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Acetylsalicylic acid interferes with embryonic kidney growth and development by a prostaglandin-independent mechanism

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World journal of Nephrology 2017年第1期6卷 21-28页

作者： Simon jM Welham Alexander j Sparrow David S Gardner matthew j elmes Division of Nutritional Sciences School of BiosciencesUniversity of NottinghamLoughborough School of Veterinary Medicine and Science University of NottinghamLoughborough

AIM To evaluate the effects of the non-selective, non-steroidal anti-infammatory drug （NSAID） acetylsalicylic acid （ASA）, on ex vivo embryonic kidney growth and *** Pairs of fetal mouse kidneys at embryonic day 12.5 were cultured ex vivo in increasing concentrations of ASA （0.04-0.4 mg/mL） for up to 7 d. One organ from each pair was grown in control media and was used as the internal control for the experimental contralateral organ. In some experiments, organs were treated with ASA for 48 h and then transferred either to control media alone or control media containing 10 μmol/L prostaglandin E2 （PGE2） for a further 5 d. Fetal kidneys were additionally obtained from prostaglandin synthase 2 homozygous null or heterozygous （PTGS2-/- and PTGS2-/＋） embryos and grown in culture. Kidney cross-sectional area was used to determine treatment effects on kidney growth. Whole-mount labelling to fluorescently detect laminin enabled crude determination of epithelial branching using confocal *** ASA concentration （0.1, 0.2 and 0.4 mg/mL） significantly inhibited metanephric growth （P 〈 0.05）. After 7 d of culture, exposure to 0.2 mg/mL and 0.4 mg/mL reduced organ size to 53% and 23% of control organ size respectively （ P 〈 0.01）. Addition of 10 μmol/L PGE2 to culture media after exposure to 0.2 mg/mL ASA for 48 h resulted in a return of growth area to control levels. Application of control media alone after cessation of ASA exposure showed no benefit on kidney growth. Despite the apparent recovery of growth area with 10 μmol/L PGE2, no obvious renal tubular structures were formed. The number of epithelial tips generated after 48 h exposure to ASA was reduced by 40% （0.2 mg/mL; P 〈 0.05） and 47% （0.4 mg/mL; P 〈 0.01）. Finally, growth of PTGS2-/- and PTGS2＋/- kidneys in organ culture showed no differences, indicating that PTGS2 derived PGE2 may at best have a minor *** reduces early renal growth and development but the role of

关键词： Acetylsalicylic acid Nephrogenesis Kidney culture Non-steroidal anti-infammatory drug Prostaglandins Prostaglandin synthase 2

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Construction of a sequential light-harvesting system via supramolecular copolymerization

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Chinese Chemical Letters 2023年第8期34卷 1-2页

作者： Hongwei Qian Tangxin Xiao Robert B.P.elmes Leyong Wang School of Petrochemical Engineering Changzhou UniversityChangzhou 213164China Department of Chemistry Maynooth UniversityNational University of IrelandMaynoothCo.KildareIreland State Key Laboratory of Analytical Chemistry for Life Science Jiangsu Key Laboratory of Advanced Organic MaterialsSchool of Chemistry and Chemical EngineeringNanjing UniversityNanjing 210023China

The current energy crisis is a worldwide problem and the search for clean and economic energy production is a global *** this context,the exploitation and utilization of solar energy is becoming more and more *** in nature sets an outstanding example to harvest,transfer and store solar energy[1].In most of the photosynthetic organisms such as purple photosynthetic bacteria,the rigid protein scaffolds serve as key elements to bind pigments and control their excitation energy *** energy transfer is especially intriguing in this field to make full use of full-band solar *** mimic natural photosynthesis[2].

关键词： becoming harvesting store

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Construction of molecular nanotubes with precise length,diameter and chirality

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Chinese Chemical Letters 2023年第9期34卷 3-4页

作者： Qiaona Zhang Hongwei Qian Tangxin Xiao Robert B.P.elmes Leyong Wang School of Petrochemical Engineering Changzhou UniversityChangzhou 213164China Department of Chemistry Maynooth UniversityNational University of IrelandMaynoothCo.KildareIreland State Key Laboratory of Analytical Chemistry for Life Science Jiangsu Key Laboratory of Advanced Organic MaterialsSchool of Chemistry and Chemical EngineeringNanjing UniversityNanjing 210023China

Molecular nanotubes are nanoscale organic materials with tubular architecture,that show potential applications in molecular recognition/separation,cross-membrane transportation,catalysis in confined spaces,and nanoelectronics[1].However,the precise construction of molecular nanotubes with well-defined cavity sizes and shapes is non-trivial.

关键词： precise sizes molecular

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Dynamic materials fabricated from water soluble pillar[n]arenes bearing triethylene oxide groups

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Chinese Chemical Letters 2019年第2期30卷 271-276页

作者： Tangxin Xiao Ling Zhou Lixiang Xu Weiwei Zhong Wei Zhao Xiao-Qiang Sun Robert B.P.elmes School of Petrochemical Engineering Advanced Catalysis and Green Manufacturing Collaborative Innovation Center Changzhou University Department of Chemistry Maynooth University National University of Ireland

Pillar[n]arenes are a new kind of supramolecular macrocyclic hosts which have developed rapidly due to their unique topology and high functionality, giving rise to many applications in the construction of interesting and functional materials. Among them, water-soluble pillar[n]arenes bearing triethylene oxide (TEO) chains have drawn increasing research interest due to their advantageous properties. In this review, we summarized the recent progress of dynamic materials fabricated from water soluble pillar[n]arenes bearing TEO groups, including thermo responsive materials with lower critical solution temperature (LCST) behavior, cyclic host liquids, and smart windows. It is anticipated that more and more ‘smart' supramolecular materials based on modified pillar[n]arenes will be developed in this burgeoning area of research.

关键词： Pillar[n]arenes Host-guest interactions LCST Thermoresponsive materials Smart window

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An amphiphilic molecule with a single fluorophore exhibits multiple stimuli-responsive behavior

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Chinese Chemical Letters 2023年第11期34卷 159-162页

作者： Dongxing Ren Lu Tang Zhiying Wu Qiaona Zhang Tangxin Xiao Robert B.P.elmes Leyong Wang School of Petrochemical Engineering Changzhou UniversityChangzhou 213164China Department of Chemistry Maynooth UniversityNational University of IrelandMaynoothCo.KildareIreland jiangsu Key Laboratory of Advanced Organic Materials School of Chemistry and Chemical EngineeringNanjing UniversityNanjing 210023China

Fluorescent materials that respond to multiple stimuli have broad applications ranging from sensing and bioimaging to information ***,we report the design and synthesis of a single-fluorophorebased amphiphile DCSO,which shows temperature-,solvent-,humidity-,and radiation-dependent *** consists of a dicyanostilbene(DCS)group as a rigid hydrophobic core with oligo(ethylene glycol)(OEG)chains at both ends as a flexible hydrophilic *** DCS group acts as a highly efficient fluorophore,while the OEG chain endows the molecule with *** colors can vary from blue to green to yellow in response to external *** the basis of light radiation,we demonstrate that this system can be applied to time-dependent information encryption,in which the correct information can only be read at a specific time under *** work further demonstrates the usefulness and application of single-fluorophore-based luminescent materials with multiple stimuli-responsive functions.

关键词： Self-assembly Multi-responsive fluorescence Single fluorophore Information encryption Smart materials

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Artificial light-harvesting systems fabricated by supramolecular host–guest interactions

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Chinese Chemical Letters 2019年第1期30卷 31-36页

作者： Tangxin Xiao Weiwei Zhong Ling Zhou Lixiang Xu Xiao-Qiang Sun Robert B.P.elmes Xiao-Yu Hu Leyong Wang School of Petrochemical Engineering Advanced Catalysis and Green Manufacturing Collaborative Innovation Center Changzhou University Department of Chemistry Maynooth University National University of Ireland Key Laboratory of Mesoscopic Chemistry of MOE School of Chemistry and Chemical Engineering Nanjing University

Artificial light-harvesting systems(LHSs) have drawn increasing research interest in recent times due to the energy crisis worldwide. Concurrently, macrocycle-based host–guest interactions have played an important role in the development of supramolecular chemistry. In recent years, studies towards artificial LHSs driven by macrocycle-based host–guest interactions are gradually being disclosed. In this mini-review, we briefly introduce the burgeoning progress of artificial LHSs driven by host–guest interactions. We believe that an increasing number of reports of artificial LHSs driven by host–guest interactions will appear in the near future and will provide a viable alternative for the future production of renewable energy.

关键词： Light-harvesting systems Macrocycle Host-guest interactions Supramolecular chemistry Self-assembly

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