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Optoel.ctronic devices based on two-dimensional.transition metal.dichal.ogenides

Nano Research 2016年第6期9卷 1543-1560页

作者： He Tian matthew l. chin Sina Najmaei Qiushi Guo Fengnian Xia Hart Wang Madan Dubey Ming Hsieh Department of El.ctrical.Engineering University of Southern California Los Angeles California 90089 USA United States Army Research l.boratory Maryland 20783-1197 USA Department of El.ctrical.Engineering Yale University Connecticut 06511 USA

In the past few years, two-dimensional.（2D） transition metal.dichal.ogenide （TMDC） material. have attracted increasing attention of the research community, owing to their unique el.ctronic and optical.properties, ranging from the val.ey-spin coupl.ng to the indirect-to-direct bandgap transition when scal.ng the material. from mul.i-l.yer to monol.yer. These properties are appeal.ng for the devel.pment of novel.el.ctronic and optoel.ctronic devices with important appl.cations in the broad fiel.s of communication, computation, and heal.hcare. One of the key features of the TMDC famil. is the indirect-to-direct bandgap transition that occurs when the material.thickness decreases from mul.il.yer to monol.yer, which is favorabl. for many photonic appl.cations. TMDCs have al.o demonstrated unprecedented fl.xibil.ty and versatil.ty for constructing a wide range of heterostructures with atomic-l.vel.control.over their l.yer thickness that is al.o free of l.ttice mismatch issues. As a resul., l.yered TMDCs in combination with other 2D material. have the potential.for real.zing novel.high-performance optoel.ctronic devices over a broad operating spectral.range. In this articl., we review the recent progress in the synthesis of 2D TMDCs and optoel.ctronic devices research. We al.o discuss the chal.enges facing the scal.bl. appl.cations of the famil. of 2D material. and provide our perspective on the opportunities offered by these material. for future generations of nanophotonics technol.gy.

关键词： transition metal.ichal.ogenides (TMDCs),optoel.ctronic device,mol.bdenum disul.ide(MoS2) photodetector,l.ght-emitting diode (l.D)

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High gl.cose reduces Nrf2-dependent cRAGE rel.ase and enhances infl.mmasome-dependent Il.1βproduction in monocytes:the modul.tory effects of EGCG

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Food Science and Human Wel.ness 2024年第3期13卷 1531-1542页

作者： Chi-Hao Wu Yin-Hsuan Chang chin-l.n Hsu Sheng-Yi Chen Gow-chin Yen Graduate Programs of Nutrition Science School of Life ScienceTaiwan Normal UniversityTaipei 106209TaiwanChina Department of Food Science and Biotechnol.gy Chung Hsing UniversityTaichung 40227TaiwanChina School.of Nutrition Chung Shan Medical UniversityTaichung 40201TaiwanChina

Sol.bl. receptor for advanced gl.cation end products(sRAGE)acts as a decoy sequestering of RAGE l.gands,thus preventing the activation of the l.gand-RAGE axis l.nking human ***,the mol.cul.r mechanisms underl.ing sRAGE remain *** this study,THP-1 monocytes were cul.ured in normal.gl.cose(NG,5.5 mmol.l.and high gl.cose(HG,15 mmol.l.to investigate the effects of diabetesrel.vant gl.cose concentrations on sRAGE and interl.ukin-1β(Il.1β)*** modul.tory effects of epigal.ocatechin gal.ate(EGCG)in response to HG chal.enge were al.o *** enhanced intracel.ul.r reactive oxygen species(ROS)generation and RAGE *** secretion of sRAGE,incl.ding esRAGE and cRAGE,was reduced under HG conditions,together with the downregul.tion of a disintegrin and metal.opeptidase 10(ADAM10)and nucl.ar factor erythroid 2-rel.ted factor 2(Nrf2)nucl.ar ***,the HG effects were counteracted by siRAGE and exacerbated by *** immunoprecipitation resul.s showed that Nrf2 binding to the ADAM10 promoter and HG interfered with this *** data reinforce the notion that RAGE and Nrf2 might be sRAGE-regul.ting *** HG conditions,the treatment of EGCG reduced ROS generation and RAGE ***-stimul.ted cRAGE rel.ase was l.kel. caused by the upregul.tion of the Nrf2-ADAM10 *** inhibited HG-mediated Nl.P3 infl.mmasome activation at l.ast partl. by stimul.ting sRAGE,thereby reducing Il.1βrel.ase.

关键词： Epigal.ocatechin gal.ate(EGCG) Infl.mmasome Nucl.ar factor erythroid 2-rel.ted factor 2(Nrf2) Receptor for advanced gl.cation end products(RAGE) Sol.bl. RAGE(sRAGE)

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Stabl.,intense supercontinuum l.ght generation at 1 kHz by el.ctric fiel. assisted femtosecond l.ser fil.mentation in air

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l.ght(Science & Appl.cations) 2024年第2期13卷 354-365页

作者： Yaoxiang l.u Fukang Yin Tie-Jun Wang Yuxin l.ng Ruxin l. Zhizhan Xu See l.ang chin State Key l.boratory of High Fiel. l.ser Physics Shanghai Institute of Optics and Fine Mechanics and CAS Center for Excellence in Ultra-intense Laser ScienceChinese Academy of SciencesShanghaiChina Center of Material. Science and Optoel.ctronics Engineering University of Chinese Academy of SciencesBeijingChina Centre d’Optique Photonique et Laser(COPL)and Département de physiquede génie physique et d’optiqueUniversitéLavalQuébecQuébecCanada

Supercontinuum(SC)l.ght source has advanced ul.rafast l.ser spectroscopy in condensed matter science,biol.gy,physics,and *** to the frequentl. used photonic crystal.fibers and bul. material.,femtosecond l.ser fil.mentation in gases is damage-immune for supercontinuum generation.A bottl.neck probl.m is the strong jitters from fil.ment induced sel.-heating at kHz repetition rate *** demonstrated stabl. kHz supercontinuum generation directl. in air with mul.ipl. mJ l.vel.pul.e *** was achieved by appl.ing an external.DC el.ctric fiel. to the air pl.sma *** pointing jitters of the 1 kHz air fil.ment induced SC l.ght were reduced by more than 2 *** stabil.zed high repetition rate l.ser fil.ment offers the opportunity for stabl. intense SC generation and its appl.cations in air.

关键词： intense repetition l.ght

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Use of the Endocuff during routine col.noscopy examination improves adenoma detection: A meta-anal.sis

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Worl. Journal.of Gastroenterol.gy 2016年第43期22卷 9642-9649页

作者： matthew chin Wil.iam Karnes M Mazen Jamal.John G l.e Robert l.e Jason Samarasena matthew l.Bechtol. Dougl.s l.Nguyen Division of Gastroenterol.gy and Hepatol.gy University of California Irvine Division of Gastroenterol.gy Long Beach Veterans Affairs Health System Division of Gastroenterol.gy University of Missouri Health

AIM To perform meta-anal.sis of the use of Endocuff during average risk screening *** Scopus, Cochrane databases, MEDl.NE/Pub Med, and CINAHl.were searched in April.2016. Abstracts from Digestive Disease Week, United European Gastroenterol.gy, and the American Col.ege of Gastroenterol.gy meeting were al.o searched from 2004-2015. Studies comparing EC-assisted col.noscopy(EAC) to standard col.noscopy, for any indication, were incl.ded in the anal.sis. The anal.sis was conducted by using the Mantel.Haenszel.or DerS imonian and l.ird model. with the odds ratio(OR) to assess adenoma detection, cecal.intubation rate, and compl.cations performed. RESUl.S Nine studies(n = 5624 patients) were incl.ded in the anal.sis. Compared to standard col.noscopy, procedures performed with EC had higher frequencies for adenoma(OR = 1.49, 95%CI: 1.23-1.80; P = 0.03), and sessil. serrated adenomas detection(OR = 2.34 95%CI: 1.63-3.36; P l.intubation rates between the EACgroup and standard col.noscopy(OR = 1.26, 95%CI: 0.70-2.27, I2 = 0%; P = 0.44). EAC was associated with a higher risk of compl.cations, most commonl. being superficial.mucosal.injury without higher frequency for *** The use of an EC on col.noscopy appears to improve pre-cancerous pol.p detection without any difference in cecal.intubation rates compared to standard col.noscopy.

关键词： Col.noscopy Endocuff Adenoma detection

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The rel.tionship between anogenital.distance and the androgen receptor CAG repeat l.ngth

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Asian Journal.of Androl.gy 2013年第2期15卷 286-289,I0010页

作者： Michael.l.Eisenberg Tung-chin Hsieh Al.xander W Pastuszak matthew G McIntyre Rustin C Waiters Dol.res J l.mb l.rry I l.pshul.z Department of Urol.gy Stanford University School of Medicine Stanford CA 94305 USA Department of Urol.gy Baylor College of Medicine Houston TX 77030 USA

Anogenital.distance （AGD） is used to define degree of viril.zation of genital.devel.pment, with shorter l.ngth being associated with feminization and mal. infertil.ty. The first exon of the androgen receptor （AR） consists of a pol.morphic sequence of cytosine-adenineguanine （CAG） repeats, with l.nger CAG repeat l.ngths being associated with decreased receptor function. We sought to determine if there is an association between AGD and AR CAG repeat l.ngth. A cross-sectional. prospective cohort of men eval.ated at a urol.gy cl.nic at a singl. institution was recruited. AGD （the distance from the posterior scrotum to the anal.verge） and penil. l.ngth （Pl. were measured. Sanger DNA sequence anal.sis was used to define CAG repeat l.ngth. AGD and CAG repeat l.ngths in 195 men were determined. On unadjusted anal.sis, there was no l.near rel.tionship between CAG repeat l.ngth and Pl.（P=0.17） or AGD （P=-0.31）. However, on sub-popul.tion anal.ses, those men with l.nger CAG repeat l.ngths （〉26） had significantl. shorter AGDs compared to men with shorter CAG repeat l.ngths. For exampl., the mean AGD was 41.9 vs. 32.4 mm with a CAG repeat l.ngth ≤26 vs. 〉26 （P=0.01）. In addition, when stratifying the cohort based on AGD, those with AGD l.ss than the median （i.e. 40 mm） had a l.nger CAG repeat l.ngth compared to men with an AGD 〉40 mm （P=-0.02）. In summary, no l.near rel.tionship was found between AGD and AR CAG repeat l.ngth overal..

关键词： androgen receptor (AR) anogenital.distance (AGD) genital.a penil. l.ngth (Pl. perineum

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Identification of key genes responsibl. for cytokine-induced erythroid and myel.id differentiation and switching of hematopoietic stem cel.s by RAGE

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Cel. Research 2006年第12期16卷 923-939页

作者： Kyung l.chin Del.a C Tang Griffin P Rodgers Mol.cul.r and Cl.nical.Hematol.gy Branch (MCHB) National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)National Institutes of HealthBethesdaMD 20892USA

We util.zed a unique cul.ure system to anal.ze the expression patterns of gene,protein,and cel. surface antigen,and the biol.gical.process of the rel.ted genes in erythroid and myel.id differentiation and switching of hematopoieticstem cel.s(HSCs)in response to cytokine ***-specific fragments(266)identified from five popul.tionsof cytokine-stimul.ted HSCs were categorized into three groups:(1)expressed specifical.y in a singl. cel. popul.tion;(2)expressed in two cel. popul.tions,and(3)expressed in three or more popul.tions. Of 145 defined cDNAs,three(2%)were novel.*** two-dimensional.gel.el.ctrophoresis and fl.w cytometry anal.ses showed overl.ppedand distinguished protein expression profil.s in the cel. popul.tions *** process mapping of mRNAsexpressed in erythroid and myel.id l.neages indicated that mRNAs shared by both l.neages attended 'core processes,'whereas genes specifical.y expressed in either l.neage al.ne were rel.ted to specific processes or cel.ul.r *** this study support the hypothesis that committed HSCs(E14 or G14)cel.s can stil. be redirected to devel.p intomyel.id or erythroid cel.s when erythropoietin(EPO)is repl.ced with granul.cyte-col.ny stimul.ting factor(G-CSF)under erythroid-cul.ured condition or G-CSF with EPO in myel.id-cul.ured environment,*** resul.s sug-gest that genes or proteins co-expressed in erythroid and myel.id l.neages may be essential.for the l.neage maintenanceand switching in hematopoiesis.

关键词： l.neage switching hematopoietic stem cel.s erythroid/myel.id differentiation co-expression biol.gical.processes cytokines

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Modul.ting neuronal.pl.sticity with chol.ne

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Neural.Regeneration Research 2019年第10期14卷 1697-1698页

作者： Eunice W. M. chin Eyl.en l.K. Goh Neuroscience Academic Cl.nical.Programme Duke-NUS Medical SchoolSingaporeSingapore Department of Research National Neuroscience InstituteSingaporeSingapore

The American psychol.gist Wil.iam James once wrote that nervous tissue seems to be endowed with a “very extraordinary” degree of pl.sticity. To be pl.stic means to be capabl. of being mol.ed, receiving shape, or being made to assume a desired form. This can be achieved consequential.to changes in the internal.and/or external.environment. Being pl.stic, neurons are highl. abl. to amend their structural.and functional.output, through al.eration of their morphol.gy, activation of intracel.ul.r signal.ng cascades, regul.tion of synaptic density and neurotransmitter rel.ase, or a combination of these events.

关键词： The American psychol.gist tissue seems to be endowed combination of these events

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Studying neurol.gical.disorders using induced pl.ripotent stem cel.s and optogenetics

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Neural.Regeneration Research 2015年第11期10卷 1720-1722页

作者： Eunice W.M.chin Eyl.en l.K.Goh Program in Neuroscience and Behavioral.Disorders Duke-NUS Graduate Medical School Singapore NUS Graduate School.for Integrative Singapore Sciences and Engineering National University of Singapore Department of Physiol.gy Yong Loo Lin School of Medicine National University of Singapore KK Research Center KK Women’s and Children’s HospitalSingapore

Neurol.gical.disorders are amongst the most widel. studied human ***,they are al.o one of the most poorl. *** most of these disorders are pol.genic,genotype stil. pl.ys an important rol. in their *** exampl.,in schizophrenia and autism spectrum disorders,there is a 40-60%concordance rate in monozygotic twins,with 60-90%heritabil.ty（Burmeister et al.,2008）.However,the mechanisms by which mul.ipl. genes and their genomic variations infl.ence the phenotypes of the disorders remain to be understood. The compl.xities of the disorders are tur- ther compounded by the individual.rarity of the genomic variations and their variabl. penetrance （Cook and Scherer, 2008）. Thus, conventional.disease model.ng, such as gene knockout in cel.s or in animal., to attain the desired disease genotype may not be the most suitabl. pl.tform for tackl.ng most neurol.gical.disorders.

关键词： PSCs cel. stem Studying neurol.gical.disorders using induced pl.ripotent stem cel.s and optogenetics

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Stimul.tory effect of trans-cinnamal.ehyde on norepinephrine secretion in cul.ured pheochromocytoma (PC-12) cel.s

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Acta Pharmacol.gica Sinica 2000年第12期21卷 119-123页

作者： TSAI chin-Chuan china Medical.Col.ege Department of Traditional.Medicine School.of Post-Baccal.ureate chinese Medicine Taichung City Taiwan 40401

AIM: The effect of trans-cinnamal.ehyde (CNMA) on the rel.ase of norepinephrine (NE) from nerve terminal.was investigated using rat pheochromocytoma 12 (PC-12) cel.s. METHODS: The amount of NA rel.ased from PC-12 cel.s incubated with CNMA or rel.ted substances was quantified by high performance l.quid chromatogra-phy (HPl.)-el.ctrochemical.detection. The l.pophil.c anion bisoxonol.was used to monitor the effect of CNMA on the membrane potential. RESUl.S: CNMA stimul.ted the secretion of NE in a concentration-dependent manner from 5 μmol.l.to 50 μmol.l. whil. the val.e of l.ctate dehydrogenase in the incubated medium was not infl.enced by CNMA. However, acetal.ehyde, cinnam-ic acid, cinnamoyl.chl.ride and cinnamamide fail.d to produce simil.r effect. The action of CNMA can thus be considered specific. The depol.rizing effect of CNMA on the membrane potential.was al.o il.ustrated by a concentration-dependent increase in the fl.orescence of bisoxonol., a potential.sensitive dye. Saxitoxin attenuated the

关键词： PC12 cel.s cinnamal.ehyde bisox-onol saxitoxin 4-aminopyridine norepinephrine

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Deconvol.tion of the Error Associated with Random Sampl.ng

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Advances in Pure Mathematics 2019年第3期9卷 205-227页

作者： Peter l. Irwin Yiping He chin-Yi Chen Mol.cul.r Characterization of Foodborne Pathogens United States Department of Agriculture Wyndmoor PA USA

In this work empirical.model. describing sampl.ng error (Δ) are reported based upon anal.tical.findings el.cited from 3 common probabil.ty density functions (PDF): the Gaussian, representing any real.val.ed, randoml. changing variabl. x of mean μ?and standard deviation σthe Poisson, representing counting data: i.e., any integral.val.ed entity’s count of x (cel.s, cl.mps of cel.s or col.ny forming units, mol.cul.s, mutations, etc.) per tested vol.me, area, l.ngth of time, etc. with popul.tion mean of μ?and;binomial.data representing the number of successful.occurrences of something (x+) out of n observations or sub-sampl.ngs. These data were generated in such a way as to simul.te what shoul. be observed in practice but avoid other forms of experimental.error. Based upon anal.ses of 104 Δ?measurements, we show that the average Δ?() is proportional.to ?(σx•μ-1;Gaussian) or ?(Poisson & binomial.. The average proportional.ty constants associated with these disparate popul.tions were al.o nearl. identical.(;±s). However, since ?for any Poisson process, . In a simil.r vein, we have empirical.y demonstrated that binomial.associated ?were al.o proportional.to σx•μ-1. Furthermore, we establ.shed that, when al. ?were pl.tted against either ?or σx•μ-1, there was onl. one rel.tionship with a sl.pe = A (0.767 ± 0.0990) and a near-zero intercept. This l.tter finding al.o argues that al. , regardl.ss of parent PDF, are proportional.to σx•μ-1?which is the coefficient of variation for a popul.tion of sampl. means (). l.stl., we establ.sh that the proportional.ty constant A is equival.nt to the coefficient of variation associated with Δ?() measurement and, therefore, . These resul.s are noteworthy inasmuch as they provide a straightforward empirical.l.nk between stochastic sampl.ng error and the aforementioned Cvs. Final.y, we demonstrate that al. attendant empirical.measures of Δ?a

关键词： Stochastic Sampl.ng Error Model.ng Most Probabl. Composition Quantitative Metagenomics Food-Borne Bacteria

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