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Circulating miRNAs could serve as biomarkers for melanoma

中华医学会第十八次全国皮肤性病学术年会

作者：齐瑞群 matthew weiland 高兴华 Henry Ford Immunology Program Henry Ford Health SystemDetroitMI Department of Dermatology Henry Ford Health SystemDetroitMI 中国医科大学第一附属医院皮肤科

Background MiRNAs are ubiquitous in many different human cell free body fluids,like serum,plasma, urine,saliva,tears,breast milk and cerebrospinal ***,rapidly accumulated paper claim miRNAs are promising biomarkers for many cancers,liver injury,cardiovascular disease,sepsis,and so ***, so far,no ideal confident endogenous control genes were well established in circulating *** is

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Circulating miRNAs could serve as biomarkers for melanoma

Deletion of HDAC3 in Pancreatic beta cells Results in Glucose Intolerance and Enhanced Susceptibility to STZ-induced Diabetes

中华医学会第十八次全国皮肤性病学术年会

作者： matthew weiland Laila M.Poisson David Nathanson Henry W.Lim Department of Public Health Sciences Henry Ford Health System DetroitMI Department of Surgery Henry Ford Health System DetroitMI

Objective Recently,it has been discovered that circulating blood contains ample amounts of miRNA for detection and that circulating miRNAs can serve as biomarkers for a variety of disease and *** hypothesize that serum miRNAs could be a novel class of blood-based biomarker for malignant melanoma (MM). Research Design And Methods Serum RNAs were isolated from 34 melanoma patients and 34 age and

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Deletion of HDAC3 in Pancreatic beta cells Results in Glucos...

Apples to oranges:environmentally derived,dynamic regulation of serotonin neuron subpopulations in adulthood?

中华医学会第十二次全国内分泌学学术会议

作者： wenbin chen matthew weiland li Zhou Ling Gao Qingsheng Mi Jiajun Zhao Henry Ford Immunology Program Henry Ford Health Systems Department of Endocrinology Shandong Provincial Hospital affiliated to Shandong University Dept of Internal Medicine Henry Ford Health Systems Shandong Clinical Medical Center of Endocrinology and Metabolism Institute of Endocrinology and Metabolism Shandong Academy of Clinical Medicine

Background & Objective Previous studies showed the important role of histone deacetylases(HDACs) in ontogenic *** HDAC3 deletion in mice was found to induce metabolism dysfunction and malformation in liver and *** its effect on pancreatic beta-cell was still unknown. Here,we made pancreatic beta-cell specific HDAC3 knockout mice to investigate the effect of HDAC3 ablation on mice as well as pancreatic beta-cells development and function.

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Neural Regeneration Research 2025年第9期20卷 2596-2597页

作者： Christopher J.O’Connell matthew J.Robson Department of Genetics College of MedicineHarvard UniversityBostonMAUSA James L.Winkle College of Pharmacy Division of Pharmaceutical SciencesUniversity of CincinnatiCincinnatiOHUSA Neuroscience Graduate Program College of MedicineUniversity of CincinnatiCincinnatiOHUSA

Traumatic brain injury(TBI)is a public health problem with an undue economic burden that impacts nearly every age,ethnic,and gender group across the globe(Capizzi et al.,2020).TBIs are often sustained during a dynamic range of exposures to energetic environmental forces and as such outcomes are typically heterogeneous regarding severity and pathology(Capizzi et al.,2020).

关键词： sustained orange dynamic

The role of zonal flows in reactive fluid closures

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Plasma Science and Technology 2018年第7期20卷 41-49页

作者： jan weiland Chalmers University of Technology and EURATOM-VR Association SE-41296 GothenburgSweden

We will give an overview of results obtained by our reactive fluid model. It is characterised as a fluid model where all moments with sources in the experiment are kept. Furthermore, full account is taken for the highest moments appearing in unexpanded denominators also including full toroidicity. It has been demonstrated that the strength of zonal flows is dramatically larger in reactive fluid closures than in those which involve dissipation. This gives a direct connection between the fluid closure and the level of excitation of turbulence. This is because zonal flows are needed to absorb the inverse cascade in quasi 2D turbulence. This also explains the similarity in structure of the transport coefficients in our model with a reactive closure in the energy equation and models which have a reactive closure because of zero ion temperature such as the Hasegawa-Wakatani model. Our exact reactive closure unifies several well-known features of tokamak experiments such as the L-H transition, internal transport barriers and the nonlinear Dimits upshift of the critical gradient for onset of transport. It also gives transport of the same level as that in nonlinear gyrokinetic codes. Since these include the kinetic resonance this confirms the validity of the thermodynamic properties of our model. Furthermore, we can show that while a strongly nonlinear model is needed in kinetic theory a quasilinear model is sufficient in the fluid description. Thus our quasilinear fluid model will be adequate for treating all relevant problems in bulk transport. This is finally confirmed by the reproduction by the model of the experimental power scaling of the confinement time Te ~ P-2/3. This confirms the validity of our reactive fluid model. This also gives credibility to our ITER simulations including the H-mode barrier. A new result is here, that alpha heating strongly reduces the slope of the H-mode barrier. This should significantly reduce the effects of ELM＇s.

关键词： turbulent transport improved mixing length estimates zonal flows toroidicity

Usage Scenarios for Byte-Addressable Persistent Memory inHigh-Performance and Data Intensive Computing

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Journal of Computer Science & Technology 2021年第1期36卷 110-122页

作者： Michèle weiland Bernhard Homölle EPCC The University of EdinburghEdinburgh EH89BTU.K. System Vertrieb Alexander GmbH Paderborn 33106Germany

Byte-addressable persistent memory(B-APM)presents a new opportunity to bridge the performance gap between main memory and *** this paper,we present the usage scenarios for this new technology,based on the capabilities of Intel’s *** outline some of the basic performance characteristics of DCPMM,and explain how it can be configured and used to address the needs of memory and I/O intensive applications in the HPC(high-performance computing)and data intensive *** decision trees are presented to advise on the configuration options for BAPM;their use is illustrated with two *** show that the flexibility of the technology has the potential to be truly disruptive,not only because of the performance improvements it can deliver,but also because it allows systems to cater for wider range of applications on homogeneous hardware.

关键词： byte-addressable data intensive memory intensive persistent

Complement-dependent neuroinflammation in spinal cord injury:from pathology to therapeutic implications

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Neural Regeneration Research 2025年第5期20卷 1324-1335页

作者： Hassan Saad Bachar El Baba Ali Tfaily Firas Kobeissy Juanmarco Gutierrez Gonzalez Daniel Refai Gerald R.Rodts Christian Mustroph David Gimbel Jonathan Grossberg Daniel L.Barrow matthew F.Gary Ali M.Alawieh Department of Neurosurgery Emory University School of MedicineAtlantaGAUSA Department of Neurology Yale UniversityNew HavenCTUSA Center for Neurotrauma Multiomics&Biomarkers(CNMB)Morehouse School of MedicineAtlantaGAUSA

Spinal cord injury remains a major cause of disability in young adults,and beyond acute decompression and rehabilitation,there are no pharmacological treatments to limit the progression of injury and optimize recovery in this *** the thorough investigation of the complement system in triggering and propagating cerebral neuroinflammation,a similar role for complement in spinal neuroinflammation is a focus of ongoing *** this work,we survey the current literature investigating the role of complement in spinal cord injury including the sources of complement proteins,triggers of complement activation,and role of effector functions in the *** study relevant data demonstrating the different triggers of complement activation after spinal cord injury including direct binding to cellular debris,and or activation via antibody binding to damage-associated molecular *** effector functions of complement have been implicated in spinal cord injury,and we critically evaluate recent studies on the dual role of complement anaphylatoxins in spinal cord injury while emphasizing the lack of pathophysiological understanding of the role of opsonins in spinal cord *** this pathophysiological review,we systematically review the different translational approaches used in preclinical models of spinal cord injury and discuss the challenges for future translation into human *** review emphasizes the need for future studies to dissect the roles of different complement pathways in the pathology of spinal cord injury,to evaluate the phases of involvement of opsonins and anaphylatoxins,and to study the role of complement in white matter degeneration and regeneration using translational strategies to supplement genetic models.

关键词： complement neuroinflammation neuroplasticity regeneration spinal cord injury targeted therapy

Excitation of Zonal Flows by ion-temperature-gradient Modes Excited by the Fluid Resonance

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Chinese Physics Letters 2015年第11期32卷 80-84页

作者：王冠琼马骏 weiland J. ZAGORODNY A. Institute of Plasma Physics Chinese Academy of Sciences Hefei 230031 Centre for Magnetic Fusion Theory Chinese Academy of Sciences Hefei 230031 Centre for Fusion Energy Science and Technology China Academy of Engineering Physics Beijing 100094 Chalmers University of Technology and EURATOM-VR Association Gothenburg Sweden Bogoliubov Institute for Theoretical Physics Kiev 03680 Ukraine

We apply the reductive perturbation method to the simple electrostatic ion-temperature-gradient mode in an advanced fluid description. The fluid resonance turns out to play a major role for the excitation of zonal flows. This is the mechanism recently found to lead to the low-to-high （L-H） mode transition and to the nonlinear Dimits upshift in transport code simulations. It is important that we have taken the nonlinear temperature dynamics from the Reynolds stress as the convected diamagnetic flow. This has turned out to be the most relevant effect as found in transport simulations of the L-H transition, internal transport barriers and Dimits shift. This is the first time that an analytical method is applied to a system which numerically has been found to give the right experimental dynamics.

关键词： Excitation of Zonal Flows by ion-temperature-gradient Modes Excited by the Fluid Resonance

Simulations of the L-H transition dynamics with different heat and particle sources

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Chinese Physics B 2015年第11期24卷 314-322页

作者：李会东王占辉 Jan weiland 冯灏孙卫国 School of Science Research Center for Advanced Computation Xihua University Southwestern Institute of Physics Department Applied Physics Chalmers.University of Technology and Euratom-VR Association Institute of Atomic and Molecular Physics Sichuan University

It is crucial to increase the total stored energy by realizing the transition from a low confinement （L-mode） state to a high confinement （H-mode） state in magnetic confinement fusion. The L-H transition process is simulated by using the predictive transport code based on weiland＇s fluid model. Based on the equilibrium parameters obtained from equilibrium fitting （EFIT） in the experiment, the electron density ne, electron temperature Te, ion temperatures lq, ion poloidal Vp, and toroidal momenta Vt are simulated self-consistently. The L-H transition dynamic behaviors with the formation of the transport barriers of ion and electron temperatures, the electron density, and the ion toroidal momenta are analyzed. During the L-H transition, the strong poloidal flow shear in the edge transport barrier region is observed. The crashes of the electron and ion temperature pedestals are also observed during the L-H transition. The effects of the heating and particle sources on the L-H transition process are studied systematically, and the critical power threshold of the L-H transition is also found.

关键词： magnetic fusion tokamak plasma L-H transition transport barriers

Development and evaluation of a vision driven sensor for estimating fuel feeding rates in combustion and gasification processes

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Energy and AI 2024年第1期15卷 44-54页

作者： Yngve Ören Alexey Sepman Ehsan Fooladgar Fredrik weiland Henrik Wiinikka RISE AB Box 726 SE-94128PiteåSweden Energy Engineering Division of Energy ScienceLuleåUniversity of TechnologySE 97187LuleåSweden

A machine vision driven sensor for estimating the instantaneous feeding rate of pelletized fuels was developed and tested experimentally in combustion and gasification *** feeding rate was determined from images of the pellets sliding on a transfer chute into the *** the images the apparent area and velocity of the pellets were *** was determined by a segmentation model created using a machine learning framework and velocities by image registration of two subsequent *** measured weight of the pelletized fuel passed through the feeding system was in good agreement with the weight estimated by the *** observed variations in the fuel feeding correlated with the variations in the gaseous species concentrations measured in the reactor core and in the *** the developed sensor measures the ingoing fuel feeding rate prior to the reactor,its signal could therefore help improve process control.

关键词： Fuel feeding Process monitoring Image processing Neural network Combustion Gasification