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A novel technique for unilateral dissection of the penile neurovascular bundle to prevent loss of penile sensation during treatment of Peyronie's disease-Initial results of a pilot study

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Current Urology 2023年第4期17卷 299-302页

作者： Alexandr M.Pinkhasov matthew beamer Daniel Shulman Rachel Yakubov Esther Pinkhasov Sergey Kravchick Department of Urology SUNY Upstate Medical University HospitalSyracuseNY 13202USA

Background:Plaque incision/excision and grafting are surgical techniques used to treat patients with Peyronie's disease who are refractory to less invasive interventions,have severe penile curvature,or have an hourglass ***,the procedure carries the risk of penile sensory loss because of the need for dissection of the neurovascular bundle(NVB).The aim of this study was to assess the feasibility of a novel technique for unilateral NVB dissection and its ability to preserve penile sensitivity while maintaining adequate correction of the penile *** and methods:Charts of patients who underwent unilateral NVB dissection during Peyronie's plaque incision/excision and grafting were retrospectively *** patients received preprocedural intracavernosal injections of TriMix,and the curvature was measured to be>70 *** 3 cases,an incision and minimal excision of the plaque were performed at the point of maximum curvature on the concave side of the *** 3 cases,Tutoplast allografts(Coloplast US,Minneapolis,MN)were used,whereas autografts were used in 2 other *** patients were examined at 1,3,and 6 months after the procedure when curvature and penile sensation were ***:Five patients underwent this *** mean age of patients was 55 years(45-70 years).All plaques were dorsally *** mean preoperative curvature was 78 degrees(75-90 degrees).At the 6-month follow-up,all patients had<15 degrees residual curvature and were satisfied with their cosmetic *** 1 patient continued with phosphodiesterase-5 inhibitors to improve potency at the 6-month *** patients reported normal penile glans *** patients experienced decreased sensation at the site of NVB dissection,but this was only detected when compared with the contralateral *** 2 patients reported a difference after 6 months,and only a minor area of involvement was ***:Unilateral NVB dissection is a feasi

关键词： Peyronie's disease Neurovascular bundle dissection

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A simplified treatment algorithm for chronic scrotal content pain syndrome

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Current Urology 2024年第4期18卷 251-256页

作者： Sergey Kravchick Sijo J.Parekattil Gennady Bratslavsky matthew R.beamer Robert Moldwin Daniel Shulman J.Curtis Nickel Arthur Smith Institute for Urology of the Northwell Health System RiverheadNYUSA Avant Concierge Urology Winter GardenFLUSA Department of Urology SUNY Upstate Medical UniversitySyracuseNYUSA Arthur Smith Institute for Urology of the Northwell Health System Lake SuccessNYUSA Binghamton University BinghamtonNYUSA Department of Urology Queen's UniversityKingstonOntarioCanada

Background Chronic scrotal content pain(CSCP)is a devastating condition characterized by localized scrotal pain that persists for≥3 months and interferes with daily *** 2.5%of all urology outpatient visits are associated with *** urologists may have difficulty treating these patients because of uncertainties regarding the etiology and pathophysiology of ***,we aimed to provide a simplified diagnostic and treatment approach for CSCP by subdividing it into distinct *** and methods We systematically reviewed the published literature in the PubMed,MEDLINE,and Cochrane databases for all reports on CSCP diagnosis and treatment using the keywords“chronic scrotal content pain,”“testicular pain,”“orchialgia,”“testicular pain syndrome,”“microdenervation of the spermatic cord,”“post-vasectomy pain syndrome,”“post-inguinal hernia repair pain,”“testialgia,”and“pudendal neuralgia.”This review included only CSCP-related articles published in English *** We subdivided CSCP syndrome into 5 clinical presentation types,including hyperactive cremasteric reflex,pain localized in the testicles,pain in the testis,spermatic cord,and groin,pain localized in the testicles,spermatic cord,groin,and pubis,and pain in the testicles,spermatic cord/groin,and penis/*** were adjusted stepwise for each type and *** included more information regarding the role of pudendal neuroglia in CSCP syndrome and discussed more options for nerve blocks for *** microsurgical spermatic cord denervation failure,we included treatment options for salvage ultrasound-guided targeted cryoablation,Botox injections,and posterior-inferior scrotal *** Different CSCP subtypes could help general urologists assess the appropriate diagnostic and treatment approaches for scrotal pain management in daily practice.

关键词： Chronic scrotal content pain Testicular pain Orchialgia Testicular pain syndrome Microdenervation of the spermatic cord Postvasectomy pain syndrome Postinguinal hernia repair pain Testialgia Pudendal neuralgia

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Characterization of the Expression of the ATP-Gated P2X7 Receptor Following Status Epilepticus and during Epilepsy Using a P2X7-EGFP Reporter Mouse

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Neuroscience Bulletin 2020年第11期36卷 1242-1258页

作者： James Morgan Mariana Alves Giorgia Conte Aida Menendez-Mendez Laura de Diego-Garcia Gioacchino de Leo Edward beamer Jonathon Smith Annette Nicke Tobias Engel Department of Physiology and Medical Physics Royal College of Surgeons in IrelandDublin D02 YN77Ireland FutureNeuro Science Foundation Ireland Research Centre for Chronic and Rare Neurological DiseasesRoyal College of Surgeons in IrelandDublin D02 YN77Ireland Walther Straub Institute of Pharmacology and Toxicology Faculty of MedicineLudwig-Maximilians-Universitat Miinchen80336 MunichGermany

Mounting evidence suggests that the ATP-gated P2X7 receptor contributes to increased hyperexcitability in the *** increased expression of P2X7 in the hippocampus and cortex following status epilepticus and during epilepsy has been repeatedly demonstrated,the cell type-specific expression of P2X7 and its expression in extra-hippocampal brain structures remains incompletely *** this study,P2X7 expression was visualized by using a transgenic mouse model overexpressing P2X7 fused to the fluorescent protein *** results showed increased P2X7-EGFP expression after status epilepticus induced by intra-amygdala kainic acid and during epilepsy in different brain regions including the hippocampus,cortex,striatum,thalamus and cerebellum,and this was most evident in microglia and *** of P2X7-EGFP with cell type-specific markers was not detected in neurons or *** data suggest that P2X7 activation is a common pathological hallmark across different brain structures,possibly contributing to brain inflammation and neurodegeneration following acute seizures and during epilepsy.

关键词： Purinergic signaling P2X7 Green fluorescence protein Status epilepticus Epilepsy Cell typespecific expression

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笑话:童“谚”童语

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疯狂英语（初中天地） 2012年第5期 58-59,60页

作者： beamer 非然

一位教一年级的老师收集了一些广为人知的谚语，他给班里的孩子每人一句谚语的前半部分，让他们完成后半部分。以下是孩子们的回答：

关键词：童语笑话一年级谚语孩子

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那些美好不会消逝

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新东方英语（中英文版） 2005年第9期 82-83页

作者： Lisa beamer 穆艾

本文作者莉莎的丈夫托德·比默(Todd beamer) 在“9·11”事件中丧生,本文是莉莎缅怀丈夫时对自己经历的一则往事的回忆。她想要告诉大家,请留意身边的人和物,珍惜每一天。

关键词：课堂丈夫讲台事件回忆恐怖分子作者面包经历课本

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永生难忘的一天(节选)

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新东方英语（中英文版） 2006年第9期 68-73页

作者： Lisa beamer 赵玉鑫

“9·11”事件中,在被恐怖分子劫持的美联航93次航班上,乘客们采取了行动,迫使飞机坠毁在无人居住的宾夕法尼亚荒地上,从而粉碎了恐怖分子企图让飞机撞击华盛顿国会山的计划。在电话录音中,人们听到乘客Toddbeamer的最后一句话是他发起... 详细信息

“9·11”事件中,在被恐怖分子劫持的美联航93次航班上,乘客们采取了行动,迫使飞机坠毁在无人居住的宾夕法尼亚荒地上,从而粉碎了恐怖分子企图让飞机撞击华盛顿国会山的计划。在电话录音中,人们听到乘客Toddbeamer的最后一句话是他发起攻击的号召:“Areyouready,guys?Let'sroll!”“(哥们,准备好了吗?动手吧!”)。在“9.11”后的美国“,Let'sroll!”成了一句纪念美联航93次航班英雄们的著名话语。Toddbeamer的妻子Lisabeamer写了一本纪念丈夫的书,书名就是“Let'sRoll!”。本文即节选自本书的第一章。

关键词：航班航空公司飞机坠毁电话录音恐怖分子甲骨文节选旧金山乘客播音员

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