检索结果-南通市图书馆

Delayed diagnosis of alpha-1-antitrypsin deficiency following post-hepatectomy liver failure: A case report

World Journal of Gastroenterology 2016年第11期22卷 3289-3295页

作者： Benjamin Norton Jemimah Denson Christopher Briggs matthew bowles David Stell Somaiah Aroori Peninsula College of Medicine and Dentistry Tamar Science Park Department of Histopathology Plymouth Hospitals NHS Trust Peninsula HPB Unit Derriford Hospital

Post-hepatectomy liver failure(PHLF) is a leading cause of morbidity and mortality following major liver resection. The development of PHLF is dependent on the volume of the remaining liver tissue and hepatocyte function. Without effective pre-operative assessment, patients with undiagnosed liver disease could be at increased risk of PHLF. We report a case of a 60-year-old male patient with PHLF secondary to undiagnosed alpha-1-antitrypsin deficiency(AATD) following major liver resection. He initially presented with acute large bowel obstruction secondary to a colorectal adenocarcinoma, which had metastasized to the liver. There was no significant past medical history apart from mild chronic obstructive pulmonary disease. After colonic surgery and liver directed neo-adjuvant chemotherapy, he underwent a laparoscopic partially extended right hepatectomy and radio-frequency ablation. Post-operatively he developed PHLF. The cause of PHLF remained unknown, prompting reanalysis of the histology, which showed evidence of AATD. He subsequently developed progressive liver dysfunction, portal hypertension, and eventually an extensive parastomal bleed, which led to his death; this was ultimately due to a combination of AATD and chemotherapy. This case highlights that formal testing for AATD in all patients with a known history of chronic obstructive pulmonary disease, heavy smoking, or strong family history could help prevent the development of PHLF in patients undergoing major liver resection.

关键词： Post-hepatectomy liver failure Alpha-1-antitrypsin deficiency Hepatectomy Functional liver remnant Liver resection

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Apples to oranges:environmentally derived,dynamic regulation of serotonin neuron subpopulations in adulthood?

引用

Neural Regeneration Research 2025年第9期20卷 2596-2597页

作者： Christopher J.O’Connell matthew J.Robson Department of Genetics College of MedicineHarvard UniversityBostonMAUSA James L.Winkle College of Pharmacy Division of Pharmaceutical SciencesUniversity of CincinnatiCincinnatiOHUSA Neuroscience Graduate Program College of MedicineUniversity of CincinnatiCincinnatiOHUSA

Traumatic brain injury(TBI)is a public health problem with an undue economic burden that impacts nearly every age,ethnic,and gender group across the globe(Capizzi et al.,2020).TBIs are often sustained during a dynamic range of exposures to energetic environmental forces and as such outcomes are typically heterogeneous regarding severity and pathology(Capizzi et al.,2020).

关键词： sustained orange dynamic

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Sex determination in mammalian germ cells

引用

Asian Journal of Andrology 2015年第3期17卷 427-432页

作者： Cassy M Spiller Josephine bowles Institute for Molecular Bioscience The University of Queens/and Brisbane QLD 4072 Australia

Germ cells are the precursors of the sperm and oocytes and hence are critical for survival of the species. In mammals, they are specified during fetal life, migrate to the developing gonads and then undergo a critical period during which they are instructed, by the soma, to adopt the appropriate sexual fate. In a fetal ovary, germ cells enter meiosis and commit to oogenesis, whereas in a fetal testis, they avoid entry into meiosis and instead undergo mitotic arrest and mature toward spermatogenesis. Here, we discuss what we know so far about the regulation of sex-specific differentiation of germ cells, considering extrinsic molecular cues produced by somatic cells, as well as critical intrinsic changes within the germ cells. This review focuses almost exclusively on our understanding of these events in the mouse model.

关键词： germ cells meiosis oocytes sex determination processes spermatozoa

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Complement-dependent neuroinflammation in spinal cord injury:from pathology to therapeutic implications

引用

Neural Regeneration Research 2025年第5期20卷 1324-1335页

作者： Hassan Saad Bachar El Baba Ali Tfaily Firas Kobeissy Juanmarco Gutierrez Gonzalez Daniel Refai Gerald R.Rodts Christian Mustroph David Gimbel Jonathan Grossberg Daniel L.Barrow matthew F.Gary Ali M.Alawieh Department of Neurosurgery Emory University School of MedicineAtlantaGAUSA Department of Neurology Yale UniversityNew HavenCTUSA Center for Neurotrauma Multiomics&Biomarkers(CNMB)Morehouse School of MedicineAtlantaGAUSA

Spinal cord injury remains a major cause of disability in young adults,and beyond acute decompression and rehabilitation,there are no pharmacological treatments to limit the progression of injury and optimize recovery in this *** the thorough investigation of the complement system in triggering and propagating cerebral neuroinflammation,a similar role for complement in spinal neuroinflammation is a focus of ongoing *** this work,we survey the current literature investigating the role of complement in spinal cord injury including the sources of complement proteins,triggers of complement activation,and role of effector functions in the *** study relevant data demonstrating the different triggers of complement activation after spinal cord injury including direct binding to cellular debris,and or activation via antibody binding to damage-associated molecular *** effector functions of complement have been implicated in spinal cord injury,and we critically evaluate recent studies on the dual role of complement anaphylatoxins in spinal cord injury while emphasizing the lack of pathophysiological understanding of the role of opsonins in spinal cord *** this pathophysiological review,we systematically review the different translational approaches used in preclinical models of spinal cord injury and discuss the challenges for future translation into human *** review emphasizes the need for future studies to dissect the roles of different complement pathways in the pathology of spinal cord injury,to evaluate the phases of involvement of opsonins and anaphylatoxins,and to study the role of complement in white matter degeneration and regeneration using translational strategies to supplement genetic models.

关键词： complement neuroinflammation neuroplasticity regeneration spinal cord injury targeted therapy

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Male sex determination： insights into molecular mechanisms

引用

Asian Journal of Andrology 2012年第1期14卷 164-171,180页

作者： Kathryn McClelland Josephine bowles Peter Koopman Institute for Molecular Bioscience The University of Queensland Brisbane QLD 4072 Australia

Disorders of sex development often arise from anomalies in the molecular or cellular networks that guide the differentiation of the embryonic gonad into either a testis or an ovary, two functionally distinct organs. The activation of the Y-linked gene Sry （sex- determining region Y） and its downstream target Sox9 （Sry box-containing gene 9） triggers testis differentiation by stimulating the differentiation of Sertoli cells, which then direct testis morphogenesis. Once engaged, a genetic pathway promotes the testis development while actively suppressing genes involved in ovarian development. This review focuses on the events of testis determination and the struggle to maintain male fate in the face of antagonistic pressure from the underlying female programme.

关键词： gonadal knockout mice sex determination sex-determining region Y protein sex disorders sex reversal sexual development testis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The consequences of genomic architecture on ecological speciation in postglacial fishes

引用

Current Zoology 2013年第1期59卷 53-71页

作者： Sean M. ROGERS Jonathan A. MEE Ella bowles Department of Biological Sciences University of Calgary 2500 University Drive NW Calgary Alberta T2N 1N4 Canada

The quest for the origin of species has entered the genomics era. Despite decades of evidence confirming the role of the environment in ecological speciation, an understanding of the genomics of ecological speciation is still in its infancy. In this review, we explore the role of genomic architecture in ecological speciation in postglacial fishes. Growing evidence for the num- ber, location, effect size, and interactions among the genes underlying population persistence, adaptive trait divergence, and re- productive isolation in these fishes reinforces the importance of considering genomic architecture in studies of ecological speci- ation. Additionally, these populations likely adapt to new freshwater environments by selection on standing genetic variation, as de novo mutations are unlikely under such recent divergence times. We hypothesize that modular genomic architectures in post- glacial fish taxa may be associated with the probability of population persistence. Empirical studies have confirmed the genic na- ture of ecological speciation, implicating surprisingly extensive linkage disequilibrium across the genome. An understanding of these genomic mosaics and how they contribute to reproductive barriers remains unclear, but migration rates and the strength of selection at these loci is predicted to influence the likelihood of population divergence. Altogether, understanding the role of ge- nomic architecture is an important component of speciation research and postglacial fishes continue to provide excellent organ- isms to test these questions, both from the perspective of variation in architectures among taxa, and with respect to the distinct environments they have colonized. However, more empirical tests of ecological speciation predictions are needed [Current Zoo- logy 59 （1）： 53-71, 2013].

关键词： Adaptation Ecological speciation Genomic architecture Modularity Postglacial fishes QTL

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Dickens and the stenographic mind

Dickens and the stenographic mind

引用

作者： Hugo bowles.

来源：南通市图书馆图书评论

学校读者我要写书评

暂无评论

Genetic basis for body size variation between an anadromous and two derived lacustrine populations of threespine stickleback Gasterosteus aculeatus in southwest Alaska

引用

Current Zoology 2016年第1期62卷 71-78页

作者： Ella bowles Rebecca A. JOHNSTON Stevi L. VANDERZWAN Sean M. ROGERS Department of Biological Sciences University of Calgary 2500 University Dr. N.W. Calgary Alberta T2N 1N4Canada

Body size is a highly variable trait among geographically separated populations. Size-assortative reproductive isolation has been linked to recent adaptive radiations of threespine stickleback （Gasterosteus aculeatus） into freshwater, but the genetic basis of the commonly found size differ- ence between anadromous and derived lacustrine sticklebacks has not been tested. We studied the genetic basis of size differences between recently diverging stickleback lineages in southwest Alaska using a common environment experiment. We crossed stickleback within one anadromous （Naknek River） and one lake （Pringle Lake） population and between the anadromous and two lake populations （Pringle and JoJo Lakes）, and raised them in a salinity of 4-6 ppt. The F1 anadromous and freshwater forms differed significantly in size, whereas hybrids were intermediate or exhibited dominance toward the anadromous form. Additionally, the size of freshwater Fls differed from their wild counterparts, with within-population Fls from Pringle Lake growing larger than their wild counterparts, while there was no size difference between lab-raised and wild anadromous fish. Sexual dimorphism was always present in anadromous fish, but not in freshwater, and not always in the hybrid crosses. These results, along with parallel changes among anadromous and fresh- water forms in other regions, suggest that this heritable trait is both plastic and may be under di- vergent and/or sexual selection.

关键词： adaptation body size common garden genetic basis threespine stickleback.

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A MONOTONE DOMAIN DECOMPOSITION ALGORITHM FOR SOLVING WEIGHTED AVERAGE APPROXIMATIONS TO NONLINEAR SINGULARLY PERTURBED PARABOLIC PROBLEMS

引用

Journal of Computational Mathematics 2008年第1期26卷 76-97页

作者： Igor Boglaev matthew Hardy Institute of Fundamental Sciences Massey UniversityPrivate Bag 11-222Palmerston NorthNew Zealand Mathematical Sciences Institute Australian National UniversityCanberraAustralia 0200

This paper presents and analyzes a monotone domain decomposition algorithm for solving nonlinear singularly perturbed reaction-diffusion problems of parabolic type. To solve the nonlinear weighted average finite difference scheme for the partial differential equation, we construct a monotone domain decomposition algorithm based on a Schwarz alternating method and a box-domain decomposition. This algorithm needs only to solve linear discrete systems at each iterative step and converges monotonically to the exact solution of the nonlinear discrete problem. domain decomposition algorithm is estimated The rate of convergence of the monotone Numerical experiments are presented.

关键词： Parabolic reaction-diffusion problem Boundary layers O-method Monotone domain decomposition algorithm Uniform convergence

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Schreibersite on the early Earth:Scenarios for prebiotic phosphorylation

引用

Geoscience Frontiers 2017年第2期8卷 329-335页

作者： matthew A.Pasek School of Ceoscience University of South FloridaTampaFL 33620USA

The mineral schreibersite,（Fe,Ni）_3P,provides a reactive source of phosphorus capable of forming phosphorylated *** molecules may have been an important component of prebiotic chemistry,allowing their build-up and eventual commencement of *** here are potential geochemical routes to providing schreibersite,as a potentially important prebiotic mineral,to the Hadean *** routes are identified：delivery of phosphides by meteoritic material and the reduction of phosphates to phosphides by high-temperature,low-redox *** 1-10% of all crustal phosphorus is estimated to have been in schreibersite during the Hadean,making the long-term reaction of this mineral with organic-laden water plausible for many ***,such conditions would have been conducive to the formation of life as we know it today.

关键词： Phosphorus Hadean Meteorites Thermodynamics Origin of life Prebiotic chemistry

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：