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Extracellular DNA and autoimmune diseases

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Cellular & Molecular Immunology 2018年第8期15卷 746-755页

作者： Hantao Lou matthew C pickering Molecular Immunology Imperial College LondonLondon W120NNUK Centre for Complement and Inflammation Research Imperial College LondonLondon W120NNUK

Extracellular DNA is secreted from various sources including apoptotic cells,NETotic neutrophils and bacterial *** DNA can stimulate innate immune responses to induce type-I IFN production after being *** process is central in antiviral responses but it also plays important role in the pathogenesis of a range of autoimmune diseases such as systemic lupus *** discuss the recent advances in the understanding of the role of extracellular DNA,released from apoptotic and NETotic cells,in autoimmunity.

关键词： DNA type I IFN autoimmunity

Evaluation of a software positioning tool to support SMEs in adoption of big data analytics

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Journal of Electronic Science and Technology 2024年第1期22卷 13-24页

作者： matthew Willetts Anthony S.Atkins Faculty of Digital TechnologyInnovationand BusinessStaffordshire UniversityStoke-on-TrentST42DEUnited Kingdom

Big data analytics has been widely adopted by large companies to achieve measurable benefits including increased profitability,customer demand forecasting,cheaper development of products,and improved stock *** and medium sized enterprises(SMEs)are the backbone of the global economy,comprising of 90%of businesses ***,only 10%SMEs have adopted big data analytics despite the competitive advantage they could *** research has analysed the barriers to adoption and a strategic framework has been developed to help SMEs adopt big data *** framework was converted into a scoring tool which has been applied to multiple case studies of SMEs in the *** paper documents the process of evaluating the framework based on the structured feedback from a focus group composed of experienced *** results of the evaluation are presented with a discussion on the results,and the paper concludes with recommendations to improve the scoring tool based on the proposed *** research demonstrates that this positioning tool is beneficial for SMEs to achieve competitive advantages by increasing the application of business intelligence and big data analytics.

关键词： Big data analytics Evaluation Small and medium sized enterprises (SMEs) Strategic framework

Strong observability as a sufficient condition for non-singularity and lossless convexification in optimal control with mixed constraints

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Control Theory and Technology 2022年第4期20卷 475-487页

作者： Sheril Kunhippurayil matthew W.Harris Torc Robotics Inc.405 Partnership DriveBlacksburg 24060VirginiaUSA Department of Mechanical and Aerospace Engineering Utah State University4130 Old Main HillLogan 84322UtahUSA

This paper analyzes optimal control problems with linear time-varying dynamics defined on a smooth manifold in addition to mixed constraints and pure control *** main contribution is the identification of sufficient conditions for the optimal controls to be non-singular,which enables exact(or lossless)convex relaxations of the control *** problem is analyzed in a geometric framework using a recent maximum principle on manifolds,and it is shown that strong observability of the dual system on the cotangent space is the key *** minimum time problems are analyzed and solved.A minimum fuel planetary descent problem is then analyzed and relaxed to a convex *** enables its efficient solution in less than one second without any initial guess.

关键词： Optimal control Strong observability Lossless convexification

MEASURING AND LOCATING ZONES OF CHAOS AND IRREGULARITY

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Journal of Systems Science & Complexity 2014年第3期27卷 494-506页

作者： GARNER David matthew LING Bingo Wing-Kuen Department of Biological and Medical Sciences Oxford Brookes UniversityHeadington CampusGipsy LaneOxford OX3 0BPUnited Kingdom University of Lincoln Brayford PoolLincolnLN6 7TSUnited Kingdom

The new measures computed here are the spectral detrended fluctuation anatysls （sDFA） and spectral multi-taper method （sMTM）. sDFA applies the standard detrended fluctuation analysis （DFA） algorithm to power spectra, sMTM exploits the minute increases in the broadband response, typical of chaotic spectra approaching optimal values. The authors chose the Brusselator, Lorenz, and Duffing as the proposed models to measure and locate chaos and severe irregularity. Their series of chaotic parametric responses in short time-series is advantageous. Where cycles have only a limited number of slow oscillations such as for systems biology and medicine. It is difficult to create, locate, or monitor chaos. From 50 linearly increasing starting points applied to the chaos target function （CTF）; the mean percentage increases in Kolmogorov-Sinai entropy （KS-Entropy） for the proposed chosen models; and p-values when the models were compared statistically by Kruskal-Wallis and ANOVA1 test with distributions assumed normal are Duffing （CTF： 31%： p 〈0.03）; Lorenz （CTF： 2%： p 〈0.03）, and I3russelator （CTF： 8%： p 〈0.01）. principal component analysis （pCA） is applied to assess the significance of the objective functions for tuning the chaotic response. From pCA the conclusion is that CTF is the most beneficial objective function overall delivering the highest increases in mean KS-Entropy.

关键词： Chaos entropy optimization signal processing systems biology.

STABILITY OF STEADY MULTI-WAVE CONFIGURATIONS FOR THE FULL EULER EQUATIONS OF COMpRESSIBLE FLUID FLOW

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Acta Mathematica Scientia 2018年第5期38卷 1485-1514页

作者： Gui-Qiang G.CHEN matthew RIGBY Mathematical Institute University of OxfordOxfordOX2 6GGU

We are concerned with the stability of steady multi-wave configurations for the full Euler equations of compressible fluid flow. In this paper, we focus on the stability of steady four-wave configurations that are the solutions of the Riemann problem in the flow direction, consisting of two shocks, one vortex sheet, and one entropy wave, which is one of the core multi-wave configurations for the two-dimensional Euler equations. It is proved that such steady four-wave configurations in supersonic flow are stable in structure globally, even under the BV perturbation of the incoming flow in the flow direction. In order to achieve this, we first formulate the problem as the Cauchy problem （initial value problem） in the flow direction, and then develop a modified Glimm difference scheme and identify a Glimm-type functional to obtain the required BV estimates by tracing the interactions not only between the strong shocks and weak waves, but also between the strong vortex sheet/entropy wave and weak waves. The key feature of the Euler equations is that the reflection coefficient is always less than 1, when a weak wave of different family interacts with the strong vortex sheet/entropy wave or the shock wave, which is crucial to guarantee that the Glimm functional is decreasing. Then these estimates are employed to establish the convergence of the approximate solutions to a global entropy solution, close to the background solution of steady four-wave configuration.

关键词： stability multi-wave configuration vortex sheet entropy wave shock wave BV perturbation full Euler equations steady wave interactions Glimm scheme

The Integration of a Canonical Workflow Framework with an Informatics System for Disease Area Research

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Data Intelligence 2022年第2期4卷 186-195页

作者： Vivek Navale matthew McAuliffe Center for Information Technology National Institutes of HealthBethesdaMaryland 20892USA

A recurring pattern of access to existing databases,data analyses,formulation of new hypotheses,use of an experimental design,institutional review board approvals,data collection,curation,and storage within trusted digital repositories is observable during clinical research *** workflows that support the repeated nature of these activities can be ascribed as a Canonical Workflow Framework for Research(CWFR).Disease area clinical research is protocol specific,and during data collection,the electronic case report forms can use Common Data Elements(CDEs)that have precisely defined questions and are associated with the specified value(s)as *** CDE-based CWFR is integrated with a biomedical research informatics computing system,which consists of a complete stack of technical layers including the protocol and Form Research Management *** unique data dictionaries associated with the CWFR for Traumatic Brain Injury and parkinson's Disease resulted in the development of the Federal Interagency Traumatic Brain Injury and parkinson's Disease Biomarker *** to a canonical workflow,these two systems can use similar tools,applications,and service modules to create findable,accessible,interoperable,and reusable Digital *** Digital Objects for Traumatic Brain Injury and parkinson's disease contain all relevant information needed from the time data is collected,validated,and maintained within a Storage Repository for future *** Traumatic Brain Injury and parkinson's Disease studies can be shared as Research Objects that can be produced by aggregating related resources as information packages and is findable on the Internet by using unique ***,the integration of CWFR with an informatics system has resulted in the reuse of software applications for several National Institutes of Health-supported biomedical research programs.

关键词： Canonical Workflow Framework for Research Informatics system Traumatic brain injury parkinson's disease

Refining safety considerations for intradialytic blood flow restriction exercise. Commentary on “Concerns on the application of blood-flow restriction resistance exercise and thrombosis risk in hemodialysis patients”

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Journal of Sport and Health Science 2024年第4期13卷 455-456页

作者： matthew J.Clarkson Institute for Health and Sport Victoria UniversityMelbourneVIC 8001Australia

I read with great interest the article“Concerns on the application of blood flow restriction resistance exercise and thrombosis risk in hemodialysis patients”by Correa et al.1 The study presents complementary data from a previous randomized controlled trial,2 exploring the application of intradialytic blood flow restriction exercise for hemodialysis patients.

关键词： patients hemodialysis

power Factor Estimation of Distributed Energy Resources Using Voltage Magnitude Measurements

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Journal of Modern power Systems and Clean Energy 2021年第4期9卷 859-869页

作者： Samuel Talkington Santiago Grijalva matthew J.Reno School of Electrical and Computer Engineering Georgia Institute of TechnologyAtlantaGA 30318USA Electric power Systems Research Department Sandia National LaboratoriesAlbuquerqueNM 87123USA

This paper presents a new method for the estimation of the injection state and power factor of distributed energy resources (DERs) using voltage magnitude measurements only. A physics-based linear model is used to develop estimation heuristics for net injections of real and reactive power at a set of buses under study, allowing a distribution engineer to form a robust estimate for the operating state and the power factor of the DER at those buses. The method demonstrates and exploits a mathematical distinction between the voltage sensitivity signatures of real and reactive power injections for a fixed power system model. Case studies on various test feeders for a model of the distribution circuit and statistical analyses are presented to demonstrate the validity of the estimation method. The results of this paper can be used to improve the limited information about inverter parameters and operating state during renewable planning, which helps mitigate the uncertainty inherent in their integration.

关键词： Decentralized power system control detection and estimation power factor sparse approximation

Can Weather Influence the prevalence of Acute-on-chronic Liver Failure?

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Journal of Clinical and Translational Hepatology 2019年第4期7卷 285-286页

作者： matthew McMillin Central Texas Veterans Health Care System TempleTXUSA Department of Internal Medicine University of Texas at Austin Dell Medical SchoolAustinTXUSA

Acute-on-chronic liver failure(ACLF) results from an acute insult that occurs in patients with chronic liver disease,ultimately leading to liver *** underlying chronic liver dysfunction can be characterized into three categories:chronic liver disease with no cirrhosis;compensated liver cirrhosis;decompensated *** underlying chronic liver diseases are numerous and include alcoholic liver disease,viral hepatitis(types B and C),nonalcoholic fatty liver disease,and other underlying etiologies.1 Acute liver injury can arise from viral hepatitis infections(types A,B,and E),acetaminophen toxicity,drug-induced liver injury,toxin exposure,and numerous other hepatic and extrahepatic causes including heat stroke.2 Due to the numerous aspects of pathology that can generate both the chronic and acute components of ACLF,these patients can have significantly different pathology *** makes ACLF difficult to clas-sify,and this is evident by the different ACLF definitions being used by the Asian pacific Association for the Study of the Liver,the European Association for the Study of the Liver–Chronic Liver Failure Consortium,and the North American Consortium for the Study of End-Stage Liver Disease with regards to mor-tality,presence of organ failure,inclusion/exclusion criteria,and other disease characteristics.3,4 In addition,these differ-ent definitions of ACLF,depending on which definition is used,could potentially influence the outcomes of studies depending upon the metric investigated.

关键词： Liver Acute acute