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Severe acute kidney injury due to oxalate crystal induced severe interstitial nephritis:A case report

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World Journal of Nephrology 2024年第2期13卷 24-30页

作者： maulik k.lathiya Praveen Errabelli Sasmit Roy Neeharik Mareedu Department of Emergency Medicine Mayo Clinic Health SystemEau ClaireWI 54703United States Department of Nephrology Mayo Clinic Health SystemEau ClaireWI 54703United States Department of Nephrology Centra Lynchburg General HospitalLynchburgVA 24551United States Department of Nephrology UPMC Western MarylandCumberlandMD 21502United States

BACkGROUND Acute kidney injury(AkI)due to interstitial nephritis is a known condition primarily attributed to various *** medication-induced interstitial nephritis is common,occurrences due to non-pharmacological factors are *** report presents a case of severe AkI triggered by intratubular oxalate crystal deposition,leading to interstitial *** aim is to outline the case and its management,emphasizing the significance of recognizing uncommon causes of interstitial *** SUMMARY A 71-year-old female presented with stroke-like symptoms,including weakness,speech difficulties,and cognitive *** hypertension had been managed with hydrochlorothiazide(HCTZ)for over two *** admis-sion,severe hypokalemia and AkI were noted,prompting discontinuation of HCTZ and initiation of prednisolone for acute interstitial *** investigations,including kidney biopsy,confirmed severe acute interstitial nephritis with oxalate crystal deposits as the underlying *** treatment,initial renal function showed minimal ***,with prednisolone therapy and supportive measures,her condition gradually improved,high-lighting the importance of comprehensive *** This case underscores the importance of a thorough diagnostic approach in identifying and addressing uncommon causes of interstitial *** occurrence of interstitial nephritis due to oxalate crystal deposition,especially without typical risk factors,emphasizes the need for vigilance in clinical practice.

关键词： Acute kidney injury Interstitial nephritis Oxalate crystal Hydrochlorothiazide Hypokalemia Case report

A call for enhanced data-driven insights into wind energy flow physics

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Theoretical & Applied Mechanics Letters 2024年第1期14卷 6-10页

作者： Coleman Moss Romit maulik Giacomo Valerio Iungo Wind Fluids and Experiments(WindFluX)Laboratory Mechanical Engineering DepartmentThe University of Texas at DallasRichardson 75080USA College of Information Sciences and Technology The Pennsylvania State UniversityState College 16801USA

With the increased availability of experimental measurements aiming at probing wind resources and wind turbine operations,machine learning(ML)models are poised to advance our understanding of the physics underpinning the interaction between the atmospheric boundary layer and wind turbine arrays,the generated wakes and their interactions,and wind energy ***,the majority of the existing ML models for predicting wind turbine wakes merely recreate Computational fluid dynamics(CFD)simulated data with analogous accuracy but reduced computational costs,thus providing surrogate models rather than enhanced data-enabled physics *** ML-based surrogate models are useful to overcome current limitations associated with the high computational costs of CFD models,using ML to unveil processes from experimental data or enhance modeling capabilities is deemed a potential research direction to *** this letter,we discuss recent achievements in the realm of ML modeling of wind turbine wakes and operations,along with new promising research strategies.

关键词： Machine learning Wake Wind turbine Wind farm Supervisory control and data acquisition

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World Journal of Nephrology 2023年第3期12卷 66-72页

作者： maulik k.lathiya Praveen Errabelli Salvatore Mignano Susan M Cullinan Department of Emergency Medicine Mayo Clinic Health SystemEau ClaireWI 54703United States Department of Nephrology Mayo Clinic Health SystemEau ClaireWI 54703United States Department of Pathology Mayo ClinicRochesterMN 55905United States

BACkGROUND Anaplasmosis is a tick-borne disease with a range of clinical manifestations,from a flu-like illness with fever and myalgias to a severe systemic disease with multisystem organ *** renal involvement is not a common presentation,there have been few cases reporting acute kidney injury from *** SUMMARY We present a 55-year-old female with anaplasmosis who developed acute kidney injury due to membranoproliferative glomerulonephritis(MPGN).The patient originally presented with cough and shortness of *** was admitted to the hospital with a diagnosis of community acquired pneumonia and received *** the hospital course she developed severe acute renal *** serological work up didn’t provide any conclusive ***,she underwent kidney biopsy which showed MPGN pattern suggesting autoimmune,multiple myeloma or infectious *** work up was undertaken which was negative for autoimmune diseases,vasculitis panel,paraproteinemias but tested positive for IgG anaplasma with high titers indicating *** Our case shows a unique presentation of severe acute renal failure from MPGN from tick borne *** is usually seen with autoimmune diseases,hepatitis C virus infections,***,we suggest that tick borne illness should also be considered when evaluating acute renal failure cases in tick borne prevalent regions.

关键词： Acute kidney injury Membranoproliferative glomerulonephritis Tick-borne Anaplasmosis Case report

Severe hypernatremia in hyperglycemic conditions;managing it effectively:A case report

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World Journal of Critical Care Medicine 2023年第1期12卷 29-34页

作者： maulik k.lathiya Praveen Errabelli Susan M Cullinan Emeka J Amadi Department of Emergency Mayo Clinic Health SystemEau ClaireWI 54703United States Department of Nephrology Mayo Clinic Health SystemEau ClaireWI 54703United States Hospital Internal Medicine Mayo Clinic Health SystemEau ClaireWI 54703United States

BACkGROUND Diabetic ketoacidosis(DkA)and hyperglycemic hyperosmolar state(HHS)are common acute complications of diabetes mellitus with a high risk of *** combined with hypernatremia,the complications can be even *** is a rarely associated with DkA and HHS as both are usually accompanied by normal sodium or *** a result,a structured and systematic treatment approach is *** discuss the therapeutic approach and implications of this uncommon *** SUMMARY A 62-year-old man with no known past medical history presented to emergency department with altered mental *** work up in emergency room showed severe hyperglycemia with a glucose level of 1093 mg/dL and severe hypernatremia with a serum sodium level of 169 mEq/*** was admitted to the intensive care unit(ICU)and was started on insulin drip as per DkA *** 12 h of ICU admission,blood sugar was 300 mg/*** his mental status didn’t show much *** was dehydrated and had a corrected serum sodium level of>190 mEq/*** a result,dextrose 5%in water and ringer's lactate were *** was also given free water via an nasogastric(NG)tube and IV Desmopressin to improve his free water deficit,which improved his serum sodium to 140 mEq/*** The combination of DkA,HHS and hypernatremia is rare and extremely challenging to manage,but the most challenging part of this condition is selecting the correct type of fluids to treat these *** case illustrates that desmopressin and free water administration via the NG route can be helpful in this situation.

关键词： Diabetic ketoacidosis Hyperglycemic hyperosmolar state Hypernatremia Hyperglycemia Desmopressin Case repot

Getting to know the fetal genome non-invasively:now a reality

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Protein & Cell 2012年第10期3卷 723-725页

作者： maulik M Dhandha School of Medicine St.Louis University1402 S Grand BlvdSt.LouisMO 63110USA

Prenatal screening tests of genetic disorders are routinely performed in modern day obstetrics to diagnose fetal genomic abnormalities including trisomies 13,18 and *** include amniocentesis and chorionic villi sampling,both of which are invasive testing processes and post a small but significant risk to the fetus(Evans and Wapner 2005).

关键词： fetal routine fetus

Dynamic modeling of the horizontal eddy viscosity coefficient for quasigeostrophic ocean circulation problems

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Journal of Ocean Engineering and Science 2016年第4期1卷 300-324页

作者： Romit maulik Omer San School of Mechanical and Aerospace Engineering Oklahoma State UniversityStillwaterOK 74078USA

This paper puts forth a simplified dynamic modeling strategy for the eddy viscosity coefficient parameterized in space and *** eddy viscosity coefficient is dynamically adjusted to the local structure of the flow using two different nonlinear eddy viscosity functional forms to capture anisotropic dissipation mechanism,namely,(i)the Smagorinsky model using the local strain rate field,and(ii)the Leith model using the gradient of the vorticity *** proposed models are applied to the one-layer and two-layer wind-driven quasigeostrophic ocean circulation problems,which are standard prototypes of more realistic ocean *** show that both models capture the quasi-stationary ocean dynamics and provide the physical level of eddy viscosity distribution without using any a priori ***,it is found that slightly less dissipative results can be obtained by using the dynamic Leith ***-layer numerical experiments also reveal that the proposed dynamic models automatically parameterize the subgrid-scale stress terms in each active ***,the proposed scale-aware models dynamically provide higher values of the eddy viscosity for smaller resolutions taking into account the local resolved flow information,and addressing the intimate relationship between the eddy viscosity coefficients and the numerical resolution employed by the quasigeostrophic models.

关键词： Eddy viscosity Dynamic Smagorinsky model Dynamic Leith model Anisotropic dissipation One-layer problem Two-layer problem

Vasopressin-induced hyponatremia in an adult normotensive trauma patient:A case report

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World Journal of Critical Care Medicine 2023年第1期12卷 35-40页

作者： maulik k.lathiya Emily Pepperl Daniel Schaefer Hussam Al-Sharif Adel Zurob Susan M Cullinan Antonios Charokopos Department of Emergency Medicine Mayo Clinic Health SystemEau ClaireWI 54703United States Department of Pulmonary and Critical Care Medicine Mayo Clinic Health SystemEau ClaireWI 54703United States

BACkGROUND Arginine vasopressin is a neuropeptide produced in the hypothalamus and released by the posterior pituitary *** addition to maintaining plasma osmolarity,under hypovolemic or hypotensive conditions,it helps maintain plasma volume through renal water reabsorption and increases systemic vascular *** synthetic analogues are widely used in the intensive care unit as a continuous infusion,in addition to hospital floors as an intravenous or intranasal dose.A limited number of cases of hyponatremia in patients with septic or hemorrhagic shock have been reported previously with *** report for the first time a normotensive patient who developed vasopressin-induced *** SUMMARY A 39-year-old man fell off a forklift and sustained an axial load injury to his *** had no history of previous *** was normal except for motor and sensory *** Imagine test showed endplate fracture at C7 and acute traumatic disc at C7 with cortical *** underwent cervical discectomy and fusion,laminectomy,and posterior instrumented *** intensive care unit admission post-surgery,he developed hyponatremia of 121-124 mEq/L post phenylephrine and vasopressin infusion to maintain blood pressure *** was evaluated for syndrome of inappropriate secretion of antidiuretic hormone,hypothyroid,adrenal-induced,or diuretic-induced *** the end of extensive evaluation for the underlying cause of hyponatremia,vasopressin was *** was also put on fluid restriction,given exogenous desmopressin,and a dextrose 5%in water infusion to prevent osmotic demyelination syndrome caused by sodium overcorrection which improved his sodium level to 135 mmol/*** The presentation of vasopressin-induced hyponatremia is uncommon in normotensive patients,and the most difficult aspect of this condition is determining the underlying cause of *** case illustrates that,considering the vast diffe

关键词： Hyponatremia Vasopressin Normotensive Therapy Case report

Coagonist of glucagon-like peptide-1 and glucagon receptors ameliorates kidney injury in murine models of obesity and diabetes mellitus

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World Journal of Diabetes 2018年第6期9卷 80-91页

作者： Vishal J Patel Amit A Joharapurkar Samadhan G kshirsagar Brijesh k Sutariya maulik S Patel Hiren M Patel Dheerendra k Pandey Rajesh H Bahekar Mukul R Jain Department of Pharmacology and Toxicology Zydus Research CentreCadila Healthcare Limited

AIM To investigate the role of glucagon-like peptide-1(GLP-1)/glucagon receptors coagonist on renal dysfunction associated with diabetes and obesity. METHODS Chronic high-fat diet fed C57 BL/6 J mice, streptozotocintreated high-fat diet fed C57 BL/6 J mice and diabeticC57 BLkS/J db/db mice were used as models of diabetes-induced renal dysfunction. The streptozotocintreated high-fat diet fed mice and db/db mice were treated with the GLP-1 and glucagon receptors coagonist(Aib2 C24 Chimera2, 150 μg/kg, sc) for twelve weeks, while in chronic high-fat diet fed mice, coagonist(Aib2 C24 Chimera2, 150 μg/kg, sc) treatment was continued for forty weeks. kidney function, histology, fibrosis, inflammation, and plasma biochemistry were assessed at the end of the treatment. RESULTS Coagonist treatment decreased body weight, plasma lipids, insulin resistance, creatinine, blood urea nitrogen, urinary albumin excretion rate and renal lipids. In kidney, expression of lipogenic genes(SREBP-1 C, FAS, and SCD-1) was decreased, and expression of genes involved in β-oxidation(CPT-1 and PPAR-α) was increased due to coagonist treatment. In plasma, coagonist treatment increased adiponectin and FGF21 and decreased IL-6 and TNF-?. Coagonist treatment reduced expression of inflammatory(TNF-α, MCP-1, and MMP-9) and pro-fibrotic(TGF-β, COL1 A1, and α-SMA) genes and also improved histological derangement in renal *** Coagonist of GLP-1 and glucagon receptors alleviated diabetes and obesity-induced renal dysfunction by reducing glucose intolerance, obesity, and hyperlipidemia.

关键词： Coagonist Glucagon Renal dysfunction Glucagon-like peptide-1 Insulin sensitivity

A Rare Case of Superior Mesenteric Vein Aneurysm Secondary to Portal Hypertension

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International Journal of Clinical Medicine 2013年第1期4卷 66-68页

作者： Anjana V. Trivedi maulik C. Jethva Malek Mohmed Anwar Chetna k. Dodia Jagruti G. kalola Radiology Department PDU Medical College & Sanya GIC Imaging Centre Rajkot India

Venous aneurysms are less common than arterial aneurysms in clinical practice, and the occurrence of such cases is a topic for publication. Aneurysms of the superior mesenteric vein (SMV) are rare, and their origin is unknown. Many aneurysms are asymptomatic, and the diagnosis is established from radiologic findings. Others are diagnosed after complications such as gastrointestinal bleeding or thrombosis with associated abdominal pain. Because of the rarity of this disease, therapy must be adapted to fit each case. A 55-year-old woman presented with pain in abdomen since 2 months. The diagnosis of this anomaly was made after Computed tomography (CT) scans, that demonstrated a mass. Apart from various etiological theories, portal hypertension was more likely cause of her SMV aneurysm. Case was treated by medical treatment like Sorbitrate, Propranolol, Omeprazole and Lasix. No aneurysm growth or complication was observed even after 2 years of follow-up.

关键词： Venous Aneurysm Superior Mesenteric Vein (SMV) CT Scan