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Quality of Life in Men Treated for Early Prostate Cancer: A Prospective Patient Preference Cohort Study

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Journal of Cancer Therapy 2011年第4期2卷 448-457页

作者： Carmel nirupa Anandadas Susan Elizabeth Davidson noel William Clarke Stephen Charles William Brown John Paul Logue Lynne Gilmore Richard Swindell Gerald nicholas collins Patrick Henry O’Reilly Guy David Wemyss-Holden maurice Waiming Lau Pradip Madhukar Javle Vijay Alini Chandi Ramani Richard James Brough James Pinson Wylie Richard Andrew Cowan 不详

Objectives: In 1997, a study was launched to investigate the treatment of early prostate cancer. Using a patient preference design, health-related quality-of-life (HRQOL) and disease specific HRQOL was assessed prospectively to compare men undergoing radical prostatectomy (RP), hypo-fractionated conformal radiotherapy (CRT) or brachytherapy (BT). Methods: Patients with localised prostate cancer were counselled by a urological surgeon, clinical oncologist and specialist uro-oncology nurse. Patients received treatment according to individual preference. 430 men chose and received RP (n = 217), CRT (n = 161) and BT (n = 52). 354 (82%) completed pre-treatment RAnD 36-Item Short-Form Health survey version-2 (SF36v2) and University of California, Los Angeles Prostate cancer index (UCLA-PCI) questionnaires. HRQOL score changes from baseline to 24 months were compared using Kruskall-Wallis test. Results: Pre-treatment, the CRT cohort scored lower for physical function (p = 0.0029) and general health perception (p = 0.0021). The BT cohort reported better baseline scores for urinary function (p = 0.0291), urinary bother (p = 0.0030), sexual function (p = 0.0009) and bowel bother (p = 0.0063). At 24 months, bowel function was similar for CRT and BT but both modalities were worse than RP (p = 0.0010). Urinary continence deteriorated most following RP (p nary bother (p = 0.0153). Sexual function deteriorated most following RP and BT (p ntages of patients achieving erections adequate for sexual activity (from baseline to 24 months) were 66% to 29% for RP, 62% to 49% for CRT and 88% to 65% for BT. Conclusion: This data demonstrates significant differences in disease specific quality-of-life between RP, CRT and BT and should be available for men with early prostate cancer making treatment decisions.

关键词： Early Prostate Cancer Quality of Life Patient Preference Prostatectomy Hypo-Fractionated Radiotherapy Brachytherapy

热机械加工对Ti-V-n钢显微组织和机械性能的影响

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钢铁钒钛 1991年第1期12卷 81-93页

作者： Dogan B.collins L.E.Boyd J.D. 王苹加拿大渥太华CAnMET

根据用凸轮式塑性计和淬火-变形膨胀仪分别对一种Ti-V微合金钢的奥氏体变形行为和连续冷却转变行为所做的研究,设计了钢板轧制程序,以得到:(ⅰ)再结晶奥氏体,(ⅱ)未再结晶奥氏体,(ⅲ)变形铁素体+未再结晶奥氏体。研究了奥氏体状态和冷... 详细信息

根据用凸轮式塑性计和淬火-变形膨胀仪分别对一种Ti-V微合金钢的奥氏体变形行为和连续冷却转变行为所做的研究,设计了钢板轧制程序,以得到:(ⅰ)再结晶奥氏体,(ⅱ)未再结晶奥氏体,(ⅲ)变形铁素体+未再结晶奥氏体。研究了奥氏体状态和冷却速度对最终显微组织和机械性能的影响。为了从理论上解释最终铁素体晶粒尺寸随不同热机械加工工艺制度的变化,除了要考虑铁素体成核点的密度外,还必须考虑铁素体晶粒长大动力学,说明了膨胀仪研究在确定某一钢最佳变形工艺制度和冷却速度方面的好处。拉伸和冲击性能的范围宽,是由于所研究的显微组织不同造成的。屈服强度随变形铁素体、贝氏体或马氏体量的增多而提高,随铁素体晶粒尺寸的减小而提高,冲击韧性受铁素体晶粒尺寸和轧制平面出现分层的影响最为强烈。

关键词：热机械加工显微组织机械性能

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Left Ventricular Diastolic Dysfunction and Silent Myocardial Ischemia amongst Asymptomatic Type 2 Diabetic Patients in Two Referral Hospitals in Cameroon

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World Journal of Cardiovascular Diseases 2022年第7期12卷 374-381页

作者： Joshua njimbuc Walinjom Jerome Boombhi Martine Etoa collins Chenwi Ambe Emerentia Eho Alain Menanga Samuel Kingue Faculty of Medicine and Biomedical Sciences (FMBS) University of Yaoundé I Yaoundé Cameroon Medical and Cardiology Unit General Hospital Yaoundé Yaoundé Cameroon Central Hospital Yaoundé Yaoundé Cameroon Mvangan District Hospital Mvangan Cameroon

Background: Cardiovascular events, the leading cause of death among diabetic patients, are usually under-diagnosed due to subclinical presentation. Methods: We conducted a cross-sectional study from March-2019 to September-2020, in two reference hospitals in Yaoundé, Cameroon, to assess the prevalence of asymptomatic Left Ventricular Diastolic Dysfunction (LVDD) and Silent Myocardial Infarction (SMI) and potentially associated factors. Results: Out of 95 participants (mean age ± SD: 43 ± 7 years;M/F sex-ratio 1.6), 22 (23.1%;95% CI: 15.8% - 32.6%) had LVDD and fewer (n = 13, 13.6%;95% CI: 8.2% - 22.0%) had SMI, p = 0.86. Though not statistically significant, patients with ≥5 years diabetes duration, as well as patients with HbA1C ≥ 7.5% had two-fold increased risk of LVDD (p = 0.22 and p = 0.15 respectively). LVDD was significantly higher in patients with SMI (29% vs 6.3%, p Conclusion: The significant presence of asymptomatic cardiovascular manifestations in this population entails mandatory preventive screening, especially, in patients with long standing diabetes and poor glycemic control, to allow timely detection and management.

关键词： Asymptomatic Cardiovascular Manifestations Left ventricular Diastolic Dysfunction Silent Myocardial Ischemia Type 2 Diabetes Cameroon

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好运的5级领导者

经理人 2001年第7期 46-50页

作者： Jim collins 马小龙

是什么推动公司从普通向伟大跃进?一个历时5年,极具针对性的项目研究,其结果足以改变我们对领导者的传统看法。1971年,一个貌似平常的人-达尔文·史密斯(oar州n ***),被任命为金佰利公司(Kimber.丫一Clark)的首席执行官。

关键词：领导者史密斯首席执行官达尔文钢铁公司纸业公司项目研究董事会针对性持续发展

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骨转移瘤与骨髓瘤扩散加权MRI影像的优化与可重复性的评估

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国际医学放射学杂志 2011年第5期 506-507页

作者： C.Messiou D.J.collins V.A.Morgan n.M.deSouza 王翠 MRI Department Institute of Cancer Research and Royal Marsden NHS Foundation Trust

目的建立不同年龄范围正常人的骨髓表面扩散系数(ADC)值,并与骨转移瘤和骨髓瘤病人的骨髓ADC值对照研究,确定其可重复性与最佳b值。方法本研究对象包

关键词：骨瘤转移骨髓瘤扩散MRI

Tongxinluo Improves Apolipoprotein E-Deficient Mouse Heart Function

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Chinese Medical Journal 2018年第5期131卷 544-552页

作者： Guo-Qiang Yuan Song Gao Yong-Jian Geng Yao-Ping Tang Min-Juan Zheng Harnath S Shelat Scott collins Han-Jing Wu Yi-Ling Wu 'Department of Collateral Disease Research Institute of Integrated Traditional Chinese Medicine and Western Medicine of Hebei Shijiazhuang Hebei 050035 China Department of Cardiovascular Disease Hebei Yiling Hospital Shijiazhuang Hebei 050091 China Department of Internal Medicine McGovern Medical School The University of Texas Health Science Center at Houston Houston TX 77030 USA Center for Cell Signaling Institute of Molecular Medicine Houston Health Science Center The University of "IX Houston TX 77030 USA Department of Pediatric Cardiology Baylor College of Medicine Houston TX 77030 USA

Background： Our previous studies have shown that Tongxinluo （TXL）, a compound Chinese medicine, can decrease myocardial ischemia-reperfusion injury, protect capillary endothelium function, and lessen cardiac ventricle reconstitution in animal models. The aim of this study was to illuminate whether TXL can improve hypercholesterolemia-impaired heart function by protecting artery endothelial function and increasing microvascular density （MVD） in heart. Furthermore, we will explore the underlying molecular mechanism of TXL cardiovascular protection. Methods： After intragastric administration of TXL （0.1 ml/10 g body weight） to C57BL/6J wild-type mice （n = 8） and ApoE-/- mice （n=8）, total cholesterol, high-density lipoprotein-cholesterol, very-low-density lipoprotein （VLDL）-cholesterol, triglyceride, and blood glucose levels in serum were measured. The parameters of heart rate （HR）, lelt ventricular diastolic end diameter, and left ventricular systolic end diameter were harvested by ultrasonic cardiogram. The left ventricular ejection fraction, stroke volume, cardiac output, and let1 ventricular fractional shortening were calculated. Meanwhile, aorta peak systolic flow velocity （PSV）, end diastolic flow velocity, and mean flow velocity （MFV） were measured. The pulsatility index （PI） and resistant index were calculated in order to evaluate the vascular elasticity and resistance. Tile endothelium-dependent vasodilatation was evaluated by relaxation of aortic rings in response to acetylcholine. Western blotting and real-time quantitative reverse transcription polymerase chain reaction were performed for protein and gene analyses of vascular endothelial growth factor （VEGF）. lnamunohistochenaical detection was perlbrmed for myocardial CD34 expression. Data in this study were compared by one-way analysis of variance between groups. A value of P 〈 0.05 was considered statistically significant. Results： Although there was no significant decrease of cholesterol level （F = 2.300

关键词： Heart Function: Microvascular Protection:Tongxinluo

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A Stabilized Finite Element Method for Modified Poisson-nernst-Planck Equations to Determine Ion Flow Through a nanopore

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Communications in Computational Physics 2014年第1期15卷 93-125页

作者： Jehanzeb Hameed Chaudhry Jeffrey Comer Aleksei Aksimentiev Luke n.Olson Department for Mathematics Colorado State UniversityFort CollinsCO 80523USA. Department for Physics University of Illinois at Urbana-ChampaignUrbanaIL 61801USA. Department for Computer Science University of Illinois at Urbana-ChampaignUrbanaIL 61801USA

The conventional Poisson-nernst-Planck equations do not account for the finite size of ions *** leads to solutions featuring unrealistically high ionic concentrations in the regions subject to external potentials,in particular,near highly charged surfaces.A modified form of the Poisson-nernst-Planck equations accounts for steric effects and results in solutions with finite ion ***,we evaluate numerical methods for solving the modified Poisson-nernst-Planck equations by modeling electric field-driven transport of ions through a *** describe a novel,robust finite element solver that combines the applications of the newton’s method to the nonlinear Galerkin form of the equations,augmented with stabilization terms to appropriately handle the drift-diffusion *** make direct comparison with particle-based simulations possible,our method is specifically designed to produce solutions under periodic boundary conditions and to conserve the number of ions in the solution *** test our finite element solver on a set of challenging numerical experiments that include calculations of the ion distribution in a volume confined between two charged plates,calculations of the ionic current though a nanopore subject to an external electric field,and modeling the effect of a DnA molecule on the ion concentration and nanopore current.

关键词： Steric effects nucleic acids ionic current continuum transport theory ion channels PnP SUPG finite element method.

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秋季苜蓿品质和化学成份的变化

秋季苜蓿品质和化学成份的变化

Suitability of Kabanyolo Soils for Fruit and Vegetable Production

“加强世界饲草——牲畜系统”第十四届国际草地会议

作者： S.C.FLEMInG M.collins n.A.JORGEnSEn 刘富渊 University of Wisconsin

苜蓿秋季收获对某一特殊季节提供足够的饲草有着很大的潜力。有关苜蓿的品质或化学成分的变化却知其甚少。本次试验主要是对生长在美国威斯康星的苜蓿品种秋季的化学组成变化、干物质量及它的表观消化率进行测定。

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Open Journal of Soil Science 2017年第2期7卷 19-33页

作者： Paul Okiror Julius Bunny Lejju Joseph Bahati Grace Kagoro Rugunda collins Inno Sebuuwufu Patrick Mulindwa Jolly Joe Ocan Faculty of Science Mbarara University of Science and Technology Mbarara Uganda School of Forestry Environmental and Geographical Sciences Makerere University Kampala Uganda School of Engineering Makerere University Kampala Uganda

This paper presents results of soil analysis for samples extracted from Makerere University Agricultural Research Institute Kabanyolo. The study was aimed at ascertaining the suitability of MUARIK soils for fruit (pineapple, passion fruit and watermelon) and vegetable (cabbage, eggplant, tomato and pumpkin) growth, yield and maturity. Soil morphological, physical and chemical properties were probed by excavating a 1.86 meter soil profile pit and sampling soils in 9 equidistant locations at MUARIK. The soil morphology and physical properties were described using the Munsel colour chart and USDA classification system while chemical parameters were determined in Makerere University Soil Laboratory following procedures described by Okalebo et al. [1]. Three pedon layers (RSK-H1, RSK-H3 and RSK-H5) had gradual boundaries while RSK-H4 was continuous. However, RSK-H2 and RSK-H6 had abrupt boundary layers. The texture of the profiles was clayey (52%). The soils were acidic with a pH of 6.08 (sub soil) to 6.12 (top soil). On comparison with standard requirements for target fruits and vegetables, the site was deficient in most of the minerals including P (8.88-12.42 pmm), Ca (6.46-7.92 pmm), K (0.06-0.47 pmm), Mg (1.37-1.70 pmm), na (0.17-0.23 pmm), n (0.18-0.19 pmm), and soil organic matter (4.53%-4.81%). Sand and clay had the highest negative significant correlation (r = ǂ.94, p n the top soil. The highest positive significant correlation was observed between Ca and Mg both in the topsoil (r = 0.96, p nd subsoil (r = 0.99, p ng cabbage and pumpkin. However, for improved growth, yields and maturity, the soils should be amended with manure (watermelon), lime (passion fruit and tomato) and sulphur (eggplant and pineapples).

关键词： Fruits Kabanyolo Vegetables Soil Suitability