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World Journal of Clinical Cases 2023年第22期11卷 5344-5350页

作者： Laura Abbruzzese Giulia Martinelli Giulia Salti Benedetta Basagni Alessio Damora Cristiano Scarselli Giulia Peppoloni Aleksandra Podgorska Giuliana Rosso Marco Bacci Alba Rosa Alfano MAURO mancuso CRT Tuscany Rehabilitation ClinicMontevarchiArezzo 52025Italy Physical and Rehabilitative Medicine Unit NHS ASL-Tuscany South EstGrosseto 58100Italy Department of Internal Medicine and Medical Specialties UOC GeriatricsSapienza University of RomeRome 00185Italy

Meningitis is a possible complication of pneumococcal infection concerning acute otitis media and *** might compromise cognitive function,both for the infection itself and the vascular events that sometimes follow the acute *** SUMMARY Here we describe the case of a 32-year-old female patient admitted to the emergency room due to extensive pneumococcal meningitis as a consequence of sinus *** presented with extensive laminar ischemic damage in the acute phase,resulting in severe cognitive and behavioural *** years of follow-up,through neuropsychological assessments and neuroradiological investigations,demonstrated the presence of subsequent vascular events,3 months and 2 years after *** The case is discussed in light of scientific knowledge of the long-term outcomes of this pathology in order to potentially improve diagnosis and promote better outcomes.

关键词： Pneumococcal meningitis Stroke,Cognitive and behavioural functioning Long-term outcome Case report

Hepatocellular Carcinoma and Liver Transplantation:State of the Art

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Journal of Clinical and Translational Hepatology 2014年第3期2卷 176-181页

作者： Andrea mancuso Giovanni Perricone Epatologia e Gastroenterologia Ospedale Niguarda Ca'GrandaMilanoItaly Medicina Interna 1 Azienda di Rilievo Nazionale ad Alta Specializzazione Civico-Di Cristina-BenfratelliPalermoItaly

Hepatocellular carcinoma (HCC) is an aggressive tumor that often occurs in chronic liver disease and *** incidence of HCC is growing *** respect to any other available treatment for liver cancer,liver transplantation (LT) has the highest potential to *** for removal at once of both the tumor ("seed")and the damaged-hepatic tissue ("soil") where cancerogenesis and chronic liver disorders have progressed *** Milan criteria (MC) have been applied worldwide to select patients with HCC for LT,yielding a 4-year survival rate of 75%.These criteria represent the benchmark for patient selection and are the basis for comparison with any other suggested ***,MC are often considered to be too restrictive,and recent data show that between 25% and 50% of patients with HCC are currently transplanted beyond conventional ***,any unrestricted expansion of selection criteria will increase the need for donor organs,lengthen waiting periods,increase drop-out rates,and impair outcomes on intention-to-treat *** of HCC recurrence after LT is *** are a few reports available regarding the safety and efficacy of sorafenib for HCC recurrence after LT,but the data are heterogeneous.A multi-center prospective randomized controlled trial comparing placebo with sorafenib is ***,a metaanalysis of patient survival with sorafenib for HCC recurrence after LT could be helpful to characterize the therapeutic benefit and safety of ***,we review the use of LT for HCC,with particular emphasis on the selection criteria for transplantation in patients with HCC and management of HCC recurrence after LT.

关键词： Hepatocellular carcinoma Liver transplantation Selection criteria Milan criteria Recurrence Sorafenib

Observation of a single protein by ultrafast X-ray diffraction

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Light(Science & Applications) 2024年第1期13卷 80-90页

作者： Tomas Ekeberg Dameli Assalauova Johan Bielecki Rebecca Boll Benedikt J.Daurer Lutz A.Eichacker Linda E.Franken Davide E.Galli Luca Gelisio Lars Gumprecht Laura H.Gunn Janos Hajdu Robert Hartmann Dirk Hasse Alexandr Ignatenko Jayanath Koliyadu Olena Kulyk Ruslan Kurta Markus Kuster Wolfgang Lugmayr Jannik Lübke Adrian P.mancuso Tommaso Mazza Carl Nettelblad Yevheniy Ovcharenko Daniel E.Rivas Max Rose Amit K.Samanta Philipp Schmidt Egor Sobolev Nicusor Timneanu Sergey Usenko Daniel Westphal Tamme Wollweber Lena Worbs Paul Lourdu Xavier Hazem Yousef Kartik Ayyer Henry N.Chapman Jonas A.Sellberg Carolin Seuring Ivan A.Vartanyants Jochen Küpper Michael Meyer Filipe R.N.C.Maia Laboratory of Molecular Biophysics Department of Cell and Molecular BiologyUppsala UniversityHusargatan 3(Box 596)SE-75124 UppsalaSweden Deutsches Electronen-Synchrotron DESY Notkestrasse 8522607 HamburgGermany European XFEL Holzkoppel 422869 SchenefeldGermany Diamond Light Source Harwell Science&Innovation CampusDidcot OX110DEUK University of Stavanger Centre Organelle ResearchRichard-Johnsensgate 44021 StavangerNorway Leibniz Institute for Experimental Virology(HPI) Centre for Structural Systems BiologyNotkestraße 8522607 HamburgGermany Dipartimento di Fisica“Aldo Pontremoli” Universitàdegli Studi di Milanovia Celoria 1620133 MilanoItaly Center for Free-Electron Laser Science DESY22607 HamburgGermany Plant Biology Section School of Integrative Plant ScienceCornell UniversityIthacaNY 14853USA PNSensor GmbH Otto-Hahn-Ring 6D-81739 MünchenGermany Biomedical and X-Ray Physics Department of Applied PhysicsAlbaNova University CenterKTH Royal Institute of TechnologySE-10691 StockholmSweden ELI Beamlines/IoP Institute of Physics AS CR v.v.i.Na Slovance 218221 Prague 8Czech Republic Multi-User CryoEM Facility Centre for Structural Systems BiologyNotkestr.8522607 HamburgGermany University Medical Center Hamburg-Eppendorf(UKE) Martinistrasse 5220246 HamburgGermany The Hamburg Center for Ultrafast Imaging Universität HamburgLuruper Chaussee 14922761 HamburgGermany Department of Physics Universität HamburgLuruper Chaussee 14922761 HamburgGermany Department of Chemistry and Physics La Trobe Institute for Molecular ScienceLa Trobe UniversityMelbourneVIC 3086Australia Division of Scientific Computing Science for Life LaboratoryDepartment of Information TechnologyUppsala UniversityBox 337SE-75105 UppsalaSweden European Molecular Biology Laboratory c/o DESYNotkestrasse 8522607 HamburgGermany Department of Physics and Astronomy Uppsala UniversityBox 516SE-75120 UppsalaSweden Max Planck Institute for the Structure and Dynamics of Matter Luruper Chaussee 14922761 HamburgGe

The idea of using ultrashort X-ray pulses to obtain images of single proteins frozen in time has fascinated and inspired *** was one of the arguments for building X-ray free-electron *** to theory,the extremely intense pulses provide sufficient signal to dispense with using crystals as an amplifier,and the ultrashort pulse duration permits capturing the diffraction data before the sample inevitably *** was first demonstrated on biological samples a decade ago on the giant *** then,a large collaboration has been pushing the limit of the smallest sample that can be *** ability to capture snapshots on the timescale of atomic vibrations,while keeping the sample at room temperature,may allow probing the entire conformational phase space of *** we show the first observation of an X-ray diffraction pattern from a single protein,that of Escherichia coli GroEL which at 14 nm in diameter is the smallest biological sample ever imaged by X-rays,and demonstrate that the concept of diffraction before destruction extends to single *** the pattern,it is possible to determine the approximate orientation of the *** experiment demonstrates the feasibility of ultrafast imaging of single proteins,opening the way to single-molecule time-resolved studies on the femtosecond timescale.

关键词： smallest intense ultrafast

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铝抑制拟南芥根尖PIN2循环和囊泡运输

科学通报 2008年第15期53卷 1785-1792页

作者：沈宏侯凌艳 SCHLICHT Markus WAN Ying Lang mancuso Stefano BALUSKA Frantisek 华南农业大学资源环境学院广州510642 Institute of Cellular and Molecular Botany University of BonnBonn D-53115Germany Electrophysiology Laboratory Department of HorticultureUniversity of FlorenceFlorence 1-50019Italy

铝对植物毒害作用最明显的症状是迅速抑制根尖生长.然而,铝抑制根尖生长的机制并不清楚.本文研究了铝对生长素和生长素运输载体(PIN2)囊泡运输的影响.结果表明,铝抑制拟南芥根尖生长素运输,其中过渡区生长素抑制率最高,达66%.布雷菲尔... 详细信息

铝对植物毒害作用最明显的症状是迅速抑制根尖生长.然而,铝抑制根尖生长的机制并不清楚.本文研究了铝对生长素和生长素运输载体(PIN2)囊泡运输的影响.结果表明,铝抑制拟南芥根尖生长素运输,其中过渡区生长素抑制率最高,达66%.布雷菲尔德菌素(Brefeldin A,BFA,一种囊泡运输抑制剂)明显诱导PIN2囊泡在细胞内形成点状结构,铝处理降低点状结构的大小,表明铝抑制PIN2囊泡在细胞内的运输.实时定量PCR和蛋白印迹反应发现,铝增加PIN2基因的转录表达,促进PIN2蛋白在细胞膜水平方向累积.细胞骨架解聚药物处理表明,铝抑制PIN2囊泡的运输,主要通过破坏肌球蛋白微丝来完成.铝处理下,拟南芥根尖伸长区细胞比过渡区具有较少的铝吸收和较低的囊泡运输频率.上述结果表明,通过调节生长素运输载体(PIN2)在质膜与胞内移动,阻碍生长素的运输,铝抑制了拟南芥根尖的生长.

关键词：铝处理 PIN2 拟南芥细胞骨架生长素运输

Development of a sensor for the detection of Escherichia coli in brackish waters

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Journal of Coastal Life Medicine 2016年第3期4卷 200-202页

作者： mancuso Monique Grossi Marco Rappazzo Alessandro Ciro Zaccone Renata Caruso Gabriella RiccòBruno Bergamasco Alessandro Institute for Coastal Marine Environment(IAMC-CNR)-Section of Messina Spianata S.Raineri 8698122Italy Department of Electronic Engineering(D.E.I.S.)Bologna-University of Bologna Via Zamboni 3340126 BolognaItaly

Monitoring of bacterial pathogens is important for marine environmental protection,because the presence of these microorganisms can be a serious risk for human *** this reason,a portable sensor implemented as an electronic embedded system featuring disposable measurement cells was used to evaluate the ability and sensitivity of detection of Escherichia coli(***)as an indicator of fecal pollution in transitional environments and a water sample added with ***(10^(2) CFU/mL)was *** first result obtained from the laboratory experiment seems promising for the determination of *** in environmental samples,though further improvements will be needed for the field application of this sensor in marine and brackish waters.

关键词： Monitoring Waters Escherichia coli Portable sensor Fecal pollution Environment

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社交媒体上应该避免的七个致命失误

成功营销 2014年第11期 66-67页

作者： Karen Stuth Joan mancuso 5 Square Research研究公司

确保你的社交媒体经理、团队或者信息收集小组在社交媒体采用的方式、论调、音量和态度都能保持同步,这样你就能迅速成为社交媒体营销界的一个明星了。社交媒体作为主流营销工具的重要性和有效性对我们来说已经不是新闻。HubSpot的最新... 详细信息

确保你的社交媒体经理、团队或者信息收集小组在社交媒体采用的方式、论调、音量和态度都能保持同步,这样你就能迅速成为社交媒体营销界的一个明星了。社交媒体作为主流营销工具的重要性和有效性对我们来说已经不是新闻。HubSpot的最新调研报告显示,在过去两年间,全球消费者在社交媒体上花费的时间增长了250%。即使是中小零售商也已经认识到社交媒体作为一个高效经济的营销工具的重要性。

关键词：媒体营销社交营销工具媒体作为中小零售商信息收集有效性消费者

Left bundle branch block and myocardial infarction, a diagnosis not always easy: Our experience and review of literature

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World Journal of Cardiovascular Diseases 2012年第2期2卷 90-94页

作者： Angela Sansone Francesca Bonura Fabiana Castellano Rosanna Iacona Dario mancuso Giuseppina Novo Pasquale Assennato Salvatore Novo Department of Internal Medicine Cardiovascular and Nephro-Urological Disease Unit of Cardiology University of Studies “P. Gi-accone” Palermo Palermo Italy

The occurrence of left bundle branch block (LBBB) is quite common in clinical practice. The changes in cardiac repolarization, caused by this disorder of electric conduction, may mask the presence of an acute myocardial infarction (AMI), delaying the diagnostic-therapeutic iter, with an important impact on prognosis. We describe the case of a woman of 59 years with LBBB, came to our observation for a constrictive chest pain associated with dyspnea. The diagnostic workup for suspected acute coronary syndrome (ACS), initially conducted only on the analysis of the electrocardiogram (negative TnI at entry), showed the presence of coronary arteries free of stenosis. However, the diagnostic confirmation of AMI was completed after the rise of cardiac markers and the electrocardiographic changes. This case confirm the difficulty about the diagnosis of AMI in patients with LBBB and stresses, however, as the use of some criteria proposed in the literature [1-3] can guide to its identification, directing patient to an appropriate treatment.

关键词： Left Bundle Branch Block (LBBB) Myocardial Infarction Electrocardiogram.

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两种大型联轴器的结构及其选用

汽轮机技术 1987年第4期 16-18页

作者： JONR mancuso 涂以德福建三明重机厂

圆盘联轴器和隔盘联轴器虽然类似,但其功能却不同,一旦用错就可能导致设备严重损坏。

关键词：联轴器挠性连轴器力学性能隔盘圆盘

THERAPY FOR PRIMATE COLOR BLINDNESS

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THERAPY FOR PRIMATE COLOR BLINDNESS

Budd-Chiari syndrome management:Lights and shadows

第十八届国际眼科研究大会

作者： K.mancuso J.Neitz M.C.Mauck J.A.Kuchenbecker M.Neitz Department of Ophthalmology Medical College of WisconsinMilwaukeeWIU.S.A.

＜正＞It has been suggested that in primate evolution,red-green color vision arose when a new class of middle-（M-） to-long-（L-） wavelength cone produced red-green spectrally opponent receptive fields by exploiting a pre-existing midget pathway,or its predecessor, that served spatial ***,adapting circuitry that evolved to process achromatic

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World Journal of Hepatology 2011年第10期3卷 262-264页

作者： Andrea mancuso Epatologia e Gastroenterologia Ospedale Niguarda Ca'Granda

Budd-Chiari syndrome (BCS) is a rare disease whose management should follow a step by step *** and medical therapy should be the first line *** or TIPS are indicated in case of no response to medical *** should be indicated as a rescue therapy and anticoagulation be started soon after ***,no clear indica-tion can actually be given about the timing of different ***,there is some concern about treatment of some subgroup of patients,especially regarding the risk of recurrence after liver *** topic of this paper is to critically review the actual knowledge of BCS management.

关键词： Budd-Chiari syndrome Management Liver transplantation