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Laparoscopic, Endoscopic and Robotic Surgery 2022年第2期5卷 78-81页

作者： matthew mancuso Benjamin B.Beech David W.Chapman Blair St Martin Faculty of Medicine and Dentistry University of AlbertaEdmontonT6G 2R7Canada Division of Urology Department of SurgeryUniversity of AlbertaEdmontonT6G 2R7Canada

With an incidence of 1/500,a horseshoe kidney is not *** discovered in horseshoe kidney however are quite rare,and prove difficult to surgically manage due to complex vascular *** variable surgical approaches previously described,only a select few robot-assisted cases have been *** case describes one such robot-assisted laparoscopic heminephrectomy,with the use of indocyanine green and an endovascular stapler to successfully demarcate ischemia and achieve hemostasis *** complications were encountered,and pathology revealed a pT1bN0 clear cell renal cell carcinoma with negative surgical margins,demonstrating the feasibility of our approach.

关键词： Horseshoe kidney Robot-assisted Laparoscopic Partial nephrectomy Tumour

Final results of the first phase of the PROTO-SPHERA experiment: obtainment of the full current stable screw pinch and first evidences of the jet + torus combined plasma configuration

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Plasma Science and Technology 2024年第2期26卷 31-43页

作者： Paolo MICOZZI Franco ALLADIO Alessandro mancuso Vincenzo ZANZA Gerarda APRUZZESE Francesca BOMBARDA Luca BONCAGNI Paolo BURATTI Francesco FILIPPI Giuseppe GALATOLA TEKA Francesco GIAMMANCO Edmondo GIOVANNOZZI Andrea GROSSO Matteo IAFRATI Alessandro LAMPASI Violeta LAZIC Simone MAGAGNINO Simone MANNORI Paolo MARSILI Valerio PIERGOTTI Giuliano ROCCHI Alessandro SIBIO Benedetto TILIA Onofrio TUDISCO FSN Dipartimento Fusione e tecnologie per la Sicurezza Nucleare ENEA Agenzia Nazionale per Le Nuove Tecnologie Energia e lo Sviluppo Economico SostenibileFrascati(Rome)00044Italy IAPS Istituto di Astrofisica e Planetologia Spaziali INAF Istituto Nazionale di AstrofisicaRome O133Italy Physics Department University of Pisa Faculty of Natural Sciences Mathematics and PhysicsPisa 56127 Italy

In astrophysics, the boundary conditions for plasma phenomena are provided by nature and the astronomer faces the problem of understanding them from a variety of observations [Hester J J et al 1996 Astrophys. J. 456 225], on the other hand, in laboratory plasma experiments the electromagnetic boundary conditions become a major problem in the set-up of the machine that produces the plasma, an issue that has to be investigated step by step and to be modified and adapted with great patience, in particular in the case of an innovative plasma confinement experiment. The PROTO-SPHERA machine [Alladio F et al 2006 Nucl. Fusion 46 S613] is a magnetic confinement experiment, that emulates in the laboratory the jet + torus plasma configurations often observed in astrophysics: an inner magnetized jet of plasma centered on the(approximate) axis of symmetry and surrounded by a magnetized plasma torus orthogonal to this jet. The PROTO-SPHERA plasma is simply connected, i.e., no metal current conducting rod is linked to the plasma torus, while instead it is the inner magnetized plasma jet(in the following always called the plasma centerpost) that is linked to the torus. It is mandatory that no spurious plasma current path modifies the optimal shape of the plasma centerpost. Moreover, as the plasma torus is produced and sustained, in absence of any applied inductive electric field, by the inner plasma centerpost through magnetic reconnections [Taylor J B and Turner M F 1989 *** 29 219], it is required as well that spurious current paths do not surround the torus on its outboard, in order not to lower the efficiency of the magnetic reconnections that maintain the plasma torus at the expense of the plasma centerpost. Boundary conditions have been corrected,up to the point that the first sustainment in steady state has been achieved for the combined plasma.

关键词： laboratory plasmas magnetic confinement astrophysical plasmas

Gut-brain axis:does intestinal inflammation affect hippocampal neurogenesis and medulloblastoma development?

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Neural Regeneration Research 2023年第11期18卷 2381-2382页

作者： Arianna Casciati Mariateresa mancuso Roberta Vitali Simonetta Pazzaglia Biomedical Technologies Laboratory Agenzia Nazionale per le Nuove Tecnologiel’Energia e lo Sviluppo Economico Sostenibile(ENEA)RomeItaly

Gut-brain axis:does intestinal inflammation affect hippocampal neurogenesis and medulloblastoma development?Inflammatory bowel diseases (IBD) are a group of disorders that cause chronic inflammation in the intestines,associated with altered intestinal permeability,which in turn causes an immune response to enteric antigens in a gen etically susceptible *** incidence is high in industrialized countries and continuously rises in emerging economies.

关键词： inflammation diseases continuously

Palladium Iodide-Catalyzed Selective Carbonylative Double Cyclization of 4-(2-Aminophenyl)-3-yn-1-ols to Dihydrofuroquinolinone Derivatives

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Chinese Journal of Chemistry 2023年第21期41卷 2801-2809页

作者： Raffaella mancuso Alex De Salvo Patrizio Russo Aurelia Falcicchio Nicola Della Ca’ Leonardo Pantoja Munoz Bartolo Gabriele Laboratory of Industrial and Synthetic Organic Chemistry(LISOC) Department of Chemistry and Chemical TechnologiesUniversity of CalabriaVia Pietro Bucci 12/C87036 Acavacata di Rende(CS)Italy Institute of Crystallography National Research CouncilVia Amendola122/O70126 BariItaly Department of Chemistry Life Sciences and Environmental Sustainability(SCVSA)University of ParmaParco Area delle Scienze17/A43124 ParmaItaly Department of Natural Sciences Faculty of Science and TechnologyMiddlesex UniversityThe BurroughsNW44BT LondonUK

The PdI_(2)/KI-catalyzed oxidative carbonylation of 4-(2-aminophenyl)-3-yn-1-ols,bearing two potential nucleophilic groups in suitable position selectively leads to dihydrofuroquinolinone derivatives in fair to high yields(60%—89%)and excellent turnover numbers(180—267 mol of product per mol of Pd)over 19 examples,through a mechanistic pathway involving initial O-cyclization followed by *** such process,the selective catalytic construction of two rings and three new bonds is achieved in one synthetic step to afford high value added fused heterocyclic structures starting from readily available materials.

关键词： Carbonylation Cyclization Heterocycles Palladium Polycyclic heterocycles

Next-generation surgicalmeshes for drug delivery and tissue engineering applications:materials,design and emerging manufacturing technologies

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Bio-Design and Manufacturing 2021年第2期4卷 278-310页

作者： Francesca Corduas Dimitrios A.Lamprou Elena mancuso Nanotechnology and Integrated Bio-Engineering Centre(NIBEC) Ulster UniversityJordanstown CampusNewtownabbey BT370QBUK School of Pharmacy Queen’s University BelfastBelfast BT97BLUK

Surgical meshes have been employed in the management of a variety of pathological conditions including hernia,pelvic floor dysfunctions,periodontal guided bone regeneration,wound healing and more recently for breast plastic surgery after *** common pathologies affect a wide portion of the worldwide population;therefore,an effective and enhanced treatment is crucial to ameliorate patients’living conditions both from medical and aesthetic points of *** present,non-absorbable synthetic polymers are the most widely used class of biomaterials for the manufacturing of mesh implants for hernia,pelvic floor dysfunctions and guided bone regeneration,with polypropylene and poly tetrafluoroethylene being the most *** prostheses,such as surgical grafts,have been employed mainly for breast plastic surgery and wound healing *** the advantages of mesh implants to the treatment of these conditions,there are still many drawbacks,mainly related to the arising of a huge number of post-operative complications,among which infections are the most *** a mesh that could appropriately integrate with the native tissue,promote its healing and constructive remodelling,is the key aim of ongoing research in the area of surgical mesh *** this end,the adoption of new biomaterials including absorbable and natural polymers,the use of drugs and advanced manufacturing technologies,such as 3D printing and electrospinning,are under investigation to address the previously mentioned challenges and improve the outcomes of future clinical *** aim of this work is to review the key advantages and disadvantages related to the use of surgical meshes,the main issues characterizing each clinical procedure and the future directions in terms of both novel manufacturing technologies and latest regulatory considerations.

关键词： 3D printing Electrospinning Manufacturing technologies Biomaterials Drug delivery Surgical mesh implants

Food additives can act as triggering factors in celiac disease:Current knowledge based on a critical review of the literature

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World Journal of Clinical Cases 2019年第8期7卷 917-927页

作者： Clara mancuso Donatella Barisani Department of Medicine and Surgery University of Milano-Bicocca

Celiac disease(CeD) is an autoimmune disorder, mainly affecting the small intestine, triggered by the ingestion of gluten with the diet in subjects with a specific genetic status. The passage of gluten peptides through the intestinal barrier, the uptake by antigen presenting cells and their presentation to T cells represent essential steps in the pathogenesis of the disease. CeD prevalence varies in different populations, but a tendency to increase has been observed in various studies in recent years. A higher amount of gluten in modern grains could explain this increased frequency, but also food processing could play a role in this phenomenon. In particular, the common use of preservatives such as nanoparticles could intervene in the pathogenesis of CeD, due to their possible effect on the integrity of the intestinal barrier, immune response or microbiota. In fact, these alterations have been reported after exposure to metal nanoparticles,which are commonly used as preservatives or to improve food texture,consistency and color. This review will focus on the interactions between several food additives and the intestine, taking into account data obtained in vitro and in vivo, and analyzing their effect in respect to the development of CeD in genetically predisposed individuals.

关键词： Celiac disease Food additives Metallic nanoparticles Gluten Intestine Immune system

Palladium-Catalyzed Carbonylation of Multifunctionalized Substituted Alkynes to Quinolinone Derivatives under Mild Conditions

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Chinese Journal of Chemistry 2023年第23期41卷 3223-3228页

作者： Aleksandr Voronov Francesco Pancrazzi Ana Maria Constantin Raimondo Maggi Raffaella mancuso Bartolo Gabriele Diego Olivieri Carla Carfagna Alessandro Casnati Francesco Rispoli Laura Baldini Nicola Della Ca Department of Chemistry Life Sciences and Environmental Sustainability (SCVSA)University of ParmaParco Area delle Scienze17/A43124 Parma (PR)Italy Center for Energy and Environment (CIDEA) University of ParmaParco Area delle Scienze 181/A43124 Parma (PR)Italy Laboratory of Industrial and Synthetic Organic Chemistry (LISOC) Department of Chemistry and Chemical TechnologiesUniversity of CalabriaVia P.Bucci 12/C87036 Arcavacata di RendeCosenza (CS)Italy Department of Biomolecular Sciences University of Urbino “Carlo Bo”Piazza Rinascimento 661029 Urbino (PU)Italy Department of Industrial Chemistry “T.Montanari” University of BolognaViale Risorgimento 440136 Bologna (BO)Italy

A highly selective palladium-catalyzed carbonylation of 2-alkynylanilines bearing an amide moiety to condensed six-membered heterocyclic structures has been developed under mild conditions(room temperature and atmospheric pressure of CO).The carbonylative protocol is also compatible with CO surrogates,such as benzene-1,3,5-triyl triformate(TFBen)or the newly developed calix[6]arenes functionalized with six formate groups(CLX[6]CO),which are both capable to release CO in situ.A series of tricyclic fused heterocycles containing the important oxazino-quinolinone scaffold have been selectively obtained(only the 6-endo-dig cyclization mode has been observed)in good to excellent yields(up to 99%).

关键词： Pd-catalysis Carbonylation Alkynes CO surrogates 6-endo-dig Calixarenes C1 building blocks Domino reactions

How to Form a Nonprofit Corporation 5th

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Persistent dysexecutive syndrome after pneumococcal meningitis complicated by recurrent ischemic strokes:A case report

2002年

作者： mancuso, Anthony

Includes index.

ISBN: (纸本)9780873378062

Includes index.

关键词： Nonprofit organizations--Law and legislation--United States--Popular works Incorporation--United States--Popular works

来源：畅想之星图书光盘版（南... 评论

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World Journal of Clinical Cases 2023年第22期11卷 5344-5350页

作者： Laura Abbruzzese Giulia Martinelli Giulia Salti Benedetta Basagni Alessio Damora Cristiano Scarselli Giulia Peppoloni Aleksandra Podgorska Giuliana Rosso Marco Bacci Alba Rosa Alfano MAURO mancuso CRT Tuscany Rehabilitation ClinicMontevarchiArezzo 52025Italy Physical and Rehabilitative Medicine Unit NHS ASL-Tuscany South EstGrosseto 58100Italy Department of Internal Medicine and Medical Specialties UOC GeriatricsSapienza University of RomeRome 00185Italy

Meningitis is a possible complication of pneumococcal infection concerning acute otitis media and *** might compromise cognitive function,both for the infection itself and the vascular events that sometimes follow the acute *** SUMMARY Here we describe the case of a 32-year-old female patient admitted to the emergency room due to extensive pneumococcal meningitis as a consequence of sinus *** presented with extensive laminar ischemic damage in the acute phase,resulting in severe cognitive and behavioural *** years of follow-up,through neuropsychological assessments and neuroradiological investigations,demonstrated the presence of subsequent vascular events,3 months and 2 years after *** The case is discussed in light of scientific knowledge of the long-term outcomes of this pathology in order to potentially improve diagnosis and promote better outcomes.

关键词： Pneumococcal meningitis Stroke,Cognitive and behavioural functioning Long-term outcome Case report

Revisiting the Plant＇s Dilemma

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Molecular Plant 2016年第1期9卷 7-9页

作者： Jeffrey Leung Nadia Bazihizina Stefano mancuso Christiane Valon Institut de Biologie Inté grative de la Cellule Universit&eacute de Paris Saclay-Centre d'Energie Atomique Centre National de la Recherche Scientifique UMR9198 1 Avenue de la Terrasse B&acirc timent 23 91198 Gif-sur-Yvette Cedex France LINV-DISPAA Universit&agrave degli Studi di Firenze Viale delle idee 30 50019 Sesto Fiorentino Italy

In the opening salvos of his engaging article, How Stomata Resolve the Dilemma of Opposing Priorities, Raschke （1976） wrote that “Land plants are in a dilemma throughout their lives： assimilation of CO2 from the atmosphere requires intensive gas exchange; the prevention of excessive water loss demands that gas exchange be kept low.” What seemed a rarefied musing of a plant academic nearly 40 years ago has since broadened into alobal environmental concerns.

关键词： ABSCISIC-ACID CO2