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How to identify better candidate to radioembolization in case of hepatocellular carcinoma and portal vein tumoral thrombosis

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Hepatobiliary Surgery and Nutrition 2019年第1期8卷 63-64页

作者： Giovanni Battista levi Sandri Michel Rayar Department of Surgical Sciences Sapienza University of RomeRomeItaly Service de Chirurgie Hépatobiliaire et Digestive CHU RennesRennesFrance

Hepatocellular carcinoma(HCC)is the most common primary liver cancer and the fifth most common malignant tumor *** resection is a curative treatment for HCC and can be safety performed by a minimally invasive procedure in all liver segments without size limitations(1,2).Nevertheless,some patients are diagnosed with HCC and portal vein tumor thrombosis(PVTT).According to the staging system of the Barcelona Clinic Liver Cancer(BCLC),patients with macrovascular invasion are staged as *** those patients,the prognosis is generally ***,the management of HCC with macrovascular invasion is still ***,recent studies proposed different surgical procedure such as one-stage resection or associating liver partition and portal vein ligation,with promising results(3-5).

关键词： invasion thrombosis Liver

Food safety inspection and the adoption of traceability in aquatic wholesale markets: A game-theoretic model and empirical evidence

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Journal of Integrative Agriculture 2021年第10期20卷 2807-2819页

作者： JIN Cang-yu Retsef levi LIANG Qiao Nicholas RENEGAR ZHOU Jie-hong China Academy for Rural Development School of Public AffairsZhejiang UniversityHangzhou 310058P.R.China Sloan School of Management Massachusetts Institute of TechnologyCambridgeMA 02139USA Operations Research Center Massachusetts Institute of TechnologyCambridgeMA 02139USA

Supply chain traceability is key to reduce food safety risks,since it allows problems to be traced to their sources. Moreover,it allows regulatory agencies to understand where risk is introduced into the supply chain,and offers a major disincentive for upstream agricultural businesses engaging in economically motivated adulteration. This paper focuses on the aquatic supply chain in China,and seeks to understand the adoption of traceability both through an analytical model,and empirical analysis based on data collected through an extensive (largest ever) field survey of Chinese aquatic wholesale markets. The field survey includes 76 managers and 753 vendors,covering all aquatic wholesale markets in Zhejiang and Hunan provinces. The analytical and empirical results suggest that the adoption of traceability among wholesale market vendors is significantly associated with inspection intensity,their individual history of food safety problems,and their risk awareness. The effect of inspection intensity on traceability adoption is stronger in markets which are privately owned than in markets with state/collective ownership. The analysis offers insights into the current state of traceability in China. More importantly,it suggests several hypothesized factors that might affect the adoption of traceability and could be leveraged by regulatory organizations to improve it.

关键词： food safety traceability supply chain wholesale markets China

Active compounds of medicinal plants,mechanism for antioxidant and beneficial effects

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Phyton-International Journal of Experimental Botany 2019年第1期88卷 1-10页

作者： orozco Montes F A Vázquez-Hernández B Fenton-Navarro Glycobiology Laboratory Postgraduate Studies DivisionFaculty of Medicine and Biological Sciences“Dr.Ignacio Chávez”Michoacán University of Saint Nicholas of Hidalgo(UMSNH)MoreliaMichoacánMexico Hospital of Specialties CMN SXXIIMSSMéxico CityMéxico

An increased interest in the antioxidant effects of medicinal plants has developed in recent *** antioxidant compounds present in medicinal plants and elucidating the mechanism by which they prevent oxidation have been the focus of the research *** performed a systematic and exhaustive review aimed at analyzing the available data regarding the beneficial effects of secondary metabolites in *** result of this review is presented as a description of free radicals,as well as cellular and physiological oxidative stress,is *** origin and source of antioxidant compounds,and the cellular and molecular mechanism by which they exert antioxidant effects,have been *** absorption,distribution and,elimination of antioxidants are *** beneficial effects of secondary metabolites of medicinal plants in various high incidence disease conditions were also ***,disease states that benefit from antioxidant compounds includes diabetes,cancer,cardiovascular diseases,and liver,brain and,intestinal diseases.

关键词： Antioxidants Free radicals Secondary metabolites Polyphenols Oxidative stress Medicinal plants

Liquid biopsy to detect resistance mutations against anti-epidermal growth factor receptor therapy in metastatic colorectal cancer

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World Journal of Gastrointestinal Oncology 2022年第9期14卷 1654-1664页

作者： Guillermo Valenzuela mauricio Burotto Katherine Marcelain Jaime Gonzalez-Montero Department of Basic and Clinical Oncology University of ChileSantiago 8380453Chile Department of Internal Medicine Hospital del SalvadorSantiago 7500922Chile Department of Oncology Bradford-Hill Clinical Research CenterSantiago 8420383Chile

Colorectal cancer(CRC) is a major cause of mortality worldwide, associated with a steadily growing prevalence. Notably, the identification of KRAS, NRAS, and BRAF mutations has markedly improved targeted CRC therapy by affording treatments directed against the epidermal growth factor receptor(EGFR) and other anti-angiogenic therapies. However, the survival benefit conferred by these therapies remains variable and difficult to predict, owing to the high level of molecular heterogeneity among patients with CRC. Although classification into consensus molecular subtypes could optimize response prediction to targeted therapies, the acquisition of resistance mutations to targeted therapy is, in part, responsible for the lack of response in some patients. However, the acquisition of such mutations can induce challenges in clinical practice. The utility of liquid biopsy to detect resistance mutations against anti-EGFR therapy has recently been described. This approach may constitute a new standard in the decision algorithm for targeted CRC therapy.

关键词： Colorectal neoplasms Precision medicine Liquid biopsy Cetuximab Panitumumab

Pressure drop analysis on the positive half-cell of a cerium redox flow battery using computational fluid dynamics: mathematical and modelling aspects of porous media

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Frontiers of Chemical Science and Engineering 2021年第2期15卷 399-409,F0004页

作者： Fernando F.Rivera Berenice Miranda-Alcantara German orozco Carlos Ponce de Leon Luis F.Arenas National Council of Science and Technology(CONACYT) Mexico City 03940Mexico Center of Research and Technological Development in Electrochemistry(CIDETEQ) Queretaro 76703Mexico Electrochemical Engineering Laboratory Energy Technology Research GroupFaculty of Engineering and Physical SciencesUniversity of SouthamptonSouthampton SO171BJUK

Description of electrolyte fluid dynamics in the electrode compartments by mathematical models can be a powerful tool in the development of redox flow batteries(RFBs)and other electrochemical *** order to determine their predictive capability,turbulent Reynolds-averaged Navier-Stokes(RANS)and free flow plus porous media(Brinkman)models were applied to compute local fluid velocities taking place in a rectangular channel electrochemical flow cell used as the positive half-cell of a cerium-based RFB for laboratory *** different platinized titanium electrodes were considered,a plate plus a turbulence promoter and an expanded metal *** pressure drop was validated against experimental data obtained with typical cerium *** was found that the pressure drop values were better described by the RANS approach,whereas the validity of Brinkman equations was strongly dependent on porosity and permeability values of the porous media.

关键词： CFD simulation porous media porous electrode pressure drop redox flow battery

Influence of the Accumulative Roll Bonding Process Severity on the Microstructure and Superplastic Behaviour of 7075 Al Alloy

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Journal of Materials Science & Technology 2016年第8期32卷 774-782页

作者： R Hidalgo-Manrique A.orozco-Caballero C.M.Cepeda-Jimenez O.A.Ruano, F.Carreno Department of Physical Metallurgy CENIM CSIC Av. Gregorio del Amo 8 28040 Madrid Spain School of Materials The University of ManchesterManchester M1 7SH UK. IMDEA Materials Institute. C/Eric Kandel 2 28906 Getafe MadridSpain

The 7075 Al alloy was processed by accumulative roll bonding （ARB） at 350 ℃ using 2：1, 3：1 and 4：1 thickness reductions per pass （Rp） up to 8, 6 and 3 passes, respectively. Microstructural examinations of the processed samples revealed that ARB leads to a microstructure composed of equiaxed crystallites with a mean size generally lower than 500 nm. It was found that, due to both the stored energy through- out the processing and the particle pinning effect, the alloy is affected by discontinuous recrystallisation during the inter-pass heating stages, the precise microstructural evolution being dependent on Rp. Me- chanical testing of the ARBed samples revealed that the main active deformation mechanism in the ARBed samples in the temperature range from 250 to 350 ℃ at intermediate and high strain rates is grain bound- ary sliding, the superplastic properties being determined by both the microstructure after ARB and its thermal stability.

关键词： Accumulative roll bonding (ARB) Al-Zn-Mg-Cn alloys Grain refining Precipitate coarsening Recrystallisation Superplastic deformation

Modeling height growth for teak plantations in Colombia using the reducible stochastic differential equation approach

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Journal of Forestry Research 2021年第3期32卷 1035-1045页

作者： Sergio Orrego Cristian Montes Héctor IRestrepo Bronson PBullock mauricio Zapata Departamento de Ciencias Forestales Universidad Nacional de ColombiaSede MedellínCra 65 No 59A-110MedellínColombia Warnell School of Forestry and Natural Resources University of GeorgiaAthensGA 30602USA

Teak(Tectona grandis L.f.)plantations are increasingly being established in tropical regions to meet a rising demand for its highly valued *** plantations have been established in the Atlantic Coastal Plain region of Colombia,a region climatically suitable for teak growth by having a monsoon climate with a unimodal precipitation *** diameter at breast height(DBH,1.3 m above ground)and mean top height,periodically measured over a 17-year period in 44 permanent sampling plots of size 0.06 and 0.10 ha,were used in this study.A stochastic differential equation(SDE),along with a Bertalanffy–Richards-type height growth model,was used to model and estimate top height growth of teak plantations in *** noise and height measurement errors were explicitly considered as the main uncertainty sources of mean top height *** best model for estimating mean top height,based on statistical performance and biological rationale,had the asymptote defined as a local parameter and the growth rate and shape specified as global *** model outperformed its counterpart that had the growth rate specified as a local parameter and asymptote and shape as global *** selected model also outperformed alternative approaches such as the mixed-effects model,generalized algebraic difference approach,and the dummy variable *** trajectories for the mean top height of teak in Colombia are biologically sound based on the measured height series and previous studies in Latin *** suggest that most of the uncertainty associated with the mean top height growth of teak plantations in Colombia was largely explained by environmental *** best estimated model using the SDE approach can be useful for predicting height growth and evaluating site productivity of teak plantations in Colombia and in neighbouring countries with biophysical characteristics similar to those where teak has been planted in Colombia.

关键词： Mean top height Stochastic differential equation Forest productivity Timber production Timberland investment

Pendulum systems for harvesting vibration energy from railroad tracks and sleepers during the passage of a high-speed train: A feasibility evaluation

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Theoretical & Applied Mechanics Letters 2019年第4期9卷 229-235,I0005页

作者： Franco E.Dotti mauricio D.Sosa Grupo de Investigación en Multifísica Aplicada Universidad Tecnológica NacionalFacultad Regional Bahía Blanca.Consejo Nacional de Investigaciones Científicas y Técnicas.Argentina Grupo de Investigación en Multifísica Aplicada Universidad Tecnológica NacionalFacultad Regional Bahía Blanca.Argentina

We evaluate the feasibility of recovering energy from the vibrations of track and sleepers,during passage of a high-speed train,by means of a pendulum harvester.A simple mathematical model of the parametric pendulum is employed to obtain numerical predictions,while measured data of vibration tests during the passage of a Thalys high-speed train are considered as input *** a sustained rotation is the most energetic motion of a pendulum,the possibility of achieving such state is evaluated,taking into account the influence of initial conditions,damping and other *** simulations show that rotating pendulum harvesters with sufficiently low viscous damping could be able to generate a usable average power on the order of 5–6 W per *** a modular arrangement of devices,such energy is enough to feed variety of rail-side equipment,as wireless sensors or warning light ***,a suitable choice of initial conditions could be a difficult task,leading to the need of a control action.

关键词： Energy harvesting Parametric pendulum Railroad safety Train induced vibration

Designing and managing the supply chain :concepts, strategies, and cases

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