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Tess of the d'Urbervilles

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作者： Thomas hardy backgrounds and sources criticism edited by Scott Elledge.

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John hardy与大自然对话

中华手工 2010年第9期 24-27页

作者：何心 John hardy

从河水流过的圆石、或圆或缺的月亮,到巴厘岛上独有的地理特质,都是设计师的灵感之源,John hardy的每件首饰都俨如在跟大自然对话。

关键词：大自然对话 hardy 设计师水流

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Jude the Obscure

Jude the Obscure

GRP78 expression beyond cellular stress:A biomarker for tumor manipulation

作者： Thomas hardy edited by Ralph Pite University of Bristol.

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World Journal of Immunology 2015年第2期5卷 78-85页

作者： Britta hardy Annat Raiter Felsenstein Medical Research Center Tel-Aviv University School of MedicineRabin Medical Center

Physiological stress takes place in the endoplasmicreticulum （ER） of cells where activation and up-regulationof genes and proteins are primarily induced to enhancepro-survival mechanisms such as the unfolded protein response （UPR）. A dominant protein in the UPR response is the heat shock GRP78 protein. Although GRP78 is primarily located in the ER, under certain conditions it is transported to the cell surface, where it acts as a receptor inducing pathways of cell signaling such as proliferation or apoptosis. In the prolonged chronic stress transportation of the GRP78 from the ER to the cell membrane is a major event where in addition to the presentation of the GRP78 as a receptor to various ligands, it also marks the cells that will proceed to apoptotic pathways. In the normal cell that under stress acquires cell surface GRP78 and in the tumor cell that already presents cell surface GRP78, cell surface GRP78 is an apoptotic fag. The internalization of GRP78 from the cell surface in normal cells by ligands such as peptides will enhance cell survival and alleviate cardiovascular ischemic diseases. The absence of cell surface GRP78 in the tumor cells portends proliferative and metastatic tumors. Pharmacological induction of cell surface GRP78 will induce the process of apoptosis and might be used as a therapeutic modality for cancer treatment.

关键词： Cell surface GRP78 Apoptosis Endoplasmic reticulum stress Tumor cells Cancer Cardiovascular ischemia Hypoxia

Hazard Mitigation through a Systemic Model of Accident to a Socio-Technical System： A Case Study

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Journal of Energy and Power Engineering 2013年第4期7卷 775-787页

作者： Karim hardy Franck Guarnieri Aeronautics Department Worldwide Campus Embry-Riddle Aeronautical University Daytona Beach FL 32114 USA Center for Research on Risk and Crisis Mines ParisTech Sophia-Antipolis 06904 France

This paper presents the STAMP （system-theoretic accident modeling and processes） accident model, based on systems theory, and describes its application in the context of risk prevention related to the remediation of contaminated sediments. The implementation of the model is described, and results are presented both in methodological and technical terms. The goal of this article is to emphasize the need of new approaches to take into account hazards and accidents within socio-technical systems.

关键词： Hazard analysis hazards engineering accident analysis contaminated sediments STAMP systems theory models.

The Beneficial Effect of Niobium Alloying in Gray Cast Iron-Fundamentals and Applications

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The Beneficial Effect of Niobium Alloying in Gray Cast Iron-...

New era in cancer immunotherapy: Twenty years to the discovery of monoclonal antibodies harnessing the immune system to eradicate tumors

中国机械工程学会第十一届全国铸造年会

作者： hardy Mohrbacher Niobium Products Company GmbH Steinstrasse 28 40210 DüsseldorfGermany

＜正＞Abstract: Gray cast machinable iron consists of flake or spheroidal graphite in a ferritic, pearlitic, austenitic or martensitic matrix. This variety of microstructural combinations is used in a multitude of applications. Typical examples are vehicle brake systems, combustion engine blocks and machinery equipment. The particular microstructural design of gray iron and thus its characteristic properties is controlled by the alloying concept and by the casting as well as heat - treating process. The standard alloying elements in gray cast iron besides of carbon are silicon and manganese. Other elements like nickel, molybdenum, vanadium and magnesium are added to influence the microstructure. The research work on the effect of niobium in cast iron during the last 30 years allows to make the following general statements: - Nb additions up to 0. 3% improves the mechanical properties of gray iron resulting from a reduction in the cell size and correspondingly blunt graphite flake size. - Nb decreases the tendency to produce chill carbides due to an inoculating effect and the increase in cell count. - Nb is a mild pearlite stabilizer and refiner. - Nb additions of more than 0. 5 weight percent leads to the formation of primary MC - type carbides of high hardness improving the wear resistance of cast iron. Based on these effects specific applications of niobium - alloyed cast iron have been developed leading to appreciable technical and economical benefits. Work rolls for steel mills are often niobium - alloyed giving the advantage of reduced wear and thus longer endurance. Alloying of niobium to brake discs and drums allows to increase the graphite content at a given strength level and thus to optimize the heat conduction and damping behavior. The strength increasing effect of niobium can also be of advantage for the production of thin walled engine blocks. Additionally niobium helps to avoid the formation of chill structures which are difficult to machine. The present

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Advances in Bioscience and Biotechnology 2013年第4期4卷 34-37页

作者： Britta hardy Annat Raiter Felsenstein Medical Research Center Tel-Aviv University School of Medicine Rabin Medical Center Petach-Tikva Israel

The better understanding of the mechanism in which the immune system responds to the developing cancer provided the outcome in a new era in cancer immunotherapy. The tumor suppressive effect on the immune system is caused by negative T cell receptor signaling that abrogate immunity against the cancer cells. Novel monoclonal antibodies that target co-inhibitory receptors on T cells block the tumor induced inhibition of the immune system and enable the immune system to eradicate the tumors. The development of such antibodies started twenty years ago by the preparation of a monoclonal antibody termed BAT. A single administration of the antibody to tumor bearing mice resulted in striking anti tumor activity that was mediated by the lymphocytes. These studies provided a basis for the new era of cancer immunotherapy. The present review summarizes twenty years to the discovery of monoclonal antibodies harnessing the immune system to eradicate tumors.

关键词： Cancer Immunotherapy Monoclonal Antibodies Anergy T Cell Receptors

Modelling and Hazard Analysis for Contaminated Sediments Using STAMP Model and STPA Tool

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Journal of Energy and Power Engineering 2013年第3期7卷 496-500页

作者： Karim hardy Franck Guarnieri Center for Catastrophic Risk Management Haas Business School University of California Berkeley CA 94720 USA Center for Research on Risk and Crisis Mines ParisTech Sophia-Antipolis 06904 France

The goal of this article is dual： first, introducing a new model of accident named STAMP （systems-theoretic accident modeling and processes）; then applying the model to an innovative process for the treatment of contaminated substances and the re-use of treated substances. This article is a demonstration for a need of a new tool to take into account hazards and safety within socio-technical systems.

关键词： Model of accident safety engineering environment contaminated substances re-use.

Development,current situation and future potential of Nb-technology in the special steel industry

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Development,current situation and future potential of Nb-tec...