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Envita’s Precision Cancer Care: 35-Fold Improvement in Response Rates

Journal of Cancer Therapy 2024年第4期15卷 99-120页

作者： Sheba Goklany John C. Oertle III Ronald matthias Jr. Daniel Warren David Medina Rory Sears Robert Zieve Kendra Quart Christopher Aussems Jon Moma Shannon Miller Zach Poteet Conner Coffin Courtney Middleton Erika Ware Phylicia Zarnosky Julie Nowak Winlove Suasin Daniel Conway Chad Burk Ruth Tan-Lim Dino Prato Envita Medical Centers Scottsdale AZ USA

New clinical approaches are imperative beyond the widely adopted National Comprehensive Cancer Network (NCCN) guidelines, utilized by prominent cancer institutions. Cancer is the leading cause of death among individuals younger than 85 years within the United States. Despite significant technological advances, including the expenditure of hundreds of billions, treatment outcomes and overall survival have not notably improved for most types of advanced cancer over the last several decades. Over the past 24 years, Envita Medical Centers has pioneered a unique form of personalized treatment approach for late-stage and refractory cancer patients, introducing groundbreaking innovations in the field. Our integrated algorithm utilizes advanced genomics, transcriptomics, and highly tailored immunotherapy, resulting in remarkable outcome improvements. This study presents Envita’s innovative personalized treatment algorithms and examines the response outcomes of 199 late-stage cancer patients treated at Envita Medical Centers over a two-year period. Compared to standard of care and palliative chemotherapy, Envita’s treatment demonstrated a remarkable 35-fold improvement in overall response rates (Figure 1). Moreover, 88% of the patients, the majority presenting with Stage 3 or 4 cancer, experienced a 43-fold improvement in quality of life with minimal side effects, as compared to standard of care chemotherapy and palliative care. This revolutionary success is attributed to Envita’s personalized therapeutic algorithms, which incorporate customized immunotherapy. Envita’s precision care approach has also achieved a 100% better response rate compared to over 65 global chemotherapy clinical trials with more than 2700 patients. The results from this study suggest that a wider utilization of Envita’s personalized approach can significantly benefit patients with late-stage and refractory cancer.

关键词： Envita Medical Centers Late-stage Cancer Overall Response Rate Quality of Life Circulating Tumor Cells (CTCs) Mutant Allele Frequency (MAF) Precision Care

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Stochastic Runge-Kutta–Munthe-Kaas Methods in the Modelling of Perturbed Rigid Bodies

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Advances in Applied Mathematics and Mechanics 2022年第2期14卷 528-538页

作者： Michelle Muniz matthias Ehrhardt Michael Günther Renate Winkler Institute of Mathematical Modelling Analysis and Computational Mathematics(IMACM)Applied Mathematics and Numerical AnalysisBergische Universität WuppertalGaußstraße 2042119 WuppertalGermany

In this paper we present how nonlinear stochastic Itˆo differential equations arising in the modelling of perturbed rigid bodies can be solved numerically in such a way that the solution evolves on the correct *** this end,we formulate an approach based on Runge-Kutta–Munthe-Kaas(RKMK)schemes for ordinary differ-ential equations on ***,we provide a proof of the mean-square convergence of this stochastic version of the RKMK schemes applied to the rigid body problem and illustrate the effectiveness of our proposed schemes by demonstrating the structure preservation of the stochastic RKMK schemes in contrast to the stochastic Runge-Kutta methods.

关键词： Stochastic Runge-Kutta method Runge-Kutta–Munthe-Kaas scheme nonlinear Itˆo SDEs rigid body problem

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Simulating Temporally and Spatially Correlated Wind Speed Time Series by Spectral Representation Method

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Complex System Modeling and Simulation 2023年第2期3卷 157-168页

作者： Qing Xiao Lianghong Wu Xiaowen Wu matthias Rätsch School of Information and Electrical Engineering Hunan University of Science and TechnologyXiangtan 411201China Image Understanding and Interactive Robotics Group Reutlingen UniversityReutlingen D-72762Germany.

In this paper,it aims to model wind speed time series at multiple *** five-parameter Johnson mdistribution is deployed to relate the wind speed at each site to a Gaussian time series,and the resultant-Z(t)dimensional Gaussian stochastic vector process is employed to model the temporal-spatial correlation of mwind speeds at different *** general,it is computationally tedious to obtain the autocorrelation functions Z(t)(ACFs)and cross-correlation functions(CCFs)of Z(t),which are different to those of wind speed times *** order to circumvent this correlation distortion problem,the rank ACF and rank CCF are introduced to Z(t)characterize the temporal-spatial correlation of wind speeds,whereby the ACFs and CCFs of can be analytically ***,Fourier transformation is implemented to establish the cross-spectral density matrix Z(t)mof,and an analytical approach is proposed to generate samples of wind speeds at different ***,simulation experiments are performed to check the proposed methods,and the results verify that the five-parameter Johnson distribution can accurately match distribution functions of wind speeds,and the spectral representation method can well reproduce the temporal-spatial correlation of wind speeds.

关键词： multivariate wind speed time series rank autocorrelation function rank cross-correlation function cross-spectral density matrix five-parameter Johnson distribution

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What are the contributions of maternal and paternal traits to fecundity and offspring development?A case study in an amphibian species,the spined toad Bufo spinosus

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Current Zoology 2023年第5期69卷 527-534页

作者： matthias Renoirt Frédéric Angelier Marion Cheron François Brischoux Centre d’Etudes Biologiques de Chizé CEBC UMR 7372 CNRS-La Rochelle Université79360 Villiers en BoisFrance

Assessing the determinants of reproductive success is critical but often complicated because of complex interactions between parental traits and environmental conditions occurring during several stages of a reproductive ***,we used a simplified ecological situation-an amphibian species lacking post-oviposition parental care-and a laboratory approach to investigate the relationships between parental(both maternal and paternal)phenotypes(body size and condition)and reproductive success(fecundity,egg size,embryonic and larval duration,larval and metamorphic morphology).We found significant effects of maternal phenotype on fecundity,hatching success,and tadpole size,as well as on the duration of larval ***,and more surprisingly,we also found a potential contribution of the paternal phenotype occurring during early(embryonic development duration)offspring *** our study focused on life-history traits such as body size and development duration,additional mechanisms involving physiological costs of development may well mediate the relationships between parental phenotypes and offspring *** studies are required to decipher the mechanisms underlying our findings in order to clarify the mechanistic basis of the links between parental phenotypes and offspring development.

关键词： clutch quality embryonic development larval development phenotype reproductive success

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Acupuncture for the management of dry eye disease

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Frontiers of Medicine 2022年第6期16卷 975-983页

作者： Julia Prinz Nicola Maffulli matthias Fuest Peter Walter Frank Hildebrand Filippo Migliorini Department of Ophthalmology RWTH Aachen UniversityPauwelsstr.3052074AachenGermany Department of Medicine Surgery and DentistryUniversity of SalernoVia S.Allende84081BaronissiSAItaly Queen Mary University of London Barts and the London School of Medicine and DentistryMile End Hospital275 Bancroft RoadLondonEI 4DGEngland School of Pharmacy and Bioengineering Keele University Faculty of MedicineThornburrow DriveStoke on TrentEngland Department of Orthopedics University Clinic AachenRWTH Aachen University Clinic52064AachenGermany

The effectiveness of using acupuncture for dry eye disease(DED)is ***,this systematic review investigated the effectiveness and feasibility of using acupuncture for DED in accordance with the 2020 PRISMA *** outcomes of interests were(1)to evaluate the efficacy of acupuncture in improving the ocular surface disease index(OSDI),Schirmer I test score,and tear breakup time from baseline to the last follow-up;(2)to determine possible complications of using acupuncture;and(3)to investigate the superiority of acupuncture over other commonly used treatments for *** from 394 patients were *** showed that acupuncture significantly prolonged the tear breakup time(P<0.0001),significantly increased the Schirmer I test score(P<0.0001),and significantly reduced the OSDI(P<0.0001)from baseline to the last *** with the control group,the acupuncture group had significantly greater Schirmer I test score(P<0.0001),significantly longer tear breakup time(P=0.0004),and significantly lower OSDI(P=0.002).These results suggest that acupuncture is effective and feasible in improving symptoms and signs of *** severe adverse effects of acupuncture were observed.

关键词： dry eye disease xerophthalmus acupuncture

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中国卵巢组织冻存与移植后自然妊娠第2例报道

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中国医刊 2024年第5期59卷 567-570页

作者：阮祥燕杜娟金凤羽谷牧青程姣姣李扬璐代荫梅 matthias Korell Markus Montag JanaLiebenthron Alfred O Mueck 首都医科大学附属北京妇产医院/北京妇幼保健院内分泌科北京100026 德国诺伊斯约翰娜艾蒂安医院妇产科诺伊斯41462德国德国Ilabcomm GmbH 圣奥古斯丁53757德国德国杜塞尔多夫大学妇产医院生育力保护中心杜塞尔多夫40225德国德国图宾根大学妇产医院内分泌与绝经中心图宾根72076德国

我国首个卵巢组织冻存库由首都医科大学附属北京妇产医院阮祥燕教授团队创建,该团队先后于2016年完成中国首例卵巢组织冻存与移植,2020年完成中国首例卵巢组织冻存与移植后妊娠,2021年报道中国首例卵巢组织冻存与移植后活产,至2024年已... 详细信息

我国首个卵巢组织冻存库由首都医科大学附属北京妇产医院阮祥燕教授团队创建,该团队先后于2016年完成中国首例卵巢组织冻存与移植,2020年完成中国首例卵巢组织冻存与移植后妊娠,2021年报道中国首例卵巢组织冻存与移植后活产,至2024年已成功开展26例卵巢组织冻存与移植,移植患者全部恢复了卵巢功能并长期维持。本文报道再生障碍性贫血获得临床妊娠的患者,为中国第2例卵巢组织冻存与移植后妊娠病例。患者于外院经骨髓穿刺诊断为再生障碍性贫血(重型),2017年因药物、输血治疗效果欠佳,拟行异基因造血干细胞移植,因未婚未育,强烈要求生育力与卵巢功能保护,首都医科大学附属北京妇产医院对其进行综合评估后决定实施卵巢组织冻存,在全身麻醉下行腹腔镜下右侧卵巢切除术,手术顺利,取下的卵巢组织转运至首都医科大学附属北京妇产医院卵巢组织冻存库保存。造血干细胞移植后,患者于2018年行卵巢组织复苏与移植手术,手术顺利,无并发症发生。患者卵巢组织冻存与移植5年后结婚,卵巢功能维持良好,并于备孕4个月后自然妊娠,末次月经时间为2023年12月18日。

关键词：卵巢组织冻存卵巢组织移植再生障碍性贫血妊娠

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Can propensity score matching replace randomized controlled trials?

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World Journal of Methodology 2024年第1期14卷 58-70页

作者： matthias Yi Quan Liau En Qi Toh Shamir Muhamed Surya Varma Selvakumar Vishalkumar Girishchandra Shelat Lee Kong Chian School of Medicine Nanyang Technological UniversitySingapore 308232Singapore Department of General Surgery Tan Tock Seng HospitalSingapore 308433Singapore Surgical Science Training Centre Tan Tock Seng HospitalSingapore 308433Singapore

Randomized controlled trials(RCTs)have long been recognized as the gold standard for establishing causal relationships in clinical *** that,various limitations of RCTs prevent its widespread implementation,ranging from the ethicality of withholding potentially-lifesaving treatment from a group to relatively poor external validity due to stringent inclusion criteria,amongst ***,with the introduction of propensity score matching(PSM)as a retrospective statistical tool,new frontiers in establishing causation in clinical research were opened *** predicts treatment effects using observational data from existing sources such as registries or electronic health records,to create a matched sample of participants who received or did not receive the intervention based on their propensity scores,which takes into account characteristics such as age,gender and *** its retrospective nature and its use of observational data from existing sources,PSM circumvents the aforementioned ethical issues faced by *** of RCTs exclude elderly,pregnant women and young children;thus,evidence of therapy efficacy is rarely proven by robust clinical research for this *** the other hand,by matching study patient characteristics to that of the population of interest,including the elderly,pregnant women and young children,PSM allows for generalization of results to the wider population and hence greatly increases the external *** of replacing RCTs with PSM,the synergistic integration of PSM into RCTs stands to provide better research outcomes with both methods complementing each *** example,in an RCT investigating the impact of mannitol on outcomes among participants of the Intensive Blood Pressure Reduction in Acute Cerebral Hemorrhage Trial,the baseline characteristics of comorbidities and current medications between treatment and control arms were significantly different despite the randomization ***,PS

关键词： Propensity score matching Randomized controlled trials Randomization Clinical practice Validity Ethics

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Research trends of microplastics in the soil environment: Comprehensive screening of effects

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Soil Ecology Letters 2022年第2期4卷 109-118页

作者： Shin Woong Kim matthias C.Rillig Institute of Biology Freie Universität Berlin14195 BerlinGermany Berlin-Brandenburg Institute of Advanced Biodiversity Research 14195 BerlinGermany Konkuk University 120 Neungdong-roGwangjin-guSeoul 05029Korea

We collated and synthesized previous studies that reported the impacts of microplastics on soil *** data were classified and integrated to screen for the proportion of significant effects,then we suggest several directions to alleviate the current data limitation in future *** compiled 106 datasets capturing significant effects,which were analyzed in *** found that polyethylene and pellets(or powders)were the most frequently used microplastic composition and shape for soil *** significant effects mainly occurred in broad size ranges(0.1–1 mm)at test concentrations of 0.1%–10%based on soil dry *** chloride and film induced significant effects at lower concentrations compared to other compositions and shapes,*** adopted a species sensitivity distribution(SSD)and soil property effect distribution(SPED)method using available data from soil biota,and for soil properties and enzymes deemed relevant for microplastic *** predicted-no-effect-concentration(PNEC)-like values needed to protect 95%of soil biota and soil properties was estimated to be between 520 and 655 mg kg^(-1).This study was the first to screen microplastic levels with a view toward protecting the soil *** results should be regularly updated(e.g.,quarterly)with additional data as they become available.

关键词： Significant effect Species sensitivity distribution Soil Soil properties

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Trends in in ovo sexing technologies:insights and interpretation from papers and patents

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Journal of Animal Science and Biotechnology 2023年第6期14卷 2239-2262页

作者： matthias Corion Simao Santos Bart De Ketelaere Dragana Spasic Maarten Hertog Jeroen Lammertyn KU Leuven BIOSYST-MeBioS Biosensors GroupWillem de Croylaan 42Leuven B‑3001Belgium. KU Leuven BIOSYST-MeBioS Biostatistics GroupKasteelpark Arenberg 30Leuven B‑3001Belgium. KU Leuven BIOSYST-MeBioS Postharvest GroupWillem de Croylaan 42Leuven B‑3001Belgium.

Numerous researchers and institutions have been developing in ovo sexing technologies to improve animal welfare by identifying male embryos in an early embryonic stage and disposing of them before pain *** review gives a complete overview of the technological approaches reported in papers and patents by performing a thorough search using Web of Science and Patstat/Espacenet databases for papers and patents,*** on a total of 49 papers and 115 patent families reported until May 2023 worldwide,11 technology categories were defined:6 non-optical and 5 optical *** category was described for its characteristics while assessing its potential for ***,the dynamics of the publications of in ovo sexing techniques in both paper and patent fields were described through growth curves,and the interest or actual status was visualized using the number of paper citations and the actual legal status of the *** comparing the reported technologies in papers to those in patents,scientific gaps were observed,as some of the patented technologies were not reported in the scientific literature,e.g.,ion mobility and mass spectrometry ***,more diverse approaches in all categories were found in patents,although they do require more scientific evidence through papers or industrial adoption to prove their ***,although there is a recent trend for non-invasive techniques,invasive methods like analyzing DNA through PCR or hormones through immunosensing are still being reported(and might continue to be)in papers and *** was also observed that none of the technologies complies with all the industry requirements,although 5 companies already entered the *** the one hand,more research and harmony between consumers,industry,and governments is *** the other hand,close monitoring of the market performance of the currently available techniques will offer valuable insights into the potential an

关键词： Animal welfare In ovo sexing Male day-old chick culling Optical and non-optical techniques Patents and papers

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Having a Partner and Having Children:Comparisons of Adults with Congenital Heart Disease and the General Population:A 15-Year Case-Control Study

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Congenital Heart Disease 2023年第3期18卷 337-348页

作者： Siegfried Geyer Claudia Dellas Thomas Paul matthias Müller Kambiz Norozi Medical Sociology Unit Hannover Medical SchoolHannover30625Germany Department of Pediatric Cardiology Intensive Care Medicine and NeonatologyUniversity Medical Center GoettingenGoettingenGermany Department of Pediatrics Western UniversityLondonOntarioCanada Department of Pediatric Cardiology and Intensive Care Medicine Hannover Medical SchoolHannoverGermany

Objectives:To examine whether patients with congenital heart disease(CHD)are less likely to have a partner or children than individuals from the general ***:Longitudinal study with two assessments of the same patients(n=244)from a hospital population and controls(n=238)from the German Socio-Economic Panel(GSOEP)using parental education,patients age,and sex as matching *** first patient study was conducted between 5/2003 and 6/2004,the second one between 5/2017 and 4/*** were drawn from GSOEP-surveys 2004 and ***-severity was classified according to type of surgery:curative,reparative,or *** single was used as outcome measure,for offspring the outcome was having children or ***:Among women with CHD the rate of those living single was higher than among controls with the differences depending on disease complexity(curative:OR=5.5;reparative:OR=1.9;palliative:OR=2.7).No statistically significant differences between patients and controls emerged in the male study *** respect to children a marked difference emerged between women with CHD and *** patients the odds of having children were lower than among controls(curative:OR=0.3;reparative:OR=0.3;palliative:OR=0.2).The rate of patients with children with CHD(women:5.6%;men:4.9%)was higher than expected(1%)if compared with the general ***:Using partnership and children as outcome criteria,patients with CHD are disadvantaged if compared to subjects from the general *** female patients the social consequences of the disease turned out as more pervasive than in women.

关键词： Congenital heart disease children partnership panel study case-control study

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