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Deficiency of pyruvate dehydrogenase kinase 4 sensitizes mouse liver to diethylnitrosamine and arsenic toxicity through inducing apoptosis

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Liver Research 2018年第2期2卷 100-107页

作者： Jonathan Choiniere matthew junda lin Li Wang Jianguo Wu Department of Physiology and Neurobiology Institute for Systems GenomicsUniversity of ConnecticutStorrsCTUSA Veterans Affairs Connecticut Healthcare System West HavenCTUSA Department of Internal Medicine Section of Digestive DiseasesYale UniversityNew HavenCTUSA School of Pharmaceutical Sciences Wenzhou Medical UniversityWenzhouZhejiangChina

Background and Aim:Pyruvate dehydrogenase kinase 4(PDK4)is a metabolism switch that regulates glucose oxidation and the tricarboxylic acid cycle(TCA cycle)in the *** detoxifies xenobiotics and is constantly challenged by various *** study aims at understanding how the loss of the metabolism regulator PDK4 contributes to liver ***:Wild-type(WT)and Pdk4 knockout(Pdk4-/-)mice of different ages were examined for spontaneous hepatic *** or adult mice of two genotypes were insulted by diethylnitrosamine(DEN),arsenic,galactosamine(GalN)/lipopolysaccharide(LPS),anti-CD95(Jo2)antibody or carbon tetrachloride(CCl4).Liver injury was monitored by blood biochemistry *** was determined by terminal deoxynucleotidyl transferase dUTP nick end labeling(TUNEL)staining,poly(ADP-ribose)polymerase(PARP)cleavage,and caspase activity *** response was determined by nuclear factor(NF)-kB activation and the activation of NF-kB target *** hepatocytes were isolated and cell viability was evaluated by MTS ***:We showed that systematic Pdk4-/-in mice resulted in age-dependent spontaneous hepatic ***4-deficiency increased the toxicity of DEN in juvenile mice,which correlated with a lethal consequence and massive hepatic ***,chronic arsenic administration induced more severe hepatic apoptosis in Pdk4-/-mice compared to WT control *** aggravated hepatic NF-kB mediated-inflammatory response was observed in Pdk4-/-mice *** vitro,Pdk4-deficient primary hepatocytes were more vulnerable to DEN and arsenic challenges and displayed higher caspase activity than wild type ***,hepatic PDK4 mRNA level was remarkably reduced during acute liver failure induced by GalN/LPS or Jo2 *** diminished PDK4 expression was also observed in CCl4-induced acute liver ***:PDK4 may contribute to the protection from apoptotic injury in mouse liver.

关键词： Hepatocytes Cell death Liver injury Pyruvate dehydrogenase kinase 4(PDK4)

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Corrigendum to“Deficiency of pyruvate dehydrogenase kinase 4 sensitizes mouse liver to diethylnitrosamine and arsenic toxicity through inducing apoptosis”[Liver Res.2(2018)100e107]

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Liver Research 2023年第2期7卷 164-164页

The authors regret.The authors would like to apologise for any inconvenience caused.

关键词： removed Liver thank

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创新型红豆露酒的工艺探究

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酿酒 2024年第2期51卷 130-131,135页

作者：林俊达何志远杨璕中粮黑龙江酿酒有限公司黑龙江肇东151100

露酒主要是以酒基和原辅料按照生产工艺加工而成。其原辅料可供选择的品种很多,具有强大的优势。如:宫丁香、枸杞、人参、蛇、当归、动物、动物的骨骼等等,可以说,凡是中医能够入药的品种,基本上都能按照生产工艺而生产露酒。主要论述... 详细信息

露酒主要是以酒基和原辅料按照生产工艺加工而成。其原辅料可供选择的品种很多,具有强大的优势。如:宫丁香、枸杞、人参、蛇、当归、动物、动物的骨骼等等,可以说,凡是中医能够入药的品种,基本上都能按照生产工艺而生产露酒。主要论述了红豆越橘的生长环境、功效与作用及红豆酒材料的筛选、生产工艺等,为红豆酒的发展提供一些理论依据。

关键词：红豆酒功效与作用生产工艺

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Water,organic matter,nitrogen and phosphorus contents in sediment of a large-scale mariculture area in the Zhelin Bay of eastern Guangdong Province,China

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Acta Oceanologica Sinica 2008年第2期27卷 133-148页

作者： DONG Qiaoxiang lin junda SHANG Xu LI Jin HUANG Changjiang School of Environmental Science and Public Health Wenzhou Medical College Wenzhou 325035 China Florida Institute of Technology Melbourne Florida 32901 -6975 USA

The Zhelin Bay is one of the most important bays for large-scale mariculture in Guangdong Province, China. Owing to the increasing human population and the expanding mariculture in the last two decades, the ecological environment has greatly changed with frequent harmful algal blooms. A monthly survey of water content, organic matter （TOM）, and various forms of nitrogen and phosphorous in sediment from July 2002 to July 2003 in the bay was conducted. The results showed that the water content was correlated significantly with TOM and various forms of nitrogen and phosphorus and can be used as proxy for quick and rough estimate of these factors in the future surveys. TOM was also correlated significantly with various forms of nitrogen and phosphorus, indicating that it was one of the key factors affecting the concentrations and distributions of nitrogen and phosphorus in the investigated waters. Average total Kjeldhal nitrogen （TkN） content was（ 1 113.1 ± 382.5）μg/g and average total phosphorus （TP） content was（567.2± 223.3）μg/g, and both were much higher than those of similar estuaries in China and elsewhere. Average nitrogen and phosphorus tended to be higher inside than outside the bay, higher at aquaculture than non-aquaculture areas, and higher at fish-cage culture than oyster culture areas, suggesting that large-scale mariculture inside the bay played an important role in the eutrophication of the Zhelin Bay. Various forms of nitrogen and phosphorus concentrations were higher during the warm season （July--September）, which was due to the increased decomposition and concentration of organic matter resulted from the fast growth and high mortality of the cultured species. Compared with July 2002, TkN and TP contents were much higher in July 2003, in consonance with the eutrophication of the Zhelin Bay. Because exchangeable phosphorus （Ex-P）, iron-bounded phos- phorus （Fe-P） and organic phosphorus （OP） combined accounted for 34.3% of the TP and authigenic phosphorus

关键词： Zhelin Bay sediment nitrogen phosphorus water content organic matter

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Invasion and Morphological Variation of the Non- Indigenous Barnacle Chthamalus challengeri(Hoek, 1883) in Yangshan Port and its Surrounding Areas

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Journal of Ocean University of China 2015年第3期14卷 575-583页

作者： LIU Yan XUE Junzeng lin junda WU Huixian Key Laboratory of Exploration and Utilization of Aquatic Genetic Resources Shanghai Ocean UniversityMinistry of Education Department of Biological Sciences Florida Institute of Technology

Invasive species generally possess unique characteristics that allow them to survive the invasion process in order to es- tablish and spread in new habitats. Successful invaders must resist both physical and physiological stresses associated with the changing environment. A common littoral barnacle, Chthamalus challengeri Hoek, 1883 （Crustacea, Cirripedia）, which is native to Japan, South Korea and northern China, has become established in the high-littoral zone adjacent to Yangshan Port, Shanghai, China. A comparison of the morphology of Chthamlus species from Zhoushan archipelago with previous description indicates the occur- rence of C. challengeri. The new immigrant becomes a dominant species in certain high-intertidal habitats of the adjacent area to of Yangshan Port. C. challengeri was found in part of sampling sites in Zhoushan in 2010; however, it dispersed to all the eleven sam- piing sites in 2012. Densities of *** had increased over 10 times in the last 2 years, with the highest mean value reaching 39533 ± 6243 ind. m-2 in the new habitat. The specific ratios of both operculum area （Sa） to base area （SA） and average height of pa- rietal plates （H） to length of base （L） revealed that C. challengeri displays morphological changes to resist stronger currents in the new habitats for invasion.

关键词： Chthamalus challengeri marine alien species morphological variation Yangshan Port invasion

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Polyculture of the lined seahorse,Hippocampus erectus Perry,1810 with two species of macroalgae in aquaria

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Acta Oceanologica Sinica 2010年第1期29卷 26-32页

作者： XU Yongjian lin junda CHEN Shun Vero Beach Marine Laboratory Florida Institute of Technology Vero Beach FL 32963 USA Key Laboratory of Applied Marine Biotechnology Ministry of Education Ningbo UniversityNingbo 315211 China

A two-month study was conducted to test the effects of macroalgae on the growth and survivorship of juvenile lined seahorse （Hippocarapus erectus） in aquaria. Twenty-day old seahorses were cultured in the tanks with green alga Chaetomorpha linum, red alga Gracilaria tikvahiae, green plastic artificial plant （stargrass）, and black plastic net, respectively. Increases in wet mass and standard length for the seahorses were significantly higher in the tanks with macroalgae than those without macroalgae. The seahorse survivorships in the two macroalgal treatments were also significantly higher than those of the two treatments without macroalgae. In the treatments with macroalgae, the DO and pH were higher than those without marcoalgae. During the experiment, the color of seahorses was changed to certain extent. In the green background （the treatments with C. linum and stargrass）, 24.1% 28.4% of black seahorses decreased over time; whereas in the black （plastic net） or brown （G. tikvahiae） background treatments, 14.1% 16.3% of yellow seahorses decreased over time, for matching that of the background. Furthermore, the survival rate of seahorse was correlation with DO and pH, and strong correlation with standard length, wet mass and CF. Polyculture with macroalgae, survival rates of seahorse were higher than without macroaglae.

关键词： Hippocampus erectus Chaetornorpha linum Gracilaria tikvahiae growth rate survival rate water quality in aquarium

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The biological content of ballast water in China:A review

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Aquaculture and Fisheries 2017年第6期2卷 241-246页

作者： Huixian Wu Chen Chen Qiong Wang junda lin Junzeng Xue Ballast Water Detecting Lab Shanghai Ocean UniversityShanghai 201306China Key Laboratory of Exploration and Utilization of Aquatic Genetic Resources Shanghai Ocean UniversityMinistry of EducationShanghai 201306China Department of Biological Sciences Florida Institute of TechnologyMelbourneFL 32901USA

The introduction of species through the release of ballast water has become a major threats to marine biodiversity and ecosystem function *** is one of the top trading countries,yet little is known about exotic species in the ballast water of ships coming to its ***,we review the biological surveys of ballast water from major Chinese *** surveys reveal that 40 species of nonindigenous phytoplankton that,belong to 25 genera and five phyla,have been observed in ballast *** dominant species are diatoms and *** were 17 red-tide causing species observed,five of which are noxious *** species of non-indigenous zooplankton have been reported,most of them(11)*** were also 22 species of pathogenic bacteria recorded,including Vibrio alginolyticus,***,***,and *** studies show that species introduction through ballast water potentially a serious threat to the ecology and human health in *** research,including collaboration with the international community,is urgently needed to address this problem.

关键词： Ballast water Biological survey China Phytoplankton Zooplankton Bacteria

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国内国际双循环背景下中国制造业转型升级——基于对外直接投资角度

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科技和产业 2024年第14期24卷 113-125页

作者：韩雨欣赵廖恒陈舒泓秦延煜林骏达上海海关学院上海201204

国内国际双循环新发展格局逐渐形成,中国制造业逐步开始转型升级。利用2015—2021年的相关数据,建立OFDI-制造业评估体系,探索对外直接投资对其的影响。总体而言,中国对外直接投资(OFDI)促进了中国制造业高质量发展,存在逆向技术溢出的... 详细信息

国内国际双循环新发展格局逐渐形成,中国制造业逐步开始转型升级。利用2015—2021年的相关数据,建立OFDI-制造业评估体系,探索对外直接投资对其的影响。总体而言,中国对外直接投资(OFDI)促进了中国制造业高质量发展,存在逆向技术溢出的中介效应,对制造业创新发展方面的积极作用最为显著。在要素密集度和经济合作与发展组织(OECD)两种不同分类标准中,技术密集型制造业和中低级技术制造业受到的积极影响最大。最后,从政府和企业层面提出建议,为“智造2025”贡献力量。

关键词：制造业转型对外直接投资高质量发展双循环

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有机肥小分子化促进作物增产增效的研究进展

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中国农学通报 2024年第15期40卷 59-65页

作者：林思远袁军委侯俊何文祥蔡亮吴俊达刘超刘翔农业农村部长江中游作物绿色高效生产重点实验室(部省共建)/长江大学农学院湖北荆州434020 荆门法麦克斯农业科技有限公司湖北荆门448200 中化现代农业有限公司北京100032 汉川市农业技术推广中心湖北汉川431200

施用化肥能提高作物的产量,但过度施用化肥会对环境造成严重的污染;施用传统有机肥能够减少环境的污染,但其营养不足、质量不稳定、起效慢等缺点决定了它不能满足作物生长的需求。有机肥小分子化产品(小分子有机肥,下同)是一种含有多类... 详细信息

施用化肥能提高作物的产量,但过度施用化肥会对环境造成严重的污染;施用传统有机肥能够减少环境的污染,但其营养不足、质量不稳定、起效慢等缺点决定了它不能满足作物生长的需求。有机肥小分子化产品(小分子有机肥,下同)是一种含有多类小分子有机物的肥料,其能被作物根系直接吸收,提高土壤肥力和土壤微生物活性;此外,其也能和化肥化学键合,从而实现提高化肥利用效率、化肥减施和农业提质增效的目的。为了研究克服了化肥和有机肥的不足的小分子有机肥,归纳了小分子有机肥的种类,阐述其在不同作物上的施用效果以及对土壤理化性质和土壤微生物群落变化的影响,探讨了小分子有机肥的主要生产工艺、存在的问题和未来的发展方向。

关键词：有机肥有机肥小分子化生产工艺新型肥料土壤微生物活性

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草地-池塘共养条件下绍兴鸭生长、屠宰性状和肌肉品质特性

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浙江农业科学 2024年第4期65卷 967-970页

作者：许小妹李桂萍杨速操勇清林玉梅于波李国勤曾涛田勇陶争荣沈军达王冬蕾孙梅好卢立志浙江师范大学化学与生命科学学院浙江金华321004 浙江省农业科学院畜牧兽医研究所浙江杭州310021 甘肃农业大学动物科学技术学院甘肃兰州730070 景宁县农业农村局浙江丽水323500 宁波新材料科技城至源农场浙江宁波315000

为了研究草地-池塘共养环境下的绍兴鸭生长性状、屠宰性能与肌肉品质,试验选取了102只同一批18日龄绍兴公鸭,分为3组在草地-池塘环境下进行饲养,试验结束后进行屠宰分析。结果显示:绍兴鸭在草地-池塘环境下经过42 d的饲养后,60日龄的体... 详细信息

为了研究草地-池塘共养环境下的绍兴鸭生长性状、屠宰性能与肌肉品质,试验选取了102只同一批18日龄绍兴公鸭,分为3组在草地-池塘环境下进行饲养,试验结束后进行屠宰分析。结果显示:绍兴鸭在草地-池塘环境下经过42 d的饲养后,60日龄的体重为1 256.75 g,平均日增重25.13 g,屠宰率为86.91%。胸肌率为6.25%,胸肌的肌间脂肪与肌苷酸含量分别为1.46%和1.21 mg·kg^(-1)。腿肌率为13.90%,腿肌的肌间脂肪与肌苷酸含量分别为1.96%和1.37 mg·kg^(-1)。在胸肌与腿肌中共检测到11种脂肪酸,包含3种必需脂肪酸。在草地-池塘环境下生长的绍兴鸭生长性状良好,屠宰性能较优,肌肉中脂肪酸含量相对丰富,具备水环境的饲养条件有利于绍兴鸭胸肌生长,草地-池塘环境可作为饲养绍兴鸭的优秀养殖条件。

关键词：绍兴鸭草地-池塘共养生长性能屠宰性能肌肉品质

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