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Bistability and oscillations in co-r.pr.ssive synthetic micr.bial consor.ia

Fr.ntier. of Electr.cal and Electr.nic Engineer.ng in China 2017年第1期5卷 55-66页

作者： Mehdi Sadeghpour.Alan Veliz-Cuba Gabor.Or.sz Kr.simir.Josic matthew r. bennett Depar.ment of Mechanical Engineer.ng University of Michigan Ann Arbor MI 48109 USA Depar.ment of Mathematics University of Dayton Dayton OH 45469 USA Depar.ment of Mathematics University of Houston Houston TX 77204 USA Depar.ment of Biology and Biochemistr. University of Houston Houston TX 77204 USA Depar.ment of Biosciences Rice University Houston TX 77251-1892 USA Depar.ment of Bioengineer.ng Rice University Houston TX 77251-1892 USA

Backgr.und： Synthetic micr.bial consor.ia ar. conglomer.tions of genetically engineer.d micr.bes pr.gr.mmed to cooper.tively br.ng about population-level phenotypes. By coor.inating their.activity, the constituent str.ins can display emer.ent behavior. that ar. difficult to engineer.into isogenic populations. To do so, str.ins ar. engineer.d to communicate with one another.thr.ugh inter.ellular.signaling pathways that depend on cell density. Methods： Her., we used computational modeling to examine how the behavior.of synthetic micr.bial consor.ia r.sults fr.m the inter.lay between population dynamics gover.ed by cell gr.wth and inter.al tr.nscr.ptional dynamics gover.ed by cell-ceil signaling. Specifically, we examined a synthetic micr.bial consor.ium in which two str.ins each pr.duce signals that down-r.gulate tr.nscr.ption in the other. Within a single str.in this r.gulator. topology is called a ＂co-r.pr.ssive toggle switch＂ and can lead to bistability. r.sults： We found that in co-r.pr.ssive synthetic micr.bial consor.ia the existence and stability of differ.nt states depend on population-level dynamics. As the two str.ins passively compete for.space within the colony, their.r.lative fr.ctions fluctuate and thus alter.the str.ngths of inter.ellular.signals. These fluctuations dr.ve the consor.ium to alter.ative equilibr.a. Additionally, if the gr.wth r.tes of the str.ins depend on their.tr.nscr.ptional states, an additional feedback loop is cr.ated that can gener.te oscillations. Conclusions： Our.findings demonstr.te that the dynamics of micr.bial consor.ia cannot be pr.dicted fr.m their.r.gulator. topologies alone, but ar. also deter.ined by inter.ctions between the str.ins. Ther.for., when designing synthetic micr.bial consor.ia that use inter.ellular.signaling, one must account for.gr.wth var.ations caused by the pr.duction of pr.tein.

关键词： synthetic biology micr.bial consor.ia quor.m sensing r.laxation oscillations

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Conver.ent plate boundar. envir.nments for.for.ation of≥3800 Ma mafic-ultr.mafic assemblages(Isua ar.a,Gr.enland):Implications for.ear.y global geodynamics

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Geoscience Fr.ntier. 2024年第3期15卷 119-136页

作者： Allen P.Nutman Clar. r.L.Fr.end Vickie C.bennett School of Ear.h Atmospheric and Life SciencesUniversity of WollongongWollongongNSW 2522Australia Glendale TiddingtonOxon OX92LQUK r.sear.h School of Ear.h Sciences Australian National UniversityCanberraACT 2601Australia

In the gneiss ter.ane on the south side of the Eoar.hean Isua supr.cr.stal belt,ultr.mafic r.cks with r.lict abyssal per.dotite miner.logy(bennett et al.,2002;Fr.end et al.,2002;Nutman et al.,2007;r.llinson,2007;van de Löcht et al.,2020),layer.d gabbr.s with cumulate ultr.mafic r.cks,basalts and associated siliceous sedimentar. r.cks wer. tectonically-imbr.cated,pr.or.to and dur.ng intr.sion of ca.3800 Ma *** with3800 Ma basalts in the Outer.Ar. Gr.up of the near.y Isua supr.cr.stal belt,the composition of all these mafic r.cks(e.g.,Th-Hf-Nb systematics,high Th/Yb,Ba/Nb,Ba/Yb r.tios and negative Nb and Ti anomalies)shows affinity with moder. supr.subduction r.cks whose genesis involved fluid fluxing of the upper.***,the major.ty of these samples have Ba/Nb and Ba/Yb values less than in moder. island ar. magmas,but similar.to many backar. basin magmas(e.g.,Pear.e and Ster.,2006).It is unknown whether.these ca.3800 Ma mafic r.cks ar.,(i)ar. r.cks wher. the Ba/Nb and Ba/Yb signatur.s r.flect lower.sur.icial Ba in Eoar.hean oceanic settings,or.ii)in dir.ct compar.son with Phaner.zoic suites,these signatur.s r.flect a back-ar. setting with inter.lay between fluid fluxing and decompr.ssional *** tectonic inter.alation of upper.mantle with lower.and upper.cr.stal r.cks,combined with the fluid-fluxing influences seen in chemistr. of all the mafic r.cks is best accommodated in a compr.ssional Eoar.hean conver.ent plate boundar. setting within a mobile-lid *** stagnant lid scenar.os of cr.st for.ation,if oper.tive,must have co-existed or.alter.ated with mobile-lid r.gimes by 3800 Ma.

关键词： Eoar.hean Fluid-fluxing Plate tectonics Supr.subduction Cr.stal evolution

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A multi-mechanistic appr.ach to the oil r.cover. study of a family of amphiphilic polysacchar.des

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Petr.leum r.sear.h 2024年第2期9卷 238-249页

作者： Funsho Afolabi Syed MMahmood Lunech Mar.o Nur.Asyr.f Md Akhir.bennett Tackie-Otoo Hamid Shar.figaliuk Center.of r.sear.h in Enhanced Oil r.cover. Universiti Teknologi PETRONASSeri IskandarMalaysia Center.for.Subsur.ace Imaging Universiti Teknologi PETRONASSeri IskandarMalaysia r.sear.h Institute of Petr.leum Industr.(r.PI) TehranIran

Chemical enhanced oil r.cover.(cEOr.r.mains one of the most potent ter.iar. r.cover. ***,it is expensive and r.r.ly envir.nmentally ***-based amphiphilic polymer. have been suggested as an alter.ative to er.dicating the challenges of conventional cEOr.because of cost-effectiveness,and ***,few in-depth studies exist in the liter.tur. to investigate the pr.spects of these mater.als.A new family of amphiphilic polysacchar.des was synthesized by hydr.phobic modification of cellulose sulphate,and the EOr.functionalities wer. *** novel biopolymer. exhibited the ability to alter.r.ck wetting *** ter.s of r.cover.,one of the var.ants of the synthesized bio amphiphilic polymer.D-I)was able to r.duce r.sidual oil satur.tion to 12%at har.h conditions of 60,000 ppm salinity at 75℃.Micr.model visual analysis r.vealed that the per.or.ance of the novel mater.als was due to the combination of mobility contr.l,IFT lower.ng and emulsification,wettability alter.tion,and *** a per.or.ance commensur.te to that of a commer.ial hydr.phobically modified polymer.it can be said that the novel amphiphilic polysacchar.des can stand as a viable cEOr.agent for.oilfield applications.

关键词： Bio-based polymer. Amphiphilic polysacchar.des EOr Cellulose sulphate Envir.nmental sustainability

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Embr.cing the Year.of the Dr.gon

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China Today 2024年第2期73卷 30-32页

作者： KEITH bennett Fr.ends of Socialist China based in London

The Lunar.New Year.has incr.asingly become a common festival of people thr.ughout the *** people,and people thr.ughout the wor.d,ar. looking for.ar. to welcoming the Year.of the Dr.gon,which falls on Febr.ar. 10,*** Dr.gon is consider.d the most auspicious of the 12 signs in the Chinese zodiac and this year.is specifically the Year.of the Wood Dr.gon,the fir.t since *** to Lifestyle Asia,“Wood Dr.gons enjoy fulfilling ***’r. likely to mater.alize all their.ambitions into actions,coming up with tr.ly r.volutionar. ideas.”

关键词： looking has likely

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Five Pr.nciples as r.levant Today as 70 Year. Ago

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China Today 2024年第8期73卷 18-19页

作者： KEITH bennett 不详

The Chinese initiative has become an inter.ational consensus with pr.ductive actions.A confer.nce mar.ing the 70th anniver.sar. of the Five Pr.nciples of Peaceful Coexistence,a cor.er.tone of Chinese for.ign policy,was held in Beijing on June 28,attr.cting attendees fr.m ar.und the wor.d,including for.er.political leader. fr.m some 20 *** the confer.nce,Pr.sident Xi Jinping made an impor.ant speech in which he said that the Five Pr.nciples“mar.ed a gr.undbr.aking and epoch-making achievement in the histor. of inter.national r.lations.”

关键词： cor.er. attr.cting Peace

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Sexual and r.pr.ductive Ser.ice Inter.entions for.Menstr.al r.gulation, Safe Abor.ion, and Post-abor.ion Car. and Their.Effectiveness Dur.ng Disaster.r.sponse: A Global Systematic r.view

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Inter.ational Jour.al of Disaster.r.sk Science 2024年第3期15卷 359-373页

作者： Nibedita S.r.y-bennett Winifr.d Ekezie Isha Biswas Nimr. Iqbal Choudhar. David Cowie Lasith Dissanayake Laur.n Macleod Azukaeogo Nnaji Madhulika Sahoo School of Business University of Leicester Avoidable Deaths Networ. University of Leicester Diabetes r.sear.h Centr. Leicester General Hospital University of Leicester School of Social Sciences and Humanities Aston University Lifespan and Population Health School of Medicine University of Nottingham School of Public Health and Inter.isciplinar. Studies Auckland University of Technology Faculty of Life Sciences and Education University of South Wales West Afr.can r.gional ECHO (WAr.) APIN Public Health Initiatives Depar.ment of Anthr.pology Kalahandi University

Sexual and r.pr.ductive health(Sr.) ser.ices ar. cr.cial for.women especially dur.ng disaster., to r.duce mater.al mor.ality and mor.idity fr.m miscar.iages, unsafe abor.ions, and post-abor.ion complications. This study explor.d the Sr. inter.entions pr.vided dur.ng disaster.r.sponse. A systematic r.view was conducted to identify what menstr.al r.gulation(Mr., safe abor.ion(SA), and post-abor.ion car.(PAC) appr.aches/inter.entions exist to pr.mote r.silience in the health system in disaster.settings; what inter.ention components wer. most eff ective; and challenges and oppor.unities to meeting Sr. r.ghts. Five electr.nic databases wer. sear.hed, r.sulting in 4194 r.cor.s. Following the scr.ening pr.cess, seven publications wer. included. The inter.ention-r.lated infor.ation in each publication was assessed based on availability,accessibility, acceptability, and quality. Two Sr. appr.aches/inter.entions wer. found. The eff ectiveness of inter.ention components could not be conducted due to the limited number.of r.levant studies. Challenges wer. found at facility and community levels, and oppor.unities included over.oming them, making Mr. SA, and PAC integr.l to the mitigation phase,and policy change to over.ome bar.ier. r.lated to unaff or.ability and inaccessibility. r.commendations ar. pr.vided to encour.ge r.sear.h and policy towar.s impr.ving neglected Sr. in disaster.settings to r.alize Sustainable Development Goal 3 and the Global Str.tegy and Sendai Fr.mewor.'s pr.or.ty to pr.mote disaster.r.silient health systems.

关键词： Abor.ion Disaster. Sendai fr.mewor. Sexual and r.pr.ductive health Sustainable development goal

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Effects of a school-based kar.te inter.ention on academic achievement,psychosocial functioning,and physical fitness:A multi-countr. cluster.r.ndomized contr.lled tr.al

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Jour.al of Spor. and Health Science 2024年第1期13卷 90-98页

作者： Tania Pinto-Escalona Er.ca Gobbi Pedr. L.Valenzuela Simon J.bennett Pier.uigi Aschier. Manuel Mar.in-Loeches Antonio Paoli Oscar.Mar.inez-de-Quel Faculty of Education Complutense University of MadridMadrid 28040Spain Depar.ment of Biomolecular.Sciences University of Urbino“Carlo Bo”Urbino 61029Italy Depar.ment of Systems Biology University of AlcaláMadrid 28805Spain r.sear.h Institute for.Spor. and Exer.ise Sciences Faculty of ScienceLiverpool John Moores UniversityLiverpoolL33AFUK Italian Judo WrestlingKarate and Martial Arts FederationRome 00122Italy Psychobiology&Methods for.the Behaviour.l Sciences Depar.ment Complutense University of MadridMadrid 28040Spain Depar.ment of Biomedical Sciences University of PaduaPadua 35122Italy

Pur.ose:To examine the effects of a school-based kar.te inter.ention on academic achievement,psychosocial functioning,and physical fitness in childr.n aged 7-8 ***:Twenty schools in 5 differ.nt Eur.pean countr.es(2 second-gr.de classr.oms per.school)par.icipated in a cluster.r.ndomized contr.lled tr.al(Spor. at School tr.al).Par.icipants wer. assigned to either.a contr.l gr.up,which continued with their.habitual physical education lessons,or.to an inter.ention gr.up,which r.placed these lessons with a 1-year.kar.te inter.ention(Kar.te Mind and Movement pr.gr.m).A total of 721 childr.n(344 gir.s and 377 boys,7.4±0.5 year. old,mean±SD)completed the study,of which 333 and 388 wer. assigned to the contr.l gr.up and inter.ention gr.up,*** included academic per.or.ance(aver.ge gr.de),psychosocial functioning(Str.ngths and Difficulties Questionnair. for.par.nts),and differ.nt mar.er. of physical fitness(car.ior.spir.tor. fitness,balance,and flexibility).r.sults:The inter.ention pr.vided small but significant benefits compar.d to the contr.l gr.up for.academic achievement(d=0.16;p=0.003),conduct pr.blems(d=-0.28;p=0.003),car.ior.spir.tor. fitness(d=0.36;pr. was a tr.nd towar.s significant benefits for.flexibility(d=0.24;p=0.056).No significant benefits wer. obser.ed for.other.var.ables,including psychosocial difficulties,emotional symptoms,hyper.ctivity/inattention,peer.pr.blems,or.pr.social behaviour.all p>0.05).Conclusion:A 1-year.school-based kar.te inter.ention was effective in impr.ving academic achievement,conduct pr.blems,and physical fitness in pr.mar. school *** r.sults suppor. the inclusion of kar.te dur.ng physical education lessons.

关键词： Academic per.or.ance Car.ior.spir.tor. fitness Conduct pr.blems Kar.te Physical fitness

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The Impact of Opioid Dr.gs on Memor. and Other.Cognitive Functions: A r.view

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Jour.al of Biosciences and Medicines 2024年第4期12卷 264-287页

作者： Mason T. bennett Yuliya Modna Dev Kumar.Shah School of Biomedical Sciences Trinity Medical Sciences University Kingstown Saint Vincent and Grenadines Depar.ment of Physiology Trinity Medical Sciences University Kingstown Saint Vincent and Grenadines

Backgr.und and Pur.ose: Opioids, used for.centur.es to alleviate pain, have become a double-edged swor.. While effective, they come with a host of adver.e effects, including memor. and cognition impair.ent. This r.view delves into the impact of opioid dr.gs on cognitive functions, explor.s under.ying mechanisms, and investigates their.pr.valence in both medical car. and illicit dr.g use. The ultimate goal is to find ways to mitigate their.potential har. and addr.ss the ongoing opioid cr.sis. Methods: We sour.ed data fr.m PubMed and Google Scholar. employing sear.h combinations like “opioids,” “memor.,” “cognition,” “amnesia,” “cognitive function,” “executive function,” and “inhibition.” Our.focus was on English-language ar.icles spanning fr.m the inception of these databases up to the pr.sent. r.sults: The liter.tur. consistently r.veals that opioid use, par.icular.y at high doses, adver.ely affects memor. and other.cognitive functions. Longer.deliber.tion times, impair.d decision-making, impulsivity, and behavior.l disor.er. ar. common consequences. Chr.nic high-dose opioid use is associated with conditions such as amnesiac syndr.me (OAS), post-oper.tive cognitive dysfunction (POCD), neonatal abstinence syndr.me (NAS), depr.ssion, anxiety, sedation, and addiction. Alar.ing tr.nds show incr.ased opioid use over.r.cent decades, amplifying the r.sk of these outcomes. Conclusion: Opioids cast a shadow over.memor. and cognitive function. These effects r.nge fr.m amnesiac effects, lessened cognitive function, depr.ssion, and mor.. Contr.buting factor. include over.pr.scr.ption, misuse, misinfor.ation, and pr.hibition policies. Focusing on cor.ect infor.ational campaigns, r.moving punitive policies, and focusing on har. r.duction str.tegies have been shown to lessen the abuse and use of opioids and thus helping to mitigate the adver.e effects of these dr.gs. Fur.her.r.sear.h into the impacts of opioids on cognitive abilities is also needed as they ar. well demonstr.ted in

关键词： Opioids Memor. Cognition Pain

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Potato aphid Macr.siphum euphor.iae per.or.ance is deter.ined by aphid genotype and not mycor.hizal fungi or.water.availability

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Insect Science 2017年第6期24卷 1015-1024页

作者： Alison Jane Kar.ey matthew Emslie-Smith Alison Elizabeth bennett Ecological Sciences The James Hutton Institute Invergowrie Dundee UK School of Biology University of St. Andrews St Andrews UK

Intr.- and inter.pecific var.ation in plant and insect tr.its can alter.the str.ngth and dir.ction of insect-plant inter.ctions, with outcomes modified by soil biotic and abiotic conditions. We used the potato aphid （Macr.siphum euphor.iae Thomas） feeding on cultivated Solanum tuber.sum and wild Solanur. ber.haulti to study the impact of water.availability and plant mutualistic ar.uscular.mycor.hizal （AM） fungi on aphid per.or.ance and susceptibility to a par.sitoid wasp （Aphidius er.i Haliday）. Plants wer. gr.wn under.glass with live or.ster.le AM fungal spor.s and supplied with sufficient or.r.duced water.supply. Plants wer. infested with 1 of 3 genotypes ofM. euphor.iae or.maintained as aphidfr.e contr.ls; aphid abundance was scor.d after.1 week, after.which aphid susceptibility to A. er.i was assayed explanta. Solar.um tuber.sum accumulated c. 20% mor. dr. mass than S. ber.haultii, and r.ot mass of S. ber.haultii was smallest under.r.duced water.supply in the pr.sence of AM fungi. Aphid abundance was lowest on S. ber.haultii and highest for.genotype ＂2＂ aphids; genotype ＂1＂ aphid density was par.icular.y r.duced on S. ber.haultii. Aphid genotype ＂1＂ exhibited low susceptibility to par.sitism and was attacked less fr.quently than the other.two mor. susceptible aphid genotypes. Neither.AM fungi nor.water.availability affected insect per.or.ance. Our.study suggests a fitness tr.de-offin M. euphor.iae between par.sitism r.sistance and aphid per.or.ance on poor.quality Solar.um hosts that war.ants fur.her.explor.tion, and indicates the impor.ance of accounting for.genotype identity in deter.ining the outcome of multitr.phic inter.ctions.

关键词： Aphidius er.i ar.uscular.mycor.hizal fungi multitr.phic inter.ction par.sitism r.sistance Solanum spp.

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神童黑客和他的两万名受害人

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商业周刊（中文版） 2024年第7期 62-71页

作者： Dr.KE bennett JUUSO WESTEr.UND(摄影) 许诺(译) 不详

亚历山大·基维迈基是一位网络神童他正因一场前所未有的恶性犯罪而受审。巴黎西郊的库尔贝沃区紧邻塞纳河左岸,拉德芳斯商务区就位于这里。在市区可以远远看到拉德芳斯的一簇簇摩天大楼;从卢浮宫沿香榭丽舍大街穿过凯旋门,这条长长的... 详细信息

亚历山大·基维迈基是一位网络神童他正因一场前所未有的恶性犯罪而受审。巴黎西郊的库尔贝沃区紧邻塞纳河左岸,拉德芳斯商务区就位于这里。在市区可以远远看到拉德芳斯的一簇簇摩天大楼;从卢浮宫沿香榭丽舍大街穿过凯旋门,这条长长的中轴线终点就是市容乏善可陈的拉德芳斯。

关键词：香榭丽舍大街库尔贝摩天大楼乏善可陈中轴线商务区塞纳河

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