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Roles of neuronal lysosomes in the etiology of Parkinson’s disease

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Neural Regeneration Research 2024年第9期19卷 1981-1983页

作者： mattia Volta Institute for Biomedicine Eurac ResearchBolzanoItaly

Therapeutic progress in neurodegenerative conditions such as Parkinson’s disease has been hampered by a lack of detailed knowledge of its molecular *** advancements in genetics and genomics have provided fundamental insights into specific protein players and the cellular processes involved in the onset of *** this respect,the autophagy-lysosome system has emerged in recent years as a strong point of convergence for genetics,genomics,and pathologic indications,spanning both familial and idiopathic Parkinson’s ***,if not all,genes linked to familial disease are involved,in a regulatory capacity,in lysosome function(e.g.,LRRK2,alpha-synuclein,VPS35,Parkin,and PINK1).Moreover,the majority of genomic loci associated with increased risk of idiopathic Parkinson’s cluster in lysosome biology and regulation(GBA as the prime example).Lastly,neuropathologic evidence showed alterations in lysosome markers in autoptic material that,coupled to the alpha-synuclein proteinopathy that defines the disease,strongly indicate an alteration in *** this Brief Review article,I present a personal perspective on the molecular and cellular involvement of lysosome biology in Parkinson’s pathogenesis,aiming at a larger vision on the events underlying the onset of the *** attempts at targeting autophagy for therapeutic purposes in Parkinson’s have been mostly aimed at“indiscriminately”enhancing its activity to promote the degradation and elimination of aggregate protein accumulations,such as alpha-synuclein Lewy ***,this approach is based on the assumption that protein pathology is the root cause of disease,while pre-pathology and pre-degeneration dysfunctions have been largely observed in clinical and pre-clinical *** addition,it has been reported that unspecific boosting of autophagy can be ***,it is important to understand the mechanisms of specific autophagy forms and,even more,the adjustment of specific lysosome f

关键词： alpha-synuclein autophagy LRRK2 lysosome neuroprotection neurotransmission Parkinson’s disease Rit2 synapse

Tectonically asymmetric Earth:From net rotation to polarized westward drift of the lithosphere

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Geoscience Frontiers 2015年第3期6卷 401-418页

作者： Carlo Doglioni Eugenio Carminati mattia Crespi Marco Cuffaro mattia Penati Federica Riguzzi Dipartimento di Scienze della Terra Sapienza Universita di Roma DITS-Area di Geodesia e Geomatica Sapienza Universita di Roma Istituto di Geologia Ambientale e Geoingegneria CNR MOX-Dipartimento di Matematica Politecnico di Milano Istituto Nazionale di Geofisica e Vulcanologia Sez.CNTRomeItaly

The possibility of a net rotation of the lithosphere with respect to the mantle is generally overlooked since it depends on the adopted mantle reference frames, which are arbitrary. We review the geological and geophysical signatures of plate boundaries, and show that they are markedly asymmetric worldwide. Then we compare available reference frames of plate motions relative to the mantle and discuss which is at best able to fit global tectonic data. Different assumptions about the depths of hotspot sources （below or within the asthenosphere, which decouples the lithosphere from the deep mantle） predict different rates of net rotation of the lithosphere relative to the mantle. The widely used no-net-rotation （NNR） reference frame, and low （〈0.2°-0.4°/Ma） net rotation rates （deep hotspots source） predict an average net rotation in which some plates move eastward relative to the mantle （e.g., Nazca）. With fast （〉1°/Ma） net rotation （shallow hotspots source）, all plates, albeit at different velocity, move westerly along a curved trajectory, with a tectonic equator tilted about 30° relative to the geographic equator. This is consistent with the observed global tectonic asymmetries.

关键词： Asymmetric plate tectonics Plate motions Westward drift Mantle convection

Modeling cells spreading,motility,and receptors dynamics:a general framework

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Acta Mechanica Sinica 2021年第6期37卷 1013-1030,I0003页

作者： mattia Serpelloni Matteo Arricca Claudia Bonanno Alberto Salvadori Universitàdegli Studi di Brescia DIMI-The Mechanobiology research center at UNIBS-Brescia25123BresciaItaly Universitàdegli Studi di Brescia DRIMI-The Mechanobiology research center at UNIBS-Brescia25123BresciaItaly Universitàdegli Studi di Brescia DICACIM-The Mechanobiology research center at UNIBS-Brescia25123BresciaItaly

The response of cells during spreading and motility is dictated by several multi-physics events,which are triggered by extracellular cues and occur at different *** this sake,it is not completely appropriate to provide a cell with classical notions of the mechanics of materials,as for“rheology”or“mechanical response”.Rather,a cell is an alive system with constituents that show a reproducible response,as for the contractility for single stress fibers or for the mechanical response of a biopolymer actin network,but that reorganize in response to external cues in a non-exactly-predictable and reproducible *** of such complexity,in this note we aim at formulating a multi-physics framework for modeling cells spreading and motility,accounting for the relocation of proteins on advecting lipid membranes.

关键词： Mechanobiology Receptor dynamics Cell motility

Virtual earth cloud: a multi-cloud framework for enabling geosciences digital ecosystems

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International Journal of Digital Earth 2023年第1期16卷 43-65页

作者： mattia Santoro Paolo Mazzetti Stefano Nativi National Research Council of Italy Institute of Atmospheric Pollution Research-Unit of FlorenceRomaItaly Joint Research Centre of the European Commission B6 UnitIspraltaly

Humankind is facing unprecedented global environmental and social challenges in terms of food,water and energy security,resilience to natural hazards,*** address these challenges,international organizations have defined a list of policy actions to be achieved in a relatively short and medium-term *** development and use of knowledge platforms is key in helping the decision-making process to take significant decisions(providing the best available knowledge)and avoid potentially negative impacts on society and the *** knowledge platforms must build on the recent and next coming digital technologies that have transformed society–including the science and engineering *** Earth Data(BED)science aims to provide the methodologies and instruments to generate knowledge from numerous,complex,and diverse data *** science requires the development of Geoscience Digital Ecosystems(GEDs),which bank on the combined use of fundamental technology units(*** data,learning-driven artificial intelligence,and network-based computing platform)to enable the development of more detailed knowledge to observe and test planet Earth as a *** manuscript contributes to the BED science research domain,by presenting the Virtual Earth Cloud:a multi-cloud framework to support GDE implementation and generate knowledge on environmental and social sustainability.

关键词： Earth observation geosciences digital ecosystem virtual cloud big earth data multi-cloud interoperability science

Sleep to Survive Predators

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Neuroscience Bulletin 2022年第9期38卷 1114-1116页

作者： mattia Aime Antoine R.Adamantidis Department of Neurology Zentrum für Experimentelle NeurologieInselspital University Hospital Bern3010BernSwitzerland Department of Biomedical Research University of Bern3010BernSwitzerland

Sleep is a reversible behavioral state characterized by a higher arousal threshold and transient disconnection from the external ***,sleeping organisms show lowered behavioral responsiveness to sensory stimuli(such as sound,touch,and smell)in the experimental environment[1]that contrastswithheightenedauditory-evokedneuronal responses recorded in the cortex in rodents and non-human primates[2,3].These reports support the hypothesis of sensory gating,as found during sleep spindles,that ultimately preserves sleep from external ***,this strongly contrasts to the high vulnerability to predation associated with sleep states in the natural environment.

关键词： evoked auditory cortex

Temporal patterns of dengue epidemics:The case of recent outbreaks in Kaohsiung

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Asian Pacific Journal of Tropical Medicine 2017年第3期10卷 275-279页

作者： mattia Sanna Ying-Hen Hsieh Department of Public Health China Medical University Taichung Taiwan 40402 Center for Infectious Disease Education and Research China Medical UniversityTaichung Taiwan 40402

Objective:To investigate whether major dengue outbreaks in the last two decades in Kaohsiung follow a precise temporal ***:Government daily lab-confirmed dengue case data from three major dengue outbreaks occurring during the last two decades in Kaohsiung in2002,2014 and 2015,is utilized to compute the corresponding weekly cumulative percentage of total case *** divide each of the three time series data into two periods to examine the corresponding weekly cumulative percentages of case numbers for each ***’s correlation coefficient was calculated to compare quantitatively the similarity between the temporal patterns of these three ***:Three cutoff points produce the most interesting comparisons and the most different ***’s correlation coefficient indicates quantitative discrepancies in the similarity between temporal patterns of the three years when using different cutoff ***:Temporal patterns in 2002 and 2014 are comparatively more similar in early *** 2015 outbreak started late in the year,but ended more like the outbreak in 2014,both with record-breaking number of *** retrospective analysis shows that the temporal dynamics of dengue outbreaks in Kaohsiung can strongly vary from one year to another,making it difficult to identify any common predictor.

关键词： Dengue Kaohsiung Temporal pattern Cumulative percentage Pearson's correlation coefficient

Towards a knowledge base to support global change policy goals

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International Journal of Digital Earth 2020年第2期13卷 188-216页

作者： Stefano Nativi mattia Santoro Gregory Giuliani Paolo Mazzetti European Commission–DG Joint Research Centre Ispra(VA)Italy National research Council of Italy–Institute on Atmospheric research pollution Sesto Fiorentino(FI)Italy University of Geneva Institute for Environmental SciencesGenevaSwitzerland UN Environment Science DivisionGRID-GenevaGenevaSwitzerland

In 2015,it was adopted the 2030 Agenda for Sustainable Development to end poverty,protect the planet and ensure that all people enjoy peace and *** year after,17 Sustainable Development Goals(SDGs)officially came into *** 2015,GEO(Group on Earth Observation)declared to support the implementation of *** GEO Global Earth Observation System of Systems(GEOSS)required a change of paradigm,moving from a data-centric approach to a more knowledge-driven *** this end,the GEO System-of-Systems(SoS)framework may refer to the well-known Data-Information-Knowledge-Wisdom(DIKW)*** the context of an Earth Observation(EO)SoS,a set of main elements are recognized as connecting links for generating knowledge from EO and non-EO data–*** and economic *** elements are:Essential Variables(EVs),Indicators and Indexes,Goals and *** generation and use requires the development of a SoS KB whose management process has evolved the GEOSS Software Ecosystem into a GEOSS Social *** includes:collect,formalize,publish,access,use,and update *** project analysed the knowledge necessary to recognize,formalize,access,and use *** analysis recognized GEOSS gaps providing recommendations on supporting global decision-making within and across different domains.

关键词： Knowledge base from data to knowledge essential variables SDGs GEOSS interoperability science big earth data

Structural study of Yb^(3+), Eu^(3+) and Pr^(3+) doped Ca_9Lu(PO_4)_7

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Journal of Rare Earths 2015年第9期33卷 977-982页

作者： Fabio Piccinelli mattia Trevisani Jasper R.Plaisier Marco Bettinelli Luminescent Materials Laboratory DB University of Verona and INSTM UdR VeronaStrada Le Grazie 15 37134 Verona Italy Synchrotron Light Laboratory (ELETTRA) Trieste S.C.p.A. Strada Statale 14 - km 1635 in AREA Science Park

The whitlockite-like crystal structure of Ca9Lu（PO4）7 when doped with several ions （Yb3＋, EU3＋ and Pr3＋） at different concentrations （1 tool.%, 5 mol.% and 10 tool.%） was studied, by means of synchrotron X-ray diffraction. In particular for Eu3＋ and Pr3＋, the presence of the dopant ion significantly changed the occupation factors （OFs） of the Ca2＋ and Lu3＋ cations and gave rise to a distortion of the metal-oxygen polyhedra. The observed structural features clearly showed significant impact of the dopant ion on the crystal structure of the host.

关键词： Rietveld refinement crystal structure X-ray diffraction synchrotron radiation rare earths

Candidate Biomarkers of Liver Fibrosis: A Concise, Pathophysiology-oriented Review

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Journal of Clinical and Translational Hepatology 2018年第3期6卷 317-325页

作者： mattia Bellan Luigi Mario Castello Mario Pirisi Department of Translational Medicine Universita del Piemonte Orientale UPONovaraItaly Division of Internal Medicine “Sant'Andrea Hospital”VercelliItaly IRCAD Interdisciplinary Research Center of Autoimmune DiseasesNovaraItaly Emergency Medicine Department “AOU Maggiore della Carita”NovaraItaly Division of Internal Medicine “AOU Maggiore della Carita”NovaraItaly

Repair of sustained liver injury results in fibrosis(*** accumulation of extracellular matrix proteins),and ultimately the complete distortion of parenchymal architecture of the liver,which we call *** and staging of fibrosis is thus a mainstay in the management of chronic liver diseases,since many clinically relevant decisions,such as starting treatment and/or monitoring for complications including hepatocellular carcinoma,may depend on *** gold standard for fibrosis staging is liver biopsy,the role of which,however,is questioned nowadays because of cost,hazards and poor acceptance by *** the other hand,imaging techniques and/or measurement of direct and indirect serum markers have not proved to be completely satisfactory under all circumstances as alternatives to liver *** progress in this field is nowmore crucial than ever,since treatments for established fibrosis appear on the *** dissection of the pathways involved in the pathophysiology of liver diseases has put forward several novel candidate biomarkers of liver fibrosis,such as growth arrest-specific6,Mac-2-binding protein,osteopontin,placental growth factor,growth/differentiation factor 15 and hepatocyte growth *** molecules have been suggested to have potential to complement or substitute methods currently used to stage liver ***,we review the pros and cons for their use in this setting.

关键词： Liver fibrosis Staging Biomarkers Gas6 HGF PlGF