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Detailed description of Division I ice hockey concussions:Findings from the NCAA and Department of Defense CARE Consortium

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Journal of Sport and Health Science 2021年第2期10卷 162-171页

作者： Kathryn L.Van Pelt Jaclyn B.Caccese James T.Eckner Margot Putukian MAlison Brooks Kenneth L.Cameron Megan N.Houston matthew a.posner Jonathan C.Jackson Gerald T.McGinty Cameron J.Hillis Thomas W.McAllister Michael A.McCrea Steven P.Broglio Thomas A.Buckley Sanders-Brown Center on Aging University of KentuckyLexingtonKY 40536-0230USA College of Medicine School of Health and Rehabilitation Sciences The Ohio State UniversityColumbusOH 43210USA Department of Physical Medicine and Rehabilitation Michigan MedicineUniversity of MichiganAnn ArborMI 48108USA University Health Services Princeton UniversityMcCosh Health CenterPrincetonNJ 08544USA Department of Orthopedics and Rehabilitation Department of PediatricsUniversity of Wisconsin School of Medicine and Public HealthMadisonWI 53705-2281USA Keller Army Hospital United States Military AcademyWest PointNY 10996USA th Medical Group United States Air Force AcademyColorado SpringsCO 80840-4000USA Sports Medicine Athletic DepartmentUnited States Air Force AcademyU.S.Air Force AcademyCO 80840-9500USA Novant Health Charlotte Independence Soccer ClubCorneliusNC 28031USA Department of Psychiatry Indiana UniversityIndianapolisIN 46202USA Neurosurgery Medical College of WisconsinMilwaukeeWI 53226USA Michigan Concussion Center University of MichiganAnn ArborMI 48109USA Kinesiology and Applied Physiology University of DelawareNewarkDE 19713USA

Objective:Since concussion is the most common injury in ice hockey,the objective of the current study was to elucidate risk factors,specific mechanisms,and clinical presentations of concussion in men’s and women’s ice ***:Ice hockey players from 5 institutions participating in the Concussion Assessment,Research,and Education Consortium were eligible for the current *** who sustained a concussion outside of this sport were *** were 332(250 males,82 females)athletes who participated in ice hockey,and 47(36 males,11 females)who sustained a ***:Previous concussion(odds ratio(OR)=2.00;95%confidence interval(95%CI):1.02‒3.91)was associated with increased incident concussion odds,while wearing a mouthguard was protective against incident concussion(OR=0.43;95%CI:0.22‒0.85).Overall,concussion mechanisms did not significantly differ between *** were specific differences in how concussions presented clinically across male and female ice hockey players,***(9.09%)were less likely than males(41.67%)to have a delayed symptom onset(p=0.045).Additionally,females took significantly longer to reach asymptomatic(p=0.015)and return-to-play clearance(p=0.005).Within the first 2 weeks post-concussion,86.11%of males reached asymptomatic,while only 45.50%of females reached the same phase of *** males(91.67%)were cleared for return to play within 3 weeks of their concussion,compared to less than half(45.50%)of ***:The current study proposes possible risk factors,mechanisms,and clinical profiles to be validated in future concussions studies with larger female sample *** specific risk factors,concussion mechanisms,and clinical profiles of concussion in collegiate ice hockey may generate ideas for future concussion prevention or intervention studies.

关键词： Concussion risk Injury mechanism Recovery

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Modern treatment of gastric gastrointestinal stromal tumors

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World Journal of Gastroenterology 2012年第46期18卷 6720-6728页

作者： Kevin K Roggin Mitchell C posner Department of Surgery Pritzker School of Medicine University of Chicago

Gastrointestinal stromal tumors (GIST) are rare mesenchymal smooth muscle sarcomas that can arise anywhere within the gastrointestinal tract. Sporadic mutations within the tyrosine kinase receptors of the interstitial cells of Cajal have been identified as the key molecular step in GIST carcinogenesis. Although many patients are asymptomatic, the most common associated symptoms include: abdominal pain, dyspepsia, gastric outlet obstruction, and anorexia. Rarely, GIST can perforate causing life-threatening hemoperitoneum. Most are ultimately diagnosed on cross-sectional imaging studies (i.e., computed tomography and/or magnetic resonance imaging in combination with upper endoscopy. Endoscopic ultrasonographic localization of these tumors within the smooth muscle layer and acquisition of neoplastic spindle cells harboring mutations in the c-KIT gene is pathognomonic. Curative treatment requires a complete gross resection of the tumor. Both open and minimally invasive operations have been shown to reduce recurrence rates and improve long-term survival. While there is considerable debate over whether GIST can be benign neoplasms, we believe that all GIST have malignant potential, but vary in their propensity to recur after resection and metastasize to distant organ sites. Prognostic factors include location, size (i.e., > 5 cm), grade (> 5-10 mitoses per 50 high power fields and specific mutational events that are still being defined. Adjuvant therapy with tyrosine kinase inhibitors, such as imatinib mesylate, has been shown to reduce the risk of recurrence after one year of therapy. Treatment of locally-advanced or borderline resectable gastric GIST with neoadjuvant imatinib has been shown to induce regression in a minority of patients and stabilization in the majority of cases. This treatment strategy potentially reduces the need for more extensive surgical resections and increases the number of patients eligible for curative therapy. The modern surgical treatment of

关键词： Gastrointestinal stromal tumors Laparoscopic resections of gastrointestinal stromal tumors Imatinib mesylate Gastrectomy

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Transhiatal versus transthoracic esophagectomy for esophageal cancer

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World Journal of Gastroenterology 2010年第30期16卷 3804-3810页

作者： J Camilo Barreto Mitchell C posner Section of General Surgery and Surgical Oncology Department of SurgeryUniversity of Chicago Pritzker School of Medicine5841 S. Maryland AveMC 5094ChicagoIL 60637United States

Esophageal cancer continues to represent a formidable challenge for both patients and clinicians. Relative 5-year survival rates for patients have improved over the past three decades, probably linked to a combination of improved surgical outcomes, progress in systemic chemotherapy and radiotherapy, and the increasing acceptance of multimodality treatment. Surgical treatment remains a fundamental component of the treatment of localized esophageal adenocarcinoma. Multiple approaches have been described for esophagectomy, which can be thematically grouped under two major categories: either transthoracic or transhiatal. The main controversy rests on whether a more extended resection through thoracotomy provides superior oncological outcomes as opposed to resection with relatively limited morbidity and mortality through a transhiatal approach. After numerous trials have addressed these issues, neither approach has consistently proven to be superior to the other one, and both can provide excellent short-term results in the hands of experienced surgeons. Moreover, the available literature suggests that experience of the surgeonand hospital in the surgical management of esophageal cancer is an important factor for operative morbidity and mortality rates, which could supersede the type of approach selected. Oncological outcomes appear to be similar after both procedures.

关键词： Esophageal cancer Transhiatal esophageal resection Transthoracic esophageal resection

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行政法的潮涨潮落

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比较法研究 2007年第4期21卷 149-155页

作者：理查德·A·波斯纳(Richard a.posner)[美] 蒋红珍(译) 不详上海交通大学

理论学派的法律是一个在认知上并不可靠的领域。它所采用的方法和视角已经受到当下政治和观念的冲击，并且因缺乏理论与实践的互动而显得摇摆不定。在本文中，我将阐述这一看似荒谬的结论，即：随着学术界与司法界不断改变对行政法形态... 详细信息

理论学派的法律是一个在认知上并不可靠的领域。它所采用的方法和视角已经受到当下政治和观念的冲击，并且因缺乏理论与实践的互动而显得摇摆不定。在本文中，我将阐述这一看似荒谬的结论，即：随着学术界与司法界不断改变对行政法形态和价值的塑造，法律将通过不断的去法化和日趋经济学化而获得发展。

关键词：行政法理论与实践理论学派学术界经济学法律司法

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Inhibition of P-glycoprotein by two artemisinin derivatives

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Natural Products and Bioprospecting 2012年第2期2卷 59-64页

作者： Babette STEGLICH Anne MAHRINGER Ying LI Gary H.posner Gert FRICKER Thomas EFFERTH Department of Pharmaceutical Biology Institute of Pharmacy and BiochemistryJohannes Gutenberg UniversityStaudinger Weg 5551 MainzGermany Institute of Pharmacy and Molecular Biotechnology Karl Ruprecht UniversityHeidelbergGermany Department of Synthetic Chemistry Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghaiChina Department of Chemistry Johns Hopkins UniversityBaltimore MDUSA

P-Glycoprotein/MDR1 represents an important component of the blood brain barrier and contributes to multidrug *** investigated two derivatives of the anti-malarial artemisinin,SM616 and GHP-AJM-3/23,concerning their ability to interact with *** ability of the two compounds to inhibit P-glycoprotein(P-gp)activity was examined in sensitive CCRF-CEM and P-gp over-expressing and multidrug-resistant CEM/ADR5000 cells as well as in porcine brain capillary endothelial cells(PBCEC)by means of calcein-AM *** as well-known P-gp inhibitor was used as control ***/ADR5000 cells exhibited cross-resistance to GHP-AJM-3/23,but slight collateral sensitivity to ***,SM616 inhibited calcein efflux both in CEM/ADR5000 and PBCEC,whereas GHP-AJM-3/23 did only increase calcein fluorescence in PBCEC,but not CEM/*** may be explained by the fact that CEM/ADR5000 only express P-gp but not other ATP-binding cassette transporters,whereas PBCEC are known to express several ABC transporters and calcein is transported by more than one ABC ***,SM616 may be the more specific P-gp *** conclusion,the collateral sensitivity of SM616 as well as the inhibition of calcein efflux in both CEM/ADR5000 cells and PBCEC indicate that this compound may be a promising P-gp inhibitor to treat cancer therapy and to overcome the blood brain barrier.

关键词： blood brain barrier calcein multidrug resistance P-glycoprotein

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Practice in English

Practice in English

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作者： M.posner

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法律经济学与法律实用主义

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北大法律评论 2013年第1期14卷 4-12页

作者：理查德·A.波斯纳陈铭宇芝加哥大学法学院美国联邦第七巡回法院上诉法院北京大学法学院

本文主要涉及三个内容：第一，法律经济分析是法律实用主义研究方法的一个分支。一个国家的法律职业群体和学者在使用经济分析时，必须要考虑其制度结构和法律文化是否能容纳这种方法；第二，经济学的面目可能是可怕的，可能令人心生畏... 详细信息

本文主要涉及三个内容：第一，法律经济分析是法律实用主义研究方法的一个分支。一个国家的法律职业群体和学者在使用经济分析时，必须要考虑其制度结构和法律文化是否能容纳这种方法；第二，经济学的面目可能是可怕的，可能令人心生畏惧，但同时它也可能是使法律变得更为清晰、更符合直觉的有效工具；第三，作者目前关注的两个法律经济学问题：司法行为的实证分析，以及，世界经济危机和经济分析（包括法律经济分析）的失败。

关键词：法律经济分析法律实用主义研究方法司法行为世界经济危机

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使用Synopsys的DesignWare~IP实现基于AMBA~3 AXI^(TM)协议的快速设计

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中国集成电路 2010年第7期19卷 47-54页

作者： Mick posner Product Marketing Manager

为了在最短时间内成功开发基于AMBA3AXI协议的设计,不仅仅需要精通简单设计和单个IP元件,更需要一套广泛的综合实现IP、验证IP以及集成整个SoC子系统的自动化方法。AMBA3高级扩展界面（AXI）协议由于大幅度扩展了AMBA2.0片上总线的性能... 详细信息

为了在最短时间内成功开发基于AMBA3AXI协议的设计,不仅仅需要精通简单设计和单个IP元件,更需要一套广泛的综合实现IP、验证IP以及集成整个SoC子系统的自动化方法。AMBA3高级扩展界面（AXI）协议由于大幅度扩展了AMBA2.0片上总线的性能和灵活性,因而具备了更多的优势,同时也增加了设计的复杂度。

关键词： AXI协议快速设计 AMBA 自动化方法最短时间片上总线子系统 SoC

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让有线网络和无线网络完美结合

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计算机教育 2004年第5期 40-41页

作者： David posner

伦敦佛里斯特中学是一所有远见的、并且愿意接受新科技的学校.近年来,在系统管理员的建议和指导下,我校在IT人员和设备等方面都进行了很大的投资,我们认为应该让所有学生和教师都能够尽可能地使用最好的设备.我们经常更换和升级硬件设备... 详细信息

伦敦佛里斯特中学是一所有远见的、并且愿意接受新科技的学校.近年来,在系统管理员的建议和指导下,我校在IT人员和设备等方面都进行了很大的投资,我们认为应该让所有学生和教师都能够尽可能地使用最好的设备.我们经常更换和升级硬件设备,以便能够使用最新的软件.所有建筑和学院通过光纤连接到计算机中心,计算机中心安装有最先进的文件服务器,提供大量教育软件.

关键词：伦敦佛里斯特中学无线局域网计算机化教学有线网络交换机网络结构

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快速实现基于AMBA 3 AXI协议的设计

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电子设计应用 2007年第1期 83-87页

作者： Mick posner Synopsys公司

基于AMBA 3 AXI协议进行高性能SoC设计的最大障碍是综合IP和验证IP的可用性,以及在最短的时间里有效创建复杂架构的能力。DesignWare针对AMBA 3AXI协议的IP解决方案提供了3个主要的必需组件,包括综合IP、验证IP和使用Synopsys coreAssem... 详细信息

基于AMBA 3 AXI协议进行高性能SoC设计的最大障碍是综合IP和验证IP的可用性,以及在最短的时间里有效创建复杂架构的能力。DesignWare针对AMBA 3AXI协议的IP解决方案提供了3个主要的必需组件,包括综合IP、验证IP和使用Synopsys coreAssembler工具的自动化子系统集成方法。这3个组件的结合使设计者减少了花费在下一代基于AMBA 3 AXI协议的高速设计上的设计和验证时间。

关键词： AXI协议 AMBA 设计快速实现系统性能事务处理控制通道管道连接

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