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Effect of Aspergillus niger prolyl endopeptidase in patients with celiac disease on a long-term gluten-free diet

World Journal of Gastroenterology 2024年第11期30卷 1545-1555页

作者： Juan Pablo Stefanolo Verónica Segura Martina Grizzuti Abel Heredia Isabel Comino Ana Florencia Costa Roberto Puebla María Paz Temprano Sonia Isabel Niveloni Gabriel de diego María E Oregui Edgardo Gustavo Smecuol mauricio C de Marzi Elena F Verdú Carolina Sousa Julio César Bai Small Bowel Section Department of MedicineGastroenterology Hospital of Buenos Aires“Dr.C.Bonorino Udaondo”Buenos Aires 1264Argentina Department of Microbiology and Parasitology Faculty of PharmacyUniversity of SevilleSeville 41080Spain Department of Medicine Dr.C.Bonorino Udaondo Gastroenterology HospitalBuenos Aires 1264Argentina Basic and Applied Research Group in Immunology and Bioactives(GIBAIB) Institute of Ecology and Sustainable Development(INEDES)National University of LujanLuján 6700Buenos AiresArgentina Department of Medicine Farncombe Family Digestive Health Research InstituteMcMaster UniversityHamilton L8S 4L8OntarioCanada Facultad de Medicina Universidad del SalvadorBuenos Aires C1051ABBArgentina

BACKGROUND The gluten-free diet(GFD)has limitations,and there is intense research in the development of adjuvant *** To examine the effects of orally administered Aspergillus niger prolyl endopeptidase protease(AN-PEP)on inadvertent gluten exposure and symptom prevention in adult celiac disease(CeD)patients following their usual *** This was an exploratory,double-blind,randomized,placebo-controlled trial that enrolled CeD patients on a long-term *** a 4-wk run-in period,patients were randomized to 4 wk of two AN-PEP capsules(GliadinX;AVI Research,LLC,United States)at each of three meals per day or *** endpoints were:(1)Average weekly stool gluten immunogenic peptides(GIP)between the run-in and end of treatments and between AN-PEP and placebo;(2)celiac symptom index(CSI);(3)CeD-specific serology;and(4)quality of *** samples were collected for GIP testing by ELISA every Tuesday and Friday during run-ins and *** Forty patients were randomized for the intention-to-treat analysis,and three were excluded from the per-protocol ***,628/640(98.1%)stool samples were *** was undetectable(differences between treatment arms were *** 0.5%of samples had GIP concentrations sufficiently high(>0.32μg/g)to potentially cause mucosal *** GIP concentration in the AN-PEP arm was 44.7%lower than in the run-in ***-third of patients exhibiting GIP>0.08μg/g during run-in had lower or undetectable GIP after AN-PEP *** with the run-in period,the proportion of symptomatic patients(CSI>38)in the AN-PEP arm was significantly lower(Pdid not result in changes in specific *** This exploratory study conducted in a real-life setting revealed high adherence to the *** AN-PEP treatment did not significantly reduce the overall GIP stool ***,given the observation of a significantly lower prevale

关键词： Celiac disease Aspergillus niger prolyl endoprotease Gluten immunogenic peptides Trial Symptoms Real-life trial

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Understanding wound healing in obesity

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World Journal of Experimental Medicine 2024年第1期14卷 22-32页

作者： Asha Cotterell Michelle Griffin mauricio A Downer Jennifer B Parker Derrick Wan Michael T Longaker division of Plastic and Reconstructive Surgery Stanford UniversityPalo AltoCA 94301United States Stanford University School of Medicine Stanford University School of MedicinePalo AltoCA 94301United States Department of Surgery Stanford University School of MedicineHagey Laboratory for Pediatric Regenerative MedicinePalo AltoCA 94301United States

Obesity has become more prevalent in the global *** is associated with the development of several diseases including diabetes mellitus,coronary heart disease,and metabolic *** are a multitude of factors impacted by obesity that may contribute to poor wound healing *** millions worldwide classified as obese,it is imperative to understand wound healing in these *** advances in the understanding of wound healing in both healthy and diabetic populations,much is unknown about wound healing in obese *** review examines the impact of obesity on wound healing and several animal models that may be used to broaden our understanding in this *** a growing portion of the population identifies as obese,understanding the underlying mechanisms and how to overcome poor wound healing is of the utmost importance.

关键词： Obesity Wound healing Adipokines Tissue fibrosis diabetes Preclinical animal models Hypertrophic skin scarring Wound tension Metabolic syndrome

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Transarterial embolization is an acceptable bridging therapy to hepatocellular carcinoma prior to liver transplantation

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World Journal of Transplantation 2024年第2期14卷 126-134页

作者： Gabriel Lazzarotto-da-Silva Leandro A Scaffaro mauricio Farenzena Lucas Prediger Rafaela K Silva Flávia Heinz Feier Tomaz J M Grezzana-Filho Pablo D Rodrigues Alexandre de Araujo Mario Reis Alvares-da-Silva Roberta C Marchiori Cleber Rosito Pinto Kruel Marcio Fernandes Chedid Department of Liver Transplant and Hepatobiliary Surgery Unit Hospital de Clínicas de Porto AlegrePorto Alegre 90035-007Brazil Department of Interventional Radiology Unit Hospital de Clínicas de Porto AlegrePorto Alegre 90035-007Brazil Department of Gastroenterology and Hepatology Hospital de Clínicas de Porto AlegrePorto Alegre 90035-007Brazil

BACKGROUND Hepatocellular carcinoma(HCC)is an aggressive malignant neoplasm that requires liver transplantation(LT).Despite patients with HCC being prioritized by most organ allocation systems worldwide,they still have to wait for long *** therapies(LRTs)are employed as bridging therapies in patients with HCC awaiting *** largely used in the past,transarterial embolization(TAE)has been replaced by transarterial chemoembolization(TACE).However,the superiority of TACE over TAE has not been consistently shown in the *** To compare the outcomes of TACE and TAE in patients with HCC awaiting *** All consecutive patients with HCC awaiting LT between 2011 and 2020 at a single center were *** patients underwent LRT with either TACE or *** patients also underwent percutaneous ethanol injection(PEI),concom-itantly or in different treatment *** choice of LRT for each HCC nodule was determined by a multidisciplinary *** primary outcome was waitlist dropout due to tumor progression,and the secondary outcome was the occurrence of adverse *** the subset of patients who underwent LT,complete pathological response and post-transplant recurrence-free survival were also *** Twelve(18.5%)patients in the TACE group(only TACE and TACE+PEI;n=65)and 3(7.9%)patients in the TAE group(only TAE and TAE+PEI;n=38)dropped out of the waitlist due to tumor progression(P log-rank test=0.29).Adverse events occurred in 8(12.3%)and 2(5.3%)patients in the TACE and TAE groups,respectively(P=0.316).Forty-eight(73.8%)of the 65 patients in the TACE group and 29(76.3%)of the 38 patients in the TAE group underwent LT(P=0.818).Among these patients,complete pathological response was detected in 7(14.6%)and 9(31%)patients in the TACE and TAE groups,respectively(P=0.145).Post-LT,HCC recurred in 9(18.8%)and 4(13.8%)patients in the TACE and TAE groups,respectively(P=0.756).Posttransplant recurrence-free survival was simila

关键词： Hepatocellular carcinoma Transarterial embolization Transarterial chemoembolization Liver transplantation Locoregional therapy Bridging

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Feeding Calcium Salts of Linseed Oil on Metabolic Status and Reproductive Traits in Grazing Dairy Cows

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Open Journal of Animal Sciences 2024年第3期14卷 219-233页

作者： Jesica Daniela Iorio Yaliska Moreno González Maria Florencia Olmeda dino Curletto Daniel Edgardo Scandolo Martin Guillermo Maciel Rafael Alejandro Palladino mauricio Javier Giuliodori Eloy Eduardo Salado School of Agriculture of the University of Buenos Aires (FAUBA) Buenos Aires Argentina Faculty of Agricultural Sciences National University of Lomas de Zamora (UNLZ) Lomas de Zamora Argentina Rafaela Agricultural Experiment Station National Institute of Agricultural Technology (INTA) Rafaela Argentina Faculty of Veterinary Science La Plata National University (FCV) La Plata Argentina

This experiment aimed to evaluate the effect of calcium salts of linseed oil (rich in alpha-linolenic acid (ALA, C18:3n-3) on metabolic and reproductive traits in high-producing dairy cows under grazing. Thirty-six Holstein dairy cows were randomly assigned, in a complete block design, to receive ALA supplementation (0.85 kg∙day−1 of calcium salts of linseed oil) or to remain as untreated control (CON). The concentrate was formulated to offer the same amount of energy across treatments (CON cows received an extra kg of corn to compensate for the higher energy density of ALA treatment). A PMR + Alfalfa pasture was offered to all cows at the same time. A fixed time artiﬁcial insemination (FTAI) at 80 diM, preceded by a Presynch plus Ovsynch protocol was implemented for the first service and later, on return to estrus, heat detection and artiﬁcial insemination (AI) were performed. Pregnancy diagnosis was checked at 30, 42, 60, and 90 d after AI. Blood and milk samples were taken biweekly. Treatment affected plasma cholesterol concentration (160.36 vs. 186.70 mg∙dl−1, p = 0.03, for ALA and CON, respectively) and on size of corpus luteum (CL, 17.6 vs. 13.7 mm, p = 0.02, for ALA and CON, respectively). Supplementation tended (p = 0.136) to increase conception rate by 200 diM (81.69% vs. 55.43% in ALA and CON cows, respectively). However, treatment had no effect (p > 0.05) on body weight (BW), body condition score (BCS), and circulating levels of beta-hydroxybutyrate (BHBA), glucose, insulin, growth hormone (GH) and insulin-like growth factor (IGF-I). Our results suggest that supplementation with calcium salts of linseed oil could enhance ovarian function without affecting energy metabolism in early lactation dairy cows.

关键词： α-Linolenic Acid Supplementation Reproduction Grazing Dairy Cows

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Cluster Partition Function and Invariants of 3-Manifolds

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Chinese Annals of Mathematics,Series B 2017年第4期38卷 937-962页

作者： mauricio ROMO School of-Natural Sciences Institute for Advanced Study Princeton NJ 08540 USA.

The author reviews some recent developments in Chern-Simons theory on a hyperbolic 3-manifold M with complex gauge group G. The author focuses on the case of G = SL(N, C) and M being a knot complement: M = S^3\ K. The main result presented in this note is the cluster partition function, a computational tool that uses cluster algebra techniques to evaluate the Chern-Simons path integral for G = SL(N, C). He also reviews various applications and open questions regarding the cluster partition function and some of its relation with string theory.

关键词： Chern-Simons theory Knots Cluster algebras

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Soft rocks in Argentina

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International Journal of Mining Science and Technology 2014年第6期24卷 883-892页

作者： Giambastiani mauricio National University of La Rioja La Rioja Argentina

Soft rocks are a still fairly unexplored chapter in rock mechanics. Within this category are the clastic sedimentary rocks and pyroclastic volcanic rocks, of low to moderate lithification （consolidation, cemen- tation, new formed minerals）, chemical sedimentary rocks and metamorphic rocks formed by minerals witk Mohs hardness less than 3.5, such as limestone, gypsum, halite, sylvite, between the first and phyllites, graphitic schist, chloritic shale, talc, etc., among the litter. They also include any type Of rock that suffered alteration processes （hydrothermal or weathering）. In Argentina the study of low-strength rocks has not received much attention despite having extensive outcrops in the Andes and great impact in the design criteria. Correlation between geomechanical properties （UCS, deformability） to physical index （porosity, density, etc.） has shown promising results to be better studied. There are many studies and engineering projects in Argentina in soft rock geological environments, some cited in the text （Chihuido dam, N. Kirchner dam, J. Cepernic Dam, etc.） and others such as International Tunnel in the Province of Mendoza （Corredor Bioceanico）, which will require the valuable contribution from rock mechanics. The lack of consistency between some of the physical and mechanical parameters explored from studies in the country may be due to an insufficient amount of information and/or non-standardization of criteria for testing materials. It is understood that more and better academic and professional efforts in improv- ing techniques will result in benefits to the better understanding of the geomechanics of weak rocks.

关键词： Soft rocks Argentine Tunnels Dams Rock parameters

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Data Center Power System Stability-Part I: Power Supply Impedance Modeling

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CSEE Journal of Power and Energy Systems 2022年第2期8卷 403-419页

作者： Jian Sun Mingchun Xu mauricio Cespedes Mike Kauffman Rensselaer Polytechnic Institute-ECSE 1108th Street Room CII 8015Troy 12180United States Meta Platforms Inc. 1601 Willow RdMenlo ParkCalifornia 94025-1452United States

This two-part paper presents methods to predict,characterize and ensure the stability of data center power systems based on impedance *** work was motivated by recent power system resonance incidents in new data *** I presents new input impedance models for single-phase power supply units(PSUs)to enable this *** impedance models of single-phase PSU cannot meet the requirements of this application because they exclude DC voltage control that affects system stability at low frequency,or are in a dq reference frame that cannot handle the complexity of data center power *** developed new models include DC bus dynamics and are directly in the phase domain to simplify system stability analysis,avoiding the need for multiple-input-multiple-output(MIMO)system models and the generalized Nyquist criterion that are difficult to apply but necessary with dq-frame *** the converter and system level models also include the coupled current response that is characteristic of AC-DC converters and important for system stability at low *** simple form of the models and system stability analysis directly in the phase domain also make it possible to develop new PSU design methods and performance specifications that together will ensure the stability of new data center power *** developed models are validated by laboratory measurements and are used in Part II of the work to study data center power system stability.

关键词： Data center power systems frequency-domain methods impedance modeling system stability system resonance

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Gastric cancer research in Mexico:A public health priority

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World Journal of Gastroenterology 2014年第16期20卷 4491-4502页

作者： Clara Luz Sampieri mauricio Mora Instituto de Salud Pública Universidad VeracruzanaAv. Luis Castelazo AyalaCol. Industrial ánimas91190 XalapaVeracruzMéxico Facultad de Medicina Universidad Veracruzana.Médicos y OdontólogosCol. Virginia Cordero91120 XalapaVeracruzMéxico

This study aimed review studies conducted on Mexican patients diagnosed with gastric cancer and/or diseases associated with its development,in which at least one Mexican institute has participated,and to assess their contributions to the primary and secondary prevention of this disease.A search of the Medline database was conducted using the following keywords:gastric/stomach cancer,*** of the Mexican population were selected in which at least one Mexican Institute had participated and where the findings could support public policy proposals directed towards the primary or secondary prevention of gastric *** the148 studies found in the Medline database,100 were discarded and 48 were *** to the analysis presented,these studies were classified as:epidemiology of gastric cancer(5/48);risk factors and protectors relating to gastric cancer(9/48);relationship between Helicobacter pylori and pathologies associated with gastric cancer and the development of the disease(16/48);relationship between the Epstein-Barr virus and pathologies associated with gastric cancer and the development of the disease(3/48);molecular markers for the development of diseases associated with gastric cancer and gastric cancer(15/48).Mexico requires a program for the prevention and control of gastric cancer based on national health *** should be produced by a multidisciplinary committee of experts who can propose actions that are relevant in the current national *** few studies of gastric cancer conducted on the Mexican population in national institutes highlight the poor connection that currently exists between the scientific community and the health sector in terms of resolving this health *** policies for health research should support projects with findings that can be translated into benefits for the *** review serves to identify national research groups studying gastric cancer in the Mexican population.

关键词： Gastric cancer Mexico Research Prevention Public health

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Local scour around submerged angled spur dikes under ice cover

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International Journal of Sediment Research 2023年第6期38卷 781-793页

作者： Guowei Li Jueyi Sui Sanaz Sediqi mauricio Dziedzic School of Engineering University of Northern British Columbia

Local scour is a phenomenon leading to the localized lowering of the channel bed due to the imbalance of sediment *** spur dikes protrude into the natural channels,local scour could be *** estimation of local scour around spur dikes is crucial for the effectiveness of erosion control and prevention and habitat enhancement *** the current study,the correlations between the maximum scour depth and the overtopping ratio,spur dike dimensions,ice cover roughness,and grain size of the bed material are *** both open channel and ice-covered flow conditions,a variety of experiments were done in a large-scale outdoor flume with different experimental *** results revealed that the scour depths around submerged spur dikes increased with increases in the densimetric Froude number and the decreases in the overtopping ratio and alignment *** maximum scour depth around a submerged angled vertical wall spur dike is significantly affected by the presence of an ice cover on the water surface,namely,the rougher the cover,the deeper the scour *** on data collected from the laboratory experiments,an existing maximum scour depth estimation equation has been modified to consider the influence of the cover condition and the submergence *** calculated results showed high accuracy in estimation of the measured data.

关键词： Ice cover Local scour Submerged spur dike Alignment angle

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Data Center Power System Stability-Part II: System Modeling and Analysis

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CSEE Journal of Power and Energy Systems 2022年第2期8卷 420-438页

作者： Jian Sun Melaku Mihret mauricio Cespedes David Wong Mike Kauffman Rensselaer Polytechnic Institute-ECSE 1108th Street Room CII 8015Troy 12180United States Meta Platforms Inc. 1601 Willow RdMenlo ParkCalifornia 94025-1452United States

This is the second part of a two-part paper on stability study of data center power systems by impedance-based *** the basis for this application,Part I[1]developed new impedance models for power supplies that are the most dominant loads in data *** second part presents system modeling and analysis methods that can support practical data center power system design to ensure *** proposed methods comprise:1)building distribution network modeling by impedance scaling;2)system modeling and model reduction based on equivalent source impedance;3)system stability analysis in the sequence domain to include zero-sequence dynamics;and 4)expansion of system models and analyses to account for network asymmetry and uneven *** methods are used to characterize practical resonance problems observed in data centers,explain their root causes,and develop *** systems using Y-connected power supply units(PSUs),the zero sequence is identified as the weakest link and the first to become *** expanded system model and analysis reveal a new,differential-mode instability that is responsible for high frequency *** guarantee system stability,new impedance-based product and system design specifications are developed based on sufficient conditions derived from the Nyquist stability *** and field measurements are presented to substantiate the proposed methods and conclusions.

关键词： Data center power systems frequency-domain methods impedance modeling system stability system resonance

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