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Nitro-PAH exposures of occupationally-exposed traffic workers and associated urinary 1-nitropyrene metabolite concentrations

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Journal of Environmental Sciences 2016年第11期28卷 213-221页

作者： Justin P.Miller-schulze Michael Paulsen Takayuki Kameda Akira Toriba Kazuichi Hayakawa Brandon Cassidy Luke Naeher Manuel Aguilar Villalobos Christopher D.Simpson Department of Chemistry University of Washington WA 98195-1700 USA. Department of Environmental and Occupational Health Sciences University of Washington WA 98195 Seattle USA Laboratory of Hygienic Chemistry Instkute of Medical Pharmaceutical and Health Sciences Faculty of Pharmacy Kanazawa UniversityKakurna-machi Kanazawa Ishikawa 920-1192 Japan Graduate School of Natural Science and Technology Kanazawa University Kakma-machi Kanazawa Ishikawa 920-1192 Japan Department of Enuironmental Health Sciences University of Georgia Athens CA 30602-2102 USA Asociacion del Aire Ambiental Lima Peru

The assessment of occupational exposure to diesel exhaust（DE） is important from an epidemiological perspective. Urinary biomarkers of exposure have been proposed as a novel approach for measuring exposure to DE. In this study, we measured the concentrations of two urinary metabolites of 1-nitropyrene（1NP）, a nitrated polycyclic aromatic hydrocarbon that has been suggested as a molecular marker of diesel particulate matter. These two metabolites, 6-hydroxy-1-nitropyrene and 8-hydroxy-1-nitropyrene, were determined in urine samples（10 m L） from a small group of workers who were occupationally-exposed to vehicle exhaust in Trujillo, Peru, before and after their workshifts. Workshift exposures to1 NP, as well as PM_（2.5）, 2-nitropyrene and 2-nitrofluoranthene, were also *** to 1NP were similar in all studied workers, averaging 105 ± 57.9 pg/m^3（±standard deviation）. Median urinary concentrations of the average of the pre- and post-exposure samples for 6-hydroxy-1-nitropyrene and 8-hydroxy-1-nitropyrene, were found to be 3.9 and 2.3 pg metabolite/mg creatinine, respectively in the group of occupationally-exposed subjects（n = 17） studied. A direct relationship between workshift exposure to 1NP and urinary 1NP metabolites concentrations was not observed. However,the 1NP exposures and the creatinine-corrected urinary concentrations of the hydroxynitropyrene metabolites in these Peruvian traffic workers were similar to occupationally-exposed taxi drivers in Shenyang, China, and were higher than biomarker levels in office workers from Trujillo without occupational exposure to vehicle *** study provides further evidence that urinary metabolites of 1NP are associated with exposure to DE and may serve as a useful exposure biomarker.

关键词： Urinary biomarkers 1-Nitropyrene Diesel particulate matter

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超细Pb(Sc_(1/2),Nb_(1/2))O_3粉体的制备

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无机材料学报 1990年第4期5卷 312-317页

作者：冯楚德 schulze W.A. 中国科学院上海硅酸盐研究所 NYS College of Ceramies Alfred UniversityUSA

本文叙述了用受控水解反应和化学共沉淀法制备 Pb(Sc_(1/2),Nb_(1/2)O_3(PSN)超细粉体的方法。通过Nb(OC_2H_5)_5稀溶液的受控水解反应生成超细球状 Nb_2O_5粉末,然后使 Sc(NO_3)_3和 Pb(NO_3)_2混合溶液与过量(NH_4)_2CO_3溶液反应,在... 详细信息

本文叙述了用受控水解反应和化学共沉淀法制备 Pb(Sc_(1/2),Nb_(1/2)O_3(PSN)超细粉体的方法。通过Nb(OC_2H_5)_5稀溶液的受控水解反应生成超细球状 Nb_2O_5粉末,然后使 Sc(NO_3)_3和 Pb(NO_3)_2混合溶液与过量(NH_4)_2CO_3溶液反应,在球状 Nb_2O_5颗粒表面生长一层 Sc_2(CO_3)_3和 PbCO_3膜层,经过熔烧后得超细 PSN 粉末。

关键词： PSN 铁电陶瓷粉体受控水解反应

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用化学共沉淀法粉体制备的铌钪酸铅陶瓷(PSN)的特性

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无机材料学报 1990年第3期5卷 237-244页

作者：冯楚德 schulze W.A. 中国科学院上海硅酸盐研究所高性能陶瓷和超微结构开放实验室 NYS College of Ceramics Alfred University

用Nb(OC_2H_5)_5受控水解和在水解形成的 Nb_2O_3颗粒表面生长Sc和Pb的碳酸盐膜层,然后通过焙烧制成PSN超细粉体。将此粉体在不同温度下烧结及随后以不同的方式冷却形成致密的PSN陶瓷。对此PSN铁电陶瓷的介电弛豫特性和结构有序度之间... 详细信息

用Nb(OC_2H_5)_5受控水解和在水解形成的 Nb_2O_3颗粒表面生长Sc和Pb的碳酸盐膜层,然后通过焙烧制成PSN超细粉体。将此粉体在不同温度下烧结及随后以不同的方式冷却形成致密的PSN陶瓷。对此PSN铁电陶瓷的介电弛豫特性和结构有序度之间的关系进行了研究。

关键词：铌钪酸铅陶瓷 PSN 铁电陶瓷

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World Journal of Gastrointestinal Oncology 2020年第11期12卷 1288-1295页

作者： Anne Katrin Berger Michael Allgäuer Leonidas Apostolidis Anna Elisa schulze-Schleithoff Uta Merle Dirk Jaeger Georg Martin Haag Department of Medical Oncology National Center for Tumor DiseasesUniversity Hospital of HeidelbergHeidelberg 69120Germany Department of Pathology Institute of PathologyUniversity Hospital of HeidelbergHeidelberg 69120Germany Department of Gastroenterology University Hospital of HeidelbergHeidelberg 69120Germany Department of Gastroenterology and Hepatology University Hospital of HeidelbergHeidelberg 69120Germany

BACKGROUND Microangiopathic hemolytic anemia(MAHA) with thrombocytopenia and organ failure caused by tumor-associated thrombotic microangiopathy(TMA) is a lifethreatening oncological emergency. Rapid diagnosis and precise distinction from other forms of TMA is crucial for appropriate therapy, which aims at treating the underlying malignancy. However, the prognosis of patients with cancer-related(CR)-MAHA is limited. To date, less than 50 patients with gastric cancer and CRMAHA have been reported, mainly as single case reports, and detailed information on treatment strategies and outcome are scarce. We analyzed the characteristics and outcomes data of CR-MAHA patients with gastric cancer treated at our center between 2012 and *** To gain knowledge about CR-MAHA and the course of *** We retrospectively analyzed patients using an institutional prospectively maintained database. Patients who had CR-MAHA but other cancer types or cancer of unknown primary were excluded. The basic requirements for inclusion were: Histologically proven gastric adenocarcinoma;and clinical diagnosis of hemolytic anemia with schistocytes with or without thrombocytopenia. The observation period for each patient started with the first day of documented symptoms. The follow-up period for this analysis ended on February 1, *** We identified eight patients with a median age of 54 years. Histologically, all patients had(partial) diffuse subtypes of gastric adenocarcinoma with partial or complete signet cell morphology. All patients had metastatic disease and one patient had a microsatellite instability-high(MSI-H) tumor. In three patients, clinical signs of MAHA preceded the diagnosis of cancer, and in two patients, CRMAHA indicated recurrent disease. All patients had severe hemolytic anemia and thrombocytopenia. Six patients experienced severe bone pain, and five patients had dyspnea. Systemic, 5-fluorouracil-based combination chemotherapy was initiated in six patients, w

关键词： Microangiopathic hemolytic anemia Gastric cancer Chemotherapy Secondline chemotherapy Thrombocytopenia Microsatellite instability-high tumor

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陶瓷部件的浆料打印快速成型(英文)

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硅酸盐学报 2001年第4期29卷 344-349页

作者：王树海 Jang J H schulze W A Pilgrim S M 山东工业陶瓷研究设计院山东淄博255031 NYS College of Ceramics

采用Sanders公司的四打印头快速成型机进行了陶瓷部件的浆料打印成型实验 ,实际测试了所用四打印头快速成型机的打印工作条件 ,考察了石蜡和挥发性介质两种浆料技术路线 ,并采用石蜡为介质制备了钛酸钡陶瓷浆料 ,研究了其流变性能 .实... 详细信息

采用Sanders公司的四打印头快速成型机进行了陶瓷部件的浆料打印成型实验 ,实际测试了所用四打印头快速成型机的打印工作条件 ,考察了石蜡和挥发性介质两种浆料技术路线 ,并采用石蜡为介质制备了钛酸钡陶瓷浆料 ,研究了其流变性能 .实验表明 ,虽然偶联剂的加入可以降低石蜡介质浆料的粘度 ,但是粘度足够低的可打印浆料的固相含量太低 [约 3 % (involume)以下 ] ,打印成型后不能完全烧结 ,因此 ,要通过打印成型出可完全烧结的陶瓷部件便只能采用挥发性液体作为浆料介质。

关键词：陶瓷部件浆料打印成型烧结四打印头快速成型机

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Travel time and alternative configurations analysis for automated storage/retrieval systems based on geometrical method

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Journal of Southeast University(English Edition) 2007年第S1期23卷 161-167页

作者：马新露赵林度 Lothar schulze 东南大学经济管理学院南京210096 汉诺威大学物流规划与控制系德国汉诺威30167

In order to evaluate the efficiency of the automated storage/retrieval system(AS/RS)accurately,and compare different layouts of the AS/RS using mean travel time,under randomized storage conditions,an exact,geometry-based analytical model is *** model can be used to compute the expected single-command and dual-command travel time for a storage/retrieval(S/R)machine which can travel simultaneously horizontally and vertically as it moves along a storage *** rack may be either square in time or non square in ***,the alternative layouts of the AS/RS and travel-time models are *** with setting the I/O point at the left-lower corner of the rack,setting the I/O point at any point at the vertical edge can help enhance the efficiency of the AS/RS.

关键词： travel time model automated storage/retrieval system geometry method Tchebychev approximation

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基于电磁阀的喷嘴直接注入式农药喷洒系统

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农业机械学报 2013年第6期44卷 69-72,200页

作者：蔡祥 Walgenbach Martin Doerpmund Malte schulze Lammers Peter 孙宇瑞中国农业大学信息与电气工程学院北京100083 波恩大学农业机械研究所波恩53115

设计了一种喷嘴直接注入式农药喷洒系统。通过与传统喷雾机械比较,简述了喷嘴直接注入式喷雾系统的结构和喷雾执行单元。为了实现农药定量注入,设计一种基于电磁原理的快速响应阀,并论述其工作原理和闭环控制方式。通过试验测试了喷雾... 详细信息

设计了一种喷嘴直接注入式农药喷洒系统。通过与传统喷雾机械比较,简述了喷嘴直接注入式喷雾系统的结构和喷雾执行单元。为了实现农药定量注入,设计一种基于电磁原理的快速响应阀,并论述其工作原理和闭环控制方式。通过试验测试了喷雾执行单元的喷雾特性和喷杆组内各喷雾单元的一致性。结果表明在一定喷洒速率范围内,喷雾执行单元的喷水量和水压强存在多项式关系,农药注入量和PWM信号的高电平时间存在指数关系,其决定系数均高于0.9,并且同一喷杆组内6个喷雾单元的喷雾效果大体一致。

关键词：直接注入式电磁原理快速响应阀门脉宽调制变量喷雾

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Structure-function analysis of the barley MLA resistance protein

Structure-function analysis of the barley MLA resistance pro...

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中国遗传学会植物遗传和基因组学专业委员会2009年学术研讨会

作者： Paul schulze-Lefert Max Planck Institute for Plant Breeding Research CologneGermany

The barley Mla locus is exceptionally polymorphic,encoding more than 30 race-specific resistance(R) alleles against the barley powdery mildew fungus,Blumeria graminis f sp hordei(Bgh).The molecularly isolated Mla gene... 详细信息

关键词： Barley MLA Disease resistance protein

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喷嘴直接注入式农药喷洒系统控制方法研究

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农业机械学报 2016年第11期47卷 100-105页

作者：蔡祥 Martin Walgenbach Mahe Doerpmund Peter schulze Lammers 孙宇瑞赵燕东北京林业大学信息学院北京100083 波恩大学农业机械研究所波恩53115 中国农业大学信息与电气工程学院北京100083 北京林业大学工学院北京100083

为了实现农药变量喷洒,准确计量和控制农药的注入速率和注入量很有必要。提出了一种喷嘴直接注入式系统(DNIS)原型,并在此基础上研究了农药喷洒量的控制方法。该系统应用快速响应电磁阀(RRV)向水中注入农药,RRV由100 Hz的脉宽调制(PWM)... 详细信息

为了实现农药变量喷洒,准确计量和控制农药的注入速率和注入量很有必要。提出了一种喷嘴直接注入式系统(DNIS)原型,并在此基础上研究了农药喷洒量的控制方法。该系统应用快速响应电磁阀(RRV)向水中注入农药,RRV由100 Hz的脉宽调制(PWM)信号驱动,通过改变PWM信号占空比调节农药注入速率。试验室环境下设计了基于比例-积分-微分(PID)算法的闭环控制策略,将农药注入速率快速稳定在设定值。通过试验测试了RRV、DNIS系统和PID控制器的工作性能。试验结果表明,采用RRV可准确计量农药注入速率,闭环控制策略可获得较稳定的农药速率控制效果,农药注入速率可在4 s内达到设定值,注入速率的稳定性相对于没有控制策略有明显提高。

关键词：农药变量喷洒直接注入式快速响应电磁阀脉宽调制闭环控制

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Positive association between forest management, environmental change, and forest bird abundance

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Forest Ecosystems 2019年第1期6卷 26-37页

作者： Ernst Detlef schulze Dylan Craven Andrew M.Durso Jiri Reif Marcus Guderle Franz Kroiher Petra Hennig Anne Weiserbs Peter Schall Christian Ammer Nico Eisenhauer Max Planck Institute for Biogeochemistry Biodiversity Macroecology and Biogeography Faculty of forest Science and Forest Ecology University G?ttingen Institute of Environmental Studies Faculty of ScienceCharles University Thünen-Institute for Forest Ecosystems Aves-Natagora Départment Etudes Silviculture and Forest Ecology of the temperate Zones University of G?ttingen German Centre for Integrative Biodiversity Research (iDiv) and Leipzig University Institute of Biology

Background: The global decrease in wildlife populations, especially birds, is mainly due to land use change and increasing intensity of land use(Parmesan and Yohe 2003). However, impacts of management tools to mitigate biodiversity loss at regional and global scales are less apparent in forest regions that have a constant forest area,and which did not suffer from habitat degradation, and where forests are sustainably managed, such as in Central Europe or the northeastern USA. A biodiversity assessment for Germany suggested, for example, that bird populations were constant(Bundesamt für Naturschutz 2015).Results: This study shows that changes in the environment and in forest management over the past 45 years have had a significant, positive effect on the abundance of non-migratory forest bird species in Central Europe. Economy(timber prices and GDP), forest management(timber harvest and mixed forest area), and environmental factors(atmospheric CO_2 concentration and nitrogen deposition) were investigated together with changes in abundances of migratory and non-migratory forest birds using partial least squares path modeling. Climate change, resulting in longer seasons and milder winters, and forest management, promoting tree diversity, were significantly positively related to the abundance of non-migratory forest birds and explained 92% of the variation in their abundance in Europe. Regionally-migrating forest birds had stable populations with large variation, while birds migrating across continents declined in recent decades, suggesting significant, contrasting changes in bird populations in Europe. In northeastern North America we also found evidence that non-migratory forests have experienced long-term increases in abundance, and this increase was related to management. The increase of populations of nonmigratory forest birds in Europe and North America is associated with an increase in structural diversity and disturbances at the landscape ***: Our

关键词： Climate change Birds Biodiversity Timber harvest Econo my Forest management

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