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Survival in a Chilean Cohort of Thymic Tumors

Journal of Cancer Therapy 2019年第7期10卷 510-517页

作者： mauricio salinas Mozart Liessi Patricio Vallejo Cristian Ibarra School of Medicine Universidad de Chile Santiago Chile Instituto Nacional del Tórax Santiago Chile

Introduction: Thymus neoplasm is rare tumors and it has low mortality. There are scarce publications in Latin-American about this topic. We present a Chilean casuistic. Method: Retrospective cohort of every patient’s thymic epithelial tumors diagnosed in Instituto Nacional del Tórax, Santiago, Chile, between January 2007 and June 2015. Information was obtained from pathological and clinical registries. Death date was achieved from national registry. We report epidemiological data, clinical manifestations, histology type, Masaoka and WHO classification, therapies and survivor. Results: Sixty-five patients were included, with mean age 58 years and 36.9% men. Myasthenia gravis was present in 24 (36.9%) of patients. Ninety four percent of patients had a surgical biopsy. There were 60 thymomas and 5 thymic carcinomas. Most of tumors were stage I and II in Masaoka classification and type B in WHO classification. There were no deaths at 30 days. Nosocomial pneumonia was the most common complication. Conclusions: In this thymic tumor cohort there are more women and they are older than previously reported. Myasthenia gravis prevalence was similar. The survival of patients with thymomas was excellent.

关键词： Thymoma Thymus Neoplasms Thymus Gland

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Effect of phacoemulsification on intraocular pressure in patients with primary open angle glaucoma and pseudoexfoliation glaucoma

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International Journal of Ophthalmology(English edition) 2017年第9期10卷 1374-1378页

作者： Jesus Jimenez-Roman Gabriel Lazcano-Gomez Karina Martínez-Baez mauricio Turati Rosario Gulías-Canizo Luis F.Hernández-Zimbrón Lenin Ochoa-De la Paz Rubén Zamora Roberto Gonzalez-salinas Glaucoma Department Asociation to Prevent Blindness inMexicoMexico City 04030Mexico Research Department Asociation to Prevent Blindness inMexicoMexico City 04030Mexico Cell Biology Department Advanced Research CenterI.P.N.(CINVESTAV)in Mexico CityMexico City 07360Mexico

AIM：To compare the effect of phacoemulsification on intraocular pressure（IOP）in patients with primary open angle glaucoma（POAG）and pseudoexfoliation glaucoma（PXG）.METHODS：A retrospective comparative case series conducted at the Glaucoma Department at the Association to Prevent Blindness in *** study enrolled consecutive patients having phacoemulsification with intraocular lens（IOL）implantation and a diagnosis of POAG or *** about IOP values and number of glaucoma medications used was collected at baseline,1,3,6 and12mo ***：The study enrolled 88 patients（88 eyes）.After phacoemulsification,there was a statistically significant reduction in IOP values and glaucoma medications use compared to baseline in both POAG and PXG patients（P〈0.001）.In the POAG group,a 20%decrease in IOP values was evidenced,and a 56.5%reduction in the number of medications used at the one-year *** PXG group showed a 20.39%,and a 34.46%decrease in IOP and number of medications used,respectively.A significant difference in the meanΔIOP（postoperative changes in IOP）was evidenced between groups（P=0.005）.The reduction of the postsurgical IOP mean values in both groups,the POAG group showed a greater reduction in IOP values compared to the PXG ***：In both types of glaucoma,phacoemulsification cataract surgery can result in a significant IOP reduction（20%）over a 12mo follow-up *** number of medications used is also significantly reduced up to 12mo after surgery,especially in the PXG group.

关键词： cataract surgery pseudoexfoliation glaucoma secondary glaucoma primary open angle glaucoma intraocularpressure

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