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Alterations of SARS-CoV-2 Evolutionary Dynamics by Pharmaceutical Factors

Infectious Diseases & Immunity 2024年第1期4卷 35-40页

作者： matthew halma EbMCsquared CIC Bath BA24BLUnited Kingdom

The outbreak of SARS-CoV-2(severe acute respiratory syndrome coronavirus 2)has been influenced by the human response to the *** responses have undoubtedly impacted the evolutionary dynamics of the virus in ways distinct from a scenario lacking a widespread *** important pharmaceutical interventions,vaccination and the utilization of medications,particularly molnupiravir,known to have mutagenic properties,were the focus of this *** impact of molnupiravir on human health was evaluated through 3 mechanisms:viral resistance,mutagenesis of SARS-CoV-2,and mutagenesis occurring in patients undergoing ***,as well as the impact of vaccination,have inadvertently given rise to unforeseen challenges in the management of the COVID-19 *** a systems view in future pandemic responses,and taking into account the evolution of the pandemic virus,may be critical to ending the pandemic at an earlier date.

关键词： COVID-19 SARS-CoV-2 Evolution Spike protein Molnupiravir Mutagenesis

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Life under tension: the relevance of force on biological polymers

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Biophysics Reports 2024年第1期10卷 48-56页

作者： matthew T.J.halma Longfu Xu Department of Physics and Astronomy and Laser Lab Vrije Universiteit Amsterdam LUMICKS B.V.

Optical tweezers have elucidated numerous biological processes, particularly by enabling the precise manipulation and measurement of tension. One question concerns the biological relevance of these experiments and the generalizability of these experiments to wider biological systems. Here, we categorize the applicability of the information garnered from optical tweezers in two distinct categories: the direct relevance of tension in biological systems, and what experiments under tension can tell us about biological systems, while these systems do not reach the same tension as the experiment, still, these artificial experimental systems reveal insights into the operations of biological machines and life processes.

关键词： Tension Optical tweezers Molecular force

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Applied whispering gallery modes on ZnO nanorods coated glass for humidity sensing application

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Optoelectronics Letters 2021年第5期17卷 298-301页

作者： Mohd Hafiz Jali Hazli Rafis Abdul Rahim Md Ashadi Md Johari Maslinda Mat Sharif Siti halma Johari Siddharth Thokchom Habibah Mohamed Moh Yasin Sulaiman Wadi Harun Department of Electrical Engineering University of MalayaKuala Lumpur50603Malaysia Faculty of Electrical Engineering Universiti Teknikal Malaysia MelakaMelaka76100Malaysia Faculty of Electronic and Computer Engineering Universiti Teknikal Malaysia MelakaMelaka76100Malaysia Faculty of Electrical and Electronic Engineering Technology Universiti Teknikal Malaysia MelakaMelaka76100Malaysia School of Technology Assam Don Bosco UniversityGuwahatiAssam781017India Malaysia-Japan International Institute of Technology Universiti Teknologi MalaysiaKuala Lumpur54100Malaysia Department of Physics Faculty of Science and TechnologyAirlangga UniversitySurabayaIndonesia

In this letter,a humidity sensor is demonstrated by applying a whispering gallery mode(WGM)from a microsphere resonator onto the ZnO nanorods coated glass *** diameter of the microsphere was 234μm and the glass surface was coated with ZnO nanorods using the hydrothermal method at growth duration of 12 h.A significant response to humidity level ranging from 35%RH to 85%RH has been observed with the sensitivity of 0.0142 nm/%*** proposed humidity sensor has successfully employed to enhance interaction between the whispering gallery mode evanescent and surrounds analyte with the assistance of ZnO nanorods coated glass.

关键词： WGM ZnO Applied whispering gallery modes on ZnO nanorods coated glass for humidity sensing application

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OXIDATION OF BETA-O-4 LIGNIN MODEL DIMERS BY H2O2 CATALYZED BY COPPER PHENANTHROLINE

OXIDATION OF BETA-O-4 LIGNIN MODEL DIMERS BY H2O2 CATALYZED ...

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第十六届木材、纤维及制浆化学国际会议

作者： Matilte halma Dominique Lachenal AlainDeronzier Nathalie Marlin Mikhail Zarubin Département de Chimie Méleculaire Université Joseph FourierUPR CNRS 5250301 rue de la ChimieBP 53 38041 Grenoble cedex 9France LGP2-Grenoble INP-Pagora 461 rue de la PapeterieBP 6538402St Martin d'Heres cedexFrance St-Petersburg State Forest Technical Academy Institutski per.5194021St-PetersburgRussia

This work aims at elucidating some of the key steps of the oxidation pathways of lignin model compounds using Cu(II)-phenantroline as catalyst and hydrogen peroxide as *** and non-phenolic beta-O-A dimeric phenyl propane structures were selected as lignin models since they represent the most abundant structures in lignin. The compounds used in this work are not commercially available;merefore all of them were synthesized. Oxidation reactions were carried out under alkaline conditions,at 80℃for 3 *** lignin model dimer(LMD) disappearance and some of the oxidation products were identified by HPLC analyses. Products as acetaldehyde,veratric or vanillic acid,and guaiacol were identified as resultant products of LMD oxidations.A tentative mechanism which involves the oxidation of the benzylic alcohol group followed by the cleavage of the beta-ether linkages is proposed.

关键词： lignin model dimer copper-phenanthroline hydrogen peroxide oxidation catalysis

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Sensorex发布SAM-1智能水质监测仪的安卓应用程序

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电脑与电信 2015年第4期 9-10页

作者：英国豪迈 halma 英国豪迈(halma)

加利福尼亚州加登格罗夫市2015年4月28日电/美通社/--Sensorex的SAM-1？智能水质监测仪目前可在全球范围内与安卓（Android）设备兼容。苹果 iPhone 和 iPad 的用户已经将SAM-1广泛应用于实验室和现场监测，它还能够测量并记录pH、ORP... 详细信息

加利福尼亚州加登格罗夫市2015年4月28日电/美通社/--Sensorex的SAM-1？智能水质监测仪目前可在全球范围内与安卓（Android）设备兼容。苹果 iPhone 和 iPad 的用户已经将SAM-1广泛应用于实验室和现场监测，它还能够测量并记录pH、ORP、导电率和温度数值。随着其安卓应用（Android App）的发布，安卓智能手机和平板电脑用户（安卓4.0及以上版本）现在能在环境、教育和工业应用中使用这种强大、便携的水质监测仪进行准确的水质分析测量。

关键词：水质监测仪应用程序智能手机加利福尼亚州 iPhone 分析测量全球范围 iPad

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紫外线（UV）和电子束（EB）固化体系中使用的稀释剂

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油墨 2000年第1期 22-25页

作者：王延文 halma.,R

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