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Gastric cancer in Alaska Native people: A cancer health disparity

World journal of Gastroenterology 2018年第25期24卷 2722-2732页

作者： Holly A Martinson Nancy j Shelby Steven R Alberts matthew j olnes WWAMI School of Medical Education University of Alaska Anchorage Department of Oncology Mayo Clinic Cancer Center Hematology and Medical Oncology Department Alaska Native Medical Center

AIM To evaluate recent trends in gastric cancer incidence, response to treatment, and overall survival among Alaska Native(AN) people. METHODS A retrospective analysis of the Alaska Native Medical Center patient database was performed. Patient history, clinical, pathological, response to treatment and patient outcomes were collected from one-hundred and thirty-two AN gastric cancer patients. The Surveillance, Epidemiology and End Result database 18 was used to collect comparison United States non-Hispanic White(NHW) and AN gastric cancer patient data between *** AN gastric cancer patients have a higher incidence rate, a poorer overall survival, and are diagnosed at a significantly younger age compared to NHW patients. AN patients differ from NHW patients in greater prevalence of non-cardia, diffuse subtype, and signet ring cell carcinomas. AN females were more likely to be diagnosed with later stage cancer, stage IV, compared to AN males. Diminished overall survival was observed among AN patients with increasing stage, O+ blood type, < 15 lymph nodes examined at resection, and no treatment. This study is the first report detailing the clinicopathologic features of gastric cancer in AN people with outcome *** Our findings confirm the importance of early detection, treatment, and surgical resection for optimizing AN patient outcomes. Further research on early detection markers are warranted.

关键词： Alaska Native gastric cancer Helicobacter pylori gender health disparities

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