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A likely role for the PH-domain containing protein, PEPP2/ PLEKHA5, at the membrane-microtubule cytoskeleton interface

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BIOcELL 2013年第3期37卷 55-61页

作者： Yi ZOU Timothy c.cox School of Molecular Biosciences University of AdelaideAdelaideSouth Australia and Department of Anatomy&Developmental BiologyMonash UniversityClaytonVictoriaAustralia

PH(pleckstrin homology)domains are well known to bind membrane phosphoinositides with different specificities and direct PH domain-containing proteins to discrete subcellular compartments with assistances of alternative binding *** domain-containing proteins have been found to be involved in a wide range of cellular events,including signalling,cytoskeleton rearrangement and vesicular *** we showed that a novel PH domain-containing protein,PEPP2(also known as PLEKHA5),displays moderate phosphoinositide binding *** length PEPP2 was observed to variably associate with both the plasma membrane and *** membrane-associated PEPP2 nucleated at cell-cell contacts and the leading edge of migrating *** of PEPP2 increased membrane microviscosity,indicating a potential role for PEPP2 in regulating function of microtubule-dependent membrane functions.

关键词： microtubule membrane phosphoinositide microviscosity PH domain

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流体接头泄漏——怎么办?

化工设备与管道 2005年第6期42卷 I0002-I0004页

作者： John c.cox Swagelok 公司

泄漏使得工业界每年遭受数百万的损失.比如,使用6.9bar压力气体的设施有几处小小的泄漏,如果用电成本为6美分/千瓦时,每年就会损失22,000美元以上.如果100美元的已泄漏的疏水器不及时更换,每星期就会浪费50美元;由于一般的工厂在其整个... 详细信息

泄漏使得工业界每年遭受数百万的损失.比如,使用6.9bar压力气体的设施有几处小小的泄漏,如果用电成本为6美分/千瓦时,每年就会损失22,000美元以上.如果100美元的已泄漏的疏水器不及时更换,每星期就会浪费50美元;由于一般的工厂在其整个运行当中平均有几百个疏水器,疏水器泄漏每年可能造成几十万美元的损失.除了经济损失以外,泄漏若没有及时修补,还可能造成停工、产品质量受影响、污染环境,以及人员伤害.

关键词：泄漏接头流体疏水器用电成本经济损失产品质量污染环境美元工业界

Achieving ultra-high strength and ductility in Mg–9Al–1Zn–0.5Mn alloy via selective laser melting

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Advanced Powder Materials

Advanced Powder Materials 2023年第2期2卷 56-69页

作者： cheng chang Hanlin Liao Lin Yi Yilong Dai Sophie c.cox Ming Yan Min Liu Xingchen Yan Guangdong Provincial Key Laboratory of Modern Surface Engineering Technology National Engineering Laboratory of Modern Materials Surface Engineering TechnologyInstitute of New MaterialsGuangdong Academy of SciencesGuangzhou 510651China School of Materials Science and Engineering Xiangtan UniversityXiangtan 411105China IcB UMR 6303 CNRSUniv.Bourgogne Franche-ComteUTBMF-90010BelfortFrance School of chemical Engineering University of BirminghamEdgbastonBirminghamB152TTUK Department of Materials Science and Engineering Southern University of Science and TechnologyShenzhen 518055China Jiaxing Research Institute Southern University of Science and TechnologyJiaxing 314050China

Fabrication of the Mg–9Al–1Zn–0.5Mn alloy with excellent mechanical performance using selective laser melting(SLM)technology is quite difﬁcult owing to the poor weldability and low boiling *** address these challenges and seek the optimal processing parameters,response surface methodology was systematically utilized to determine the appropriate SLM parameter ***–9Al–1Zn–0.5Mn sample with high relative density(99.5±0.28%)and favorable mechanical properties(microhardness=95.6±5.28 HV_(0.1),UTS=370.2 MPa,and At=10.4%)was achieved using optimized SLM parameters(P=120 W,v=500 mm/s,and h=45μm).Sample is dominated by a random texture and microstructure is primarily constituted by quantities ofﬁne equiaxed grains(α-Mg phase),a small amount ofβ-Al_(12)Mg_(17) structures(4.96 vol%,including spherical:[2110]_(α)//[111]_(β)and long lath-like:[2110]_(α)//[115]_(β)or[1011]_(α)//[321]_(β)),and some short rod-shaped Al8Mn5 ***ﬁting from grain boundary strengthening,solid solution strengthening,and precipitation hardening of various nanoparticles(β-Al12Mg17 and Al8Mn5),high-performance Mg–9Al–1Zn–0.5Mn alloy biomedical implants can be *** hardening dominates the strengthening mechanism of the SLM Mg–9Al–1Zn–0.5Mn alloy.

关键词： Selective laser melting Mg-Zn-Al-Mn alloy Response surface analysis Microstructural evolution Mechanical properties

Three-dimensional light structure of an upland Quercus stand post-tornado disturbance

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Journal of Forestry Research 2020年第1期31卷 141-153页

作者： Kevin G.Willson Lauren E.cox Justin L.Hart Daniel c.Dey Department of Geography University of AlabamaTuscaloosaAL 35487USA Department of Environmental Science Policyand ManagementUniversity of CaliforniaBerkeleyCA 94720USA Northern Research Station USDA Forest ServiceColumbiaMO 65211USA

Light is the most common limiting factor in forest plant communities,influencing species composition,stand structure,and stand productivity in closed canopy *** vertical light structure is relatively simple under a closed canopy because most light is captured by overstory ***,wind disturbance events create canopy openings from local to landscape scales that increase understory light intensity and vertical light structural *** studied the effects of an EF-1 tornado on horizontal and vertical(***-dimensional)light structure within a Quercus stand to determine how light structure changed with increasing disturbance *** used a two-tiered method to collect photosynthetic photon flux density at 4.67 m and 1.37 m above the forest floor to construct three-dimensional light structure across a canopy disturbance severity gradient to see if light intensity varied with increasing tornado *** indicate that increased canopy disturbance closer to the tornado track increased light penetration and light structure heterogeneity at lower forest *** light intensity correlated with increased sapling density that was more randomly distributed across the plot and had shifted light capture higher in the stand *** penetration through the overstory was most strongly correlated with decreased stem density in the two most important tree species(based on relative dominance and relative density)in the stand,Quercus alba L.(r=-0.31)and Ostrya virginiana(Mill.)***(r=-0.27,pcated that understory light penetration was most affected by these two *** managers are increasingly interested in patterning silvicultural entries on natural disturbances,they must understand residual stand and light structures that occur after natural disturbance *** providing spatial light data that quantifies light structure post-disturbance,managers can use these results to improve planning required for long-term man

关键词： Photosynthetic photon flux density Midstory Blowdown Heterogeneity

Equal Sex Ratios of a Marine Green Alga, Bryopsis plumosa

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Journal of Integrative Plant Biology 2008年第6期50卷 648-652页

作者： Tatsuya Togashi Paul Alan cox Marine Biosystems Research center Chiba University Institute for Ethnomedicine Box 3464 Jackson Hole Wyoming 83001 USA Institute for Ethnomedicine Box 3464 Jackson Hole

By finding some important culture conditions as below, we succeeded in experimentally controlling the whole life history of a dioecious marine green alga, Bryopsis plumosa （Hudson） c. Agardh. In this study, we focused on the primary and secondary sex ratios （i.e. at inception and maturity） using these culture techniques. Gametogenesis was induced by culturing haploid gametophytes with Provasoli＇s enriched seawater （PES） medium under a 14：10 h light： dark cycle at 14 ℃. Formed zygotes grew into diploid sporophytes, which were cultured for 3 months with PES medium under a 14：10 h light ： nbsp;dark cycle at 18℃. Then they were transferred into Schreiber medium and cultured under a 10：14 h light： dark cycle at 22℃. Within 1 week, zoosporogenesis was observed. Zoospores were released within a couple of days. Each zoospore soon germinated and grew into a unisexual gametophyte. The primary sex ratio was examined in gametophytes that originated from a single sporophyte. The secondary sex ratio was studied in the field. Both were estimated as 1：1. Synchronized meiotic cell divisions might occur during zoosporogenesis dividing each sex-determining factor evenly among zoospores. Given the equal sex ratio at maturity, there seems to be no environmental factor that differentially affects the survival of male or female gametophytes in nature.

关键词： algal culture Bryopsis green algae life history sex ratio.

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《SHOcK》2020年第9期新观点

实用休克杂志（中英文） 2020年第5期4卷 305-307页

作者： Michael c.cox Philip A·Efron Scott c·Brakenridge 童明(译) 湖南省人民医院/湖南师范大学附属第一医院感染科急危重症代谢组学湖南省重点实验室不详

本期《休克》的16篇优秀论文增进了在休克、脓毒症、炎症和器官功能障碍领域的知识。虽然从研究的设计到研究的领域均很广泛,但在基础研究和转化研究的进步问题上有一个共同的主题。每一篇文章都有可能通过各种疾病状态来改进精准医学... 详细信息

本期《休克》的16篇优秀论文增进了在休克、脓毒症、炎症和器官功能障碍领域的知识。虽然从研究的设计到研究的领域均很广泛,但在基础研究和转化研究的进步问题上有一个共同的主题。每一篇文章都有可能通过各种疾病状态来改进精准医学模型。

关键词：器官功能障碍精准医学疾病状态脓毒症休克优秀论文

Improved resolution of mixed STR profiles using a fully automated differential cell lysis/DNA extraction method

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Forensic Sciences Research 2020年第2期5卷 106-112页

作者： Matthew c.Goldstein Jordan O.cox Lori B.Seman Tracey Dawson cruz Department of Forensic Science Virginia Commonwealth UniversityRichmondVirginiaUSA

Sexual assault evidence often contains sperm cells,which are typically separated from nonsperm cells using manual differential lysis *** goal of this study was to evaluate the automated QIAGEN QIAcube for this purpose and to compare it to manual QIAGEN and manual organic differential methods using DNA yields and STR profile data for *** yields were determined by qPcR,followed by multiplex STR amplification,cE analysis,and mixture *** automated method was capable of effective cell separation,producing DNA yields sufficient for STR ***,sperm fraction human:male DNA ratios from the QIAcube samples were consistently closer to the desired 1:1 and STR profiles were less likely to result in mixtures,with 6–8fewer female alleles detected(median 1.5 alleles).Ultimately,using the QIAcube for automated differential processing of semen-containing mixtures reduces the need for downstream mixture interpretation and improves STR profile quality with substantially less hands-on time.

关键词： Forensic sciences forensic genetics sexual assault evidence QIAcube differential lysis sperm lysis automated DNA extraction mixture analysis

clinical progress of nanomedicine-based RNA therapies

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Bioactive Materials 2022年第6期7卷 203-213页

作者： Siyoung A.Lim Alysia cox Madelynn Tung Eun Ji chung Department of Biomedical Engineering University of Southern CaliforniaLos AngelesCAUSA Mork Family Department of chemical Engineering and Materials Science University of Southern CaliforniaLos AngelesCAUSA Department of Medicine Division of Nephrology and HypertensionUniversity of Southern CaliforniaLos AngelesCAUSA Department of Surgery Division of Vascular Surgery and Endovascular TherapyUniversity of Southern CaliforniaLos AngelesCAUSA

The clinical application of nanoparticles(NPs)to deliver RNA for therapy has progressed rapidly since the FDA approval of Onpattro®in 2018 for the treatment of polyneuropathy associated with hereditary transthyretin *** emergency use authorization or approval and widespread global use of two mRNA-NP based vaccines developed by Moderna Therapeutics *** Pfizer-BioNTech in 2021 has highlighted the translatability of NP technology for RNA ***,in clinical trials,a wide variety of NP formulations have been found to extend the half-life of RNA molecules such as microRNA,small interfering RNA,and messenger RNA,with limited safety *** this review,we discuss the NP formulations that are already used in the clinic to deliver therapeutic RNA and highlight examples of RNA-NPs which are currently under evaluation for human *** also detail NP formulations that failed to progress through clinical trials,in hopes of guiding future successful translation of nanomedicine-based RNA therapeutics into the clinic.

关键词： Nanoparticles RNA therapy Drug delivery Nanomedicine clinical trials cOVID-19

Response to strict and liberalized specific carbohydrate dietin pediatric crohn's disease

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World Journal of Gastroenterology 2016年第6期22卷 2111-2117页

作者： Jennifer c Burgis Kaylie Nguyen KT Park Kenneth cox Department of Pediatrics GastroenterologyHepatology and NutritionStanford University School of MedicinePalo AltoCA 94304United States

AIM: To investigate the specific carbohydrate diet(ScD) as nutritional therapy for maintenance of remission in pediatric crohn's disease(cD). METHODS: Retrospective chart review was conducted in 11 pediatric patients with cD who initiated the ScD as therapy at time of diagnosis or flare. Two groups defined as ScD simple(diet alone, antibiotics or 5-ASA) or ScD with immunomodulators(corticosteroids and/or stable thiopurine dosing) were followed for one year and compared on disease characteristics, laboratory values and ***: The mean age at start of the ScD was 11.8 ± 3.0 years(range 6.6-17.6 years) with five patients starting the ScD within 5 wk of diagnosis. Three patients maintained a strict ScD diet for the study period and the mean time for liberalization was 7.7 ± 4.0 mo(range 1-12) for the remaining patients. In both groups, hematocrit, albumin and ESR values improved while on strict ScD and appeared stable after liberalization(P-value 0.006, 0.002, 0.002 respectively). The majority of children gained in weight and height percentile while on strict ScD, with small loss in weight percentile documented with liberalization. cONcLUSION: Disease control may be attainable with the ScD in pediatric cD. Further studies are needed to assess adherence, impact on mucosal healing and growth.

关键词： Specific carbohydrate diet crohn's disease Pediatrics Nutrition therapy