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再同步-除颤治疗心力衰竭患者可有效改善长期生存

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中国临床药理学杂志 2024年第8期40卷 1193-1193页

作者： SAPP J l SIVAkUMARAN S REDPATH C J 孟海峰

本研究为一项双盲、随机、对照的多中心临床试验。旨在确定植入式心律转复除颤器(ICD)中添加心脏再同步治疗(CRT)+最佳药物治疗与单独使用ICD+最佳药物治疗比较是否可以降低死亡率和心力衰竭入院治疗。然而,CRT对心衰患者长期生存的影... 详细信息

本研究为一项双盲、随机、对照的多中心临床试验。旨在确定植入式心律转复除颤器(ICD)中添加心脏再同步治疗(CRT)+最佳药物治疗与单独使用ICD+最佳药物治疗比较是否可以降低死亡率和心力衰竭入院治疗。然而,CRT对心衰患者长期生存的影响尚不清楚。

关键词：多中心临床试验长期生存植入式心律转复除颤器心力衰竭患者再同步心衰患者最佳药物 ICD

Neutron-activated biodegradable samarium-153 acetylacetonate-poly-l-lactic acid microspheres for intraarterial radioembolization of hepatic tumors

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World Journal of Experimental Medicine 2020年第2期10卷 10-25页

作者： Yin-How wong Hun-Yee Tan Azahari kasbollah Basri Johan Jeet Abdullah Rajendra Udyavara Acharya Chai-Hong Yeong School of Medicine Faculty of Health and Medical SciencesTaylor’s UniversitySubang Jaya 47500SelangorMalaysia School of Biosciences Faculty of Health and Medical SciencesTaylor’s UniversitySubang Jaya 47500SelangorMalaysia Medical Technology Division Malaysian Nuclear AgencyBangi 43000SelangorMalaysia Department of Electronics and Computer Engineering Ngee Ann PolytechnicSingapore 599489Singapore

BACkGROUND liver cancer is the 6 th most common cancer in the world and the 4 th most common death from cancer *** radioembolization is a minimally invasive treatment involving intraarterial administration of radioembolic *** To develop a neutron-activated,biodegradable and theranostics samarium-153 acetylacetonate(153SmAcAc)-poly-l-lactic acid(PllA)microsphere for intraarterial radioembolization of hepatic *** Microspheres with different concentrations of 152SmAcAc(i.e.,100%,150%,175%and 200%w/w)were prepared by solvent evaporation *** microspheres were then activated using a nuclear reactor in a neutron flux of 2×10^12n/cm^2/s^1,converting 152Sm to Samarium-153(153)Sm)via 152Sm(n,γ) 153Sm *** SmAcAc-PllA microspheres before and after neutron activation were characterized using scanning electron microscope,energy dispersive X-ray spectroscopy,particle size analysis,Fourier transform infrared spectroscopy,thermo-gravimetric analysis and gamma *** in-vitro radiolabeling efficiency was also tested in both 0.9% sodium chloride solution and human blood plasma over a duration of 550 *** The SmAcAc-PllA microspheres with different SmAcAc contents remained spherical before and after neutron *** mean diameter of the microspheres was about 35μ*** activity achieved for 153SmAcAc-PllA microspheres with 100%,150%,175%and 200%(w/w)SmAcAc after 3 h neutron activation were 1.7±0.05,2.5±0.05,2.7±0.07,and 2.8±0.09 GBq/g,*** activity of per microspheres were determined as 48.36±1.33,74.10±1.65,97.87±2.48,and 109.83±3.71 Bq for 153SmAcAc-PllA microspheres with 100%,150%,175%and 200%(w/w)*** energy dispersive X-ray and gamma spectrometry showed that no elemental and radioactive impurities present in the microspheres after neutron *** efficiency of 153Sm in the SmAcAc-PllA microspheres was excellent(approximately 99%)in both 0.9%sodium chloride solution and hum

关键词： Radioembolization Samarium-153 Yittrium-90 Biodegradable microsphere liver tumors Neutron activation

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基于模糊控制的参数自调节光纤章动耦合算法

激光与光电子学进展 2024年第17期16卷 132-140页

作者：郭烽高世杰刘永凯吴昊吕福睿中国科学院长春光学精密机械与物理研究所中国科学院大学

针对空间激光通信单模光纤耦合系统中，传统激光章动算法参数固定，导致系统收敛速度与收敛稳定性无法兼得的问题，提出了一种基于模糊控制的参数自调节光纤章动耦合算法。该算法以快速反射镜（Fast steering mirror, FSM）为执行单元... 详细信息

针对空间激光通信单模光纤耦合系统中，传统激光章动算法参数固定，导致系统收敛速度与收敛稳定性无法兼得的问题，提出了一种基于模糊控制的参数自调节光纤章动耦合算法。该算法以快速反射镜（Fast steering mirror, FSM）为执行单元，根据实时耦合能量反馈值，在激光章动收敛过程中自调节算法参数，以提升系统的收敛速度与稳态精度。仿真结果表明：在无扰动条件下，参数自调节章动耦合算法的耦合效率、耦合精度、耦合速度均优于传统激光章动算法；在有扰动条件下，传统激光章动算法仅对一定条件下的扰动具有较好的抑制效果，参数自调节章动耦合算法对于1～20 Hz的扰动均有着较好的抑制效果，并且在耦合效率及耦合稳定性方面有着明显优势，更加适合应用于激光通信链路。

关键词：自由空间光通信单模光纤耦合激光章动模糊控制参数自调节

Capitalizing on Superconvergence for More Accurate Multi‑Resolution Discontinuous Galerkin Methods

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Communications on Applied Mathematics and Computation 2022年第2期4卷 417-436页

作者： Jennifer k.Ryan Applied Mathematics and Statistics Colorado School of MinesGoldenCO 80401USA

This article focuses on exploiting superconvergence to obtain more accurate multi-resolution analysis. Specifcally, we concentrate on enhancing the quality of passing of information between scales by implementing the Smoothness-Increasing Accuracy-Conserving (SIAC) fltering combined with multi-wavelets. This allows for a more accurate approximation when passing information between meshes of diferent resolutions. Although this article presents the details of the SIAC flter using the standard discontinuous Galerkin method, these techniques are easily extendable to other types of data.

关键词： Multi-resolution analysis Multi-wavelets Discontinuous Galerkin Smoothness-Increasing Accuracy-Conserving(SIAC) Post-processing Superconvergence Accuracy enhancement

Contribution of rat joint tissues to elevation of MMPs activities in joint fluids after ACl injury

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Contribution of rat joint tissues to elevation of MMPs activ...

Investigation into perturbed nucleoside metabolism and cell cycle for elucidating the cytotoxicity effect of resveratrol on human lung adenocarcinoma epithelial cells

2008年全国生物流变学与生物力学学术会议

作者： k-l Paul Sung "111"project laboratory of Biomechanics and Tissue Repair Bioengineering CollegeChongqing UniversityChongqing 400044China Departments of Bioengineering and Orthopaedics University of CaliforniaSan Diego9500 Gilman DriveLa JollaCA 92093-0412USA

Introduction:The incidence of the injury to the knee ligaments has been steadily increased as a result of growing popularity of sport *** the cruciate ligaments(anterior and posterior cruciate ligaments or ACl and PCl) are the most important,which have poor healing abilities that cannot be healed after primary *** current standard treatment for ACl injuries in active adults with functional instability is ligament reconstruction but it does not restore the normal ACl *** is revealed that there was high amount of

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Chinese Journal of Natural Medicines 2019年第8期17卷 608-615页

作者： lI Zheng CHEN Qian-Qian lAM Christopher Wai kei GUO Jian-Ru ZHANG Wei-Jia WANG Cai-Yun wong Vincent kam Wai YAO Mei-Cun ZHANG Wei State key laboratory of Quality Research in Chinese Medicines and Macao Institute for Applied Research in Medicine and Health Macao University of Science and Technology Macao 999078 China Faculty of Medicine Macao Institute for Applied Research in Medicine and Health Macao University of Science and TechnologyMacao 999078 China School of Pharmaceutical Sciences Sun Yat-sen University Guangzhou 510006 China

In an effort to understand the molecular events contributing to the cytotoxicity activity of resveratrol(RSV), we investigated its effects on human lung adenocarcinoma epithelial cell line A549 at different concentrations. Cellular nucleoside metabolic profiling was determined by an established liquid chromatography-mass spectrometry method in A549 cells. RSV resulted in significant decreases and imbalances of deoxyribonucleoside triphosphates(d NTPs) pools suppressing subsequent DNA synthesis. Meanwhile, RSV at high concentration caused significant cell cycle arrest at S phase, in which cells required the highest dNTPs supply than other phases for DNA replication. The inhibition of DNA synthesis thus blocked subsequent progression through S phase in A549 cells,which may partly contribute to the cytotoxicity effect of RSV. However, hydroxyurea(HU), an inhibitor of RNR activity, caused similar dNTPs perturbation but no S phase arrest, finally no cytotoxicity effect. Therefore, we believed that the dual effect of high concentration RSV, including S phase arrest and DNA synthesis inhibition, was required for its cytotoxicity effect on A549 cells. In summary,our results provided important clues to the molecular basis for the anticancer effect of RSV on epithelial cells.

关键词： Resveratrol lC-MS Deoxyribonucleotides DNA synthesis S phase arrest

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Observation of an Even-Odd Asymmetric Transport in High landau levels

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Chinese Physics letters 2017年第3期34卷 112-116页

作者：刘广同朱玉莹王钦庞远樊洁景秀年姬忠庆杨昌黎吕力杜瑞瑞 l.N.Pfeiffer k.W.West Daniel Chee Tsui laboratory Beijing National Laboratory for Condensed Matter PhysicsInstitute of PhysicsChinese Academy of SciencesBeijing 100190 Collaborative Innovation Center of Quantum Matter Beijing 100871 International Center for Quantum Materials Peking UniversityBeijing 100871 Department of Electrical Engineering Princeton UniversityPrincetonNew Jersey 08544USA

Magnetotransport experiments including tilt fields are performed on ultrahigh mobility l-shaped Hall-bar samples of GaAs/AlGaAs quantum wells. The low-temperature longitudinal resistivity （ρxx） data demonstrate that a striking even-odd asymmetric transport exists along the [110] direction at half filling in N ≥ 2 high landau levels. Although the origin for the peculiar even-odd asymmetry remains unclear, we propose that the coupling strength between electrons within the same landau level and between the neighboring two landau levels should be considered in future studies. The tilt field data show that the in-plane field can suppress the formation of both bubble and stripe phases.

关键词： Observation of an Even-Odd Asymmetric Transport in High landau levels 110

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A transformative approach to enhance the parameter information from microwave and infrared remote sensing measurements

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Big Earth Data 2020年第3期4卷 322-347页

作者： Prabhat k.koner Earth System Science Interdisciplinary Center University of MarylandCollege ParkMDUSA

In observational science,data is the foundation of a scientific model;satellite-derived parameters serve as data for earth sciences *** building of science is imprecise if data is *** sensing‘big data’provides a wealth of information for unlocking the mysteries of earth *** parameter estimation from remote sensing measurements is extremely ill-posed and the inverse method plays a significant role in extracting parameter *** this paper,predominant stochastic inverse methods in satellite retrieval applications are critically investigated from different schools of thought and several basic flaws are revealed,*** being treated as definite *** major drawbacks of these methods include a high reliance on a priori information and binding the satellite retrievals to in situ measurements.A fundamentally different and transformative approach is explored as an alternative.A rational,reliable,and repeatable determination of geophysical parameter values from remote sensing measurements is possible using the total least squares based deterministic inverse *** is a physical model-based data-driven optimization,where the error quantity is extracted from the problem itself for regularization on a case-by-case basis using singular vector decomposition of the augmented function of the Jacobian and the *** moving from the prevalent to the proposed inverse method,a paradigm shift in results from“information loss”to‘information gain’is achieved.

关键词： Infrared microwave remote sensing radiative transfer inverse problem parameter information

GAN与Diffusion在传统纹样设计中的实验研究

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丝绸 2024年第8期61卷 9-22页

作者：李莉毛子晗吕思奇袁晨旭彭玉旭长沙理工大学设计艺术学院长沙410114 长沙理工大学计算机与通信工程学院长沙410114

传统纹样是中国优秀传统文化的重要组成部分,传统人工设计已经无法满足纹样的现代设计需求,生成式AI为传统纹样设计提供了新的设计路径和方法。文章将生成式AI应用于传统纹样设计中,通过适配实验优选基于GAN的Style GAN和基于Diffusion... 详细信息

传统纹样是中国优秀传统文化的重要组成部分,传统人工设计已经无法满足纹样的现代设计需求,生成式AI为传统纹样设计提供了新的设计路径和方法。文章将生成式AI应用于传统纹样设计中,通过适配实验优选基于GAN的Style GAN和基于Diffusion的Stable Diffusion两种主流图像生成模型进行实验,采用技术分析与艺术分析相结合,对实验结果进行多角度、多维度对比分析,为设计师选择生成设计方法提供参照。实验结果表明,两个模型均能满足基本的艺术设计需求。Style GAN模型生成的纹样图像更接近真实图像的分布,具有更高的图像质量和多样性;Stable Diffusion模型能较好地传承传统纹样的基因,艺术性与创造性兼具,更加符合传统纹样的艺术设计需求。

关键词： GAN Diffusion 传统纹样评价指标对比分析实验研究

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