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Behaviour of granular matter under gravity-induced stress gradient:A two-dimensional numerical investigation

International Journal of Mining Science and Technology 2021年第3期31卷 439-450页

作者： ruilin Li Guoqing Zhou Pin-Qiang Mo matthew r.hall Jun Chen Daqing Chen Shangyue Cai State Key Laboratory for Geomechanics and Deep Underground Engineering China University of Mining and TechnologyXuzhou 221116China GeoEnergy research Centre Faculty of EngineeringUniversity of NottinghamNottingham NG72RDUK School of Mechanics and Civil Engineering China University of Mining and TechnologyXuzhou 221116China

Gravity is the most important load source in mining and geotechnical engineering,which causes both the stress level and stress gradient inside *** from the stress level,the influence of gravity-induced stress gradient on the behaviour of the material is still *** in-deep study on it will help to promote the understanding of material behaviour,especially for those cases related to unconventional gravity such as terrestrial ng physical modelling and extraterrestrial resource exploitation(g is the terrestrial gravitational acceleration).In this study,a high-order homogenization for granular materials is proposed at first,in which the stress gradient is drawn into the constitutive representation by adopting a representative volume element(rVE).The consolidation and shear strength behaviour of rVE are then investigated by performing numerical biaxial *** results show that all the compressibility,shear strength,shear stiffness,volumetric deformation,and critical state behaviour show a stress gradient dependence.A coupling between stress gradient,stress level,and material properties is also *** observations suggest that,besides the stress level,extra attention needs to be paid to material responses related to stress gradient during engineering practices.

关键词： Stress gradient representative volume element Granular matter Gravitational field Discrete element method

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Effects of symmetric and asymmetric salt conditions on a selective solid-state nanopore assay

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Nano research 2022年第11期15卷 9936-9942页

作者： Ian D.Wadsworth Adam r.hall Virginia Tech-Wake Forest University School of Biomedical Engineering and Sciences Wake Forest School of MedicineWinston-SalemNC 27101USA Comprehensive Cancer Center Wake Forest School of MedicineWinston-SalemNC 27157USA

Conventional solid-state nanopore measurements sense all translocating entities,necessitating meticulous analysis to differentiate target *** address this,we have established a selective assay with the platform that has shown utility in quantifying several nucleic acid ***,limited detection efficiency and intrinsic noise have so far limited assay resolution to 10 *** in this value require manipulation of translocation ***,we report the effects of NaCl conditions on assay *** first investigate symmetric conditions,finding sensitivity increases with salt concentration but selectivity is maximized at 1.0 M *** then probe asymmetric conditions,showing a remarkable impact on assay sensitivity and selectivity when measurement buffer NaCl concentration in the reservoir with the translocating molecules is low and the opposite reservoir is *** optimum conditions,we demonstrate detection of target biomolecules down to a concentration of 100 pM which is an improvement of 2 orders of magnitude over past results.

关键词： solid-state nanopores biomarkers amplification-free detection salt gradient nucleic acids

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Apples to oranges:environmentally derived,dynamic regulation of serotonin neuron subpopulations in adulthood?

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Neural regeneration research 2025年第9期20卷 2596-2597页

作者： Christopher J.O’Connell matthew J.robson Department of Genetics College of MedicineHarvard UniversityBostonMAUSA James L.Winkle College of Pharmacy Division of Pharmaceutical SciencesUniversity of CincinnatiCincinnatiOHUSA Neuroscience Graduate Program College of MedicineUniversity of CincinnatiCincinnatiOHUSA

Traumatic brain injury(TBI)is a public health problem with an undue economic burden that impacts nearly every age,ethnic,and gender group across the globe(Capizzi et al.,2020).TBIs are often sustained during a dynamic range of exposures to energetic environmental forces and as such outcomes are typically heterogeneous regarding severity and pathology(Capizzi et al.,2020).

关键词： sustained orange dynamic

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A platform for initial testing of multiple camouflage patterns

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Defence Technology（防务技术） 2021年第6期17卷 1833-1839页

作者： Joanna r.hall Olivia matthews Timothy N.Volonakis Eric Liggins Karl P.Lymer roland Baddeley Innes C.Cuthill Nicholas E.Scott-Samuel School of Psychological Science University of Bristol12a Priory RoadBristolBS81TUUK School of Biological Sciences University of Bristol24 Tyndall AvenueBristolBS81TQUK QinetiQ Ltd Cody Technology ParkFarnboroughHampshireGU140LXUK Defence Science and Technology Lab Physical Sciences GroupPorton DownSalisburyWiltshireSP40JQUK

The human visual system is still an important factor in military warfare;military personnel receive training on effective search strategies,and camouflage that can effectively conceal objects and personnel is a key component of a successful integrated survivability *** methods of camouflage assessment have,amongst others,used psychophysics to generate distinctiveness ***,the population from which the human observers are drawn is often not well defined,or necessarily *** this experiment we designed a new platform for testing multiple patterns based on a camouflaged object detection task,and investigate whether trained military observers perform better than *** use a two-alternative forced choice paradigm,with participants searching images of woodland for a replica military helmet displaying Olive Green,Multi Terrain Pattern,US Marine Pattern or,as a conspicuous control,UN Peacekeeper *** data show that there is no difference in detection performance between the two observer groups but that there are clear differences in the effectiveness of the different helmet colour patterns in a temperate woodland *** conclude that when tasks involve very short stimulus presentation times,task-specific training has little effect on the success of target detection and thus this paradigm is particularly suitable for robust estimates of camouflage efficacy.

关键词： Camouflage Detection Military Civilian Expertise Training

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Complement-dependent neuroinflammation in spinal cord injury:from pathology to therapeutic implications

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Neural regeneration research 2025年第5期20卷 1324-1335页

作者： Hassan Saad Bachar El Baba Ali Tfaily Firas Kobeissy Juanmarco Gutierrez Gonzalez Daniel refai Gerald r.rodts Christian Mustroph David Gimbel Jonathan Grossberg Daniel L.Barrow matthew F.Gary Ali M.Alawieh Department of Neurosurgery Emory University School of MedicineAtlantaGAUSA Department of Neurology Yale UniversityNew HavenCTUSA Center for Neurotrauma Multiomics&Biomarkers(CNMB)Morehouse School of MedicineAtlantaGAUSA

Spinal cord injury remains a major cause of disability in young adults,and beyond acute decompression and rehabilitation,there are no pharmacological treatments to limit the progression of injury and optimize recovery in this *** the thorough investigation of the complement system in triggering and propagating cerebral neuroinflammation,a similar role for complement in spinal neuroinflammation is a focus of ongoing *** this work,we survey the current literature investigating the role of complement in spinal cord injury including the sources of complement proteins,triggers of complement activation,and role of effector functions in the *** study relevant data demonstrating the different triggers of complement activation after spinal cord injury including direct binding to cellular debris,and or activation via antibody binding to damage-associated molecular *** effector functions of complement have been implicated in spinal cord injury,and we critically evaluate recent studies on the dual role of complement anaphylatoxins in spinal cord injury while emphasizing the lack of pathophysiological understanding of the role of opsonins in spinal cord *** this pathophysiological review,we systematically review the different translational approaches used in preclinical models of spinal cord injury and discuss the challenges for future translation into human *** review emphasizes the need for future studies to dissect the roles of different complement pathways in the pathology of spinal cord injury,to evaluate the phases of involvement of opsonins and anaphylatoxins,and to study the role of complement in white matter degeneration and regeneration using translational strategies to supplement genetic models.

关键词： complement neuroinflammation neuroplasticity regeneration spinal cord injury targeted therapy

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Metrosexual masculinities

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作者： (1968-)hall matthew

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Machine Learning Techniques in Predicting Hot Deformation Behavior of Metallic Materials

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Computer Modeling in Engineering & Sciences 2025年第1期142卷 713-732页

作者： Petr Opela Josef Walek Jaromír Kopecek Department of Metallurgical Technologies Faculty of Materials Science and TechnologyVSB–Technical University of OstravaOstrava70800Czech Republic FZU—Institute of Physics of the Czech Academy of Sciences Prague18200Czech Republic

In engineering practice,it is often necessary to determine functional relationships between dependent and independent *** relationships can be highly nonlinear,and classical regression approaches cannot always provide sufficiently reliable ***,Machine Learning(ML)techniques,which offer advanced regression tools to address complicated engineering issues,have been developed and widely *** study investigates the selected ML techniques to evaluate their suitability for application in the hot deformation behavior of metallic *** ML-based regression methods of Artificial Neural Networks(ANNs),Support Vector Machine(SVM),Decision Tree regression(DTr),and Gaussian Process regression(GPr)are applied to mathematically describe hot flow stress curve datasets acquired experimentally for a medium-carbon *** the GPr method has not been used for such a regression task before,the results showed that its performance is the most favorable and practically unrivaled;neither the ANN method nor the other studied ML techniques provide such precise results of the solved regression analysis.

关键词： Machine learning Gaussian process regression artificial neural networks support vector machine hot deformation behavior

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External-beam radiation therapy should be given with androgen deprivation treatment for intermediate-risk prostate cancer： new confirmatory evidence

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Asian Journal of Andrology 2012年第1期14卷 132-133页

作者： matthew r Cooperberg Department of Urology University of California San Francisco CA 94143-1695 USA

Anewly published study, radiation Therapy Oncology Group （rTOG） trial 94-08, has demonstrated that a short-course ofneoadjuvant androgen deprivation therapy （ADT） given together with external-beam radiation therapy （EBrT） improves outcomes for men with intermediate-risk prostate cancer compared with EBrT alone） The benefits of neoadjuvant ADT for men receiving EBrT have been recognized for years, but in light of growing concerns regarding potential long-term skeletal, metabolic and cardiovascular toxicities of ADT, the demonstration of benefits with only shortterm treatment is timely.

关键词： External-beam radiation therapy intermediate-risk prostate cancer neoadjuvant ADT rTOG 94-08 brachytherapy

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Stressing over the Complexities of Multiple Stressors in Marine and Estuarine Systems

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Ocean-Land-Atmosphere research 2022年第1期1卷 27-53页

作者： Patricia M.Glibert Wei-Jun Cai Emily r.hall Ming Li Kevan L.Main Kenneth A.rose Jeremy M.Testa Nayani K.Vidyarathna University of Maryland Center for Environmental Science Horn Point LaboratoryPO Box 775CambridgeUSA School of Marine Science and Policy University of Delaware111 Robinson HallNewarkDE 19716USA Mote Marine Laboratory 1600 Ken Thompson ParkwaySarasotaFL 34236USA University of Maryland Center for Environmental Science Chesapeake Biological LaboratoryPO Box 38SolomonsUSA

Aquatic ecosystems are increasingly threatened by multiple human-induced stressors associated with climate and anthropogenic changes,including warming,nutrient pollution,harmful algal blooms,hypoxia,and changes in CO_(2) and *** stressors may affect systems additively and synergistically but may also counteract each *** resultant ecosystem changes occur rapidly,affecting both biotic and abiotic components and their ***,the complexity of interactions increases as one ascends the food web due to differing sensitivities and exposures among life stages and associated species interactions,such as competition and *** is also a need to further understand nontraditional food web interactions,such as mixotrophy,which is the ability to combine photosynthesis and feeding by a single *** complexity of these interactions and nontraditional food webs presents challenges to ecosystem modeling and *** ecological models to understand multistressor effects is further challenged by the lack of sufficient data on the effects of interactive stressors across different trophic levels and the substantial variability in climate changes on regional *** obtain data on a broad suite of interactions,a nested set of experiments can be ***,coupled,multitrophic level models will provide the flexibility to explore the additive,amplified,propagated,antagonistic,and/or reduced effects that can emerge from the interactions of multiple ***,the stressors associated with eutrophication and climate change are reviewed,and then example systems from around the world are used to illustrate their complexity and how model scenarios can be used to examine potential future changes.

关键词： additive Marine complexity

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菲律宾海板块的新生代运动:来自东印度尼西亚的古地磁证据

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海洋地质译丛 1996年第2期 25-35页

作者： r.hall 陶铮

菲律宾海板块(图1)是与俯冲过程有关的一些板块构造模式的资料来源。此板块的不同部份被用作为包括俯冲并始、洋内俯冲带发育、弧裂谷作用、弧后扩张和孤前拉张等构造过程的实例。已进行了两期大洋钻探。目的是了解其演化[深海钻井计划(... 详细信息

菲律宾海板块(图1)是与俯冲过程有关的一些板块构造模式的资料来源。此板块的不同部份被用作为包括俯冲并始、洋内俯冲带发育、弧裂谷作用、弧后扩张和孤前拉张等构造过程的实例。已进行了两期大洋钻探。目的是了解其演化[深海钻井计划(DSDP)/大洋钻探计划)(ODP)的航次58、59、60、125、126。尽管这样,对板块的第三纪运动还了解甚少。推断运动史的主要障碍是菲律宾海板块自它被俯冲带包围后而独立于全球板块变化过程。由于这个原因,它的成因和运动史成为人们争论的根源,曾提出(Uyeda等, 1972)此板块是在太平洋板块于约45Ma时沿老太平洋洋底内的转换断层俯冲时形成的,并在西菲律宾盆地内圈捕了先前的扩张中心,这个观点在解释此板块史时继续在被引证。

关键词：菲律宾海板块古地磁板块运动

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