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Refinement of saliva microRNA biomarkers for sports-related concussion

Journal of Sport and Health Science 2023年第3期12卷 369-378页

作者： Steven D.Hicks Cayce Onks Raymond Y.Kim Kevin J.Zhen Jayson Loeffert Andrea C.Loeffert Robert P.Olympia Gregory Fedorchak Samantha DeVita Zofia Gagnon Callan McLoughlin Miguel M.Madeira Scott L.Zuckerman Timothy Lee matthew heller Chuck Monteith Thomas R.Campbell Christopher Neville Elise Fengler Michael N.Dretsch Department of Pediatrics College of MedicinePennsylvania State UniversityHersheyPA 17033USA Department of Orthopaedics and Rehabilitation College of MedicinePennsylvania State UniversityHersheyPA 17033USA Department of Family Medicine College of MedicinePennsylvania State UniversityHersheyPA 17033USA Department of Emergency Medicine College of MedicinePennsylvania State UniversityHersheyPA 17033USA Department of Research and Development Quadrant Biosciences Inc.SyracuseNY 13210USA Department of Biology Marist CollegePoughkeepsieNY 12601USA Sports Concussion Center College of MedicineVanderbilt UniversityNashvilleTN 37212USA Department of Family Medicine College of Osteopathic MedicineNew York Institute of TechnologyOld WestburyNY 11568USA Department of Athletic Training Colgate UniversityHamiltonNY 13346USA Department of Rehabilitation Sciences Old Dominion UniversityNorfolkVA 23529USA Department of Physical Therapy Education Orthopedicsand NeuroscienceCollege of MedicineSUNY Upstate Medical UniversitySyracuseNY 13210USA Department of Exercise Science Syracuse UniversitySyracuseNY 13210USA Department of Medical Research—West Walter Reed Army Institute of ResearchUS Army Joint Base Lewis-McChordHillhurstWA 98433USA

Background:Recognizing sport-related concussion(SRC)is challenging and relies heavily on subjective symptom *** objective,biological marker could improve recognition and understanding of *** is emerging evidence that salivary micro-ribonucleic acids(miRNAs)may serve as biomarkers of concussion;however,it remains unclear whether concussion-related miRNAs are impacted by *** sought to determine whether40 miRNAs previously implicated in concussion pathophysiology were affected by participation in a variety of contact and non-contact *** goal was to refine a miRNA-based tool capable of identifying athletes with SRC without the confounding effects of ***:This case-control study harmonized data from concussed and non-concussed athletes recruited across 10 *** of salivary miRNAs within 455 samples from 314 individuals were measured with RNA ***-subjects testing was used to identify and exclude miRNAs that changed with either(a)a single episode of exercise(166 samples from 83 individuals)or(b)season-long participation in contact sports(212 samples from 106 individuals).The miRNAs that were not impacted by exercise were interrogated for SRC diagnostic utility using logistic regression(172 samples from 75 concussed and 97 non-concussed individuals).Results:Two miRNAs(miR-532-5p and miR-182-5p)decreased(adjusted p0.50;adjusted p0.70)to identify concussion.A

关键词： Biomarker Contact sports Football RNA Traumatic brain injury

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Paleomagnetic age and palaeobiological significance of hominoid fossil strata of Yuanmou Basin in Yunnan

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Science China Earth Sciences 2004年第5期47卷 405-411页

作者： Friedrich A. heller Institute of Geophysics ETH Zurich Switzerland CH-8093

The two sections containing hominoid fossils in the Yuanmou Basin, Yunnan Prov-ince have been studied by means of magnetostratigraphy. The results are as follows. The Xiaohe section records over 8 polarity zones corresponding to Cande-Kent95 time scale, including C3Br.1n, C3Br.1r, C3Br.2n, C3Br.2r, C4n.1n, C4n.1r, C4n.2n and C4n.2r, attaching to Late Mio-cene. This section comprises two layers of hominoid fossils: the lower layer (the 1st layer in fig. 4) which records the lower portion of C4n.2r with paleomagnetic age of 8.20—8.10 Ma and the upper layer (the 16th layer in fig. 4) which records C3Br.1r with paleomagnetic age of 7.20—7.15 Ma. So the age of hominoid fossils in the Xiaohe section is about 8.20—7.15 Ma. The Leilao section records over 11 polarity zones corresponding to Cande-Kent95 time scale, including C3Br, C3Br.1n, C3Br.1r, C3Br.2n, C3Br.2r, C4n.1n, C4n.1r, C4n.2n, C4n.2r, C4n.3n and C4n.3r, attaching to Late Miocene. This section also consists of two layers of hominoid fossils: the lower layer (the 3rd layer in fig. 3) which records C4n.2r with the age of 8.20—8.10 Ma and the upper layer(the 19th layer in fig. 3) which records the middle portion of C3Br with the age of 7.15—7.1 Ma. So the age of hominoid fossils in the Leilao section is about 8.20—7.10 Ma. Sedimentary environments reflected in both sections are extremely similar, and the ages of hominoid fossils are of correspondency. The age of the lower and upper fossil layers is 8.20—8.10 Ma and 7.20—7.10 Ma respectively, which probably imply that hominoids living in Xiaohe and Leilao basins have uniform activity areas. There were hominoids activities all along during 8.00—7.00 MaBP in this field.

关键词： Yuanmou Basin, hominoid, paleomagnetism, chronology.

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LIU TUNGSHENG'S PALAEOMAGNETIC LOESS RESEARCH IN SWITZERLAND

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第四纪研究 2009年第5期29卷 847-850页

作者： Friedrich heller Institut für Geophysik ETH-Zentrum CH-8092 Zürich

11月22日是刘东生先生的生日,在先生离开我们的一年多时间里,我们时刻在怀念他。这里我们刊登了刘先生的密友之一、瑞士的heller教授的短文,怀念与刘先生一起研究黄土磁学的点点滴滴。本文是heller教授为刘先生的纪念文集撰写的,但因故... 详细信息

11月22日是刘东生先生的生日,在先生离开我们的一年多时间里,我们时刻在怀念他。这里我们刊登了刘先生的密友之一、瑞士的heller教授的短文,怀念与刘先生一起研究黄土磁学的点点滴滴。本文是heller教授为刘先生的纪念文集撰写的,但因故未及在文集中刊出。现在本刊补登,除了表示对先生的深切怀念,也表示对heller教授的感谢和歉意。

关键词：黄土磁学研究刘东

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Preface to A Study of Agnes heller’s Thoughts on Aesthetic Modernity by Fu Qilin

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Comparative Literature:East & West 2007年第1期 57-59页

作者： Agnes heller New School for Social Research in New York

本文是阿格妮丝·赫勒为书稿《阿格妮丝·赫勒审美现代性思想研究》所写的序,肯定了此书从美学现代性角度考察其著述的新颖性与合法性,有助于帮助读者理解她的现代性理论、伦理学与历史哲学。赫勒在文中重新阐释了从现代美学起源到当代... 详细信息

本文是阿格妮丝·赫勒为书稿《阿格妮丝·赫勒审美现代性思想研究》所写的序,肯定了此书从美学现代性角度考察其著述的新颖性与合法性,有助于帮助读者理解她的现代性理论、伦理学与历史哲学。赫勒在文中重新阐释了从现代美学起源到当代的某些重要问题,也谈及其近年的美学与艺术转向。

关键词：赫勒现代美学现代性理论 heller 历史哲学审美现代性 favorite familiar

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Chronic hepatitis delta: A state-of-the-art review and new therapies

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World Journal of Gastroenterology 2019年第32期25卷 4580-4597页

作者： Christy Gilman Theo heller Christopher Koh Liver Diseases Branch National Institute of Diabetes and Digestive and Kidney Diseases National Institutes of Health

Chronic delta hepatitis is the most severe form of viral hepatitis affecting nearly 65 million people *** with this devastating illness are at higher risk for developing cirrhosis and hepatocellular *** virus is a defective RNA virus that requires hepatitis B surface antigen for propagation in *** can occur in the form of a co-infection with hepatitis B,which can be self-limiting,vs superinfection in a patient with established hepatitis B infection,which often leads to chronicity in majority of *** noninvasive tools to assess for advanced liver disease have limited utility in delta *** recommend treatment with pegylated interferon,but this is limited to patients with compensated disease and is efficacious in about 30%of those *** to limited treatment options,novel agents are being investigated and include entry,assembly and export inhibitors of viral particles in addition to stimulators of the host immune *** clinical trials should take into consideration the interaction of hepatitis B and hepatitis D as suppression of one virus can lead to the activation of the ***,surrogate markers of treatment efficacy have been proposed.

关键词： Hepatitis delta Epidemiology Treatment

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Pandemic punch:SARS-CoV-2 hits pancreas

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Signal Transduction and Targeted Therapy 2024年第5期9卷 1779-1780页

作者： Ninel Azoitei Sandra heller Alexander Kleger Institute of Molecular Oncology and Stem Cell Biology Ulm UniversityUlmGermany Division of Interdisciplinary Pancreatology Clinic of Internal Medicine IUniversity Hospital UlmUlmGermany

The COVID-19 pandemic has profoundly impacted global health systems,revealing the extensive repercussions of SARS-CoV-2 beyond respiratory ***,traditionally considered a respiratory virus,SARS-CoV-2’s showcased the ability to target multiple organ systems including pancreas,an organ crucial for regulating blood sugar levels and aiding digestion.

关键词： pancreas respiratory traditionally

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Cenozoic basin development and its indication of plateau growth in the Xunhua-Guide district

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Science China Earth Sciences 2007年第z2期50卷 277-291页

作者： LIU ShaoFeng ZHANG GuoWei P.L.heller State Key Laboratory of Geological Processes and Mineral Resources China University of Geosciences Beijing 100083 China College of Geosciences and Resources China University of Geosciences Beijing 100083 China Key Laboratory of Lithosphere Tectonics and Lithoprobing Technology of Ministry of Education China University of Geosciences Beijing 100083 China Department of Geology Northwest University Xi'an 710069 China Department of Geology and Geophysics University of Wyoming Laramie Wyoming 82071 USA

The Xunhua, Guide and Tongren Basins are linked with the Laji Mountain and the northern West Qinling thrust belts in the Xunhua-Guide district. Basin depositional stratigraphy consists of the Oligocene Xining Group, the uppermost Oligocene-Pliocene Guide Group and the Lower Pleistocene. They are divided into three basin phases by unconformities. Basin phase 1 is composed of the Xining Group, and Basin phase 2 of the Zharang, Xiadongshan, Herjia and Ganjia Conglomerate Formations in the Guide Group, and Basin phase 3 of the Gonghe Formation and the Lower Pleistocene. Three basin phases all develop lacustrine deposits at their lower parts, and alluvial-braided channel plain depositional systems at upper parts, which constitute a coarsening-upward and progradational sequence. Basin deposition, paleocurrent and provenance analyses represent that large lacustrine basin across the Laji Mountain was developed and sourced from the West Qinling thrust belt during the stage of the Xining Group (Basin phase 1), and point-dispersed alluvial fan-braided channel plain deposition systems were developed beside the thrust and uplifted Laji Mountain and sourced from it, as thrusting migrated northwards during the stage of the Guide Group (Basin phase 2). Evolution of basin-mountain system in the study area significantly indicates the growth process of the distal Tibetan Plateau. The result shows that the Tibetan Plateau expanded to the northern West-Qinling at Oligocene (29―21.4 Ma) by means of northward folded-and-thrust thickening and uplifting and frontal foreland basin filling, and across the study area to North Qilian and Liupan Mountain at the Miocene-Pliocene (20.8―2.6 Ma) by means of two-sided basement-involved-thrust thickening and uplifting and broken foreland basin filling, and the distant end of Tibetan Plateau behaved as regional erosion and intermontane basin aggradational filling during the Pliocene and early Pleistocene (2.6―1.7 Ma).

关键词： Xunhua-Guide district, Cenozoic basins, provenance analysis, basin-mountain evolution, plateau growth

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Modeling of IPMC Cantilever＇s Displacements and Blocking Forces

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Journal of Bionic Engineering 2015年第1期12卷 142-151页

作者： David Vokoun Qingsong He Ludek heller Min Yu Zhendong Dai Institute of Physics of the ASCR Prague 182 21 Czech Republic Institute of Bio-lnspired Structure and Surface Engineering Nanjing University of Aeronautics and Astronautics Nanjing 210016 China

The motion of an Ionic Polymer Metal Composite （IPMC） cantilever under a periodic voltage control is modeled. In our finite element 3D model, we follow both the free tip displacements and the blocking forces for various thicknesses and elastic constants of the ionomer membrane. It turns out that the maximum displacement of the free tip strongly depends on the value of the Young＇s modulus of the electrodes. Furthermore, the maximum blocking force, Fmax, increases with the thickness of the ionomer membrane. At constant values of Young＇s moduli of the electrodes and ionomer membrane thickness, if the Young＇s modulus of the ionomer membrane varies within the range from 0.2 MPa to 1 GPa, the change of Fmax is less than 10 %. The simulated maximal displacements, blocking forces and electrical currents are compared with the corresponding sets of ex- perimental data, respectively. Qualitative agreement between the simulated and the respective measured data profiles is ob- tained. Furthermore, it is found that the assumption of electrostatic interactions in the cation depleted region of the ionomer membrane has a negligible effect. The advantage of the model consists in its simplicity.

关键词： ionic polymer metal composite actuator blocking force finite element method

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Hepatitis D infection:from initial discovery to current investigational therapies

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Gastroenterology Report 2019年第4期7卷 231-245,I0001页

作者： Ben L.Da Theo heller Christopher Koh Digestive Diseases Branch National Institute of Diabetes&Digestive&Kidney DiseasesNational Institutes of HealthBethesdaMDUSA Liver Diseases Branch National Institute of Diabetes&Digestive&Kidney DiseasesNational Institutes of HealthBethesdaMDUSA

Hepatitis D is the most severe form of viral hepatitis associated with a more rapid progression to cirrhosis and an increased risk of hepatocellular carcinoma and mortality compared with hepatitis B *** once thought of as a disappearing disease,hepatitis D is now becoming recognized as a serious worldwide issue due to improvement in diagnostic testing and immigration from endemic *** these concerns,there is currently only one accepted medical therapy(pegylated-interferon-a)for the treatment of hepatitis D with less than desirable efficacy and significant side *** to these reasons,many patients never undergo ***,increasing knowledge about the virus and its life cycle has led to the clinical development of multiple promising new therapies that hope to alter the natural history of this disease and improve patient *** this article,we will review the literature from discovery to the current investigational therapies.

关键词： Hepatitis D hepatitis B epidemiology natural history outcome treatment novel therapies

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New perspectives on biology,disease progression,and therapy response of head and neck cancer gained from single cell RNA sequencing and spatial transcriptomics

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Oncology Research 2024年第1期32卷 1-17页

作者： GERWIN heller THORSTEN FUEREDER ALEXANDER MICHAEL GRANDITS ROTRAUD WIESER Division of Oncology Department of Medicine IMedical University of ViennaVienna1090Austria Ludwig Boltzmann Institute for Hematology and Oncology Medical University of ViennaVienna1090Austria

Head and neck squamous cell carcinoma(HNSCC)is one of the most frequent cancers *** main risk factors are consumption of tobacco products and alcohol,as well as infection with human papilloma *** therapeutic options comprise surgery,radiation,chemotherapy,targeted therapy through epidermal growth factor receptor inhibition,and immunotherapy,but outcome has remained unsatisfactory due to recurrence rates of~50%and the frequent occurrence of second *** availability of the human genome sequence at the beginning of the millennium heralded the omics era,in which rapid technological progress has advanced our knowledge of the molecular biology of malignant diseases,including HNSCC,at an unprecedented ***,microarray-based methods,followed by approaches based on next-generation sequencing,were applied to study the genetics,epigenetics,and gene expression patterns of bulk *** recently,the advent of single-cell RNA sequencing(scRNAseq)and spatial transcriptomics methods has facilitated the investigation of the heterogeneity between and within different cell populations in the tumor microenvironment(e.g.,cancer cells,fibroblasts,immune cells,endothelial cells),led to the discovery of novel cell types,and advanced the discovery of cell-cell communication within *** review provides an overview of scRNAseq,spatial transcriptomics,and the associated bioinformatics methods,and summarizes how their application has promoted our understanding of the emergence,composition,progression,and therapy responsiveness of,and intercellular signaling within,HNSCC.

关键词： Head and neck squamous cell carcinoma Tumor microenvironment Immunotherapy Gene expression Omics

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