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Diagnostic delay in inflammatory bowel diseases in a German population

World Journal of Gastroenterology 2024年第29期30卷 3465-3478页

作者： Elisabeth Blüthner Annalena Dehe Carsten Büning Britta Siegmund matthias Prager Jochen Maul Alexander Krannich Jan Preiß Bertram Wiedenmann Florian Rieder Raneem Khedraki Frank Tacke Andreas Sturm Anja Schirbel Department of Hepatology and Gastroenterology Campus Virchow-Klinikum and Campus CharitéMitteCharité-Universitätsmedizin BerlinBerlin 10117Germany Department of Gastroenterology Vivantes Klinikum im FriedrichshainBerlin 10249Germany Department of Internal Medicine Krankenhaus WaldfriedeBerlin 14163Germany Department of Gastroenterology Infectious Diseases and RheumatologyCharité-Universitätsmedizin BerlinBerlin 12203Germany Praxis für Gastroenterologie Berlin Zehlendorf Berlin 14195Germany Gastroenterologie am Bayrischen Platz Berlin 10825Germany Clinical Trial Office Charité-Universitätsmedizin BerlinBerlin 10117Germany Department of Gastroenterology Diabetology and HepatologyVivantes Klinikum NeuköllnBerlin 10117Germany Department of Gastroenterology Hepatology and NutritionDigestive Diseases and Surgery InstituteThe Cleveland Clinic FoundationClevelandOH 44195United States Department of Internal Medicine DRK Kliniken Berlin WestendBerlin 14050Germany Gastroenterologie im Havelland Straße der EinheitFalkensee 14612Germany

BACKgrOUND Early diagnosis is key to prevent bowel damage in inflammatory bowel disease(IBD).Risk factor analyses linked with delayed diagnosis in European IBD patients are scarce and no data in German IBD patients *** To identify risk factors leading to prolonged diagnostic time in a German IBD *** Between 2012 and 2022,430 IBD patients from four Berlin hospitals were enrolled in a prospective study and asked to complete a 16-item questionnaire to determine features of the path leading to IBD *** diagnostic time was defined as the time from symptom onset to consulting a physician(patient waiting time)and from first consultation to IBD diagnosis(physician diagnostic time).Univariate and multivariate analyses were performed to identify risk factors for each time *** The total diagnostic time was significantly longer in Crohn’s disease(CD)compared to ulcerative colitis(UC)patients(12.0 vs 4.0 mo;P<0.001),mainly due to increased physician diagnostic time(5.5 vs 1.0 mo;P<0.001).In a multivariate analysis,the predominant symptoms diarrhea(P=0.012)and skin lesions(P=0.028)as well as performed gastroscopy(P=0.042)were associated with longer physician diagnostic time in CD *** UC,fever was correlated(P=0.020)with shorter physician diagnostic time,while fatigue(P=0.011)and positive family history(P=0.046)were correlated with longer physician diagnostic *** We demonstrated that CD patients compared to UC are at risk of long diagnostic *** efforts should focus on shortening the diagnostic delay for a better outcome in these patients.

关键词： Diagnostic time Diagnostic delay Crohn’s disease Ulcerative colitis Germany

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点火源管理:泵安全监测的新视角

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流程工业 2024年第9期 44-45页

作者： matthias Garbsch Jumo公司

近年来,在防爆环境中,泵的安全监测已不再局限于预防性维护和运行数据的收集,点火源的监控显得尤为关键。因此,准确进行风险评估的重要性日益凸显。精确的风险评级有助于我们更好地识别和控制潜在的安全隐患,从而有效预防事故,保障生产... 详细信息

近年来,在防爆环境中,泵的安全监测已不再局限于预防性维护和运行数据的收集,点火源的监控显得尤为关键。因此,准确进行风险评估的重要性日益凸显。精确的风险评级有助于我们更好地识别和控制潜在的安全隐患,从而有效预防事故,保障生产安全和人员安全。

关键词：风险评级预防性维护点火源预防事故风险评估安全监测安全隐患新视角

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Improving the operational stability of perovskite solar cells with cesium-doped graphene oxide interlayer

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Journal of Energy Chemistry 2024年第9期96卷 483-490页

作者： Masaud Almalki Katerina Anagnostou Konstantinos Rogdakis Felix T.Eickemeyer Mostafa Othman Minas M.Stylianakis Dimitris Tsikritzis Anwar Q.Alanazi Nikolaos Tzoganakis Lukas Pfeifer Rita Therisod Xiaoliang Mo Christian M.Wolff Aïcha Hessler-Wyser Shaik M.Zakeeruddin Hong Zhang Emmanuel Kymakis Michael grätzel Laboratory of Photonics and Interfaces École Polytechnique Fédérale de Lausanne(EPFL)Lausanne 1015Switzerland Department of Electrical and Computer Engineering Hellenic Mediterranean UniversityHeraklionCrete 71410Greece Institute of Electrical and Microengineering(IEM)Photovoltaics and Thin-Film Electronics Laboratory(PV-Lab) École Polytechnique Fédérale de Lausanne(EPFL)Neuchâtel 2000Switzerland Department of Nursing Faculty of Health SciencesHellenic Mediterranean UniversityCrete 71410Greece Centre Interdisciplinaire de Microscopie Electronique École Polytechnique Fédérale de Lausanne(EPFL)Lausanne 1015Switzerland Future Energy Technology Institute King Abdulaziz City for Science and Technology(KACST)P.O.Box 6086Riyadh 11442Saudi Arabia State Key Laboratory of Photovoltaic Science and Technology Shanghai Frontiers Science Research Base of Intelligent Optoelectronics and PerceptionInstitute of OptoelectronicsDepartment of Materials ScienceFudan UniversityShanghai 200433China

Perovskite solar cells(PSCs)have made great advances in terms of power conversion efficiency(PCE),yet their subpar stability continues to hinder their *** interface between the perovskite layer and the charge-carrier transporting layers plays a crucial role in undermining the stability of *** this work,we propose a strategy to stabilize high-performance PSCs with PCE over 23%by introducing a cesium-doped graphene oxide(GO-Cs)as an interlayer between the perovskite and hole-transporting *** GO-Cs treated PSCs exhibit excellent operational stability with a projected T80(the time where the device PCE reduces to 80%of its initial value)of 2143 h of operation at the maximum powering point under one sun illumination.

关键词： Perovskite solar cells Doped graphene oxide graphene related material Long-term operational stability

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Fuzzy Henstock-Kurzweil Triple Integral on a Type 1 Quasi-Fuzzy Parallelepipedal Domain

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Journal of Applied Mathematics and Physics 2024年第3期12卷 897-911页

作者： Kumwimba Seya Didier Kasongo Ntambwe Dany Panga Lutanda grégoire Mayuke Katshongo Jean Paul Lunda Ngoy Jean Pierre Département de Mathématiques et Informatique Faculté des Sciences Université de Lubumbashi Lubumbashi Democratic Republic of the Congo

In this article, we propose by using the Hausdorff distance Simpson’s rule for the triple integral of a fuzzy-valued function and the error bound of this method, one of the variables of which is fuzzy. In addition, thin δ-fine partitions are introduced. The integration domain is a quasi-fuzzy parallelipiped. A numerical example is presented in order to show the application and the significance of the method.

关键词： Fuzzy-Valued Function Hausdorff Distance Quasi-Fuzzy Parallelipiped Henstock Integral

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Immune consequences of exercise in hypoxia:A narrative review

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Journal of Sport and Health Science 2024年第3期13卷 297-310,I0002页

作者： Johannes Burtscher Qadar Pasha Neha Chanana gregoire P.Millet Martin Burtscher Barbara Strasser Institute of Sport Sciences University of LausanneLausanne 1015Switzerland Institute of Hypoxia Research New Delhi 110067India Department of Biochemistry Jamia HamdardNew Delhi 110062India Department of Sport Science University of InnsbruckInnsbruck 6020Austria Faculty of Medicine Sigmund Freud Private UniversityVienna 1020Austria Ludwig Boltzmann Institute for Rehabilitation Research Vienna 1100Austria

Immune outcomes are key mediators of many health benefits of exercise and are determined by exercise type,dose(frequency/duration,intensity),and individual ***,reduced availability of ambient oxygen(hypoxia)modulates immune functions depending on the hypoxic dose and the individual capacity to respond to *** combined exercise and hypoxia(e.g.,high-altitude training)sculpts immune responses is not well understood,although such combinations are becoming increasingly ***,in this paper,we summarize the impact on immune responses of exercise and of hypoxia,both independently and together,with a focus on specialized cells in the innate and adaptive immune *** review the regulation of the immune system by tissue oxygen levels and the overlapping and distinct immune responses related to exercise and hypoxia,then we discuss how they may be modulated by nutritional ***,antioxidant,and anti-inflammatory mechanisms underlie many of the adaptations that can lead to improved cellular metabolism,resilience,and overall immune functions by regulating the survival,differentiation,activation,and migration of immune *** review shows that exercise and hypoxia can impair or complement/synergize with each other while regulating immune system *** acclimatization,training,and nutritional strategies can be used to avoid risks and tap into the synergistic potentials of the poorly studied immune consequences of exercising in a hypoxic state.

关键词： Altitude Exercise Hypoxia Immune response Training

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The WhatsApp Application as a Teledentistry Tool in Oral and Maxillofacial Surgery in Cameroon

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Open Journal of Stomatology 2024年第8期14卷 362-372页

作者： Karl Guy grégoire Kwedi Ruth Karen Katia Kwedi Fred-Cyrille Goethe Doualla Charles Eboa Kwedi Charles Bengondo Messanga Department of Oral Maxillofacial and Periodontal Surgery Faculty of Medicine and Biomedical Sciences University of Yaound 1 Yaound Cameroon Department of Public Health School of Health Sciences Catholic University of Central Africa Yaound Cameroon Society & Education Technologies Yaound Cameroon Health Medical School Douala Cameroon

Introduction: Technological advances have greatly influenced the healthcare sector. The ability to transmit information and deliver services using telecommunication tools continues to transform the way healthcare is delivered around the world. The aim of this study was to highlight the epidemiological, clinical and therapeutic profile of oral and maxillofacial surgery patients consulted using the WhatsApp application. Methodology: This was a three-year descriptive study with a retrospective data collection, from 2021 to 2023, of WhatsApp communications between our team and oral and maxillofacial surgeons in Cameroon. In this study, the type/content of messages received, the epidemiological data of practitioners and patients, the various pathologies diagnosed and the procedures performed were evaluated. Results: 319 communications were received for a total of 146 cases. Written messages associated with images (photographs and/or X-rays) were the most frequently received, at 85.62%. Hospitals in urban areas were the most represented at 93.84%. Oral health professionals in the private sector sent more messages (65.75%). In terms of diagnoses, tumour and cystic pathologies were the most common (28.08%), followed by impacted/retained teeth (22.6%). Patients were referred to our hospital for treatment in 62.33% of cases. Conclusion: The WhatsApp application is an easy-to-use telecommunications tool. It facilitates exchanges between practitioners and improves patient care in oral and maxillofacial surgery.

关键词： Teledentistry WhatsApp Oral and Maxillofacial Surgery Cameroon

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Global warming scenarios for the Eastern Adriatic Sea indicate a higher risk of invasiveness of non-native marine organisms relative to current climate conditions

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Marine Life Science & Technology 2024年第1期6卷 143-154页

作者： Branko Glamuzina Lorenzo Vilizzi Marina Piria Ante Zuljevic Ana Bratos Cetinic Ana Pesic Branko Dragicevic Lovrenc Lipej Marijana Pecarevic Vlasta Bartulovic Sanja grđan Ivan Cvitkovic Tatjana Dobroslavic Ana Fortic Luka Glamuzina Borut Mavric Jovana Tomanic Marija Despalatovic Domen Trkov Marina Brailo Scepanovic Zoran Vidovic Predrag Simonovic Sanja Matic-Skoko Pero Tutman Department of Applied Ecology University of DubrovnikDubrovnikCroatia Department of Ecology and Vertebrate Zoology Faculty of Biology and Environmental ProtectionUniversity of LodzLodzPoland Faculty of Agriculture Department of FisheriesApicultureWildlife Management and Special ZoologyUniversity of ZagrebZagrebCroatia Institute of Oceanography and Fisheries SplitCroatia Institute of Marine Biology University of MontenegroKotorMontenegro National Institute of Biology Marine Biology Station PiranPiranSlovenia Teacher Education Faculty University of BelgradeBelgradeSerbia Faculty of Biology University of BelgradeBelgradeSerbia

Globally,marine bioinvasions threaten marine ecosystem structure and function,with the Mediterranean Sea being one of the most affected *** invasions are expected to increase due to climate *** conducted a risk screening of marine organisms(37 fishes,38 invertebrates,and 9 plants),both extant and‘horizon’(i.e.,not present in the area but likely to enter it).Based on expert knowledge for the Eastern Adriatic Sea coasts of Slovenia,Croatia,and Montenegro,screenings were conducted under both current and predicted climate conditions indicating with an increase in sea surface temperature and salinity of the Adriatic Sea together with changes in precipitation *** aims were to:(1)identify non-native extant and horizon marine species that may pose threats to native biodiversity and(2)evaluate the risk of invasiveness of the selected species under current and predicted climate *** the 84 species screened,there was an increase in those ranked as‘high risk’from 33(39.3%)under current climate conditions and to 47(56.0%)under global warming *** those ranked as‘very high’risk,the increase was from 6(7.1%)to 21(25.0%).Amongst the screened species,the already established high-risk species Pacific oyster Magallana gigas and Atlantic blue crab Callinectes sapidus represent a threat to ecosystem *** the under-representation of marine species in the current European Union List,the species we have ranked as high to very high risk should be included.

关键词： AS-ISK Early detection Introduction vectors/pathways Invasive species Rapid response

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Nutraceutical Potentiality of Fruits of Red Variety of Pseudospondias microcarpa (A. Rich) Engl.

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Food and Nutrition Sciences 2024年第3期15卷 224-234页

作者： Babouongolo Sévère-grébel Niang Lahat Nkounkou-Loumpangou Célestine Bonazaba Milandou Longin Justin Clair Ouamba Jean-Maurille Plant and Life Chemistry Unit (UC2V in French) Faculty of Science and Techniques University Marien Ngouabi Brazzaville Republic of the Congo Eau-Energie-Environnement and Industrial Processes Laboratory (LE3PI in French) University of Dakar Dakar Sénégal

The red fruits of Pseudospondias microcarpa (A. Rich) Engl. are widely consumed by the populations of northern Congo for their sweet and tangy flavor as well as for their characteristic smell. The objective of this study was to show the food potential of the fruits of this plant for their valorization. Organic solvent extracts were prepared and subjected to phytochemical screening to determine the nutrients and phytonutrients of this fruit. Raw juice was extracted by trituration without adding water and subjected to physicochemical and biochemical analyses in order to determine its quality and its antiradical activity. The raw juice obtained is moderately acidic (pH 3.28), very cloudy and colored (turbidity of 1019 NTU). It has a dry matter content of 3.771% ± 0.013% reflecting the 70% dominance of water in the weight of the fruit and the presence of dissolved organic matter in its juice. Energy nutrients (sugars, amino acids), carotenoids, coumarins, tannins, flavonoids, terpenes and sterols have been highlighted as nutrients with therapeutic potential commonly called phytonutrients of this fruit. The juice presented a dominance in polyphenols (134.8500 ± 0.0023 mg gallic acid/100 g) than in carotenoids (5.100 ± 0.010 mg carotene/100 g), high levels of mineral macroelements (calcium: 3570.00 ± 2.05 mg and potassium: 4576.00 ± 9.49 mg) and trace elements (copper: 11.13 ± 0.10 mg, iron: 3.02 ± 0.03 mg and zinc: 2.57 ± 0.08 mg). These compounds exhibited good antioxidant activity. The presence of these nutrients and phytonutrients in these fruits is interesting for the proper functioning of certain organs and the prevention of certain diseases. This fruit is therefore an energizing and functional food that can compete with conventional fruits whose juices are marketed.

关键词： Alicament Fruit Juice Pseudospondias microcarpa Phytochemistry

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Beyond the Expected-Residual Risk and Cases of Overload in the Context of Managing Alpine Natural Hazards

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International Journal of Disaster Risk Science 2021年第2期12卷 205-219页

作者： Sönke Hartmann Lydia Pedoth Cristina Dalla Torre Stefan Schneiderbauer Eurac Research Institute for Earth Observation39100BolzanoSouth TyrolItaly Eurac Research Institute for Regional Development39100BolzanoSouth TyrolItaly Institute for Environment and Human Security United Nations University53113BonnGermany

Structural protection measures are designed to protect the population and infrastructure against natural hazards up to a specific predefined protection *** events with intensities that exceed the capacity of these protection structures are called“cases of overload”and are associated with“residual risks”that remain after the implementation of protection *** order to address residual risks and to reduce the damages from overload events,a combination of structural protection measures with additional,nonstructural measures is *** on data collected through a literature review,a questionnaire survey,expert interviews,and an expert workshop we highlight the status quo as well as key challenges of dealing with residual risks and cases of overload in Alpine countries in the context of geohydrological hazards and gravitational mass *** present a holistic conceptual framework that describes the relationships of residual risks,cases of overload,and protection goals in the context of both risk governance and integrated risk *** framework is valuable for decision makers aiming at an improved management of natural hazards that takes adequate account of residual risk and cases of overload in Alpine countries and mountain areas worldwide.

关键词： Alpine countries Cases of overload Integrated risk management Natural hazards Residual risk Risk governance

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涂层辊筒技术——非织造布整理用涂层辊筒装置的多功能工艺理念

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纺织导报 2009年第9期 77-78页

作者： Bernhard Funger Kerstin grnke Andritz Küsters(安德里兹寇司德)公司

单面低加料率的涂层辊简装置应用在非织造布工业中有着悠久的历史，绝大多数用于非织造尿布顶层的低加料率，单面亲水或永久亲水。Andritz Küsters（安德里兹寇司德）为进行高速生产的非织造布工业客户（速度高至1000m／min）提供量身... 详细信息

单面低加料率的涂层辊简装置应用在非织造布工业中有着悠久的历史，绝大多数用于非织造尿布顶层的低加料率，单面亲水或永久亲水。Andritz Küsters（安德里兹寇司德）为进行高速生产的非织造布工业客户（速度高至1000m／min）提供量身定做的neXkiss涂层辊简产品系列。最新开发的neXkissplus拥有特殊的灵活性和最大的生产多功能性。

关键词：非织造布工业多功能性涂层装置工艺整理技术辊筒

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