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Enhancing XRF sensor-based sorting of porphyritic copper ore using particle swarm optimization-support vector machine(PSO-SVM)algorithm

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International Journal of Mining Science and Technology 2024年第4期34卷 545-556页

作者： Zhengyu Liu Jue Kou Zengxin Yan Peilong Wang Chang Liu Chunbao Sun Anlin Shao Bern klein School of Civil and Resources Engineering University of Science and TechnologyBeijing 100083China Institute of Minerals Research University of Science and TechnologyBeijing 100083China State Key Laboratory of Mineral Processing Beijing 102628China Ansteel Group Mining Co.Ltd. Anshan 114000China Norman B.Keevil Institute of Mining Engineering University of British ColumbiaVancouverBC V6T 1Z4Canada

X-ray fluorescence(XRF)sensor-based ore sorting enables efficient beneficiation of heterogeneous ores,while intraparticle heterogeneity can cause significant grade detection errors,leading to misclassifications and hindering widespread technology *** classification models are crucial to determine if actual grade exceeds the sorting threshold using localized XRF *** studies mainly used linear regression(LR)algorithms including simple linear regression(SLR),multivariable linear regression(MLR),and multivariable linear regression with interaction(MLRI)but often fell short attaining satisfactory *** study employed the particle swarm optimization support vector machine(PSO-SVM)algorithm for sorting porphyritic copper ore ***-scale results showed PSO-SVM out-performed LR and raw data(RD)models and the significant interaction effects among input features was *** poor input data quality,PSO-SVM demonstrated exceptional ***-scale sorting achieved 93.0%accuracy,0.24%grade increase,84.94%recovery rate,57.02%discard rate,and a remarkable 39.62 yuan/t net smelter return(NSR)increase compared to no *** improvements were achieved by the PSO-SVM model with optimized input combinations and highest data quality(T=10,T is XRF testing times).The unsuitability of LR methods for XRF sensor-based sorting of investigated sample is *** element selection and mineral association analysis elucidate element importance and influence mechanisms.

关键词： XRF sensor-based sorting PSO-SVM algorithm Copper ore pebble Receiver operating curve(ROC) Net smelter return(NSR)

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Use of Patient-Specific “4D” Tele-Education to Enhance Actual and Perceived Knowledge in Congenital Heart Disease (CHD) Patients

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Congenital Heart Disease 2024年第1期19卷 5-17页

作者： Molly Clarke Karin Hamann Nancy klein Laura Olivieri Yue-Hin Loke Department of Inpatient Cardiology Boston Children’s HospitalBoston02115USA Department of Cardiology Children’s National HospitalWashington20001USA Department of Cardiology Noninvasive Cardiac ImagingUniversity of Pittsburgh Medical Center Children’s Hospital of PittsburghPittsburgh15224USA

Background:Patients with congenital heart disease(CHD)will transition to lifelong adult congenital cardiac ***,their structural heart disease is challenging to convey via two-dimensional *** study utilized a tele-educational environment,with personalized three-dimensional(3D)modeling and health Details(3D+Details=“4D”),to improve actual and perceived knowledge,both important components of transition readiness in CHD ***:Participants aged≥13 years with a history of CHD and cardiac magnetic resonance imaging(MRI)studies were *** MRI datasets were then used to segment and create 3D heart models(using Mimics,Materialize Inc.).Participantsﬁrst completed the MyHeart Questionnaire,a validated survey of actual knowledge.A tele-educational session was then scheduled,during which participants were shown a 3D model of a normal heart,followed by their personal 3D heart model and speciﬁc health *** then repeated the actual knowledge survey,in addition to questionnaires assessing perceived knowledge pre-and post-session,as well as a satisfaction ***:Twenty-two patients were *** knowledge increased from 75%±15%to 89%±20%(p=0.00043)and perceived knowledge increased inﬁve of seven *** knowledge correlated with perceived knowledge(r=0.608,p<0.0001).Ninety-one percent of participants ranked the 3D model as“very satisfactory”and ninety-ﬁve percent ranked the educational session as“very help-ful”or“extremely helpful.”Conclusions:The use of“4D”tele-education increased both actual and perceived knowledge and may help improve transition readiness in CHD patients.

关键词： Congenital heart disease tele-education transition

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烧伤创面处理:绪论

继续医学教育 2007年第13期21卷 1-9页

作者： matthew B.klein 赵珊珊杨世兵美国华盛顿大学医学院

复苏和危急期护理技术的进步显著提高了烧伤后存活率。最终，存活率仍然是依据创伤处理的有效性和创伤闭合的完全性而随机的。现代烧伤的处理方法是基于人皮肤生理生物学以及烧伤病理生理学理解基础之上的。

关键词：烧伤后创面处理绪论创伤处理病理生理学护理技术皮肤生理存活率

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COVID-19 Patient with Multifocal Pneumonia and Respiratory Difficulty Resolved Quickly: Possible Antiviral and Anti-Inflammatory Benefits of Quercinex (Nebulized Quercetin-NAC) as Adjuvant

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Advances in Infectious Diseases 2020年第3期10卷 45-55页

作者： Robert Schettig Trevor Sears matthew klein Ruth Tan-Lim Ronald Matthias Jr. Christopher Aussems Michael Hummel Rory Sears Zachary Poteet Daniel Warren John Oertle Dino Prato Envita Medical Center Scottsdale USA

Background: SARS-CoV-2 (COVID-19) is a viral pandemic with no current vaccine or effective treatment. Hydroxychloroquine and azithromycin are not without cardiovascular risk or complications, and these treatments can fail to aid in full recovery from COVID-19. As new treatments become approved for the pandemic, an inexpensive, non-toxic, and safe adjunctive therapy is needed. Case Presentation: A 59-year-old male presented with respiratory symptoms. Chest X-ray revealed classic indications of COVID-19 pneumonia. A PCR nasopharyngeal swab test confirmed a COVID-19 infection and hospital doctors prescribed Rocephin, azithromycin, and hydroxychloroquine. The patient was then prescribed Quercinex, a nebulized formula of quercetin-(cyclodextrin) (20 mg/mL) and N-acetylcysteine (100 mg/mL) three times daily for 14 days by physicians at Envita Medical Center for continued COVID-19 respiratory symptoms. Following 30 minutes after each nebulization treatment, the patient experienced immediate deep breathing relief that lasted for multiple hours. Within the following 48 hours after the first treatment, respiratory symptoms continued to diminish and resolve quickly. Finally, post-treatment follow-up chest X-rays revealed no pulmonary fibrosis (scarring) and clear lung fields. Conclusion: The Quercinex formula appeared to greatly alleviate the unresolved respiratory symptoms rapidly. Several mechanisms of the formula, namely antiviral and anti-inflammatory action, with direct administration via nebulizer to the deep lung tissue, could potentially explain the fast and complete recovery. We recommend that the Quercinex formula be considered for further clinical study as an adjuvant or on its own for COVID-19 and possibly other viral pulmonary conditions.

关键词： Quercetin N-Acetylcysteine (NAC) SARS-CoV-2 (COVID-19) Quercinex Envita Zinc Pneumonia Case Study Severe Acute Respiratory Syndrome Flavonoid Lung Antiviral Human

Melatonin: A Powerful Integrative Adjunctive Agent for Oncology

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Journal of Cancer Therapy 2020年第9期11卷 571-596页

作者： Robert Schettig Trevor Sears matthew klein Ruth Tan-Lim Ronald Matthias Christopher Aussems Michael Hummel Rory Sears Zachary Poteet Daniel Warren John Oertle Connor Coffin Dino Prato Envita Medical Center Scottsdale AZ USA

Melatonin is an established hormone supplement and has been well recognized for its effect on the circadian cycle to improve sleep, REM (rapid eye movement), and aiding in jetlag recovery. The utility of melatonin extends beyond sleep aid, however. This hormone also possesses less well-known antioxidant action and even robust anticancer activity. Melatonin may be a key supplement for addressing age-related neurologic decline while serving as a valuable adjunctive cancer treatment that reduces drug resistance in tumors and downregulates angiogenesis. In immunotherapy, melatonin activates Natural Killer (NK) cells nested within tumoral tissue and does not have the side effect profile of other immunoreactive agents used for chemotherapy. Since melatonin is found in high concentrations in the brain and other hormone-linked tissues, the relevance of melatonin is increased for the treatment of estrogen-linked cancers. The immunomodulatory effect of melatonin may also help with chronic inflammation seen in patients with autoimmune disorders. All of these effects together represent a unique and versatile therapeutic agent for integrative medicine. No other commercially available drug possesses all of these therapeutic mechanisms while having a very minimal side effect profile and being considered overall to be safe to use. Currently, melatonin is underutilized in medicine, especially in the field of integrative oncology and represents a crucial supportive adjuvant to improve the lives of patients.

关键词： Melatonin Oncology Immunotherapy Chronic Inflammation Autoimmune Envita Antioxidant Anticancer Antiangiogenesis Telomerase Metastasis Anti-Proliferation Pro-Apoptosis Immune System Activation Cancer Adjuvant Chemotherapy Synergy

Ageism: Millennial Persistence

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Advances in Aging Research 2024年第1期13卷 1-14页

作者： Alejandro klein Oxford Institute of Population Ageing University of Guanajuato Leon Mexico

This work develops the idea that is possible to affirm that beyond its nuances. Ageism has shown a surprising force of prevalence in western society. Nourished by mythical, empirical, ideological and health elements, it has been enormously successful in imposing an image of vulnerability, decrepitude and illness on older adults. Since 1969, when the first academic article on the subject was published, much has been written on the subject, but little progress has been made in terms of social and state policies and community awareness. When an attempt has been made to propose an alternative to decrepit (Aristotelian as we suggest in this paper) ageism, nothing has emerged but a new kind of ageism that has imposed the supposed need that the older adult “must” be “productive”, “young”, “vigorous”, posing the impossibility, in short, once again, of the older adult living spontaneously as an older adult.

关键词： Ageism Stereotypes Prejudices

PathoDNA, an Advanced Diagnostic for Lyme Disease &Co-Infections Utilizing Next Generation DNA Sequencing with Greater Sensitivity and Selectivity than ELISA/Western Blot

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Advances in Infectious Diseases 2021年第4期11卷 405-429页

作者： Robert Schettig Ruth Tan-Lim Daniel Warren Zachary Poteet Rory Sears Michael Hummel Connor Coffin Kendra Quart Christopher Aussems Ronald Matthias Jr. David Medina matthew klein Gayle Roberts John C. Oertle III Dino Prato Envita Scottsdale USA

The controversial subject of chronic Lyme disease has occupied medical discourse for years while contributing to unprecedented patient suffering in the United States and abroad. A general misunderstanding of Lyme disease and overconfidence in the Center for Disease Control’s (CDC) recommended two-step test for Lyme disease has led to misdiagnosis and incorrect treatment over the years. This leads to increasing medical expenses and worse outcomes for patients. The two-step test, an ELISA immunoblot followed by a confirmatory Western blot, yields accuracy rates as low as 29% for acute Lyme disease and 75% for chronic Lyme disease. While these practices have been a staple of microbiology for decades, these accuracy rates are unacceptable for diagnostic tests when better technology is available. PathoDNA, a Next-Generation DNA sequencing test for Lyme disease and other tick-borne pathogens, achieves accuracy rates of 98% for B. burgdorferi and 95% or greater for other common tick-borne pathogens with superior sensitivity and selectivity. PathoDNA is a Clinical Laboratory Improvement and Amendments (CLIA)-validated laboratory test that achieves these results utilizing Next Generational DNA Sequencing and a proprietary bioinformatics database. Thus, it allows for rapid results and specific identification of tick-borne illnesses. In this article, we will compare this promising technology against the existing standards for diagnosing and testing Lyme disease. We believe that PathoDNA can set a new standard for identifying Borrelia and diagnosing Lyme disease along with other tick-borne infections.

关键词： Lyme Disease Ticks Tick-Borne Borrelia Sequencing Diagnosis

Tribologically induced nanostructural evolution of carbon materials: A new perspective

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Friction 2024年第1期12卷 144-163页

作者： Guilherme Oliveira NEVES Nicolás ARAYA Diego Berti SALVARO Thiago de Souza LAMIM Renan Oss GIACOMELLI Cristiano BINDER Aloisio Nelmo klein JoséDaniel Biasoli de MELLO Laboratório de Materiais Universidade Federal de Santa CatarinaSanta Catarina 88040-900Brazil Departamento de Ingeniería Mecánica Facultad de IngenieríaUniversidad del Bío-BíoConcepcion 4070-386Chile Universidad de Concepción Concepcion 4070-386Chile SENAI Innovation Institute for Laser Processing Santa Catarina 89218-153Brazil Universidade Federal de Uberlândia Minas Gerais 38408-100Brazil

Carbon-based solid lubricants are excellent options to reduce friction and wear,especially with the carbon capability to adopt different allotropes *** the macroscale,these materials are sheared on the contact along with debris and contaminants to form tribolayers that govern the tribosystem *** a recently developed advanced Raman analysis on the tribolayers,it was possible to quantify the contactinduced defects in the crystalline structure of a wide range of allotropes of carbon-based solid lubricants,from graphite and carbide-derived carbon particles to multi-layer graphene and carbon *** addition,these materials were tested under various dry sliding conditions,with different geometries,topographies,and solid-lubricant application *** of the initial tribosystem conditions and allotrope level of atomic ordering,there is a remarkable trend of increasing the point and line defects density until a specific saturation limit in the same order of magnitude for all the materials tested.

关键词： carbon nanostructures tribology Raman spectroscopy defects quantification tribolayer solid lubrication

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基于指针神经网络的细粒度缺陷定位

软件学报 2024年第4期35卷 1841-1860页

作者：王尚文刘逵林博黎立 Jacques klein TegawendéFrançois BISSYANDÉ 毛晓光国防科技大学计算机学院湖南长沙410073 南京航空航天大学计算机科学与技术学院江苏南京210016 Monash University Clayton VIC 3800Australia University of Luxembourg Luxembourg L-1359Luxembourg

软件缺陷定位是指找出与软件失效相关的程序元素.当前的缺陷定位技术仅能产生函数级或语句级的定位结果.这种粗粒度的定位结果会影响人工调试程序和软件缺陷自动修复的效率和效果.专注于细粒度地识别导致软件缺陷的具体代码令牌,为代码... 详细信息

软件缺陷定位是指找出与软件失效相关的程序元素.当前的缺陷定位技术仅能产生函数级或语句级的定位结果.这种粗粒度的定位结果会影响人工调试程序和软件缺陷自动修复的效率和效果.专注于细粒度地识别导致软件缺陷的具体代码令牌,为代码令牌建立抽象语法树路径,提出基于指针神经网络的细粒度缺陷定位模型来预测出具体的缺陷代码令牌和修复该令牌的具体操作行为.开源项目中的大量缺陷补丁数据集包含大量可供训练的数据,且基于抽象语法树构建的路径可以有效捕获程序结构信息.实验结果表明所训练出的模型能够准确预测缺陷代码令牌并显著优于基于统计的与基于机器学习的基线方法.另外,为了验证细粒度的缺陷定位结果可以贡献于缺陷自动修复,基于细粒度的缺陷定位结果设计两种程序修复流程,即代码补全工具去预测正确令牌的方法和启发式规则寻找合适代码修复元素的方法,结果表明两种方法都能有效解决软件缺陷自动修复中的过拟合问题.

关键词：缺陷定位缺陷自动修复神经网络

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