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A scalable decentralized system for fair token distribution and seamless users onboarding

Blockchain(Research and Applications) 2022年第1期3卷 40-48页

作者： Francesco Bruschi Manuel Tumiati Vincenzo Rana mattia bianchi Donatella Sciuto Politecnico di Milano Milano20133Italy KNOBS srl Milan20121Italy

Tokens are digital,transferable,and programmable assets and one of the most promising tools offered by *** could enable a wide range of applications,from down to earth to *** of the main issues in achieving wide adoption of tokens is onboarding:main platforms require users to deal with specific tools such as wallets,transaction fees,key generation,and *** most common solution to offer a familiar experience to naive users are custodial intermediaries,which have the important drawback of centralizing the process,and keeping users away from the advantages of selfsovereign assets *** this paper,we present a process for the distribution of digital tokens to end users,exploiting“physical”objects for initial *** process is aimed at making the onboarding of users not yet accustomed to blockchain tools and concepts as easy as possible,in a secure and decentralized way.

关键词： Blockchain Tokens Onboarding Wallets

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Viability of thermal imaging in detecting nests of the invasive hornet Vespa velutina

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Insect Science 2021年第1期28卷 271-277页

作者： Simone Lioy Ettore bianchi Alessandro Biglia mattia Bessone Daniela Laurino Marco Porporato Department of Agriculture Forest and Food SciencesUniversity of TurinGrugliasco(Turin)Italy School of Biological and Environmental Science Liverpool John Moores UniversityLiverpoolUK

Vespa velutina is an invasive hornet species that is colonising Europe,generating considerable impacts on honeybees,beekeeping and *** and early warning strategies for this species are mainly based on monitoring plans and procedures of nest detection and *** tools(harmonic radar,radio-telemetry)have been developed to increase the probabilities of nest detection in new *** hornets are able to regulate nest temperature,thermography may represent an additional technique that may be used,both alone or in support to other *** this study,the viability of thermal imaging in detecting nests of *** was evaluated in controlled *** influence of different environmental and operative variables(time of the day,presence/absence of leaves covering the nest,distance between the nest and the operator)were tested on three nests detected during August 2018 in *** the nests were detectable by thermal imaging,but environmental and operative variables affect their *** temperature difference between the nests and the surrounding reaches its maximum before sunrise and without a tree canopy covering the *** nests were visible in some cases from 30 m,the detectability was higher at shorter distances,even if this variable may also depend on infrared camera *** increase in the environmental temperature also generates a decrease of nest *** some limitations could occur,these results show the applicability of thermography in detecting V velutina nests before the beginning of the reproductive phase,and consequently its potentiality in control strategies.

关键词： alien species Asian yellow-legged hornet monitoring nest detection remote sensing thermography

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The challenge of molecular selection in liver-limited metastatic colorectal cancer for surgical resection: a systematic review and meta-analysis in the context of current and future approaches

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Oncology Research 2024年第9期32卷 1407-1422页

作者： ROSSANA RONCATO JERRY POLESEL FEDERICA TOSI ELENA PERUZZI ERIKA BRUGUGNOLI CLAUDIA LAURIA PANTANO MARIA FURFARO FILIPPO DI GIROLAMO ALESSANDRO NANI ARIANNA PANI NOEMI MILAN ELENA DE mattia ANDREA SARTORE-bianchi ERIKA CECCHIN Experimental and Clinical Pharmacology Unit Centro di Riferimento Oncologico di Aviano(CRO)IRCCSAviano33081Italy Department of Medicine(DMED) University of UdineUdine33100Italy Unit of Cancer Epidemiology Centro di Riferimento Oncologico di Aviano(CRO)IRCCSAviano33081Italy Department of Oncology and Hemato-Oncology Universitàdegli Studi di MilanoMilan20122Italy Department of Hematology Oncologyand Molecular MedicineGrande Ospedale Metropolitano NiguardaMilan20122Italy Oncology Pharmacy Unit IRCCS Istituto Romagnolo per lo Studio dei Tumori Dino AmadoriMeldola47014Italy Pharmacy Unit Fondazione IRCCS Istituto Tumori di MilanoMilan20122Italy Department of Pharmacy Ca’Foncello Treviso Regional HospitalPiazzale Ospedale 1Treviso31100Italy Department of Medical Surgical and Health Sciences University of TriesteTrieste34127Italy Hospital Pharmacy Cattinara HospitalAzienda Sanitaria Universitaria Giuliano IsontinaTrieste34148Italy Department of Oncology and Onco-Hematology Postgraduate School of Clinical Pharmacology and ToxicologyUniversity of MilanMilan20122Italy

Objectives:Treatment of metastatic colorectal cancer(mCRC)includes resection of liver metastases(LM),however,no validated biomarker identifies patients most likely to benefit from this *** meta-analysis aimed to assess the impact of the most relevant molecular alterations in cancer-related genes of CRC(i.e.,RAS,BRAF,SMAD4,PIK3CA)as prognostic markers of survival and disease recurrence in patients with mCRC surgically treated by LM ***:A systematic literature review was performed to identify studies reporting data regarding survival and/or recurrence in patients that underwent complete liver resection for CRC LM,stratified according to RAS,BRAF,PIK3CA,and SMAD4 mutational *** ratios(HRs)from multivariate analyses were pooled in the meta-analysis and various adjustment strategies for confounding factors were *** search was conducted in numerous databases,including MEDLINE(PubMed),Embase,Cumulative Index to Nursing and Allied Health Literature(CINAHL)(EBSCO host),and WHO Global Index Medicus,through March 18th,***-analyses,editorials,letters to the editor,case reports,studies on other primary cancers,studies with primary metastatic sites other than the liver,studies lacking specific oncological outcome variables or genetic data,non-English language studies,and studies omitting residual disease data from liver metastasectomy were *** remaining 47 studies were summarized in a descriptive table which outlines the key characteristics of each study and final results were graphically ***:RAS mutation status was negatively associated with overall survival(OS)(HR,1.68;95%CI,1.54–1.84)and recurrence free survival(RFS)(HR,1.46;95%CI,1.33–1.61).A negative association was also found for BRAF regarding OS(HR,2.64;95%CI,2.15–3.24)and RFS(HR,1.89;95%CI,1.32–2.73)and SMAD4 regarding OS(HR,1.93;95%CI,1.56–2.38)and RFS(HR,1.95;95%CI,1.31–2.91).For PIK3CA only three studies were eligible and no significant associati

关键词： Metastasectomy Liver metastases RAS BRAF SMAD4 PIK3CA Colorectal

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