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Eviendep~ reduces number and size of duodenal polyps in familial adenomatous polyposis patients with ileal pouchanal anastomosis

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World Journal of Gastroenterology 2013年第34期19卷 5671-5677页

作者： Carlo Calabrese Chiara Praticò Andrea Calafiore maurizio coscia Lorenzo Gentilini Gilberto Poggioli Paolo Gionchetti Massimo Campieri Fernando Rizzello Dipartimento di Scienze Mediche e Chirurgiche (DIMEC) University of Bologna

AIM:To evaluate if 3 mo oral supplementation with Eviendep was able to reduce the number of duodenal polyps in familial adenomatous polyposis(FAP)patients with ileal pouch-anal anastomosis(IPAA).METHODS:Eleven FAP patients with IPAA and duodenal polyps were *** underwent upper gastrointestinal(GI)endoscopy at the baseline and after 3 mo of *** patient received 5 mg Eviendep twice a day,at breakfast and dinner time,for3 *** endoscopists evaluated in a blinded manner the number and size of duodenal *** GI endoscopies with biopsies were performed at the baseline(T0)with the assessment of the Spigelman ***>10 mm were removed during endoscopy and at the end of the procedure a new Spigelman score was determined(T1).The procedure was repeated 3 mo after the baseline(T2).Four photograms were examined for each patient,at T1 and *** examined area was divided into 3 segments:duodenal bulb,second and third portion *** specimens were taken from all polyps>10 mm and from all suspicious ones,defined by the presence of a central depression,irregular surface,or irregular vascular *** was classified according to the updated Vienna ***:At baseline the mean number of duodenal detected polyps was 27.7 and mean sizes were 15.8mm;the mean Spigelman score was *** polypectomy the mean number of duodenal detected polyps was 25.7 and mean sizes were 7.6 mm;the mean Spigelman score was *** 3 mo of Eviendep bid,all patients showed a reduction of number and size of duodenal *** mean number of duodenal polyps was 8(P=0.021)and mean size was 4.4 mm;the mean Spigelman score was *** agreement was ***>1 cm found a very good degree of concordance(kappa 0.851)and a good concordance was as well encountered for smaller lesions(kappa 0.641).CONCLUSION:Our study demonstrated that shortterm(90 d)supplementation with Eviendep in FAP patients with IPAA and with recurrent adenomas in t

关键词： Familial adenomatous polyposis Ileal pouch-anal anastomosis Duodenal polyps Eviendep

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