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World Journal of Gastroenterology 2014年第45期20卷 17049-17064页

作者： Toni Urbanik Bruno Christian Koehler Laura Wolpert Christin Elbner Anna-Lena Scherr Thomas Longerich Nicole Kautz Stefan Welte Nadine Hovelmeyer Dirk Jager Ari Waisman Henning schulze-Bergkamen National Center for Tumor Diseases Department of Medical Oncology University Clinic of Heidelberg 69120 HeidellbergBade-WuerrtembergGermany Institute of Pathology University Hospital Heidelberg 69120 HeidelbergBaden-WuerrtembergGermany Institute for Molecular Medicine Johannes Gutenberg-University Mainz 55131 MainzRheinland-PalatlnateGemany

AIM:To analyze the role of CYLD for receptor-mediated cell death of murine hepatocytes in acute liver injury ***:Hepatocyte cell death in CYLD knockout mice(CYLD-/-)was analyzed by application of liver injury models for CD95-(Jo2)and tumor necrosis factor(TNF)-α-[D-Gal N/lipopolysaccharide(LPS)]induced *** injury was assessed by measurement of serum transaminases and histological *** induction was quantified by cleaved PARP staining and Western blotting of activated *** factor(NF)-κB,ERK,Akt and jun amino-terminal kinases signaling were *** Hepatocytes were isolated by two step-collagenase perfusion and treated with recombinant TNF-αand with the CD95-ligand *** viability was analyzed by ***:Livers of CYLD-/-mice showed increased anti-apoptotic NF-κB *** both applied liver injury models CYLD-/-mice showed a significantly reduced apoptosis *** D-Gal N/LPS treatment CYLD-/-mice exhibited significantly lower levels of alanine aminotransferase(ALT)(295 U/L vs 859 U/L,P<0.05)and aspartate aminotransferase(AST)(560 U/L vs 1025 U/L,P<0.01).After Jo injection CYLD-/-mice showed 2-fold lower ALT(50 U/L vs 110 U/L,P<0.01)and lower AST(250 U/L vs 435 U/L,P<0.01)serumlevels compared to WT *** addition,isolated CYLD-/-primary murine hepatocytes(PMH)were less sensitive towards death receptor-mediated apoptosis and showed increased levels of Bcl-2,XIAP,c IAP1/2,survivin and c-FLIP expression upon TNF-and CD95-receptor triggering,*** of NF-κB activation by the inhibitor of NF-κB phosphorylation inhibitor BAY 11-7085 inhibited the expression of antiapoptotic proteins and re-sensitized CYLD-/-PMH towards TNF-and CD95-receptor mediated cell ***:CYLD is a central regulator of apoptotic cell death in murine hepatocytes by controlling NF-κB dependent anti-apoptotic signaling.

关键词： CYLD Apoptosis Nuclear factor-κB Tumo rnecrosis factor-α CD95 Liver

Fireworks MX 2004网页图形编辑标准教材中文版中文

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Investigation of Temperature Dependency of Morphological Properties of Thermoplastic Polyurethane using WAXS and SAXS Monitoring

2004年

作者：（美）Patti schulze 赵宏峰杨常青译

本书介绍了Fireworks中位图图像和矢量图像制作的基础知识，并详细讲解了一些高级技术，且介绍了Fireworks与Dreamweaver的集成特性。

ISBN: (纸本)7121001586

本书介绍了Fireworks中位图图像和矢量图像制作的基础知识，并详细讲解了一些高级技术，且介绍了Fireworks与Dreamweaver的集成特性。

关键词：制作网页软件工具

来源：畅想之星图书光盘版（南... 评论

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Journal of Chemistry and Chemical Engineering 2015年第8期9卷 494-499页

作者： Steffen Thomas Witzleben Katharina Walbrueck Stephanie Elisabeth Klein Margit schulze Department of Natural Sciences Bonn-Rhein-Sieg University of Applied Sciences von-Liebig-Strasse 20 Rheinbach D53359Germany

Polyether and polyether/ester based TPU （thermoplastic polyurethanes） were investigated with wide-angle XRD （X-ray diffraction） and SAXS （small angle X-ray scattering）. Furthermore, SAXS measurements were performed in the temperature range of 30 ℃ to 130 ℃. Polyether based polymers exhibit only one broad diffraction signal in a region of 2 θ 15° to 25°. In case of polyurethanes with ether/ester modification, the broad diffraction signal arises with small sharp diffraction signals. SAXS measurements of polymers reveal the size and shape of the crystalline zones of the polymer. Between 30 ℃ and 130 ℃ the size of the crystalline zone changes significantly. The size decreases in most of investigated TPU. In the case of Desmopan 9365D an increase of the particle size was observed.

关键词： Thermoplastic polyurethanes morphology mechanical properties SAXS WAXS temperature influence crystallinity

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工程师的机会

机电设备 2012年第2期29卷 18-19页

作者： schulze SSB风能系统公司

Schu1ze博士，ssB风能系统公司总经理，他曾获得风机一空气动力．学博士学位，曾从事航天技术及驱动及自动化技术行业工作。这两个行业知识的结合为其研发变桨系统奠定了基础。

关键词：工程师风能系统博士学位自动化技术空气动力航天技术总经理 ssB

Testicular expression of survivin and human telomerase reverse transcriptase(hTERT)associated with spermatogenic function in infertile patients

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Asian Journal of Andrology 2006年第1期8卷 95-100页

作者： Steffen Weikert Frank Christoph Wolfgang schulze Hans Krause Carsten Kempkensteffen Martin Schostak Kurt Miller Mark Schrader Department of Urology Charité-Universittsmedizin BerlinCampus B.FranklinD-12200 BerlinGermany Department of Andrology University of HamburgD-20246 HamburgGermany

Aim： To characterize the coexpression of survivin, an inhibitor of apoptosis （IAF）, and human telomerase reverse transcriptase （hTERT） in human testes with varying spermatogenic function. Methods： Transcript levels of survivin mRNA and hTERT mRNA were determined in normal testes （n = 11） and testes with defective spermatogenesis （n = 28） using real-time reverse-transcription polymerase chain reaction （RT-PCR）. The histological work-up was performed according to a modified Johnsen score. Results： Expressions of both survivin and hTERT were highest at median levels of 96.8 and 709 in normal spermatogenesis and dropped to 53.3 and 534 in testes with postmeiotic spermatogenic arrest （n = 10）. In severe spermatogenic failure （n = 18）, survivin expression was lacking in most specimens （n = 16）, whereas at least low levels of testicular hTERT expression were largely detectable with a normalized expression of 73 in premeiotic spermatogenic arrest （n = 7） and 45 in patients with Sertoli cell-only syndrome （SCOS）（n = 3）. Both survivin and hTERT expressions increased with a progressing Johnsen score （P for trend = 0.001）. Conclusion： Although both survivin and hTERT are correlated with spermatogenic function, they show different expression patterns in testes of infertile patients. These findings substantiate results from studies in the rodent testis suggesting a predominant expression of survivin in meiotically dividing germ cells. （Asian J Andro12006 Jan; 8： 95-100）

关键词： survivin human telomerase reverse transcriptase apoptosis azoospermia male infertility spermatogenesis

Genetics of hepatocellular carcinoma

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World Journal of Gastroenterology 2007年第16期13卷 2271-2282页

作者： Andreas Teufel Frank Staib Stephan Kanzler Arndt Weinmann Henning schulze-Bergkamen Peter R Galle Department of Medicine Johannes Gutenberg University Mainz Germany

The completely assembled human genome has made it possible for modern medicine to step into an era rich in genetic information and high-throughput genomic analysis. These novel and readily available genetic resources and analytical tools may be the key to unravel the molecular basis of hepatocellular carcinoma (HCC). Moreover, since an efficient treatment for this disease is lacking, further understanding of the genetic background of HCC will be crucial in order to develop new therapies aimed at selected targets. We report on the current status and recent developments in HCC genetics. Special emphasis is given to the genetics and regulation of major signalling pathways involved in HCC such as p53, Wnt- signalling, TGFβ, Ras, and Rb pathways. Furthermore, we describe the influence of chromosomal aberrations as well as of DNA methylation. Finally, we report on the rapidly developing field of genomic expression profiling in HCC, mainly by microarray analysis.

关键词： Hepatocellular carcinoma Liver cancer Genetics Genomics Chromosome Mutation Pathway

不同粗糙度尺度下预测表层土壤孔隙率量化指数比较研究

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应用基础与工程科学学报 2009年第1期17卷 69-76页

作者：张慧娟孙宇瑞林剑辉 P. schulze Lammers 王聪颖中国农业大学精细农业研究中心北京100083 德国波恩大学农业工程研究所德国波恩53115

针对当前精细农业对农田信息快速采集的需求,本研究提出了基于土壤粗糙度预测表层土壤孔隙率的方法,而采用何种量化指数表征土壤粗糙度是深化研究的关键.本文首先系统总结了几种已有的衡量土壤粗糙度的量化指数,进而提出一种新的基于小... 详细信息

针对当前精细农业对农田信息快速采集的需求,本研究提出了基于土壤粗糙度预测表层土壤孔隙率的方法,而采用何种量化指数表征土壤粗糙度是深化研究的关键.本文首先系统总结了几种已有的衡量土壤粗糙度的量化指数,进而提出一种新的基于小尺度的土壤粗糙度指数Rd.根据对4种不同耕作方式下应用地面激光扫描仪获取的原始试验数据进行初步处理,并将4种粗糙度量化指数与表层土壤孔隙率的相关性做了比较研究,得出了两个重要结论:(1)与其它粗糙度量化指数相比,Rd与表层土壤孔隙率的相关性最高(R2=0.752);(2)基于激光扫描方法快速分析表层土壤孔隙率具有潜在的应用价值.

关键词：表层土壤孔隙率土壤粗糙度地面激光扫描仪

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大别山超高压变质带层析地震调查

地质论评 2000年第3期46卷 288-294页

作者：彭聪姜枚宿和平史大年 A.schulze T.Ryberg 中国地质科学院矿床地质研究所 GeoForschungsZentrum Potsdam Telegrafenberg A 17 14473 Potsdam Germany

1997年3月中德合作进行了大别山科学钻探选址区层析地震调查,研究结果揭示出大别山超高压变质带(UHP)地壳精细结构。郯庐断裂带近垂直延伸至Moho界面(可能更深),在Moho界面以上郯庐断裂带西侧大别山地壳物质没有迁移进入其东侧。在主测... 详细信息

1997年3月中德合作进行了大别山科学钻探选址区层析地震调查,研究结果揭示出大别山超高压变质带(UHP)地壳精细结构。郯庐断裂带近垂直延伸至Moho界面(可能更深),在Moho界面以上郯庐断裂带西侧大别山地壳物质没有迁移进入其东侧。在主测线(横中至潜山镇)20km深度发现一个由西向东倾斜的强反射层,推测可能是一个大的滑脱层。超高压变质岩石(或地幔物质)可能由地幔深处通过郯庐断裂带再沿此滑脱层折返到地壳上部,经后期剥蚀出露地表。

关键词：大别山超高压变质带郯庐断裂地震层析成像

高对映选择性环氧化物水解酶产生菌的筛选及特性研究

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微生物学通报 2001年第5期28卷 14-17页

作者：唐燕发许建和武慧渊叶勤 schulze Birgit 华东理工大学生物反应器工程国家重点实验室生物催化研究室上海200237 DSM Research P.O.Box18

从土壤中分离的芽孢杆菌BacillusmegateriumECU1 0 0 1所产环氧化物水解酶能高对映选择性水解缩水甘油苯基醚 (对映选择率E值可达 47 8) ,当转化率为 5 5 9%时 ,剩余的 (S) 缩水甘油苯基醚的光学纯度 (对映体过量值 ,ee)可达 99 5 % ... 详细信息

从土壤中分离的芽孢杆菌BacillusmegateriumECU1 0 0 1所产环氧化物水解酶能高对映选择性水解缩水甘油苯基醚 (对映选择率E值可达 47 8) ,当转化率为 5 5 9%时 ,剩余的 (S) 缩水甘油苯基醚的光学纯度 (对映体过量值 ,ee)可达 99 5 % ;当底物浓度提高到 60mmol/L时 ,光学纯 (S) 缩水甘油苯基醚的收率达到 2 5 6%

关键词：缩水甘油苯基醚手性环氧化物巨大芽孢杆菌环氧化物水解酶菌株筛选对映选择性水解