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Trends in in ovo sexing technologies:insights and interpretation from papers and patents

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Journal of Animal Science and Biotechnology 2023年第6期14卷 2239-2262页

作者： matthias Corion Simao Santos Bart De Ketelaere Dragana Spasic Maarten Hertog Jeroen Lammertyn KU Leuven BIOSYST-MeBioS Biosensors GroupWillem de Croylaan 42Leuven B‑3001Belgium. KU Leuven BIOSYST-MeBioS Biostatistics GroupKasteelpark Arenberg 30Leuven B‑3001Belgium. KU Leuven BIOSYST-MeBioS Postharvest GroupWillem de Croylaan 42Leuven B‑3001Belgium.

Numerous researchers and institutions have been developing in ovo sexing technologies to improve animal welfare by identifying male embryos in an early embryonic stage and disposing of them before pain *** review gives a complete overview of the technological approaches reported in papers and patents by performing a thorough search using Web of Science and Patstat/Espacenet databases for papers and patents,*** on a total of 49 papers and 115 patent families reported until May 2023 worldwide,11 technology categories were defined:6 non-optical and 5 optical *** category was described for its characteristics while assessing its potential for ***,the dynamics of the publications of in ovo sexing techniques in both paper and patent fields were described through growth curves,and the interest or actual status was visualized using the number of paper citations and the actual legal status of the *** comparing the reported technologies in papers to those in patents,scientific gaps were observed,as some of the patented technologies were not reported in the scientific literature,e.g.,ion mobility and mass spectrometry ***,more diverse approaches in all categories were found in patents,although they do require more scientific evidence through papers or industrial adoption to prove their ***,although there is a recent trend for non-invasive techniques,invasive methods like analyzing DNA through PCR or hormones through immunosensing are still being reported(and might continue to be)in papers and *** was also observed that none of the technologies complies with all the industry requirements,although 5 companies already entered the *** the one hand,more research and harmony between consumers,industry,and governments is *** the other hand,close monitoring of the market performance of the currently available techniques will offer valuable insights into the potential an

关键词： Animal welfare In ovo sexing Male day-old chick culling Optical and non-optical techniques Patents and papers

Having a Partner and Having Children:Comparisons of Adults with Congenital Heart Disease and the General Population:A 15-Year Case-Control Study

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Congenital Heart Disease 2023年第3期18卷 337-348页

作者： Siegfried Geyer Claudia Dellas Thomas Paul matthias Müller Kambiz Norozi Medical Sociology Unit Hannover Medical SchoolHannover30625Germany Department of Pediatric Cardiology Intensive Care Medicine and NeonatologyUniversity Medical Center GoettingenGoettingenGermany Department of Pediatrics Western UniversityLondonOntarioCanada Department of Pediatric Cardiology and Intensive Care Medicine Hannover Medical SchoolHannoverGermany

Objectives:To examine whether patients with congenital heart disease(CHD)are less likely to have a partner or children than individuals from the general ***:Longitudinal study with two assessments of the same patients(n=244)from a hospital population and controls(n=238)from the German Socio-Economic Panel(GSOEP)using parental education,patients age,and sex as matching *** first patient study was conducted between 5/2003 and 6/2004,the second one between 5/2017 and 4/*** were drawn from GSOEP-surveys 2004 and ***-severity was classified according to type of surgery:curative,reparative,or *** single was used as outcome measure,for offspring the outcome was having children or ***:Among women with CHD the rate of those living single was higher than among controls with the differences depending on disease complexity(curative:OR=5.5;reparative:OR=1.9;palliative:OR=2.7).No statistically significant differences between patients and controls emerged in the male study *** respect to children a marked difference emerged between women with CHD and *** patients the odds of having children were lower than among controls(curative:OR=0.3;reparative:OR=0.3;palliative:OR=0.2).The rate of patients with children with CHD(women:5.6%;men:4.9%)was higher than expected(1%)if compared with the general ***:Using partnership and children as outcome criteria,patients with CHD are disadvantaged if compared to subjects from the general *** female patients the social consequences of the disease turned out as more pervasive than in women.

关键词： Congenital heart disease children partnership panel study case-control study

Dynamics and functions of E‑cadherin complexes in epithelial cell and tissue morphogenesis

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Marine Life Science & Technology 2023年第4期5卷 585-601页

作者： Na Zhang matthias Häring Fred Wolf Jörg Großhans Deqing Kong Department of Biology Philipps University35043 MarburgGermany Göttingen Campus Institute for Dynamics of Biological Networks(CIDBN) Georg August University Göttingen37073 GöttingenGermany

Cell–cell adhesion is at the center of structure and dynamics of epithelial tissue.E-cadherin–catenin complexes mediate Ca^(2+)-dependent trans-homodimerization and constitute the kernel of adherens *** the basic function of cell–cell adhesion,recent progress sheds light the dynamics and interwind interactions of individual E-cadherin–catenin complex with E-cadherin superclusters,contractile actomyosin and mechanics of the cortex and *** nanoscale architecture of E-cadherin complexes together with cis-interactions and interactions with cortical actomyosin adjust to junctional tension and mechano-transduction by reinforcement or weakening of specific features of the *** post-translational modifications such as phosphorylation and glycosylation have been implicated,their role for specific aspects of in E-cadherin function has remained ***,we provide an overview of the E-cadherin complex in epithelial cell and tissue morphogenesis focusing on nanoscale architectures by super-resolution approaches and post-translational modifications from recent,in particular in vivo,***,we review the computational modelling in E-cadherin complexes and highlight how computational modelling has contributed to a deeper understanding of the E-cadherin complexes.

关键词： Nanoscale architectures Phosphorylation Glycosylation Computational modelling

Effects of progesterone on T-type-Ca^(2+)-channel expression in Purkinje cells

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Neural Regeneration Research 2022年第11期17卷 2465-2471页

作者： Annika Eickhoff Jonas Tjaden Sarah Stahlke matthias Vorgerd Verena Theis Veronika Matschke Carsten Theiss Department of Cytology Institute of AnatomyRuhr-University BochumBochumGermany Department of Neurology Neuromuscular Center RuhrgebietUniversity Hospital BergmannsheilRuhr-Universität BochumBochumGermany

Plasticity of cerebellar Purkinje cells(PC)is influenced by progeste rone via the classical progeste rone receptors PR-A and PR-B by stimulating dendritogenesis,spinogenesis,and synaptogenesis in these *** PC cultures were used to analyze progeste rone effects at a molecular level on the voltage-gated T-type-Ca^(2+)-channels Ca_(v)3.1,Ca_(v)3.2,and Ca_(v)3.3 as they helped determine neuronal plasticity by regulating Ca^(2+)-influx in neuronal *** results showed direct effects of progesterone on the mRNA expression of T-type-Ca^(2+)-channels,as well as on the protein kinases A and C being involved in downstream signaling pathways that play an important role in neuronal *** the mRNA expression studies of T-type-Ca^(2+)-channels and protein kinases of the signaling cascade,laser microdissection and purified PC cultures of diffe rent maturation stages were *** staining was also performed to characte rize the localization of T-type-Ca^(2+)-channels in *** rimental progesterone treatment was performed on the purified PC culture for 24 and 48 *** results show that progesterone increases the expression of Ca_(v)3.1 and Ca_(v)3.3 and associated protein kinases A and Cin PC at the mRNA level within 48 hours after treatment at *** effects extend the current knowledge of the function of progesterone in the central nervous system and provide an explanatory approach for its influence on neuronal plasticity.

关键词： Ca_(v)3.1 Ca_(v)3.2 Ca_(v)3.3 neuronal plasticity progesterone protein kinase A protein kinase C Purkinje cells rat cerebellum T-type-Ca^(2+)-channels

Estimation of radiation-induced health hazards from a“dirty bomb”attack with radiocesium under different assault and rescue conditions

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Military Medical Research 2022年第1期9卷 106-125页

作者： Alexis Rump Stefan Eder Cornelius Hermann Andreas Lamkowski Patrick Ostheim Michael Abend matthias Port Bundeswehr Institute of Radiobiology Neuherberg Str.1180937 MunichGermany

In the case of a terrorist attack by a“dirty bomb”,blast injuries,external irradiation and the incorporation of radioactivity are to be *** from information about the radiological attack scenario with cesium-137 in the *** Scenario Planning Guide,we estimated the radiological doses *** calculations were performed for a smaller plume size and a detonation in a *** conditions as described in the ***,the committed effective dose amounted to a maximum of 848 mSv,even for very unfavorable *** bone marrow equivalent doses are insufcient to induce acute radiation sickness(ARS).In the case of a smaller plume size,the ARS threshold may be exceeded in some *** a subway bombing,doses are much higher and the occurrence of ARS should be *** health hazards from a dirty bomb attack will depend on the location and the explosive *** derived Haddon matrix indicates that preparing for such an event includes education of all the medical staff about radiation effects,the time lines of radiation damages and the treatment *** determinants of the outcome include rapid evacuation even from difficult locations,the availability of a specific triage tool to rapidly identify victims at risk for ARS,the availability of an antidote stockpile and dedicated hospital beds to treat seriously irradiated victims.

关键词： Medical NRBC protection Terrorism Radiological emergency Dirty bomb Combined injuries Triage Acute radiation sickness Radionuclide incorporation

Identification of a female murder victim found in Burgenland,Austria in 1993

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Forensic Sciences Research 2022年第2期7卷 308-318页

作者： Christine Lehn Andreas Rossmann matthias Graw Gareth R.Davies Institute of Legal Medicine Ludwig-Maximilians-University of MunichMunichGermany Laboratory for Stable Isotope Analytics Isolab GmbHSchweitenkirchenGermany Faculty of Earth and Life Sciences Vrije Universiteit AmsterdamAmsterdamThe Netherlands

In 1993,the skeletal remains of a female corpse were found in Burgenland,*** identification of the approximately 25–35-year-old female appeared impossible,but the case was reopened 23 years *** applying biogeochemical isotope methods to her body tissues,the geographical origin of the unknown corpse could be *** results of the C,N,S,H,Sr,and Pb isotope analyses suggested that the female did not originate from Europe and most likely spent her youth in the northern *** these findings,the police were able to identify the woman within 2 *** female came from the Dominican Republic and resided in Austria for only a short period before she was *** case shows that isotope biogeochemistry investigations can provide the police with crucial information that enables unknown persons to be identified.

关键词： Forensic sciences forensic anthropology human identification provenance stable isotope analysis bio-elements geo-elements

Retinal microvascular signs and recurrent vascular events in patients with TIA or minor stroke

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Stroke & Vascular Neurology 2023年第5期8卷 379-386,I0001-I0007页

作者： Philipp Klyscz Thomas Ihl Inga Laumeier Maureen Steinicke matthias Endres Georg Michelson Heinrich J Audebert Neurology Charité-Universitätsmedizin BerlinBerlinGermany Center for Stroke Research Berlin Charité-Universitätsmedizin BerlinBerlinGermany Berlin Institute of Health BerlinGermany Excellence Cluster NeuroCure Charité-Universitätsmedizin BerlinBerlinGermany German Center for Neurodegenerative Diseases partner site BerlinGermany German Center for Cardiovascular Research partner site BerlinGermany Ophthalmology Friedrich-Alexander-Universität Erlangen-Nürnberg Medizinische FakultätErlangenGermany Talkingeyes&More GmbH ErlangenGermany

Background and purpose Retinal pathologies are an independent risk factor for ischaemic stroke,but research on the predictive value of retinal abnormalities for recurrent vascular events in patients with prior stroke is *** investigated the association of retinal pathologies with subsequent vascular *** In a substudy of the Intensified secondary prevention intending a reduction of recurrent events in TIA and minor stroke patients(INSPiRE-TMS)trial,we enrolled patients with recent transient ischaemic attack(TIA)or minor stroke with at least one modifiable risk *** outcome was the composite of subsequent vascular *** photographs were taken at baseline and categorised into three different fundus groups by a telemedically linked *** 722 patients participated in the current study and 109 major vascular events *** multivariable adjustments,we did not find a significant association between fundus categories and risk for subsequent vascular events(HRs for moderate vascular retinopathy and vascular retinopathy with vessel rarefaction in comparison to no vascular retinopathy 1.03(95%CI 0.64 to 1.67),p=0.905 and 1.17(95%CI 0.62 to 2.20),p=0.626).In a selective post hoc analysis in patients with diabetes mellitus and hypertension,patients with vascular retinopathy with vessel rarefaction had a higher risk for recurrent stroke(HR 24.14(95%CI 2.74 to 212.50),p=0.004).Conclusions Retinal changes did not predict major subsequent vascular events in patients with recent TIA or minor *** studies are needed to examine the utility of fundus photography in assessing the risk of stroke recurrence in patients with diabetes mellitus and hypertension.

关键词： patients Retinal prevention

Gold-catalysed synthesis of phosphonatesubstituted oxetan-3-ones–an easy access to highly strained HWE reagents

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Organic Chemistry Frontiers 2022年第1期9卷 117-122页

作者： Shaista Tahir Jonas F.Wunsch matthias Rudolph Frank Rominger A.Stephen K.Hashmi Organisch-Chemisches Institut Heidelberg UniversityIm Neuenheimer Feld 27069120 HeidelbergGermany Chemistry Department Faculty of ScienceKing Abdulaziz University21589 JeddahSaudi Arabia

A convenient approach for the attainment of strained phosphonate-substituted oxetan-3-ones,starting from easy to synthesise alkynyl phosphonates,is *** the aid of a pyridine-N-oxide,in a goldcatalysed step anα-oxo carbene species is generated as a key *** formal OH-insertion,synthetically useful HWE reagents can be *** synthetic utility of the obtained building blocks could be demonstrated,which yielded the 2-alkenyl oxetan-3-one scaffold in high yields after the HWE reaction.

关键词： reaction substituted synthesis

Efficacy and safety of desmopressin on frequency and urgency in female patients with overactive bladder and nocturia, current clinical features and outcomes: A systematic review

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Asian Journal of Urology 2022年第1期9卷 27-34页

作者： Bara Barakat Knut Franke matthias May Ulrich Gauger Thomas-Alexander Vogeli Hospital Viersen Department of Urology and Pediatric UrologyViersenGermany Hospital St.Elisabeth Department of UrologyStraubingGermany Institute for Medical Statistics BerlinGermany University Hospital RWTH Aachen Department of Urology and Pediatric UrologyAachenGermany

Objective To evaluate the efficacy and safety of desmopressin on frequency and urgency in female patients with overactive bladder(OAB)and *** A selective database search was conducted to validate the effectiveness of desmopressin in patients with OAB and *** Reporting Items for Systematic Reviews and Meta-Analyses guidelines were *** meta-analysis included 378 women(five studies)with *** clinical outcomes and adverse events were *** The treatment strategy of all the studies included can be divided into three categories:(1)The effect of desmopressin compared with baseline,(2)desmopressin compared with placebo,and(3)desmopressin and anticholinergic combination versus desmopressin *** was a significant(50%)reduction in nocturia and urgency episodes after using desmopressin *** desmopressin and anticholinergic led to a decrease in the frequency of nocturia voids when only using anticholinergic(65%vs.33.2%).The time increased in the middle to the first nightly voids in the combination arm(65.11 min;p=0.045).The mean incidence(standard deviation)of leak-free episodes was higher under desmopressin than under placebo in the first 4 h(62%[35%]vs.48%[40%])and in the first 8 h(55%[37%]vs.40%[41%]).The safety profile was comparable between *** Available data indicate that desmopressin is efficacious in significantly reducing nighttime urine production,episodes of nocturia,and urgency *** affectivity of the combination therapy was very high with least side effects for the treatment of OAB/nocturnal polyuria.

关键词： Overactive bladder Nocturia Desmopressin Urinary urgency Lower urinary tract