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二十一世纪国家艺术博物馆

建筑创作 2016年第6期 170-183页

作者： Zaha Hadid Patrik Schumacher Anja Simons Paolo Matteuzzi Fabio Ceci Mario mattia Maurizio Meossi Paolo Zilli Luca Peralta Maria Velceva Matteo Grimal Ana M.Cajiao Barbara Pfenningstorff Dillon Lin Kenneth Bostock Raza Zahid Lars Teichmann Adriano de Gioannis Amin Taha Caroline Voet Gianluca Ruggeri Luca Segarelli

建筑设计概念以及城市策略：可能性领域的划分通过维持与原军队营房的索引关系,博物馆的设计提出了建筑与其所在城市文脉的问题。这绝不是对地貌混合拼凑的尝试,而是为了应对平衡场地周边的强势街区脉络,所提出的对弱城市肌理的延续。

关键词：艺术博物馆城市肌理建筑设计二十一世纪城市文脉 texture correlative directional looking Floor

Lymph node pick up by separate stations: Option or necessity?

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World Journal of Gastrointestinal Surgery 2015年第5期7卷 71-77页

作者： Paolo Morgagni Oriana Nanni Elisa Carretta mattia Altini Luca Saragoni Fabio Falcini Domenico Garcea department of General Surgery Morgagni-Pierantoni Hospital Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS Pathology Unit Morgagni-Pierantoni Hospital

AIM: To evaluate whether lymph node pick up by separate stations could be an indicator of patients submitted to appropriate surgical treatment. METHODS: One thousand two hundred and three consecutive gastric cancer patients submitted to radical resection in 7 general hospitals and for whom no information was available on the extension of lymphatic dissection were included in this retrospective study. RESULTS: Patients were divided into 2 groups: group A, where the stomach specimen was directly formalinfixed and sent to the pathologist, and group B, where lymph nodes were picked up after surgery and fixed for separate stations. Sixty-two point three percent of group A patients showed des compared to 19.4% of group B(P dependently of T or N stage. In multivariate analysis, group A also showed a higher risk of death than group B(HR = 1.24; 95%CI: 1.05-1.46).CONCLUSION: Separate lymphatic station dissection increases the number of retrieved nodes, leads to better tumor staging, and permits verification of the surgical dissection. The number of dissected stations could potentially be used as an index to evaluate the quality of treatment received.

关键词： Gastric cancer Lymph node Separatestation pick up Lymphadenectomy

Duodenal Duplication of Unusual Discovery:Case Report Chambery Hospital French

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Surgical Science 2018年第7期9卷 222-226页

作者： Konate Madiassa Traore Amadou dembele Bakary Tientigui Karembe Boubacar Amadou Issa Mangane Moustaphissa Diop Thierno Madani Togo Adegnepierre Kante Lassana Traore Alhassane Bah Amadou Sidibe Boubacaryoro Diamoutene Kolo Samake Moussa Mounimezie Diarra Diakite Ibrahim Coulibaly Yacaria Keita Soumaila Legros Jean Remy mattia Stella demane Sofia Al Naasan Irchid Diallo Gangaly Faculty of Medicine and Odonto-Stomatology BamakoMali

We report the case of a 33-year-old man having presented the episodes of abdominal pains since a few months in 2014. He was handled by the anal-gesic and the anti spasmodic by his regular doctor. Symptoms in started up again with renewed vigor in February, 2015. The physical examination was normal. The complementary examinations must be known by the ultrasound the scanner and the magnetic resonance imaging which were in favour of a mass under person suffering from a liver complaint the normal blood balance assessment. The patient was exclusively operated by the way of coelioscopy and the anatomopathology examination of the operating room ended has a duplication duodenal. The operating consequences were simple until one year.

关键词： Duplication Duodenal Hospital Chambéry French

Health Staff Ready to Work without Borders

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Journal of Health Science 2018年第5期6卷 343-350页

作者： Franco Locatelli Sabina Tangerini mattia Viano Chiara Schiavo Lisa Di Mascolo Alessia Montanari Laura Palmucci Marilena Bertini Comitato Collaborazione Medica International NGO Turin 10152 Italy

Effect of genetic factors on the association between coronary artery disease and PTPN22 polymorphism

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World Journal of Cardiology 2014年第6期6卷 376-380页

作者： Fulvia Gloria-Bottini Patrizia Saccucci Maria Banci Paolo Nardi mattia Scognamiglio Antonio Pellegrino Egidio Bottini Luigi Chiariello department of Biomedicine and Prevention School of MedicineUniversity of Rome Tor Vergata00133 RomeItaly department of Cardiology Valmontone Hospital department of Cardiac Surgery University of Rome Tor VergataSchool of Medicine

PTPN22 has been previously found associated with coronary artery disease(CAD). In the present note we have studied the effect of p53 codon 72,acid phosphatse locus 1(ACP1) and adenosine deaminase(ADA) genetic polymorphism on the strength of association between PTPN22 and CAD. We have studied 133 non diabetic subjects with CAD,122 non diabetic cardiovascular patients without CAD and 269 healthy blood donors. Informed written consent was obtained from all subjects and the study was approved by the Ethical Committee. A high significant association between PTPN22 and CAD is observed in carriers of *A allele of ACP1 with a higher proportion of *T allele carriers in non diabetic subjects with CAD as compared to controls and to non diabetic subjects with cardiovascular diseasewithout CAD. A similar pattern is observed in carriers of *Pro allele of p53 codon 72 with a higher proportion of *T allele carriers in non diabetic subjects with CAD as compared to other groups. A highly significant association between PTPN22 and CAD is observed in carriers of ADA2 *2 allele with higher proportion of *T allele carriers in non diabetic subjects with CAD as compared to other group. There is a high significant correlation between the number of factors that contributes to increase the strength of association between PTPN22 *T and CAD and the proportion of *T carriers in CAD. ACP1,p53 codon 72 and ADA are involved in immune reaction and give an important additive contribution to the strength of association between PTPN22 and CAD. This study stresses the importance of the simultaneous analysis of multiple genes functionally related to a specific disease: the approach may give important hints to understand multifactorial disorders.

关键词：冠的动脉疾病 PTPN22 酸 phosphatse 地点 1 腺苷脱氨基酶 2 p53 codon 72

免疫疗法联合立体定向放疗治疗非小细胞肺癌脑转移:一项AIRO多中心回顾性研究

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中国肺癌杂志 2022年第4期25卷 I0007-I0022页

作者： Silvia SCOCCIANTI Emanuela OLMETTO Valentina PINZI mattia Falchetto OSTI Rossella Di FRANCO Saverio CAINI Paola ANSELMO Paolo MATTEUCCI Davide FRANCESCHINI Cristina MANTOVANI Giancarlo BELTRAMO Francesco PASQUALETTI Alessio BRUNI Paolo TINI Emilia GIUDICE Patrizia CIAMMELLA Anna MERLOTTI Sara PEDRETTI Marianna TRIGNANI Marco KRENGLI NiccolòGIAJ-LEVRA Isacco deSIdeRI Guido PECCHIOLI Paolo MUTO Ernesto MARANZANO Laura FARISELLI Pierina NAVARRIA Umberto RICARDI Vieri SCOTTI Lorenzo LIVI 王绿化(翻译/校对) Radiation Oncology Unit Ospedale Santa Maria AnnunziataDepartment of OncologyBagno a RipoliFlorenceItaly Radiation Oncology Unit Azienda Ospedaliero Universitaria CareggiDepartment of Experimental and Clinical Biomedical Sciences"Mario Serio"FlorenceItaly U.O Radioterapia Fondazione IRCCS Istituto Neurologico Carlo BestaDepartment of NeurosurgeryMilanItaly U.O.C Radioterapia A.O.U Sant'Andrea Facolta Medicina e Psicologia Universita SapienzaDepartment of MedicineSurgery and Translational MedicineRomeItaly Istituto Nazionale Tumori IRCCS Fondazione G.PascaleDepartment of RadiotherapyNaplesItaly Institute for Cancer Research Prevention and Clinical Network(ISPRO)Cancer Risk Factors and Life-Style Epidemiology UnitFlorenceItaly Radiotherapy Oncology Center S.Maria HospitalDepartment of OncologyTerniItaly Humanitas Research Hospital Radiotherapy and Radiosurgery DepartmentRozzanoItaly Radiotherapy Unit Department of OncologyTurinItaly Cyberknife Centro Diagnostico Italiano Department of RadiologyMilanItaly Radiation Oncology Azienda Ospedaliero Universitaria PisanaDepartment of Translational MedicinePisaItaly Radiotherapy Unit University Hospital of ModenaDepartment of Oncology and HematologyModenaItaly Radiotherapy Unit University of SienaDepartment of Radiotherapy and OncologySienaItaly UOC di Radioterapia Policlinico Universitario Tor VergataDepartment of Onco-HaematologyRomeItaly Radioterapia Oncologica"G.Prodi "AO-IRCCS Arcispedale S.Maria NuovaDepartment of Oncology and Advanced TechnologyReggio EmiliaItaly Radiation Oncology A.S.O.S.Croce e Carle Department of Radiation OncologyCuneoItaly U.O.Radioterapia Oncologica Department of Radiation OncologyASST Spedali Civili di Brescia e Universita degli studi di BresciaBresciaItaly U.O.C.Radioterapia Oncologica Ospedale Clinicizzato SS Annunziata-Universita Chieti G.D'AnnunzioDepartment of Radiation OncologyChietiItaly Radiation Oncology University Hospital Maggiore della CaritdDepartment of Translational Medicine

背景与目的通过意大利放射治疗和临床肿瘤学学会(Italian Association of Radiotherapy and Clinical Oncology, AIRO)的一项多中心回顾性研究,明确免疫疗法(immunotherapy, IT)和立体定向放疗(stereotactic radiotherapy,SRT)包括放射外科治疗(radiosurgery, RS)或大分割立体定向放疗(hypofractionated stereotactic radiotherapy, HFSRT)治疗非小细胞肺癌(non-small cell lung cancer, NSCLC)脑转移的疗效和毒性。方法对来自19个意大利中心接受SRT+IT的NSCLC伴脑转移患者进行分析,并与单独接受SRT的对照组患者进行比较。结果共纳入SRT+IT组100例和单独SRT组50例。接受SRT+IT的患者有更长的颅内局部无进展生存期(intracranial local progression-free survival, i LPFS)(经倾向性评分调整后,P=0.007)。在诊断为脑转移时接受IT合并有颅外进展的患者中(n=24),接受SRT后再进行IT与较好的总生存期(overall survival, OS)相关(P=0.037)。多因素分析显示组织学类型为非腺癌、卡氏体能状态(Karnofsky performance status,KPS)评分=70分以及接受HFSRT与显著减少的生存期相关(P值分别为0.019、0.017和0.007)。与SRT和IT治疗间隔>7天(n=10)相比,治疗间隔≤7天(n=90)与更长的OS相关(经倾向性评分调整后,P=0.008)。联合治疗耐受性良好。在放射性坏死方面,接受SRT+IT的患者与单独SRT的患者无显著差异。SRT和IT的治疗间隔对毒性发生率无影响。结论 SRT+IT是一种安全的联合治疗方法,与单独SRT相比,具有更长的i LPFS。

关键词：立体定向放疗回顾性研究脑转移倾向性评分临床肿瘤学免疫疗法放射治疗