检索结果-南通市图书馆

Do Immaturity, Dehydratation or Alkalosis Predispose to Intraoperative Complications at Pyloromyotomy?

Open Journal of Pediatrics 2016年第3期6卷 203-212页

作者： Ralf-Bodo Tröbs Lars Burghardt Micha Bahr matthias nissen Department of Pediatric Surgery Clinic Marien Hospital Herne St. Elisabeth Gruppe Ruhr-Universit?t Bochum Herne Germany

Background: Hypertrophic pyloric stenosis is the most important cause for propulsive non-bilious vomiting in infants of the first trimester. Extramucous splitting of the hypertrophic pyloric muscle is the surgical gold standard for treatment. Serious major complications of pyloromyotomy (PM) are mucosal perforation and incomplete muscle splitting. The aim of the presented study is to find out if intraoperative complications are predisposed by biometric or biochemical factors. Furthermore, we looked for the influence of the board certification of the primary surgeon. Patients and Methods: 162 infants with IHPS were operated during a six-year period (n = 150 laparoscopic operations). We had 8 major complications (4.9%): iatrogenic mucosal perforation occurred in 6 cases, and incomplete PM in 2 infants. Preoperative demographic data and data resulting from the blood acid-base- and ion-analysis were compared with data of a previously published reference group from our institution (Tr?bs RB. Open J Pediatr, 2014;4: 208-215). Results: The duration of vomiting, the grade of dehydration and the severity of blood alkalosis did not differ between both groups. Furthermore, we found no influence of the gestational age and birth weight on the occurrence of intraoperative complications. It seems that early postnatal age (p = 0.07) and low body weight at surgery (p = 0.055) may contribute to surgical problems. Board certification as a paediatric surgeon did not influence the rate of intraoperative complications. Conclusions: Laboratory data did not show any predisposition to intraoperative complications. It is assumed that small infants with early occurring symptoms carry an elevated risk for intraoperative events. Our data support the hypothesis that the rate of intraoperative complications at PM is mainly influenced by skills and experience of the surgeon.

关键词： Hypertrophic Pyloric Stenosis Pyloromyotomy Complication Perforation Alkalosis Surgical Training

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Pyloric Stenosis and Nonbilious Vomiting in Infants: Negative Base Excess and Hypercapnia—Two Opposing Points of One Scale a Comparative Case Series

引用

Open Journal of Pediatrics 2023年第1期13卷 104-112页

作者： Ralf-Bodo Tröbs Tomasz Baranski Andreas Lipphaus matthias nissen Department of Pediatric Surgery St. John’s Hospital Helios Kliniken GmbH Duisburg Germany Biomechanics Research Group Chair of Product Development Faculty of Mechanical Engineering Ruhr University Bochum Bochum Germany Department of Pediatric Surgery Ruhr-University of Bochum St. Marie’s Hospital Witten Sankt Elisabeth Gruppe Witten Germany

Background: Blood pH and bicarbonate estimations are basal acid-base laboratory tests that are performed in infants with infantile hypertrophic pyloric stenosis (IHPS). This study aimed to define the clinical value of pCO2 and BE in infants suspected to have IHPS. Methods: We collected data from 80 “surgical” infants younger than 100 days with prolonged nonbilious vomiting who were suspected to have IHPS. In 65 infants, pyloric stenosis was confirmed, and 15 infants had nonsurgical conditions. Capillary blood was tested for standard acid-base parameters and lactate. The two groups were compared. Results: Eighty-eight percent of the IHPS infants had elevated standard bicarbonate levels (st bicarb) > 25 mmol/l, and 60% had BE > 3.5 mmol/l;12% of the infants showed hypercapnia (pCO2 ≥ 50 mmHg) associated with markedly increased standard bicarbonate and BE. Infants with nonsurgical vomiting were older at admission (p = 0.002), had a longer duration of vomiting (p 2 (p = 0.021), lower st bicarb (p < 0.001) and lower BE (p = 0.001). In addition, nonsurgical infants showed a trend to anemia (p = 0.002). Conclusions: In infants with IHPS/nonbilious vomiting, acid-base analysis (ABA) is equivocal or inconclusive. These findings may be misleading and could result in a false clinical decision. Nonsurgical vomiting is associated with a lower degree of alkalosis, normocapnia to slight hypercapnia and a base deficit. However, even infants with IHPS may present with a negative BE. In infants with IHPS and severe alkalosis, hypercapnia carries a risk for respiratory depression. Monitoring the infant’s respiration allows for the early detection of respiratory deterioration.

关键词： Pyloric Stenosis Nonbilious Vomiting Hypoventilation Base Excess Hypercapnia

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

An Optimized Perfectly Matched Layer for the Schrödinger Equation

引用

Communications in Computational Physics 2011年第1期9卷 147-179页

作者： Anna nissen Gunilla Kreiss Department of Information Technology Uppsala UniversityP.O.Box 337SE-75105 UppsalaSweden.

We derive a perfectly matched layer(PML)for the Schrödinger equation using a modal *** derive approximate error formulas for the modeling error from the outer boundary of the PML and the error from the discretization in the layer and show how to choose layer parameters so that these errors are matched and optimal performance of the PML is *** computations in 1D and 2D demonstrate that the optimized PML works efficiently at a prescribed accuracy for the zero potential case,with a layer of width less than a third of the de Broglie wavelength corresponding to the dominating frequency.

关键词： Schrödinger equation perfectly matched layer

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A Differential Algebraic Method for the Solution of the Poisson Equation for Charged Particle Beams

引用

Communications in Computational Physics 2015年第1期17卷 47-78页

作者： B.Erdelyi E.nissen S.Manikonda Department of Physics Northern Illinois UniversityDeKalbIL60115USA European Organization for Nuclear Research CH-1211 Geneva 23Switzerland Advanced Magnet Lab Palm BayFL32905USA

The design optimization and analysis of charged particle beam systems employing intense beams requires a robust and accurate Poisson *** paper presents a new type of Poisson solver which allows the effects of space charge to be elegantly included into the system *** is done by casting the charge distribution function into a series of basis functions,which are then integrated with an appropriate Green’s function to find a Taylor series of the potential at a given point within the desired distribution *** order to avoid singularities,a Duffy transformation is applied,which allows singularity-free integration and maximized convergence region when performed with the help of Differential Algebraic *** method is shown to perform well on the examples *** implementation choices and some of their limitations are also explored.

关键词： Charged particle beams mean field limit Poisson equation orthogonal polynomials differential algebra

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Animal models of pancreatitis: Can it be translated to human pain study?

引用

World Journal of Gastroenterology 2013年第42期19卷 7222-7230页

作者： Jing-Bo Zhao Dong-Hua Liao Thomas Dahl nissen Mech-Sense Department of Gastroenterology and SurgeryAalborg University HospitalDK 9000 AalborgDenmark Institute of Clinical Medicine Aarhus UniversityDK 8200 Aarhus NDenmark The College of Bioengineering Chongqing University Biomedical Research Laboratory Aalborg University HospitalDK 9000 AalborgDenmark

Chronic pancreatitis affects many individuals around the world,and the study of the underlying mechanisms leading to better treatment possibilities are important ***,animal models are needed to illustrate the basic study of ***,animal models of acute and chronic pancreatitis have been thoroughly reviewed,but few reviews address the important aspect on the translation of animal studies to human *** is well known that pancreatitis is associated with epigastric pain,but the understanding regarding to mechanisms and appropriate treatment of this pain is still *** animal models to study pancreatitis associated visceral pain is difficult,however,these types of models are a unique way to reveal the mechanisms behind pancreatitis associated visceral *** this review,the animal models of acute,chronic and un-common pancreatitis are briefly outlined and animal models related to pancreatitis associated visceral pain are also addressed.

关键词： Animal model Pancreatitis Visceral pain Mechanism

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cytomegalovirus in inflammatory bowel disease： Asystematic review

引用

World Journal of Gastroenterology 2016年第3期22卷 1321-1330页

作者： Tessa EH Römkens Geert J Bulte Loes HC nissen Joost PH Drenth Department of Gastroenterology and Hepatology Radboud University Nijmegen Medical Centre6500 HB NijmegenThe Netherlands Department of Gastroenterology and Hepatology Jeroen Bosch Hospital5200 ME HertogenboschThe Netherlands

AIM: To identify definitions of cytomegalovirus(CMV) infection and intestinal disease, in inflammatory bowel disease(IBD), to determine the prevalence associated with these ***: We conducted a systematic review and interrogated Pub Med, EMBASE and Cochrane for literature on prevalence and diagnostics of CMV infection and intestinal disease in IBD patients. As medical headings we used "cytomegalovirus" OR "CMV" OR "cytomegalo virus" AND "inflammatory bowel disease" OR "IBD" OR "ulcerative colitis" OR "colitis ulcerosa" OR "Crohn's disease". Both Me SH-terms and free searches were performed. We included all types of English-language(clinical) trials concerning diagnostics and prevalence of CMV in ***: The search strategy identified 924 citations, and 52 articles were eligible for inclusion. We identified 21 different definitions for CMV infection, 8 definitions for CMV intestinal disease and 3 definitions for CMV reactivation. Prevalence numbers depend on used definition, studied population and region. The highest prevalence for CMV infection was found when using positive serum PCR as a definition, whereas for CMV intestinal disease this applies to the use of tissue PCR > 10 copies/mg tissue. Most patients with CMV infection and intestinal disease had steroid refractory disease and came from East ***: We detected multiple different definitions used for CMV infection and intestinal disease in IBD patients, which has an effect on prevalence numbers and eventually on outcome in different trials.

关键词： Inflammatory bowel disease Cytomegalovirus Ulcerative colitis Crohn's disease Systematicreview

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Theory- and Evidence- Based Intervention： Practice-Based Evidence Integrating Positive Psychology Into a Clinical Psychological Assessment and Intervention Model and How to Measure Outcome

引用

Psychology Research 2011年第2期1卷 91-105页

作者： Poul nissen University of Aarhus Copenhagen Denmark

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

大鼠胚胎视网膜前体细胞的分离、体外培养及鉴定

引用

中华眼科杂志 2006年第2期42卷 104-110页

作者：杨静 Mogens Holst nissen 王薇北京大学第三医院眼科中心 100083 丹麦哥本哈根大学Punum研究所

目的探讨流式细胞分析技术、免疫荧光及3HThymidine分析对大鼠胚胎视网膜前体细胞性质及其体外增殖进行鉴定的可行性。方法来源于19d胚胎大鼠视网膜的视网膜前体细胞,使用流式细胞分析及免疫荧光技术从数量及形态上对细胞性质进行鉴定... 详细信息

目的探讨流式细胞分析技术、免疫荧光及3HThymidine分析对大鼠胚胎视网膜前体细胞性质及其体外增殖进行鉴定的可行性。方法来源于19d胚胎大鼠视网膜的视网膜前体细胞,使用流式细胞分析及免疫荧光技术从数量及形态上对细胞性质进行鉴定。采用无血清培养基体外培养,通过3HThymidine分析、形态学观察及统计学分析,研究细胞增殖情况。结果从胚胎大鼠全层视网膜分离出的原代视网膜前体细胞,流式细胞分析结果显示:培养0d时,22.23%的细胞神经上皮干细胞蛋白(Nestin)呈阳性表达,16.04%的细胞Sox2呈阳性表达,19.66%的细胞钙结合蛋白呈阳性表达,其余终末视网膜细胞标记物(胶质纤维酸性蛋白、CD90、视紫红质、C反应蛋白、突触前膜列阵蛋白)均呈极微量阳性或阴性。免疫荧光结果显示大部分细胞及细胞球(>90%)Nestin呈阳性表达。培养6d后,流式细胞分析显示43.36%的细胞Nestin阳性,免疫荧光显示Nestin及胶质纤维酸性蛋白呈阳性。连续4d3HThymidine分析及形态学观察、统计学分析原代视网膜前体细胞初期增殖良好。结论流式细胞分析、免疫荧光及3HThymidine等免疫学技术可很好的对视网膜前体细胞性质及其增殖情况进行鉴定。大鼠胚胎原代视网膜前体细胞表现出神经干细胞的特性,根据检测手段不同,阳性结果不同,其原代视网膜前体细胞体外培养初期增殖良好。

关键词：视网膜干细胞细胞,培养的细胞分裂流式细胞术

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Hepatosplenic T-cell lymphoma in a 47-year-old Crohn's disease patient on thiopurine monotherapy

引用

World Journal of Gastroenterology 2016年第47期22卷 10465-10470页

作者： Maartje M van de Meeberg Lauranne AAP Derikx Harm AM Sinnige Peet Nooijen D Lucette Schipper Loes HC nissen Department of Gastroenterology and Hepatology Jeroen Bosch Hospital Department of Hematology Jeroen Bosch Hospital Department of Pathology Jeroen Bosch Hospital

Hepatosplenic T-cell lymphoma(HSTCL) is a rare nonHodgkin lymphoma with a high mortality rate. Higher incidence is reported in patients with inflammatory bowel disease, specifically in male patients that are younger than 35 years, and have been treated with thiopurine and tumor necrosis factor(TNF)-α inhibitor combination therapy for over 2 years. In this case report we describe a 47-year-old patient with Crohn's disease(CD) who developed HSTCL after having been treated with thiopurine monotherapy for 14 years. To our best knowledge, only eleven cases exist of patients with CD who developed HSTCL while on thiopurine monotherapy. We report the first patient with CD, older than 35 years, who developed HSTCL while on thiopurine monotherapy. This emphasizes that HSTCL risk is not limited to young men receiving both thiopurines and TNF-α inhibitors.

关键词： Hepatosplenic T-cell lymphoma Thiopurine Crohn’s disease Immunosuppression

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Ciclosporin does not attenuate intracranial hypertension in rats with acute hyperammonaemia

引用

World Journal of Hepatology 2013年第9期5卷 513-520页

作者： Rikke Hebo Larsen Mette S Kjr Martin Eefsen Fin Stolze Larsen Peter nissen Bjerring Department of Hepatology RigshospitaletUniversity Hospital of Copenhagen2100 CopenhagenDenmark

AIM:To investigate the neuroprotective potential of ciclosporin during acute liver failure. We evaluated the effect of intrathecally administered ciclosporin on intracranial pressure, brain water content and aquaporin-4 expression in a rat model with acute ***:Twenty-four male Wistar rats with portacaval anastomosis were randomised into four groups receiving ciclosporin or vehicle and ammonia or saline infusion. Ciclosporin or vehicle was given intrathecally prior to the ammonia or saline infusion. The ammonia or saline infusion was given intravenously for 4 h,while intracranial pressure and arterial pressure was recorded. At the end of the experiment, cerebral cortex and cerebellar brain tissue was analysed for water and aquaporin-4 ***:The following intracranial pressures were found at the end of the experiment:ammonia + ciclosporin:10.0±1.7 mmHg, ammonia + vehicle:6.8±1.0mmHg, saline + ciclosporin:3.1±0.5 mmHg, saline +vehicle:3.3 ± 0.6 mmHg. Ammonia infusion had a significant effect on intracranial pressure and brain water content, which both were higher in the groups receiving ammonia(P0.2 micromolar)but did not reduce intracranial pressure after 4 h. Furthermore, ciclosporin did not attenuate the increase in cerebral water content, and did not affect ***:Intrathecal administration of ciclosporin does not attenuate intracranial hypertension or brain oedema in rats with portacaval anastomosis and 4 h of ammonia infusion.

关键词： Brain oedema Acute liver failure Neuroprotection Hyperammonaemia Ciclosporin

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：