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Hepatocellular carcinoma surveillance: an open question

Hepatobiliary Surgery and Nutrition 2019年第4期8卷 431-432页

作者： maurizio biselli Francesca Garuti Andrea Neri Department of Medical and Surgical Sciences Semeiotica Medica Alma Mater Studiorum University of Bologna Bologna Italy

We were very interested to read the study recently published in Gastroenterology by Moon et al. (1). Performed as a case-control study within the US Veterans Affairs health care system, the study aimed to assess the association between screening for hepatocellular carcinoma (HCC) and cancer related-mortality in patients with cirrhosis. The authors did not find any evidence that screening patients with cirrhosis by abdominal ultrasound (US) or alpha-fetoprotein (AFP) levels decreases HCC-related mortality.

关键词： mortality al. cirrhosis

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Hepatitis C virus reinfection after liver transplantation: Is there a role for direct antiviral agents?

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World Journal of Gastroenterology 2014年第28期20卷 9253-9260页

作者： Marco Dall’Agata Annagiulia Gramenzi maurizio biselli Mauro Bernardi Semeiotica Medica - Policlinico S.Orsola-Malpighi Dipartimento di Scienze Mediche e ChirurgicheUniversity of Bologna

Recurrence of hepatitis C virus(HCV)infection following liver transplantation(LT)is almost universal and can accelerate graft cirrhosis in up to 30%of *** development of effective strategies to treat or prevent HCV recurrence after LT remains a major challenge,considering the shortage of donor organs and the accelerated progression of HCV in LT *** antiviral therapy with pegylated-interferon plus ribavirin is the current treatment of choice for HCV LT recipients,even though the combination is not as effective as it is in immunocompetent patients.A sustained virological response in the setting of LT improves patient and graft survival,but this is only achieved in 30%-45%of patients and the treatment is poorly *** improve the efficacy of pre-and post-transplant antiviral therapy,a new class of potent direct-acting antiviral agents (DAAs)has been *** aim of this review is to summarize the use of DAAs in LT HCV ***,Cochrane Library,MEDLINE,EMBASE,Web of Science and clinical trial databases were searched for this *** date,only three clinical studies on the topic have been published and most of the available data are in abstract *** a moderately successful early virological response has been reported,DAA treatment regimens were associated with severe toxicity mitigating their potential ***,the ongoing nature of data,the lack of randomized studies,the small number of enrolled patients and the heterogeneity of these studies make the results largely anecdotal and *** conclusion,large welldesigned clinical studies on DAAs in HCV LT patients are required before these drugs can be recommended after transplantation.

关键词： Hepatitis C virus Liver transplantation Direct antiviral agents Peginterferon/ribavirin Immunosuppressive agents

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