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Transcranial magnetic stimulation research on reading and dyslexia:a new clinical intervention technique for treating dyslexia?

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Neuroimmunology and Neuroinflammation 2015年第1期2卷 145-152页

作者： maurits van den noort Esli Struys Peggy Bosch Department of Linguistics Vrije Universiteit Brussel1050 BrusselsBelgium Research Group of Pain and Neuroscience Kyung Hee UniversitySeoul 130-701South Korea Centre for Cognition Donders Institute for BrainCognition and BehaviourRadboud University Nijmegen6500 GL NijmegenGelderlandthe Netherlands Psychiatric Research Institute LVR-Klinik Bedburg-Hau47551 Bedburg-HauGermany

Nowadays,several noninvasive neuroimaging techniques,including transcranial magnetic stimulation(TMS),*** working mechanism behind TMS is a rapidly changing magnetic field that generates an electric current via electromagnetic *** the coil is placed on the scalp,the magnetic field generates a physiological reaction in the underlying neural *** TMS-induced change in the participant’s behavior is used by researchers to investigate the causal relations between specific brain areas and cognitive functions such as language.A variant of TMS has been developed,which is called rapid-rate TMS(rTMS).In this review,three databases(Medline,Educational Resources Information Center,and Scopus)were searched for rTMS studies on normal reading and dyslexia with a cut-off date of October 31,*** was found to be a valuable tool for investigating questions related to reading research,both on the word and the sentence ***,it can be successfully used in research on ***,(high-frequency)rTMS has been used as a“clinical”intervention technique for treating dyslexia and for improving reading performance by exciting underactive reading pathways in the ***,we end the paper with a discussion of future directions in the field of rTMS research and dyslexia,for instance,the promising prospect of combining TMS with simultaneous electroencephalographic imaging.

关键词： Clinical intervention dyslexia sentence reading transcranial magnetic stimulation word reading

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Acupuncture treatment of a male patient suffering from long-term schizophrenia and sleep disorders

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Journal of Traditional Chinese Medicine 2017年第6期37卷 862-867页

作者： Peggy Bosch Heike Staudte Sujung Yeo Sook-Hyun Lee Sabina Lim maurits van den noort Donders Centre for Cognition Radboud University NijmegenNijmegen 6525 HRThe Netherlands Psychiatric Research Institute LVR-Klinik Bedburg-HauBed-burg-Hau 47551Germany Psychiatric Research Institute LVR-Klinik Bedburg-HauBedburg-Hau 47551Germany Department of Acupuncture&Meridian of Oriental Medicine Sang Ji UniversityWonju 26339Republic ofKorea Research Group of Pain and Neuroscience Kyung Hee UniversitySeoul 130-701Republic of Korea Research Group of Pain and Neuro-science Kyung Hee UniversitySeoul 130-701Republic of Korea.Brussels Institute for Applied LinguisticsFree Univer-sity of BrusselsBrussels 1050Belgium

OBJECTIVE: To investigate the effectiveness of acupuncture in the treatment of chronic schizophrenia and co-morbid sleep ***: A 42-year-old German male outpatient,suffering from long-term schizophrenia and sleep disorders, entered the study. Acupuncture was used as a non-pharmacological intervention. In addition to his ongoing Western Medicine(pharmacological) treatment, the patient received 12 weekly(non-standardized) acupuncture treatments in the clinic. The Traditional Chinese Medicine(TCM) diagnosis, the psychological assessment and the actiwatch data were compared before and after the acupuncture ***: The TCM diagnosis revealed a Liver Fire pattern before the acupuncture treatment, which was still present, although to a lesser degree, after the treatment. The psychological assessment revealed no change in the positive symptoms, but a small decrease in the negative symptoms and the general psychopathology of the patient. This was further illustrated by the small decrease in the number of depressive symptoms. The subjective sleep disorders improved markedly after acupuncture treatment, but the daytime sleepiness did not. The actiwatch results showed that after acupuncture treatment, the patient was moving less during sleep, but no significant results were found for the other sleep ***: Acupuncture was found to be an effective non-pharmacological add-on method for treating subjective sleep disorders, and, to a lesser degree, objective sleep disorders and the negative symptoms of chronic schizophrenia. Future larger clinical trials with follow-up measurements are needed in order to replicate the present preliminary beneficial acupuncture findings and in order to determine whether the observed effects can be sustained.

关键词： Actigraphy Acupuncture Schizophre-nia Sleep weak disorders

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Traditional Chinese medicine in psychiatry： the fruit-basket-problem

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Journal of Integrative Medicine 2016年第4期14卷 239-240页

作者： Peggy Bosch Peter de Rover Sujung Yeo Sook-Hyun Lee Sabina Lim maurits van den noort Donders Center for Cognition Radboud University Nijmegen 6525 HR Nijmegen The Netherlands Psychiatric Research Institute LVR-Klinik Bedburg-Hau 47551 Bedburg-Hau Germany Division of Acupuncture & Meridian WHO Collaborating Center for Traditional Medicine East-West Medical Research Institute and School of Korean Medicine Kyung Hee University Seoul 130-701Korea Karel de Grote Hoge School 2018 Antwerp Belgium Department of Acupuncture & Meridian of Oriental Medicine Sang Ji University Wonju 26339 Korea Brussels Institute for Applied Linguistics Free University of Brussels 1050 Brussels Belgium

Traditional Chinese medicine （TCM） is gaining popularity in the treatment of psychiatric disorders that can be described and treated from either an Eastern or a Western perspective. In Eastern medicine, the disorders are described according to five diagnostic methods that are used in TCM： inspection, auscultation, olfaction, inquiry, and palpation, including tongue and pulse diagnosis.

关键词： medicine Chinese traditional diagnostic methods psychiatry

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The effect of acupuncture on mood and working memory in patients with depression and schizophrenia

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Journal of Integrative Medicine 2015年第6期13卷 380-390页

作者： Peggy Bosch maurits van den noort Sujung Yeo Sabina Lim Anton Coenen Gilles van Luijtelaar Donders Centre for Cognition Radboud University Nijmegen Psychiatric Research Institute LVR-Klinik Bedburg-Hau Division of Acupuncture & Meridian WHO Collaborating Center for Traditional MedicineEast-West Medical Research Institute and School of Korean MedicineKyung Hee University Brussels Institute for Applied Linguistics Free University of Brussels Department of Acupuncture & Meridian of Oriental Medicine Sang Ji University

BACKGROUND： In patients with depression, as well as in patients with schizophrenia, both mood and working memory performance are often impaired. Both issues can only be addressed and improved with medication to some extent. OBJECTIVE： This study investigates the mood and the working memory performance in patients with depression or schizophrenia and whether acupuncture can improve these. DESIGN, SETTING, PARTICIPANTS AND INTERVENTIONS： A pragmatic clinical trial design was used The study was conducted in a psychiatric clinic. Fifty patients with depression and 50 with schizophrenia were randomly divided into an experimental and a waiting-list group. Additionally, 25 healthy control participants were included. Twelve weeks of individualized acupuncture treatment was used as the clinical intervention. MAIN OUTCOME MEASURES： All patients were tested before （T1） and after （T2） acupuncture treatment on a mood scale （Beck Depression Inventory-II, BDI-II）, a simple working memory task （digit span）, and a complex working memory task （letter-number sequencing）; the healthy controls were tested at T1 only. RESULTS： Patients with depression scored worse than the others on the BDI-II, and patients with schizophrenia scored worse than the healthy controls. On the digit span, patients with schizophrenia did not differ from healthy controls whereas they scored worse of all on the letter-number sequencing. With respect to the acupuncture findings, first, the present study showed that the use of acupuncture to treat patients with schizophrenia was both practical and safe. Moreover, acupuncture had a positive effect on the BDI-II for the depression group, but acupuncture had no effect on the digit span and on the letter- number sequencing performance for the two clinical groups. CONCLUSION： The clinical improvement in patients with depression after acupuncture treatment was not accompanied by any significant change in a simple working memory task or in a more complex working memory t

关键词： acupuncture therapy schizophrenia depression disorder affect working memory

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Symptom severity,quality of sleep,and treatment adherence among patients suffering from schizophrenia and depression

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Neuroimmunology and Neuroinflammation 2016年第1期3卷 109-116页

作者： Peggy Bosch Janina Waberg maurits van den noort Heike Staudte Sabina Lim Jos Egger Centre for Cognition Donders Institute for BrainCognition and BehaviourRadboud University Nijmegen6500 GL Nijmegenthe Netherlands Psychiatric Research Institute LVR-Klinik Bedburg-Hau47511 Bedburg-HauGermany Research Group of Pain and Neuroscience Kyung Hee UniversitySeoul 130-701South Korea Brussels Institute for Applied Linguistics Vrije Universiteit Brussel1050 BrusselsBelgium Behavioural Science Institute Radboud University Nijmegen6500 GL Nijmegenthe Netherlands Centre of Excellence for Neuropsychiatry Vincent van Gogh Institute for Psychiatry5803 AC Venraythe Netherlands Pompe Institute for Forensic Psychiatry PRO Persona6503 CK Nijmegenthe Netherlands

Aim:Treatment non-adherence is a common problem in patients suffering from schizophrenia and *** study investigated the possible relationships between symptom severity,quality of sleep,and treatment ***:Thirty outpatients with schizophrenia and 58 outpatients with depression were enrolled in this *** beck depression Inventory-II,the positive and negative syndrome scale,and the pittsburgh sleep quality index were used to assess symptom severity and quality of sleep,and sleep log data were used to measure treatment ***:The preliminary results showed no significant relationship between symptom severity and treatment adherence or between quality of sleep and treatment adherence in patients with ***,a significant positive relationship was found between negative symptoms and treatment adherence and a significant negative relationship between quality of sleep and treatment adherence in patients with ***:The present exploratory study revealed a positive relationship between symptom severity and treatment adherence and a negative relationship between quality of sleep and treatment adherence in patients with schizophrenia,but no significant relationships in patients with depression were *** studies are needed in order to gain a better understanding of possible risk factors related to treatment non-adherence.

关键词： Depression quality of sleep schizophrenia symptom severity treatment adherence

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Transcranial magnetic stimulation for schizophrenia: potential and risks

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Neuroimmunology and Neuroinflammation 2017年第12期4卷 258-259页

作者： Peggy Bosch Sujung Yeo Heike Staudte Pia Barisch Sabina Lim maurits van den noort Psychiatric Research Group LVR-Klinik Bedburg-Hau47511 Bedburg-HauGermany Centre for Cognition Donders Institute for BrainCognition and BehaviourRadboud University Nijmegen6500 GL NijmegenGelderlandThe Netherlands College of Korean Medicine Sang Ji UniversityWonju 26339South Korea Institute of Experimental Psychology Heinrich Heine University40225 DüsseldorfGermany Research Group of Pain and Neuroscience Kyung Hee UniversitySeoul 130-701South Korea Brussels Institute for Applied Linguistics Vrije Universiteit Brussel1050 BrusselsBelgium.

Recently, transcranial magnetic stimulation (TMS) has increasingly been used to investigate the neurobiology of schizophrenia. In those studies, researchers applied TMS in combination with motor evoked potentials (TMS... 详细信息

关键词： Transcranial magnetic potential and risks transcranial magnetic stimulation

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Schizophrenia and comorbid sleep disorders

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Neuroimmunology and Neuroinflammation 2016年第1期3卷 225-227页

作者： maurits van den noort Heike Staudte Benoît Perriard Sujung Yeo Sabina Lim Peggy Bosch Research Group of Pain and Neuroscience Kyung Hee UniversitySeoul 130-701South Korea Brussels Institute for Applied Linguistics Vrije Universiteit Brussel1050 BrusselsBelgium Psychiatric Research Institute LVR-Klinik Bedburg-Hau47511 Bedburg-HauGermany Neurology Unit Laboratory for Cognitive and Neurological SciencesDepartment of MedicineFaculty of ScienceUniversity of Fribourg1700 FribourgSwitzerland Department of Acupuncture and Meridian of Oriental Medicine Sang Ji UniversityWonju 26339South Korea Centre for Cognition Donders Institute for BrainCognition and BehaviourRadboud University Nijmegen6500 GL NijmegenGelderlandthe Netherlands.

Schizophrenia is a severe psychiatric disorder that has a worldwide prevalence of 0.5%^([1])and poses a high cost to society.^([2])The disorder is characterized by positive symptoms,such as hallucinations and delusions,^([3])negative symptoms,such as impaired emotional functioning and behavioral disruptions(*** affect,difficulty in starting activities and completing them,etc.),^([4])and cognitive symptoms,such as deficits in executive functioning,impaired working memory,and attention problems.

关键词： impaired Schizophrenia morbid

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On the need to unify neuroscience and physics

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Neuroimmunology and Neuroinflammation 2016年第1期3卷 271-273页

作者： maurits van den noort Sabina Lim Peggy Bosch Research Group of Pain and Neuroscience Kyung Hee UniversitySeoul 130-701South Korea Brussels Institute for Applied Linguistics Vrije Universiteit Brussel1050 BrusselsBelgium Psychiatric Research Institute LVR-Klinik Bedburg-Hau47511 Bedburg-HauGermany Centre for Cognition Donders Institute for BrainCognition and BehaviourRadboud University Nijmegen6500 GL NijmegenGelderlandThe Netherlands

Neuroscience is a relatively new research field that,so far,has resulted in important progress in understanding the physiology,biochemistry,pharmacology,and structure of the vertebrate brain.^([1])Because of this progress,spectacular technological developments,^([2])*** emission tomography,functional magnetic resonance imaging,transcranial magnetic stimulation(TMS),diffusion tensor imaging,magneto-encephalography,electro-encephalography,etc.,and new treatments based on them,such as high-frequency repetitive TMS(rTMS),^([3])deep brain stimulation.

关键词： stimulation rTMS treatment

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B淋巴细胞克隆性免疫扩增与多发性硬化症

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上海免疫学杂志 2000年第2期20卷 69-71页

作者：秦幼棻 S.van den noort 张一平 Department of Neurology University of CaliformiaIrvine Shriners’Hospital for Children Department of Medicine McGill UniversityMontreal

免疫球蛋白(Ig)基因超突变(hypermutation),为高亲和力B细胞的发生与发展提供了基础,其中涉及B细胞克隆选择性增殖.近年来,对人类B细胞Ig基因超突变及其选择性克隆增殖的研究有了实质性的进展.人们对B细胞免疫应答的本质、生发中心的形... 详细信息

免疫球蛋白(Ig)基因超突变(hypermutation),为高亲和力B细胞的发生与发展提供了基础,其中涉及B细胞克隆选择性增殖.近年来,对人类B细胞Ig基因超突变及其选择性克隆增殖的研究有了实质性的进展.人们对B细胞免疫应答的本质、生发中心的形成、B细胞克隆的产生和发育、抗原-B细胞-T细胞相互作用及不同B细胞亚群的调节,在分子与克隆水平上重新加以认识.从而推动了对中枢神经系统(CNS)B细胞超突变、克隆性增殖与CNS自身免疫性疾病关系的研究,并取得一系列新进展.

关键词：多发性硬化症 B细胞克隆性免疫扩增

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悬臂式檐蓬营造开放特色——荷兰奈梅亨大学Grotius教学楼

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设计家 2015年第2期 54-57页

作者： Mels Crouwel Joost Vos Joost van noort Okke van den Broek Moon Brader Frank Deltrap Marcel Wassenaar Nico de Waard Cees Zuidervaart Amir Farokhian Jannes Linders

Grotiusge大楼是奈梅亨大学的新教学楼,主要为法学院建造。奈梅亨大学坐落于绿植环绕,如同公园般风景秀丽的地段。这栋布局紧凑、独立的教学楼面向四周,完美地融入绿色的校园。这座水平铰接式的教学楼占地面积很小,看起来仅有三层,事实... 详细信息

Grotiusge大楼是奈梅亨大学的新教学楼,主要为法学院建造。奈梅亨大学坐落于绿植环绕,如同公园般风景秀丽的地段。这栋布局紧凑、独立的教学楼面向四周,完美地融入绿色的校园。这座水平铰接式的教学楼占地面积很小,看起来仅有三层,事实上共有五层,地下有一层和顶层还有一层隐蔽的阁楼。汽车停车场和自行车库都位于地下层。主入口位于一个将要新建的广场区。通过主入口可以进入明亮的中庭。

关键词：奈梅亨 Grotius 悬臂式主入口地下层占地面积直射光全景图室内装饰倾泻而下

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