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Effect of the micro-environment on α-synuclein conversion and implication in seeded conversion assays

Translational Neurodegeneration 2020年第1期9卷 39-54页

作者： Niccolo Candelise matthias Schmitz Katrin thüne Maria Cramm Alberto Rabano Saima Zafar Erik Stoops Hugo Vanderstichele Anna Villar-Pique Franc Llorens Inga Zerr Department of Neurology University Medicine Goettingen and the German Center for Neurodegenerative Diseases(DZNE)Robert-Koch-Stra?e 4037075 G?ttingenGermany Biomedical Engineering and Sciences Department School of Mechanical and Manufacturing Engineering(SMME)National University of Sciences and Technology(NUST)IslamabadPakistan Department of Experimental Diagnostic and Speciality MedicineUniversity of BolognaBolognaItaly Departamento de Neuropatología y Banco de Tejidos(BT-CIEN) Fundación CIENInstituto de Salud Carlos III Centro Alzheimer Fundación Reina SofíacValderrebollo n°528031 MadridSpain ADx NeuroSciences Technologiepark 4GhentBelgium CIBERNED(Network center for biomedical research of neurodegenerative diseases) Institute Carlos IIIMadridSpain Bellvitge Biomedical Research Institute(IDIBELL) Hospitalet de LlobregatBarcelonaSpain

Background: α-Synuclein is a small soluble protein,whose physiological function in the healthy brain is poorly *** inclusions of α-synuclein,referred to as Lewy bodies(LBs),are pathological hallmarks ofαsynucleinopathies,such as Parkinson’s disease(PD)or dementia with Lewy bodies(DLB).Main body:Understanding of the molecular basis as well as the factors or conditions promoting α-synuclein misfolding and aggregation is an important step towards the comprehension of pathological mechanism ofαsynucleinopathies and for the development of efficient therapeutic *** on the conversion and aggregation mechanism of α-synuclein,novel diagnostic tests,such as protein misfolding seeded conversion assays,*** real-time quaking-induced conversion(RT-QuIC),had been *** diagnostics, α-synuclein RT-QuIC exhibits a specificity between 82 and 100%while the sensitivity varies between 70 and 100%among different *** addition,the α-synuclein RT-QuIC can be used to study the α-synuclein-seeding-characteristics of different α-synucleinopathies and to differentiate between DLB and ***:the variable diagnostic accuracy of current α-synuclein RT-QuIC occurs due to different protocols,cohorts and material etc..An impact of micro-environmental factors on the α-synuclein aggregation and conversion process and the occurrence and detection of differential misfolded α-synuclein types or strains might underpin the clinical heterogeneity of α-synucleinopathies.

关键词： RT-QuIC α-Synucleinopathies Protein misfolding Protein strains

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Assessing risks and uncertainties in forest dynamics under different management scenarios and climate change

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Forest Ecosystems 2015年第3期2卷 169-189页

作者： matthias Albert Jan Hansen Jürgen Nagel matthias Schmidt Hermann Spellmann Northwest German Forest Research Station

Background: Forest management faces a climate induced shift in growth potential and increasing current and emerging new risks. Vulnerability analysis provides decision support based on projections of natural resources taking risks and uncertainties into account. In this paper we(1) characterize differences in forest dynamics under three management scenarios,(2) analyse the effects of the three scenarios on two risk factors, windthrow and drought stress, and(3) quantify the effects and the amount of uncertainty arising from climate projections on height increment and drought ***: In four regions in northern Germany, we apply three contrasting management scenarios and project forest development under climate change until 2070. three climate runs(minimum, median, maximum) based on the emission scenario RCP 8.5 control the site-sensitive forest growth functions. the minimum and maximum climate run define the range of prospective climate ***: the projections of different management regimes until 2070 show the diverging medium-term effects of thinnings and harvests and long-term effects of species conversion on a regional scale. Examples of windthrow vulnerability and drought stress reveal how adaptation measures depend on the applied management path and the decision-maker’s risk attitude. Uncertainty analysis shows the increasing variability of drought risk projections with time. the effect of climate projections on height growth are quantified and uncertainty analysis reveals that height growth of young trees is dominated by the age-trend whereas the climate signal in height increment of older trees is ***: Drought risk is a serious issue in the eastern regions independent of the applied silvicultural scenario,but adaptation measures are limited as the proportion of the most drought tolerant species Scots pine is already high. Windthrow risk is no serious overall threat in any region, but adequate counter-measures such as spec

关键词： Climate change Silvicultural management strategies

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Analysis of drop deformation dynamics in turbulent flow

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Chinese Journal of Chemical Engineering 2016年第2期24卷 264-277页

作者： Stephanie Nachtigall Daniel Zedel matthias Kraume Chair of Chemical and Process Engineering Technische Universitat Berlin

Drop breakage and coalescence influence the particle formation in liquid-liquid dispersions. In order to reduce the influencing factors of the whole dispersion process, single drops where coalescence processes can be neglected were analyzed in this work. Drops passing the turbulent vicinity of a single stirrer blade were investi- gated by high-speed imaging. In order to gain a statistically relevant amount of drops passing the area of interest and corresponding breakage events, at least 1600 droplets were considered for each parameter set of this work. A specially developed fully automatic image analysis based on Matlab was used for the evaluation of the resulting high amount of image data. this allowed the elimination of the time-consuming manual analysis and further- more, allowed the objective evaluation of the drops＇ behavior. Different deformation parameters were consid- ered in order to describe the drop deformation dynamics properly. Regarding the ratio of both main particle axes （0axes）, which was therefore approximated through an ellipse, allowed the determination of very small de- viations from the spherical shape. the perimeter of the particle （0peri） was used for the description of highly de- formed shapes. In this work the results of a higher viscosity paraffin oil （ηd =127 mPa. s） and a low viscosity solvent （petroleum, ηd = 1.7 mPa-s） are presented with and without the addition of SDS to the continuous water phase. All results show that the experimentally determined oscillation but also deformation times underlie a wide spreading. Drop deformations significantly increased not only with increasing droplet viscosity, but also with decreasing interfacial tension. Highly deformed particles of one droplet species were more likely to break than more or less spherical particles. As droplet fragmentation results from a variety of different macro-scale de- formed particles, it is not assumed that a critical deformation value must be reached for the fragmentati

关键词： Drop deformation Drop breakage Liquid-liquid system Turbulent mixing Image analysis High-speed imaging

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Transport of airborne particulate matters originating from Mentougou, Beijing, China

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China Particuology 2007年第6期5卷 408-413页

作者： Duoxing Yang Yongwei Han Jixi Gao Jesse thé institute of Crust Dynamics CEA Beijing 100085 China Chinese Academy of Environmenial Sciences Beijing 100012 China Lakes Environmental Software Inc. 419-3 Phillips St. Waterloo ON N2L 3X2 Canada

In this study, a coupled regional air quality modeling system is applied to investigate the time spatial variations in airborne particulate matters （PM10）, originating from Mentougou to Beijing municipal area in the period of April 1-7, 2004, and the influences of complex terrain and meteorological conditions upon boundary layer structure and PM10 concentration distributions. An intercomparison of the performance with CALPUFF against the observed data is presented and an examination of scatter plots is provided. the statistics show that the correlation coefficient and STD between the modeled and observed data are 0.86 and 0.03, respectively. Analysis of model results illustrates that the pollutants emitted from Mentougou can be transported to Beijing municipal area along certain transport pathways, and PM10 concentration distributions show heterogeneity characteristics. Contributions of the Mentougou sources to the PM10 concentrations in Beijing municipal area are up to 0.1-15 μg/m^3.

关键词： Airborne particulate matters CALPUFF PM10 SMOKE Emission inventory

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Power Law or Logarithmic Law ?── A Data Analysis for Zero Pressure Gradient Turbulent Boundary Layers with Low Re _(δ2)

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Journal of thermal Science 2000年第1期9卷 23-29页

作者： matthias Buschmann (Institute of Fluid Mechanics Dresden University of Technology

the paper Presents an analysis of two-dimensional zero pressure gradient (ZPG) turbulent boundary layers (TBL) with regard to the application of Power laws. Only TBL with low Reynolds number 300 that a certain region of the mean velocity profile can be described with a power law of the form u+ = Cpow * y+α this Power law region is not a Priori identical with the overlap region. An algorithm for the determination of the wall skin friction using the power law is proposed. the method was applied with good result to ZPG TBL and to adverse pressure gradient (APG) TBL. To bridge the gap between the wall and the power law region an approach for the turbulent viscosity is suggested.

关键词： power law turbulent boundary layer scaling analysis fluid mechanics

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Studies on the Electrochemical Reduction of Cyanocobinamide

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Chinese Chemical Letters 1997年第8期8卷 715-718页

作者： Zheng, DH Lu, th Chen, HL ACAD SINICA CHANGCHUN INST APPL CHEMCHANGCHUN 130022PEOPLES R CHINA NANJING UNIV INST COORDINAT CHEMDEPT CHEMNANJING 210008PEOPLES R CHINA

It was found that cyanocobinamide (CN-Cbi) can be reduced at about -0.50V. the reduction process has an EC mechanism, i.e. the electrochemical reduction of CN-Cbi is accompanied by a decyanation of CN-Cbi. the electro... 详细信息

关键词： SCE Studies on the Electrochemical Reduction of Cyanocobinamide

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Spatial Variability of Soil Properties and Rice Yield Along Two Catenas in Southeast China

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Pedosphere 2008年第4期18卷 409-420页

作者： B. Rth B. LENNARTZ Institute for Land Use University of Rostock Justus-von-Liebig-Weg 6 18059 Rostock (Germany).

In the light of an increasing demand for staple food, especially rice, in southeast China, investigations on the specific site potential expressed as the relationship between soil and crop yield parameters gain increasing importance. Soil texture and several soil chemical parameters as well as plant properties such as crop height, biomass and grain yield were investigated along two terraced catenas with contrasting soil textures cropped with wet rice. We were aiming at identifying correlative relationships between soil and crop properties. Data were analyzed both statistically and geostatistically on the basis of semivariograms. Statistical analysis indicated a significant influence of the relief position on the spatial distribution of soil texture, total carbon and total nitrogen contents. Significant correlations were found for the catena located in a sandstone area (Catena A) between rice yield and silt as well as total nitrogen content. Corresponding relationships were not detectable for paddy fields that developed from Quaternary clays (Catena B). As suggested by the nugget to sill ratio, spatial variability of soil texture, total carbon and nitrogen was mainly controlled by intrinsic factors, which might be attributed to the erosional transport of fine soil constituents, indicating the importance of the relief position and slope in soil development even in landscapes that are terraced. the crop parameters exhibited short ranges of influence and about one third of their variability was unexplained. Comparable ranges of selected crop and soil parameters, found only for Catena A, are indicative of close spatial interactions between rice yield and soil features. Our findings show that especially in sandstone-dominated areas, a site-specific management can contribute to an environmentally safe rice production increase.

关键词： rice productivity semivariogram analysis soil properties spatial data

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Periodic Solutions of Evolution Variational Inequalities—a Method of Guiding Functions

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Chinese Annals of Mathematics,Series B 2009年第3期30卷 261-272页

作者： Samir ADLY Daniel GOELEVEN Michel thRA Département de Math'ematiques et Informatique Laboratoire XLIM(Unité Mixte 6172 du CNRS)Université de Limoges123 Avenue A.Thomas87060 Limoges CedexFrance. Laboratoire d' Informatique et de Mathématiques Université de La Réunion97400 Saint-DenisFrance.

this paper focuses on a part of the presentation given by the third author at the Shanghai Forum on Industrial and Applied Mathematics(Shanghai 2006).It is related to the existence of a periodic solution of evolution ... 详细信息

关键词： Variational inequality Differential inclusion Topological degree Guiding function Periodic solution

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Simulation of a Shock Tube with a Small Exit Nozzle

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Journal of thermal Science 2018年第1期27卷 34-38页

作者： Yigang Luan matthias Olzmann Franco Magagnato Harbin Engineering University HarbinChina Karlsruhe Institute of Technology(KIT) Institute of Physical ChemistryKaiserstrasse 1276131 KarlsruheGermany Karlsruhe Institute of Technology(KIT) Institute of Fluid MechanicsKaiserstrasse 1276131 KarlsruheGermany

Shock tubes are frequently used to rapidly heat up reaction mixtures to study chemical reaction mechanisms and kinetics in the field of combustion chemistry [1]. In the present work, the flow field inside a shock tube with a small nozzle in the end plate has been investigated to support the analysis of reacting chemical mixtures with an attached mass spectrometer and to clarify whether the usual assumptions for the flow field and the related ther- modynamics are fulfilled. In the present work, the details of the flow physics inside the tube and the flow out of the nozzle in the end plate have been investigated. Due to the large differences in the typical length scales and the large pressure ratios of this special device, a very strong numerical stiffness prevails during the simulation process. Second-order ROE numerical schemes have been employed to simulate the flow field inside the shock tube. the simulations were performed with the commercial code ANSYS Fluent [2]. Axial-symmetric boundary conditions are employed to reduce the consumption of CPU time. A density-based transient scheme has been used and vali- dated in terms of accuracy and efficiency. the simulation results for pressure and density are compared with ana- lytical solutions. Numerical results show that a density-based numerical scheme performs better when dealing with shock-tube problems [5]. the flow field near the nozzle is studied in detail, and the effects of the nozzle to pressure and temperature variations inside the tube are invcstigatcd. the results show that this special shock-tube setup can be used to study high-temperature gas-phase chemical reactions with reasonable accuracy.

关键词： CFD shock tube low pressure numerical scheme

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Existence Results for a Class of Periodic Evolution Variational Inequalities

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Chinese Annals of Mathematics,Series B 2007年第6期28卷 629-650页

作者： Samir ADLY Daniel GOELEVEN Michel thRA DMI-XLIM UMR-CNRS 6172Université de Limoges123 Avenue A.Thomas87060 Limoges CedexFrance. IREMIA Université de La Réunion97400 Saint-DenisFrance.

In this paper, using the Brouwer topological degree, the authors prove an existence result for finite variational inequalities. this approach is also used to obtain the existence of periodic solutions for a class of e... 详细信息

关键词： Variational inequalities Differential inclusions Topological degree Guiding functions Periodic solutions

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