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Acceptability of an acupuncture intervention for geriatric chronic pain: an open pilot study

Journal of Integrative Medicine 2013年第1期11卷 26-31页

作者： Marie-France Couilliot Veronique Dareest Bruno.Tenenbaum Gerard Delahaye Philippe Ercolano maud Carcaille Pavia Vytopilova Bruno Tenenbaum Eric Vicaut Public Health Department Groupe Hospitalier Universitaire Paris-Seine-Saint-Denis AssistancePublique-Hopitaux de Paris 75001 Paris France Institut de Recherche Interdisciplinaire sur les enjeux Sociaux Universit6 Paris 13 93017 Bobigny France Palliative Care Groupe Hospitalier Universitaire Paris-Seine-Saint-Denis Assistance Publique-Hopitauxde Paris 75001 Paris France Unite de Recherche Clinique Groupe Hospitalier Universitaire SLS-LRB Assistance Publique-Hopitauxde Paris 75001 Paris France

OBJECTIVE： This study investigated the acceptability and effectiveness of acupuncture for persistent musculoskeletat pain in the elderly and assessed the conditions for a future controlled trial. METHODS： A total of 60 patients, hospitalized in a geriatric hospital were enrolled. The intervention consisted of eight acupuncture sessions. The main outcome was the patient＇s participation rate. Regarding pain, the evaluation was based on pre- and post-treatment variations. As a high proportion of the patients had cognitive impairment, the behavioral pain scale DOLOPLUS-2 was chosen although self evaluation was used wherever possible. RESULTS： The mean age of the patients was 83 years. The acceptance rate was very high （89.6%） and 90% of the patients completed the entire course of treatment. After five weeks, the mean DOLOPLUS score had decreased significantly （P〈0.01）. The patients reported improved sleep quality and a reduction in their anxiety symptoms. Furthermore, caregivers noticed a decrease in patient aggressiveness making care easier. CONCLUSION： Our results suggest that acupuncture is highly acceptable and could be very useful in the management of chronic pain when performed in very old frail people with chronic physical and mental disability. TRIAL REGISTRATION IDENTIFIER： NCT01043692 ***.

关键词： acupuncture pain aged pain measurement pilot projects

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Clinical utility of circulating tumor DNA sequencing with a large panel in patients with advanced soft-tissue sarcomas

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Cancer Communications 2023年第9期43卷 1051-1054页

作者： Julie Blanchi Sofiane Taleb Arnaud Bayle Benjamin Verret maud Toulmonde Mariella Spalato-ceruso Paul Dubos Yech'an Laizet Melissa Alame Emmanuel Khalifa Antoine Italiano INSERM Unité 1312SARCOTARGET teamBordeauxFrance Department of BioPathology Institut BergoniéBordeauxFrance Drug Developpement Department Gustave RoussyVillejuifFrance Department of Medicine Gustave RoussyVillejuifFrance Sarcoma Unit Institut BergoniéBordeauxFrance Faculty of Medicine University of BordeauxBordeauxFrance

To the editor Soft-tissue sarcomas(STS)represent a very heterogeneous group of rare tumors including more than 100 different subtypes[1].Surgery and neo/adjuvant radiation therapy represent the cornerstone of treatment for ***,despite an optimal resection of the tumor,up to 40%of patients will develop metastatic relapse and will die from the disease[1].Doxorubicin represents the first-line standard of care for patients with advanced disease since the 1970s,despite several attempts to identify better *** median overall survival(OS)of patients with metastatic disease is<18 months and has only modestly improved over the past 20 years[2].

关键词： patients Surgery sarcoma

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Faecal calprotectin and magnetic resonance imaging in detecting Crohn's disease endoscopic postoperative recurrence

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World Journal of Gastroenterology 2018年第5期24卷 641-650页

作者： Pierre Baillet Guillaume Cadiot Marion Goutte Felix Goutorbe Hedia Brixi Christine Hoeffel Christophe Allimant maud Reymond Hélène Obritin-Guilhen Benoit Magnin Gilles Bommelaer Bruno Pereira Constance Hordonneau Anthony Buisson Université Clermont Auvergne CHU Clermont-Ferrand Service de radiologie CHU de Reims Service d’Hépato-Gastro Entérologie Université Clermont Auvergne Inserm 3iHP CHU Clermont-Ferrand Service d’Hépato-Gastro Entérologie Université Clermont Auvergne Inserm U1071 CH de Bayonne Service d’Hépato-Gastro Entérologie CHU de Reims Service de radiologie CHU Clermont-Ferrand DRCI Unité de Biostatistiques

AIM To assess magnetic resonance imaging(MRI) and faecal calprotectin to detect endoscopic postoperative recurrence in patients with Crohn's disease(CD).METHODS From two tertiary centers, all patients with CD who underwent ileocolonic resection were consecutively and prospectively included. All the patients underwent MRI and endoscopy within the first year after surgery or after the restoration of intestinal continuity [median = 6 mo(5.0-9.3)]. The stools were collected the day before the colonoscopy to evaluate faecal calprotectin level. Endoscopic postoperative recurrence(POR) was defined as Rutgeerts' index ≥ i2b. The MRI was analyzed independently by two radiologists blinded from clinical *** Apparent diffusion coefficient(ADC) was lower in patients with endoscopic POR compared to those with no recurrence(2.03 ± 0.32 vs 2.27 ± 0.38 × 10^(-3) mm^2/s, P = 0.032). Clermont score(10.4 ± 5.8 vs 7.4 ± 4.5, P = 0.038) and relative contrast enhancement(RCE)(129.4% ± 62.8% vs 76.4% ± 32.6%, P = 0.007) were significantly associated with endoscopic POR contrary to the magnetic resonance index of activity(Ma RIA)(7.3 ± 4.5 vs 4.8 ± 3.7; P = 0.15) and MR scoring system(P = 0.056). ADC 100%(sensitivity = 0.75, specificity = 0.81, PPV = 0.75, NPV = 0.81) were the best cutoff values to identify endoscopic POR. Clermont score > 6.4(sensitivity = 0.61, specificity = 0.82, PPV = 0.73, NPV = 0.74), Ma RIA > 3.76(sensitivity = 0.61, specificity = 0.82, PPV = 0.73, NPV = 0.74) and a MR scoring system ≥ MR1(sensitivity = 0.54, specificity = 0.82, PPV = 0.70, and NPV = 0.70) demonstrated interesting performances to detect endoscopic POR. Faecal calprotectin values were significantly higher in patients with endoscopic POR(114 ± 54.5 μg/g vs 354.8 ± 432.5 μg/g; P = 0.0075). Faecal calprotectin > 100 μg/g demonstrated high perfor

关键词： Faecal calprotectin Magnetic resonance imaging Postoperative recurrence Crohn’s disease Clermont score Magnetic resonance index of activity

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Aggressive blood pressure treatment of hypertensive intracerebral hemorrhage may lead to global cerebral hypoperfusion:Case report and imaging perspective

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World Journal of Radiology 2017年第12期9卷 448-453页

作者： Jose Gavito-Higuera Rakesh Khatri Ihtesham A Qureshi Alberto maud Gustavo J Rodriguez Department of Neurology Paul L.Foster School of MedicineTexas Tech University of Health Sciences CenterEl PasoTX 79905United States

Hypoperfusion injury related to blood pressure decrease in acute hypertensive intracerebral hemorrhage continues to be a controversial topic. Aggressive treatment is provided with the intent to stop the ongoing bleeding. However, there may be additional factors, including autoregulation and increased intracranial pressure, that may limit this approach. We present here a case of acute hypertensive intracerebral hemorrhage, in which aggressive blood pressure management to levels within the normal range led to global cerebral ischemia within multiple border zones. Global cerebral ischemia may be of concern in the management of hypertensive hemorrhage in the presence of premorbid poorly controlled blood pressure and increased intracranial pressure.

关键词： Intracranial hemorrhage Neurocritial care Stroke management Perihematoma ischemia

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苏珊姑妈的妙招

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英语学习 2012年第1期 48-52页

作者： Lucy maud Montgomery

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爱在一吻间

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英语学习 2001年第2期 34-36页

作者： Phyllis maud 李力山东医科大学外语教研室

爱有多深痛就有多深。是不是美好的东西都令人垂泪?每天下午去值夜班的时候,我都会先在养老院各处巡视一番,在每间屋子门口停一停,看一看,和老人们聊一聊。凯蒂和克里斯经常依偎着

关键词：克里斯养老院

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求婚

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英语学习 2011年第7期 43-47页

作者： Lucy maud Montgomery

她也曾经拥有如花的少女时代和美丽的容颜，但这么多年来，却一直无人向她求婚。她一直暗暗渴望被求一次婚，没想到她的愿望刚说出口，就实现了……

关键词：英语译文翻译方法阅读材料

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Acute and Sub-Acute Toxicity of Ethanolic Leaf Extracts of <i>Rumex abyssinica</i>Jacq. (Polygonaceae) and <i>Mentha spicata</i>L. (Lamiaceae)

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Pharmacology & Pharmacy 2014年第3期5卷 309-318页

作者： maud Kamatenesi Mugisha James Gakunga Ndukui Agnes Namutembi Paul Waako Ann-Karl Borg Karlson Patrick Vudriko Department of Biological Sciences School of Biosciences College of Natural Sciences Makerere University Kampala Uganda Department of Chemistry KTH Stockholm Sweden Department of Food Technology and Nutrition College of Agriculture and Environmental Sciences Makerere University Kampala Uganda Department of Pharmacology and Therapeutics College of Health Sciences Makerere University Kampala Uganda Department of Veterinary Pharmacy Clinics and Comparative Medicine College of Veterinary Medicine Animal Resources and Biosecurity Makerere University Kampala Uganda Department of Veterinary Pharmacy Clinics and Comparative Medicine College of Veterinary Medicine Animal Resources and Biosecurity Makerere Uni-versity Kampala Uganda

Rumex abyssinica Jacq. (Polygonaceae) is locally used in management of allergies and female reproductive healthcare;whereas Mentha spicata L. (Lamiaceae) is used to treat gastrointestinal and respiratory distress, dandruff, halitosis and malaria in Uganda. Owing to the paucity of data on their safety profiles, this study evaluated the acute and sub-acute toxicities of 70% ethanolic leaf extracts of both plants in mice and Wistar albino rats. The oral acute toxicity of both plants was evaluated in Swiss mice of 7-8 weeks old (16-22 g) body weight and LD50 determined. Sub-acute toxicity was evaluated in Wistar albino rats (6 per group) at dose rates of 500, 1000 and 1500 mg/kg for 28 days. The LD50 of R. abyssinica and M. spicata in mice was 7727 mg/kg and 13,606 mg/kg body weight, respectively. General signs of toxicity due to large doses of both plants extract included hyperurination, abdominal muscle twitches and convulsions. In the sub-acute toxicity test, rats treated with both extracts did not exhibit any clinical signs of toxicity;no mortality and changes in body weight were observed. R. abyssinica did not cause significant changes in haematological indices, except a significant increase in HCT (p 0.05). However, a dose dependant significant decrease in HCT (p 0.05) and a significant increase (p 0.05) in the levels of WBC, LMY and MCHC were observed in rats treated with M. spicata extract. Biochemical test showed that both extracts caused a significant dose dependent increase (p 0.05) in levels of ALT and ALP. Marked increase in the levels of AST was also observed in rats treated with M. spicata extract. Of the two extracts, only rats treated with

关键词： Histopathology Mentha spicata Rumex abyssinica Toxicity

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苹果布丁【E】

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英语学习 2017年第3期 31-35页

作者： maud Lindsay 郑洪敏

“The rose’s in her hand，the flavor in mine．”赠人玫瑰，手有余香。一位善心的老妇人，起初只想用自家的李子去换一篮做布丁要用的苹果回来，但一路上为了帮助有需要的人，先后交换了羽毛、花束、金链、小狗这些原本她并不需要... 详细信息

“The rose’s in her hand，the flavor in mine．”赠人玫瑰，手有余香。一位善心的老妇人，起初只想用自家的李子去换一篮做布丁要用的苹果回来，但一路上为了帮助有需要的人，先后交换了羽毛、花束、金链、小狗这些原本她并不需要的东西，但她安之若素，最终在不经意间得到了心之所想。

关键词：苹果 rose The the

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Optic Neuritis in Acute Neuroborreliosis (Lyme Disease) in the U.S.-Mexican Border: Case Report

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World Journal of Neuroscience 2016年第2期6卷 126-130页

作者： Ihtesham A. Qureshi Michael F. Maldonado Gustavo J. Rodriguez Salvador Cruz-Flores Alberto maud Neurology Department Texas Tech University Health Sciences Center El Paso USA Ophthalmology Department Texas Tech University Health Sciences Center El Paso USA

Objective: We describe a patient diagnosed with acute neuroborreliosis presenting with anterior optic neuritis (papillitis) in a non-endemic region. Case Presentation: A 43-year-old previously healthy right handed man admitted due to an insidious onset of severe headache and spells of ascending paresthesias from his right foot into his right arm and face followed by speech arrest and clumsiness of his right hand. His neurologic exam was significant for somnolence, nuchal rigidity and Kernig and Brudzinski signs were present. MRI of the brain with gadolinium showed diffuse hyperintense signal involving the supra and infratentorial cortical sulci, with associated faint diffuse leptomeningeal enhancement, consistent most likely with diffuse leptomeningoencephalitis. EEG: normal. CSF VDRL was negative. Dilated fundus exam revealed mild optic nerve edema more significant to the left than to the right eye, confirmed and measured by spectral domain OCT (Optical Coherence Tomography). There was an evidence of posterior uveitis with an early vitreous hemorrhage superficial to the left optic nerve. Lyme disease serum antibody (IgM) Immunoblotting was positive in 2 bands confirming the diagnosis of neuroborreliosis. Conclusion: Optic nerve involvement in Lyme disease is an uncommon complication that should be confirmed by specific diagnostic criteria to establish its causal relation.

关键词： Optic Neuritis Lyme Disease Non-Endemic Papillitis

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