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Insect Science 2017年第3期24卷 503-510页

作者： Pasquale Trematerra Annachiara Oliviero Sara Savoldelli matthias Scholler Department of Agricultural Environmental and Food Sciences University of Molise Via De Sanctis 86100 Campobasso Italy Department of Food Environmental and Nutritional Sciences Universit& degli Studi di Milano Via Celoria 2 20133 Milan Italy Faculty of Life Sciences Humboldt-Universit#t zu Berlin Lentzeallee 55/57 14195 Berlin Germany

A field experiment of 4 years＇ duration was carried out to evaluate the ef- ficacy of combining the mating disruption （MD） formulation Dismate ZETA （（9Z,12E）- tetradecadienyl acetate）, with the parasitoid Habrobracon hebetor against the Indianmeal moth Plodia interpunctella in a chocolate factory. The experimental period began early in 2011 and ended in late 2014. Begane Dismate dispensers were placed in the facility from 2011 to 2014 and H. hebetor was released in 2014. Pheromone-baited traps were used to monitor the flight activity of the male moths and oviposition Petri dish traps were placed to assess the progeny production ofP. interpunctella females. Following the start of MD, a decrease in the number ofP. interpunctella males caught in monitoring traps was observed from 2011 to 2013. A further decline in the moth population was noted in 2014, when MD was combined with the release of parasitoids. The presence of larvae in the oviposition cups was occasionally observed throughout the monitoring period, from 2011 to 2014. This study demonstrates that the combined system of MD and parasitoids is an effective and reliable technique that can be used to successfully control P. interpunctella.

关键词： control food processing integrated pest management mating disruption parasitoid Plodia interpunctella

Implicit Sampling,with Application to Data Assimilation

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Chinese Annals of Mathematics,Series B 2013年第1期34卷 89-98页

作者： Alexandre J.CHORIN matthias MORZFELD Xuemin TU Department of Mathematics University of California Lawrence Berkeley National Laboratory Department of Mathematics University of Kansas

There are many computational tasks, in which it is necessary to sample a given probability density function （or pdf for short）, i.e., to use a computer to construct a sequence of independent random vectors x~ （i ---- 1, 2, ~ ~ ~ ）, whose histogram converges to the given pdf. This can be difficult because the sample space can be huge, and more importantly, because the portion of the space, where the density is significant, can be very small, so that one may miss it by an ill-designed sampling scheme. Indeed, Markov- chain Monte Carlo, the most widely used sampling scheme, can be thought of as a search algorithm, where one starts at an arbitrary point and one advances step-by-step towards the high probability region of the space. This can be expensive, in particular because one is typically interested in independent samples, while the chain has a memory. The authors present an alternative, in which samples are found by solving an algebraic equation with a random right-hand side rather than by following a chain; each sample is independent of the previous samples. The construction in the context of numerical integration is explained, and then it is applied to data assimilation.

关键词： Importance sampling Bayesian estimation Particle filter Implicit filter Data assimilation

Additive effects of functionally dissimilar above- and belowground organisms on a grassland plant community

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Journal of Plant Ecology 2011年第4期4卷 221-227页

作者： Susanne Wurst matthias C.Rillig Plant Ecology/Functional Biodiversity Dahlem Centre of Plant SciencesInstitut für BiologieFreie Universität BerlinAltensteinstr.614195 BerlinGermany

In nature,plant communities are affected simultaneously by a variety of functionally dissimilar organisms both above and below the ***,there is a gap of knowledge on interactive effects of functionally dissimilar organisms on plant communities that is needed to be filled to better understand and predict the general impact of biotic factors on plant *** We conducted a full-factorial mesocosm study to investigate the individual and combined impacts of above-and belowground functionally dissimilar organisms on a grassland plant *** studied the effects of aboveground herbivores(Helix aspersa,Gastropoda),arbuscular mycorrhizal fungi(AMF;Glomus spp.,Glomeromycota)and endogeic earthworms(Aporrectodea spp.,Lumbricidae)on the diversity,structure and productivity of an experimental grassland plant community and each *** Findings Aboveground herbivory by snails decreased,AMF increased and earthworms had no effects on the diversity of the grassland plant community,while their combined effects were *** biomass of the plant community was negatively affected by snails and AMF,while no effects of earthworms or interaction effects were *** plant species were differently affected by snails and *** effects of the above-and belowground organisms on each other’s performance were *** the effects of the functionally dissimilar organisms on the grassland plant community were mainly independent,the results indicate that their combined effects may be predicted by knowing the individual effects,at least under the conditions used in the present mesocosm study.

关键词： aboveground–belowground interactions AMF earthworms snails

Mdm2 as a chromatin modifier

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Journal of Molecular Cell Biology 2017年第1期9卷 74-80页

作者： Magdalena Wienken Ute M. Moll matthias Dobbelstein Institute of Molecular Oncology Gottingen Center for Molecular Biosciences (GZMB) University Medical Center Gottingen Gottingen 37077 Germany Department of Pathology School of Medicine Stony Brook University Stony Brook NY 11794 USA

Mdm2 is the key negative regulator of the tumour suppressor p53, making it an attractive target for anti-cancer drug design. We recently identified a new role of Mdm2 in gene repression through its direct interaction with several proteins of the polycomb group （PcG） family. PcG proteins form polycomb repressive complexes PRC1 and PRC2. PRC2 （via EZH2） mediates histone 3 lysine 27 （H3K27） trimethyiation, and PRC1 （via RING1B） mediates histone 2A tysine 119 （H2AK119） monoubiquitination. Both PRCs mostly support a compact and transcriptionally silent chromatin structure. We found that Mdm2 regulates a gene expression pro- file similar to that of PRC2 independent of p53. Moreover, Mdm2 promotes the sternness of murine induced pluripotent stem cells and human mesenchymal stem cells, and supports the survival of tumour cells. Mdm2 is recruited to target gene promoters by the PRC2 member and histone methyltransferase EZH2, and enhances PRC-dependent repressive chromatin modifications, specif- icaUy H3K27me3 and H2AK119ubl. Mdm2 also cooperates in gene repression with the PRC1 protein RINGIB, a H2AK119 ubiqui- tin ligase. Here we discuss the possible implications of these p53-independent functions of Mdm2 in chromatin dynamics and in the stem cell phenotype. We propose that the p53-independent functions of Mdm2 should be taken into account for cancer drug design. So far, the majority of clinically tested Mdm2 inhibitors target its binding to p53 but do not affect the new functions of Mdm2 described here. However, when targeting the E3 ligase activity of Mdm2, a broader spectrum of its oncogenic activities might become druggable.

关键词： Mdm2 polycomb repressor complex histone methylation histone ubiquitination EZH2

Computer planned, image-guided combined resection and ablation for bilobar colorectal liver metastases

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World Journal of Gastroenterology 2014年第40期20卷 14992-14996页

作者： Vanessa M Banz matthias Baechtold Stefan Weber matthias Peterhans Daniel Inderbitzin Daniel Candinas Department of Visceral Surgery and Medicine Inselspital Berne University Hospital University of Berne CH-3010 Berne Switzerland ARTORG Center for Computer-Aided Surgery University of Berne CH-3010 Berne Switzerland

For patients with extensive bilobar colorectal liver metastases (CRLM), initial surgery may not be feasible and a multimodal approach including microwave ablation (MWA) provides the only chance for prolonged survival. Intraoperative navigation systems may improve the accuracy of ablation and surgical resection of so-called “vanishing lesions”, ultimately improving patient outcome. Clinical application of intraoperative navigated liver surgery is illustrated in a patient undergoing combined resection/MWA for multiple, synchronous, bilobar CRLM. Regular follow-up with computed tomography (CT) allowed for temporal development of the ablation zones. Of the ten lesions detected in a preoperative CT scan, the largest lesion was resected and the others were ablated using an intraoperative navigation system. Twelve months post-surgery a new lesion (Seg IVa) was detected and treated by trans-arterial embolization. Nineteen months post-surgery new liver and lung metastases were detected and a palliative chemotherapy started. The patient passed away four years after initial diagnosis. For patients with extensive CRLM not treatable by standard surgery, navigated MWA/resection may provide excellent tumor control, improving longer-term survival. Intraoperative navigation systems provide precise, real-time information to the surgeon, aiding the decision-making process and substantially improving the accuracy of both ablation and resection. Regular follow-ups including 3D modeling allow for early discrimination between ablation zones and recurrent tumor lesions.

关键词： Computer navigation Colorectal liver metastases Image-guidance Microwave ablation Tumor

Malnutrition affects quality of life in gastroenterology patients

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World Journal of Gastroenterology 2006年第21期12卷 3380-3385页

作者： Kristina Norman Henriette Kirchner Herbert Lochs matthias Pirlich Klinik mil Schwerpunkt Gastroenterologie Hepatologie und Endokrinologie Charité-Universit(a|¨)tsmedizin Berlin Campus MitteGermany

AIM： To investigate the association between malnutrition and quality of life in patients with benign gastrointestinal ***： Two hundred patients （104 wellnourished and 96 malnourished） were assessed according to the Subjective Global Assessment, anthropometric measurements and bioelectrical impedance analysis. Quality of life was determined with the validated Medical Outcomes Study 36-item Short-Form General Health Survey （SF 36）. Muscle function was assessed by hand grip strength and peak ***： Body mass index, body cell mass, arm muscle area and hand grip strength were significantly lower in the malnourished patients. Quality of life was generally lower when compared to norm values. Seven out of eight quality of life scales （excluding bodily pain） were significantly reduced in the malnourished patients. Comparing patients with liver cirrhosis and inflammatory bowel disease （IBD）, patients with IBD experienced significantly lower values in the perception of bodily pain, social functioning and rnenta/health. Malnourished liver cirrhotics suffered reductions in more scales （six out of eight） than malnourished IBD patients did （four out of eight）.CONCLUSION： Quality of life is generally low in benign gastrointestinal disease and is further reduced in patients who are classified as malnourished. It appears that liver cirrhosis patients experience a higher quality of life than IBD patients do, but the impact of malnutrition seems to be greater in liver cirrhosis than in IBD.

关键词： Quality of life Malnutrition Gastrointestinal disease Liver cirrhosis Inflammatory bowel disease

Experimental study on the tribo-chemical smoothening process between self-mated silicon carbide in a water-lubricated surfacecontact reciprocating test

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Friction 2019年第2期7卷 181-191页

作者： Le JIN Herbert SCHEERER Georg ANDERSOHN matthias OECHSNER Dieter HELLMANN Center for Structural Materials Technische Universit?t Darmstadt KSB

Silicon carbide(SiC) can be tribo-chemically smoothened during a self-mated sliding procedure in the aqueous environment. As well reported in the point-contact tests, this smoothening process works well due to the abundant water as oxidant. After this smoothening process, the tribo-surface is well polished, a closely mated tribo-gap naturally forms, and an ultra-low friction state is built. However, water in the tribo-gap could be insufficient in industrial applications, e.g., the seal gap in mechanical seals. In this study, the tribo-chemical smoothening behavior in such environment was researched. A surface-contact reciprocating test was used to simulate the aqueous environment where water was insufficient. After tests, compared to the published results from the point-contact tests, the same ultra-low friction state was achieved. A part of the tribo-surface was tribo-chemically smoothened. The obtained smoothened surface microstructure was consistent with the published information. Meanwhile, severe abrasive wear occurred. A porous oxygen-rich layer was found existing beneath the abrasion-induced grooves, in which numerous smashed wear debris adhered on the worn surfaces. We concluded that the shortage of water initiated the severe abrasion, meanwhile the generated wear debris aggravated the wear condition. This understanding is instructive for developing new methods to avoid the severe abrasion in the same water insufficient environment.

关键词： silicon carbide surface-contact sliding friction tribo-chemical smoothening abrasion ultra-low friction mechanical seal

Plant Surfaces:Structures and Functions for Biomimetic Innovations

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Nano-Micro Letters 2017年第2期9卷 116-155页

作者： Wilhelm Barthlott matthias Mail Bharat Bhushan Kerstin Koch Nees Institute for Biodiversity of Plants Rheinische Friedrich-Wilhelms University of BonnVenusbergweg 2253115 BonnGermany Institute of Crop Science and Resource Conservation(INRES)–Horticultural Science Rheinische Friedrich-Wilhelms University of BonnAuf dem Hugel 653121 BonnGermany

An overview of plant surface structures and their evolution is presented. It combines surface chemistry and architecture with their functions and refers to possible biomimetic applications. Within some 3.5 billion years biological species evolved highly complex multifunctional surfaces for interacting with their environments: some 10 million living prototypes(i.e., estimated number of existing plants and animals) for engineers. The complexity of the hierarchical structures and their functionality in biological organisms surpasses all abiotic natural surfaces: even superhydrophobicity is restricted in nature to living organisms and was probably a key evolutionary step with the invasion of terrestrial habitats some 350–450 million years ago in plants and insects. Special attention should be paid to the fact that global environmental change implies a dramatic loss of species and with it the biological role models. Plants, the dominating group of organisms on our planet, are sessile organisms with large multifunctional surfaces and thus exhibit particular intriguing *** and superhydrophobicity are focal points in this work. We estimate that superhydrophobic plant leaves(e.g., grasses) comprise in total an area of around 250 million km^2, which is about 50% of the total surface of our planet. A survey of structures and functions based on own examinations of almost 20,000 species is provided, for further references we refer to Barthlott et al.(Philos. Trans. R. Soc. A 374: 20160191, 1). A basic difference exists between aquatic nonvascular and land-living vascular plants; the latter exhibit a particular intriguing surface chemistry and architecture. The diversity of features is described in detail according to their hierarchical structural order. The first underlying and essential feature is the polymer cuticle superimposed by epicuticular wax and the curvature of single cells up to complex multicellular structures. A descriptive terminology for t

关键词： Bionics Superhydrophobicity Hierarchical structuring Lotus effect Salvinia effect Evolution

Phosphorus recovery from municipal and fertilizer wastewater:China's potential and perspective

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Journal of Environmental Sciences 2017年第2期29卷 151-159页

作者： Kuangxin Zhou matthias Barjenbruch Christian Kabbe Goulven Inial Christian Remy Berlin Centre of Competence for Water Berlin 10709Germany Department of Urban Water Management Technical University of BerlinBerlin 13355Germany Research&Innovation Asia Veolia EnvironmentBeijing 10004China

Phosphorus（P） is a limited resource, which can neither be synthesized nor substituted in its essential functions as nutrient. Currently explored and economically feasible global reserves may be depleted within generations. China is the largest phosphate fertilizer producing and consuming country in the world. China’s municipal wastewater contains up to 293,163 Mg year of phosphorus, which equals approximately 5.5% of the chemical fertilizer phosphorus consumed in China. Phosphorus in wastewater can be seen not only as a source of pollution to be reduced, but also as a limited resource to be recovered. Based upon existing phosphorus-recovery technologies and the current wastewater infrastructure in China, three options for phosphorus recovery from sewage sludge, sludge ash and the fertilizer industry were analyzed according to the specific conditions in China.

关键词： Phosphorus recovery Municipal Wastewater Fertilizer Industry Sewage sludge China

Ultra-fast interpretable machine-learning potentials

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npj Computational Materials 2023年第1期9卷 649-657页

作者： Stephen R.Xie matthias Rupp Richard G.Hennig Department of Materials Science and Engineering University of FloridaGainesvilleFLUSA Quantum Theory Project University of FloridaGainesvilleFLUSA Department of Computer and Information Science University of KonstanzKonstanzGermany Materials Research and Technology Department Luxembourg Institute of Science and Technology(LIST)Esch-sur-AlzetteLuxembourg

All-atom dynamics simulations are an indispensable quantitative tool in physics,chemistry,and materials science,but large systems and long simulation times remain challenging due to the trade-off between computational efficiency and predictive *** address this challenge,we combine effective two-and three-body potentials in a cubic B-spline basis with regularized linear regression to obtain machine-learning potentials that are physically interpretable,sufficiently accurate for applications,as fast as the fastest traditional empirical potentials,and two to four orders of magnitude faster than state-of-the-art machine-learning *** data from empirical potentials,we demonstrate the exact retrieval of the *** data from density functional theory,the predicted energies,forces,and derived properties,including phonon spectra,elastic constants,and melting points,closely match those of the reference *** introduced potentials might contribute towards accurate all-atom dynamics simulations of large atomistic systems over long-time scales.

关键词： method spline faster