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Aerobic bacteria associated with chronic suppurative otitis media in Angola

Infectious Diseases of Poverty 2018年第1期7卷 404-413页

作者： Fabian Udden matuba filipe Ake Reimer Maria Paul Erika Matuschek John Thegerstrom Sven Hammerschmidt Tuula Pelkonen Kristian Riesbeck Clinical Microbiology Department of Translational MedicineFaculty of MedicineLund UniversityMalmoSweden ORL-department Hospital Josina Machel Faculty of MedicineAgostinho Neto UniversityLuandaAngola Nashalsan Höllviken AB HollvikenSweden EUCAST Development Laboratory c/o Clinical MicrobiologyCentral HospitalVaxjoSweden Department of Molecular Genetics and Infection Biology University of GreifswaldGreifswaldGermany Children’s Hospital Helsinki University HospitalHelsinkiFinland and University of HelsinkiHelsinkiFinland

Background:Chronic suppurative otitis media(CSOM)is an important cause of hearing loss in children and constitutes a serious health problem globally with a strong association to resource-limited living *** antibiotics combined with aural toilet is the first-hand treatment for CSOM but antimicrobial resistance and limited availability to antibiotics are obstacles in some *** goal of this study was to define aerobic pathogens associated with CSOM in Angola with the overall aim to provide a background for local treatment ***:Samples from ear discharge and the nasopharynx were collected and cultured from 152 patients with ear discharge and perforation of the tympanic *** of bacterial species was performed with matrix-assisted laser desorption/ionization-time of flight mass spectrometry and pneumococci were serotyped using multiplex polymerase chain *** susceptibility testing was done according to ***:One hundred eighty-four samples from ear discharge and 151 nasopharyngeal swabs were collected and yielded 534 and 289 individual isolates,*** all patients,correspondence rate of isolates from 2 ears in patients with bilateral disease was 27.3%and 9.3%comparing isolates from the nasopharynx and ear discharge,*** spp.(14.7%),Pseudomonas aeruginosa(13.2%)and Enterococcus spp.(8.8%)were dominating pathogens isolated from ear discharge.A large part of the remaining species belonged to Enterobacteriaceae(23.5%).Pneumococci and Staphylococcus aureus were detected in approximately 10%of nasopharyngeal *** rates to quinolones exceeded 10%among Enterobacteriaceae and was 30.8%in ***,whereas 6.3%of *** were ***:The infection of the middle ear in CSOM is highly polymicrobial,and isolates found in nasopharynx do not correspond well with those found in ear *** associated with CSOM in Angola are dominated b

关键词： Chronic suppurative otitis media Enterobacteria Infection Otitis media Proteus Pseudomonas aeruginosa

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