariable logistic *** In our center,314 patients underwent multidisciplinary work-up before liver transplantation enlisting over a three-year *** most frequent reasons for transplant evaluation were decompensated cirrhosis(51.6%)and hepatocellular carcinoma(35.7%).The non-listing rate was 53.8%and the transplant rate was 34.4%for the whole *** hundred and five motivations for ineligibility were *** most common contraindications were psychological(9.3%),cardiovascular(6.8%),and surgical(5.9%).Inappropriate or premature referral accounted for 76(37.1%)*** multivariable analysis,a referral from another hospital(OR:2.113;95%CI:1.259–3.548)served as an independent predictor of *** A non-listing decision occurred in half of our cohort and was based on an inappropriate or premature referral in one case out of *** referral from another hospital was taken as a strong predictor of non-listing.

关键词： Controindication Eligibility Evaluation Referral Personalized medicine

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Collision nodal metastasis of bladder cancer and melanoma:The first reported case and literature review

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Current Urology 2022年第3期16卷 168-171页

作者： Francesca Sanguedolce Francesco Troiano Giovanni Musci Magda Zanelii maurizio Zizzo Stefano Ascan giuseppe Carrieri Luigi Cormio Department of Pathology University HospitalFoggia71121Italy Department of Urology and Renal Transplantation University of FoggiaFoggiaItaly Pathology Unit Azienda UnitàSanitaria Locale-IRCCS di Reggio EmiliaReggio EmiliaItaly Surgical Oncology Unit Azienda UnitàSanitaria Locale-IRCCS di Reggio EmiliaReggio EmiliaItaly Clinical and Experimental Medicine University of Modena and Reggio EmiliaModenaItaly Pathology Unit Azienda Ospedaliera Santa Maria di TerniUniversity of PerugiaTerniItaly

Collision metastasis is a rare phenomenon of concomitant localization of 2 or more different tumors in the same lymph *** most cases,primary malignancies are synchronous carcinomas arising in the same organ or area of the body.A 82-year-old man presented with hematuria and acute renal failure;he had undergone dermatological consultation ten months ago because of a large deep brown skin lesion in his dorso-lumbar region,which was not excised upon patient's *** underwent radical cystectomy with extended pelvic lymphadenectomy due to nonpapillary high-grade urothelial carcinoma,with focal squamous features,infiltrating the bladder wall and prostate *** one left iliac lymph node,small foci of metastatic urothelial carcinoma(positive for P63 and CK34betaE12)were close to melanoma cells(positive for HMB45).The patient refused further treatment and died of metastatic disease 12 months after *** is no specific clinical feature for nodal collision metastasis.A polymorphic histologic appearance poses the suspect,but immunohistochemical stains are needed to define the primary *** metastases are thought to carry a poor *** clinical relevance is linked to the fact that the patient faces 2 different metastatic tumors that may require specific multidisciplinary approach once diagnosed as *** present,to the best of our knowledge,the first case of collision nodal metastasis from bladder cancer and melanoma,and describe its clinical and histopathological characteristics to raise awareness on this rare occurrence,which portends a poorer prognosis than each single tumor.

关键词： Bladder Cancer Collision tumor Melanoma Nodal metastasis

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Unexpected me diastinal mass in a liver transplanted patient

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Hepatobiliary & Pancreatic Diseases International 2019年第2期18卷 199-201页

作者： giuseppe Losurdo giuseppe Ingravallo Antonio Mongelli Nicola maurizio Castellaneta Antonio Pisani Section of Gastroenterology Department of Emergency and Organ Transplantation University "Aldo Moro" Section of Pathology Department of Emergency and Organ Transplantation University "Aldo Moro"

To the Editor:The risk of de novo cancer increases by 2 to 7-fold after liver transplantation[1].The most common de novo cancers are both solid(non-melanoma skin cancers,colorectal carcinoma,genito-urinary and head-neck cancer)[2,3]as well as hematologic malignancies,in particular the so-called post-transplant lymphoproliferative disorder[4].

关键词： mediastinal mass liver transplanted patient post-transplant

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Ebola:a review on the state of the art on prevention and treatment

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Asian Pacific Journal of Tropical Biomedicine 2014年第12期4卷 925-927页

作者： giuseppe La Torre Vincenzo Nicosia maurizio Cardi Department of Public Health and Infectious Diseases.Sapienza University of Rome SIMVIM-Italian Society of Travel and Migration Medicine Department of Surgery "Pietro Valdoni" Azienda Policlinico Umberto ISapienza University of Rome Emergency NGO Surgical Division

The aim of this paper is to highlight the current development in the research field for helping people just exposed to Ebola virus survive(treatment) and to prevent the disease when given at various times after exposure(vaccine).Concerning the treatment,recombinant anti-Ebola monoclonal antibodies and small interfering RNAs that block the expression of essential viral proteins,are the most promising way in stopping the disease when it has already reached the *** far as concerns the prevention field,two candidate vaccines have clinical-grade vials available for phase 1 pre-licensure clinical trials,and demonstrated to have a 100%efficacy in studies on non human ***-informed communities can reduce the main ways of spread the infection,by avoiding unprotected home-based care of people who are infected and also by completely modifying traditional burial practices that are way of diffusion of the contagion.

关键词： stopping highlight modifying candidate vaccines avoiding helping prevention exposed monoclonal

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Transient elastography: A non-invasive tool for assessing liver fibrosis in HIV/HCV patients

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World Journal of Gastroenterology 2010年第41期16卷 5225-5232页

作者： Valentina Li Vecchi maurizio Soresi Claudia Colomba Giovanni Mazzola Pietro Colletti maurizio Mineo Paola Di Carlo Emanuele La Spada Giovanni Vizzini giuseppe Montalto Department of Clinical Medicine and Emerging Pathologies University of Palermo Via del Vespro 141 90127 Palermo Italy Infectious Diseases Section Department of Health Promotion Sciences University of Palermo Via del Vespro 129 90127 Palermo Italy Department of Gastroenterology and Hepatology Mediterranean Institute for Transplantation and Advanced Specialized Therapies (IsMeTT) University of Pittsburgh Medical Center Via Tricomi 1 90127 Palermo Italy

AIM: To assess the prevalence of advanced liver fibrosis (ALF) in human immunodeficiency virus (HIV), hepatitis C virus (HCV) and HIV/HCV patients using transient elastography, and to identify factors associated with ALF. METHODS: Between September 2008 and October 2009, 71 HIV mono-infected, 57 HIV/HCV co-infected and 53 HCV mono-infected patients on regular follow-up at our Center were enrolled in this study. Alcohol intake, the main parameters of liver function, presence of HCV-RNA, HIV-RNA, duration of highly active anti-retroviraltherapy (HAART) and CD4 cell count were recorded. ALF was defined as liver stiffness (LS) ≥ 9.5 kPa. To estimate liver fibrosis (LF) a further 2 reliable biochemical scores, aspartate aminotransferase platelet ratio index (APRI) and FIB-4, were also used. RESULTS: LS values of co-infected patients were higher than in either HIV or HCV mono-infected patients (χ 2M H = 4, P 9.5 kPa. There was no significant correlation between extent of LF and HAART exposure or duration of HAART exposure, in particular with specific dideoxynucleoside analogues. CONCLUSION: ALF was more frequent in co-infected than mono-infected patients. This result correlated with lower CD4 levels. Protectiv

关键词： Liver fibrosis Transient elastography Aspartate aminotransferase platelet ratio index FIB-4 test Fibrosis evaluation Human immunodeficiency virus infection Hepatitis C virus infection

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Advances in medical decision support systems for diagnosis of acute graft-versus-host disease: molecular and computational intelligence joint approaches

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Frontiers in Biology 2011年第4期6卷 263-273页

作者： maurizio FIASCHÉ Maria CUZZOLA giuseppe IRRERA Pasquale IACOPINO Francesco Carlo MORABITO DIMET University“Mediterranea”of Reggio CalabriaItaly Transplant Regional Center of Stem Cells and Cellular Therapy “A.Neri”Reggio CalabriaItaly School of Hematology University of MessinaItaly

Acute graft-versus-host disease (aGVHD) is a serious systemic complication of allogeneic hematopoietic stemcell transplantation (HSCT) causing considerable morbidity and mortality. Acute GVHD occurs when alloreactivedonor-derived T cells recognize host-recipient antigens as foreign. These trigger a complex multiphase process thatultimately results in apoptotic injury in target organs. The early events leading to GVHD seem to occur very soon,presumably within hours from the graft infusion. Therefore, when the first signs of aGVHD clinically manifest, thedisease has been ongoing for several days at the cellular level, and the inflammatory cytokine cascade is fully ***, it comes as no surprise that progress in treatment based on clinical diagnosis of aGVHD has been limited in the past30 years. It is likely that a pre-emptive strategy using systemic high-dose corticosteroids as early as possible couldimprove the outcome of aGVHD. Due to the deleterious effects of such treatment particularly in terms of infection riskposed by systemic steroid administration in a population that is already immune-suppressed, it is critical to identifybiomarker signatures for approaching this very complex task. Some research groups have begun addressing this issuethrough molecular and proteomic analyses, combining these approaches with computational intelligence techniques,with the specific aim of facilitating the identification of diagnostic biomarkers in aGVHD. In this review, we focus on theaGVHD scenario and on the more recent *** also attempt to give an overview of the classical and noveltechniques proposed as medical decision support system for the diagnosis of GVHD.

关键词： computational intelligence gene selection GVHD machine learning personalized modelling wrapper

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Relevance of Spike/Estrogen Receptor-αinteraction for endothelial-based coagulopathy induced by SARS-CoV-2

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Signal Transduction and Targeted Therapy 2023年第6期8卷 2459-2462页

作者： Silvia Stella Barbieri Franca Cattani Leonardo Sandrini Magda Maria Grillo Alessandra Amendola Carmen Valente Carmine Talarico Daniela Iaconis Gabriele Turacchio Miriam Lucariello Lucia Lione Erika Salvatori Patrizia Amadio Gloria Garoffolo Mariano Maffei Francesca Galli Andrea Rosario Beccari giuseppe Sberna Emanuele Marra Marica Zoppi Michael Michaelides giuseppe Roscilli Luigi Aurisicchio Riccardo Bertini Marcello Allegretti maurizio Pesce Centro Cardiologico Monzino IRCCSMilanoItaly Dompéfarmaceutici S.p.A. L’AquilaItaly Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani RomaItaly Institute of Experimental Endocrinology and Oncology“G.Salvatore”(IEOS) National Research CouncilNaplesItaly EXSCALATE DompéFarmaceutici S.p.ANapoliItaly Takis S.r.l. RomeItaly National Institute on Drug Abuse Intramural Research Program Baltimore21224MDUSA Johns Hopkins School of Medicine BaltimoreMDUSA Atreius S.a.s. L’AquilaItaly

Dear Editor,The severe coagulation syndrome in numerous organs is the major life-threatening conditions characterizing the acute infection by *** inflammation/dysfunction,platelet hyper-reactivity,generation of neutro... 详细信息

关键词： organs infection acute

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