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The Glacial(MIS 3-2)Outlet Glacier of the Marsyandi Nadi-icestream-network with its Ngadi Khola Tributary Glacier(Manaslu-and Lamjung Himalaya):The Reconstructed Lowering of the Marsyandi Nadi Ice Stream Tongue down in to the Southern Himalaya Foreland

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Journal of Mountain Science 2014年第1期11卷 236-287页

作者： matthias KUHLE Department of Geography and High Mountain Geomorphology University of Gottingen

For the reconstruction of past climate variations,investigations on the history of glaciers are *** the Himalaya,investigations like these have a rather short tradition in comparison with other mountains on *** the same time,this area on the southern margin of Tibet is of special interest because of the question as to the monsoon-influence that is connected with the ***,the climate of High Asia is of global *** for the further and regionally intensifying answer to this question,a glacial glacier reconstruction is submitted from the CentralHimalaya,more exactly from the *** on down-valley from the glacial-historical investigations of 1977 in the upper Marsyandi Khola(Nadi) and the partly already published results of field campaigns in the middle Marsyandi Khola and the Damodar- and Manaslu Himal in the years 1995,2000,2004 and 2007,new geomorphological and geological field- and laboratory data are introduced here from the Ngadi(Nadi) Khola and the lower Marsyandi Nadi from the inflow of the Ngadi(Nadi) Khola down to the southern mountain *** has existed a connected ice-stream-network drained down to the south by a 2,100-2,200 m thick and 120 km long Marsyandi Nadi main valley *** a height of the valley bottom of c.1,000 m *** Ngadi Khola glacier joined the still c.1,300 m thick Marsyandi parent glacier from the Himalchuli-massif(Nadi(Ngadi) Chuli) – the south spur of the Manaslu *** here the united glacier tongue flowed down about a further 44 km to the south up to c.400 m a.s.l.(27°57'38 "N/84°24'56" E) into the Himalaya fore-chains and thus reached one of or the lowest past ice margin position of the *** glacial(LGP(Last glacial period),LGM(Last glacial maximum) Würm,Stage 0,MIS 3-2) climatic snowline(ELA = equilibrium line altitude) has run at 3,900 to 4,000 m *** thus c.1,500 altitude meters below the current ELA(Stage XII) at 5,400-5,500 m *** r

关键词： Ice Age Glaciation Himalaya Manaslu Ngadi Khola Icestream network Last Glacial period

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利用择形分子筛异构化亚甲基二苯胺

Chinese Journal of Catalysis 2024年第7期62卷 124-130页

作者： Sam Van Minnebruggen Ka Yan Cheung Trees De Baerdemaeker Niels Van Velthoven matthias Degelin Galahad O’Rourke Hiroto Toyoda Andree Iemhoff Imke Muller Andrei-Nicolae Parvulescu Torsten Mattke Jens Ferbitz 吴勤明肖丰收 Toshiyuki Yokoi Nils Bottke Dirk De Vos 巴斯夫股份有限公司膜分离、吸附、催化和光谱学可持续解决方案中心(cMACS) 比利时巴斯夫股份有限公司研究组德国东京工业大学纳米空间催化研究所横滨日本浙江大学化学系浙江杭州310028

亚甲基二苯胺(MDA)被广泛用作生产聚氨酯和聚异氰脲酸酯的中间体.然而,当前MDA的生产工艺在控制(4,4’/(2,4’+2,2’))异构体比例方面还存在局限.其中,4,4’-MDA被认为是最有价值的异构体.尽管2,4'-MDA在市场上也有一定的需求,但如果能... 详细信息

亚甲基二苯胺(MDA)被广泛用作生产聚氨酯和聚异氰脲酸酯的中间体.然而,当前MDA的生产工艺在控制(4,4’/(2,4’+2,2’))异构体比例方面还存在局限.其中,4,4’-MDA被认为是最有价值的异构体.尽管2,4'-MDA在市场上也有一定的需求,但如果能将其有效地转化为4,4'-MDA,将能显著提升其附加值.本文在使用苯胺的条件下,利用β分子筛等催化剂,通过双分子机制,可以选择性地将2,4'-MDA异构化为4,4'-MDA.尽管实验显示,多种酸性沸石具有较高的异构化活性,但MCM-68(具有MSE拓扑结构)的催化性能尤为出色,它不仅展现出高异构化活性,而且具有很好的选择性.MCM-68主要催化2,4'-MDA异构化为4,4'-MDA,而2,2'-MDA和低聚物的形成则可以忽略不计.本文还深入探讨了该择形作用的原因,并详细研究了酸位置在MSE分子筛孔道限制中的关键作用.

关键词：铝分布多相催化异构化亚甲基二苯胺聚氨酯择形

High-order discontinuous Galerkin method for applications to multicomponent and chemically reacting flows

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Acta Mechanica Sinica 2017年第3期33卷 486-499页

作者： Yu Lv matthias Ihme Department of Mechanical Engineering Stanford University

This article focuses on the development of a discontinuous Galerkin (DG) method for simulations of multicomponent and chemically reacting flows. Compared to aerodynamic flow applications, in which DG methods have been successfully employed, DG simulations of chemically reacting flows introduce challenges that arise from flow unsteadiness, combustion, heat release, compressibility effects, shocks, and variations in thermodynamic properties. To address these challenges, algorithms are developed, including an entropy-bounded DG method, an entropy-residual shock indicator, and a new formulation of artificial viscosity. The performance and capabilities of the resulting DG method are demonstrated in several relevant applications, including shock/bubble interaction, turbulent combustion, and detonation. It is concluded that the developed DG method shows promising performance in application to multicomponent reacting flows. The paper concludes with a discussion of further research needs to enable the application of DG methods to more complex reacting flows.

关键词： Discontinuous Galerkin method High-order schemes Reacting flows Multicomponent flows

Quantifying the effect of persistent dryer climates on forest productivity and implications for forest planning:a case study in northern Germany

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Forest Ecosystems 2018年第4期5卷 451-471页

作者： matthias Albert Ralf-Volker Nagel Johannes Sutmoller matthias Schmidt Department of Forest Growth Northwest German Forest Research Institute GottingenGermany Department of Environmental Control Northwest German Forest Research InstituteGottingenGermany.

Background: Forest management decisions are based on expectations of future developments. For sound decisions it is essential to accurately predict the expected values in future developments and to account for their inherent uncertainty,for example the impact of climate change on forests. Changing climatic conditions affect forest productivity and alter the risk profile of forests and forest enterprises. Intensifying drought stress is seen as one major risk factor threatening forest management in the north German lowlands. Drought stress reduces tree growth and vitality and might even trigger mortality. But so far, it is not possible to quantify effects of a persistent dryer climate on forest productivity at a level suitable for forest ***: We apply a well-established single-tree forest growth simulator to quantify the effect of persistent dryer climates on future forest productivity. We analyse the growth of Scots pine(Pinus sylvestris L.), European beech(Fagus sylvatico L.) and oak(Quercus robur L. and Quercus petraea(Matt.) Liebl.) in two forest regions in the north German lowlands for a time interval of 60 years until 2070. The growth response under three different climate projections is compared to a baseline ***: The results show clear differences in volume increment to persistent dryer climates between tree species. The findings exhibit regional differences and temporal trends. While mean annual increment at biological rotation age of Scots pine and oak predominantly benefits from the projected climate conditions until 2070, beech might suffer losses of up to 3 m^3·ha^(-1)yr^(-1) depending on climate scenario and region. However, in the projection period2051 to 2070 the uncertainty ranges comprise positive as well as negative climatic effects for all ***: The projected changes in forest growth serve as quantitative contributions to provide decision support in the evaluation of, for example, species future site suita

关键词： Climate change Forest growth Forest productivity Persistent dryer climate simulation study Uncertainty

Biomarkers for hepatocellular carcinoma: What's new on the horizon?

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World Journal of Gastroenterology 2018年第35期24卷 3974-3979页

作者： matthias Ocker Department of Translational Medicine Oncology Bayer AGBerlin 13353Germany CharitéUniversity Medicine Berlin Berlin 10117Germany

Treatment of advanced hepatocellular carcinoma remains unsatisfying and so far only prognostic biomarkers like α-fetoprotein have been established. No clear predictive biomarker is currently available for standard of care therapies, including targeted therapies like sorafenib. Novel therapeutic options like immune checkpoint inhibitors may pose new challenges to identification and validation of such markers. Currently, PD-L1 expression via immunohistochemistry and tumor mutational burden via next-generation sequencing are explored as predictive biomarkers for these novel treatments. Limited tissue availability due to lack of biopsies still restricts the use of tissue based approaches. Novel methods exploring circulating or cell free nucleic acids(DNA, RNA or miRNAcontaining exosomes) could provide a new opportunity to establish predictive biomarkers. Epigenetic profiling and next-generation sequencing approaches from liquid biopsies are under development. Sample size, etiologic and geographical background need to be carefully addressed in such studies to achieve meaningful results that could be translated into clinical practice. Proteomics, metabolomics and molecular imaging are further emerging technologies.

关键词： Hepatocellular carcinoma Biomarker Nextgeneration sequencing Liquid Biopsy Functional imaging Molecular imaging Circulating free DNA Circulating tumor cells Immune checkpoint inhibitors

Absorbing Boundary Conditions for Hyperbolic Systems

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Numerical Mathematics(Theory,Methods and Applications) 2010年第3期3卷 295-337页

作者： matthias Ehrhardt Lehrstuhl für Angewandte Mathematik und Numerische Analysis Fachbereich C Mathematik und NaturwissenschaftenBergische Universitt WuppertalGaufβstrasse 2042119 WuppertalGermany

This paper deals with absorbing boundary conditions for hyperbolic systems in one and two space *** prove the strict well-posedness of the resulting initial boundary value problem in *** we establish the GKS-stability of the corresponding Lax-Wendroff-type finite difference ***,we have to extend the classical proofs,since the(discretized) absorbing boundary conditions do not fit the standard form of boundary conditions for hyperbolic systems.

关键词： Absorbing boundary conditions hyperbolic system Engquist and Majda approach,strict well-posedness GKS-stability.

Fibroblast growth factor signaling in non-alcoholic fatty liver disease and non-alcoholic steatohepatitis:Paving the way to hepatocellular carcinoma

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World Journal of Gastroenterology 2020年第3期26卷 279-290页

作者： matthias Ocker Department of Gastroenterology(CBF) Charité University Medicine Berlin

Metabolic disorders are increasingly leading to non-alcoholic fatty liver disease,subsequent steatohepatitis,cirrhosis and hepatocellular *** growth factors and their receptors play an important role in maintaining metabolic homeostasis also in the liver and disorders in signaling have been identified to contribute to those pathophysiologic conditions leading to hepatic lipid accumulation and chronic *** specific and well tolerated inhibitors of fibroblast growth factor receptor activity are currently developed for(non-liver)cancer therapy,treatment of non-alcoholic fatty liver disease and nonalcoholic steatohepatitis is still *** growth factor-mimicking or restoring approaches have recently evolved as a novel therapeutic option and the impact of such interactions with the fibroblast growth factor receptor signaling network during non-alcoholic fatty liver disease/non-alcoholic steatohepatitis development is reviewed here.

关键词： Fibroblast growth factor Fibroblast growth factor receptor Non-alcoholic fatty liver disease Non-alcoholic steatohepatitis Fibrosis Cirrhosis Hepatocellular carcinoma

A Solution for the Flow Between a Cone and a Plate at Low Reynolds Number

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Journal of Thermal Science 2002年第4期11卷 289-295页

作者： matthias H.Buschmann Institute of Fluid Mechanics Dresden University of Technology

An analysis of the flow in the gap between a rotating cone and a stationary plate at low Reynolds numbers is presented. Using series expansions for the components of the mean velocity profile and the pressure gradient the Navier-Stokes equations and the continuity equation for a Newtonian fluid written in cylindrical coordinates are solved. It is found that the solution is stable and convergent for the local Reynolds numbers Re smaller than 1.2928. The computed angle of the wall streamlines is found to be in good agreement with experimental data.

关键词： cone-plate-apparatus three-dimensional laminar flow asymptotic expansion.

Incorporating shape constraints in generalized additive modelling of the height-diameter relationship for Norway spruce

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Forest Ecosystems 2016年第2期3卷 112-125页

作者： Natalya Pya matthias Schmidt Department of Mathematics School of Science and TechnologyNazarbayev University The Northwest German Forest Research Station Department of Forest Growth

Background： Measurements of tree heights and diameters are essential in forest assessment and modelling. Tree heights are used for estimating timber volume, site index and other important variables related to forest growth and yield, succession and carbon budget models. However, the diameter at breast height （dbh） can be more accurately obtained and at lower cost, than total tree height. Hence, generalized height-diameter （h-d） models that predict tree height from dbh, age and other covariates are needed. For a more flexible but biologically plausible estimation of covariate effects we use shape constrained generalized additive models as an extension of existing h-d model approaches. We use causal site parameters such as index of aridity to enhance the generality and causality of the models and to enable predictions under projected changeable climatic conditions. Methods： We develop unconstrained generalized additive models （GAM） and shape constrained generalized additive models （SCAM） for investigating the possible effects of tree-specific parameters such as tree age, relative diameter at breast height, and site-specific parameters such as index of aridity and sum of daily mean temperature during vegetation period, on the h-d relationship of forests in Lower Saxony, Germany. Results： Some of the derived effects, e.g. effects of age, index of aridity and sum of daily mean temperature have significantly non-linear pattern. The need for using SCAM results from the fact that some of the model effects show partially implausible patterns especially at the boundaries of data ranges. The derived model predicts monotonically increasing levels of tree height with increasing age and temperature sum and decreasing aridity and social rank of a tree within a stand, The definition of constraints leads only to marginal or minor decline in the model statistics like AIC An observed structured spatial trend in tree height is modelled via 2-dimensional surface fitting. Conclusions： We

关键词： Height-diameter curve Norway spruce Shape constrained additive models Impact of climate change,Varying coefficient models